An integrated scientific framework for child survival and early childhood development.

Abstract:

:Building a strong foundation for healthy development in the early years of life is a prerequisite for individual well-being, economic productivity, and harmonious societies around the world. Growing scientific evidence also demonstrates that social and physical environments that threaten human development (because of scarcity, stress, or instability) can lead to short-term physiologic and psychological adjustments that are necessary for immediate survival and adaptation, but which may come at a significant cost to long-term outcomes in learning, behavior, health, and longevity. Generally speaking, ministries of health prioritize child survival and physical well-being, ministries of education focus on schooling, ministries of finance promote economic development, and ministries of welfare address breakdowns across multiple domains of function. Advances in the biological and social sciences offer a unifying framework for generating significant societal benefits by catalyzing greater synergy across these policy sectors. This synergy could inform more effective and efficient investments both to increase the survival of children born under adverse circumstances and to improve life outcomes for those who live beyond the early childhood period yet face high risks for diminished life prospects.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Shonkoff JP,Richter L,van der Gaag J,Bhutta ZA

doi

10.1542/peds.2011-0366

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

e460-72

issue

2

eissn

0031-4005

issn

1098-4275

pii

peds.2011-0366

journal_volume

129

pub_type

杂志文章
  • Treatment of atypical mycobacterial cervical adenitis with rifampin.

    abstract::The clinical response of atypical mycobacterial cervical adenitis to standard antituberculous therapy has been disappointing. Surgical procedures in the anterior cervical triangle are difficult and often complete excision is impossible. In each of four children with atypical mycobacterial cervical adenitis in this stu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Mandell F,Wright PF

    更新日期:1975-01-01 00:00:00

  • Eleven plasma proteins as indicators of protein nutritional status in very low birth weight infants.

    abstract::Concentrations of 11 plasma proteins were measured in 28 healthy, growing, very low birth weight, appropriate-for-gestational-age infants fed varying levels of human milk protein intake (range 1.7 to 3.9 g/kg per day). Significant positive correlations were found between mean protein intake and concentrations of 7 of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Polberger SK,Fex GA,Axelsson IE,Räihä NC

    更新日期:1990-12-01 00:00:00

  • Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis.

    abstract:OBJECTIVE:Although universal immunization against Bordetella pertussis (whooping cough) infection has resulted in dramatic reductions in the incidence of pertussis, outbreaks continue to occur in countries with excellent vaccine coverage. Treatment of infection may ameliorate symptom severity during the catarrhal phase...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.114.1.e96

    authors: Langley JM,Halperin SA,Boucher FD,Smith B,Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC).

    更新日期:2004-07-01 00:00:00

  • Infant sleep problems and postnatal depression: a community-based study.

    abstract:OBJECTIVES:To describe infant sleep patterns and investigate relationships between infant sleep problems and maternal well-being in the community setting. DESIGN:Cross-sectional community survey. Setting. Maternal and Child Health Centers in 3 middle-class local government areas in Melbourne, Australia. PARTICIPANTS:...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.6.1317

    authors: Hiscock H,Wake M

    更新日期:2001-06-01 00:00:00

  • Sleep parameters and respiratory variables in "near miss' sudden infant death syndrome infants.

    abstract::Twenty-nine near miss for sudden infant death syndrome and thirty normal infants between the ages of 3 weeks and 6 months were monitored polygraphically for 24 hours. The distribution of sleep and abnormal respiratory events were analyzed for both groups. On the basis of mixed and obstructive apnea, 12-hour nocturnal ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Guilleminault C,Ariagno R,Korobkin R,Coons S,Owen-Boeddiker M,Baldwin R

    更新日期:1981-09-01 00:00:00

  • Sweet syndrome associated with G-CSF treatment in a child with glycogen storage disease type Ib.

    abstract::Acute febrile neutrophilic dermatosis (Sweet syndrome) is rare in children and is regularly associated with underlying malignancies or inflammtory diseases. A 5-year-old girl with glycogen storage disease type Ib, neutropenia, and recurrent infections developed characteristic skin eruption of Sweet syndrome after 2 ye...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Garty BZ,Levy I,Nitzan M,Barak Y

    更新日期:1996-03-01 00:00:00

  • Pediatricians and general practitioners: a comparison of the management of children with febrile illness.

    abstract::To assess the relative competence of pediatricians and general practitioners in managing febrile illnesses in childhood, a prospective study was undertaken of 259 children less than 10 years of age seen consecutively at the emergency room of a children's hospital and a general hospital. Both groups of patients were si...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Leduc DG,Pless IB

    更新日期:1982-10-01 00:00:00

  • Incidence of mitral valve prolapse in adolescent scoliosis and thoracic hypokyphosis.

    abstract::Seventy-four patients with adolescent scoliosis underwent cardiac examination and M-mode echocardiography to detect the presence of mitral valve prolapse (MVP). Twenty-one (28%) had echocardiographic evidence of MVP, whereas 18 had auscultatory findings of a nonejection click or late systolic murmur. A subset of 41 pa...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Hirschfeld SS,Rudner C,Nash CL Jr,Nussbaum E,Brower EM

    更新日期:1982-09-01 00:00:00

  • Children in alcohol-related motor vehicle crashes.

    abstract::Review of North Carolina traffic crash data revealed that alcohol use, although associated with 7.9% of motor vehicle crashes involving children, accounted for 15.4% of the motor vehicle-related deaths and 10.4% of the injuries. The largest proportion of these deaths were child passengers in a vehicle in which the dri...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Margolis LH,Kotch J,Lacey JH

    更新日期:1986-06-01 00:00:00

  • Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection.

    abstract::Initial reports of congenital Zika virus (ZIKV) infection focused on microcephaly at birth with severe brain anomalies; the phenotype has broadened to include microcephaly that develops after birth and neurodevelopmental sequelae. In this narrative review, we summarize medical literature describing motor abnormalities...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2017-2038F

    authors: Pessoa A,van der Linden V,Yeargin-Allsopp M,Carvalho MDCG,Ribeiro EM,Van Naarden Braun K,Durkin MS,Pastula DM,Moore JT,Moore CA

    更新日期:2018-02-01 00:00:00

  • Successful resection of localized intestinal lymphangiectasia post-Fontan: role of (99m)technetium-dextran scintigraphy.

    abstract::Intestinal lymphangiectasia is a well-recognized complication of the Fontan procedure, occurring in up to 24% of patients. Because of the loss of chylous fluid into the gut lumen, protein-losing enteropathy results as well as lymphopenia and hypogammaglobulinaemia. In some cases, dilated lymphatics in the intestinal s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.3.e242

    authors: Connor FL,Angelides S,Gibson M,Larden DW,Roman MR,Jones O,Currie BG,Day AS,Bohane TD

    更新日期:2003-09-01 00:00:00

  • Discordance between male and female deaths due to the respiratory distress syndrome.

    abstract::General neonatal mortality statistics and those for the respiratory distress syndrome (RDS) were examined for the State of Wisconsin from 1979 through 1982. The objectives were to ascertain whether there are differences in total neonatal mortality related to sex and birth weight, to determine the veracity of reported ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Perelman RH,Palta M,Kirby R,Farrell PM

    更新日期:1986-08-01 00:00:00

  • Are Patients With Loeys-Dietz Syndrome Misdiagnosed With Beals Syndrome?

    abstract::Beals syndrome, also known as congenital contractural arachnodactyly (Online Mendelian Inheritance in Man: 121050), is an autosomal dominant disorder caused by a mutation in FBN2 that is typically characterized by congenital contractures and arachnodactyly. It shares a number of phenotypic features with Loeys-Dietz sy...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-1281

    authors: Woolnough R,Dhawan A,Dow K,Walia JS

    更新日期:2017-03-01 00:00:00

  • A Family-Centered Rounds Checklist, Family Engagement, and Patient Safety: A Randomized Trial.

    abstract:BACKGROUND AND OBJECTIVES:Family-centered rounds (FCRs) have become standard of care, despite the limited evaluation of FCRs' benefits or interventions to support high-quality FCR delivery. This work examines the impact of the FCR checklist intervention, a checklist and associated provider training, on performance of F...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2016-1688

    authors: Cox ED,Jacobsohn GC,Rajamanickam VP,Carayon P,Kelly MM,Wetterneck TB,Rathouz PJ,Brown RL

    更新日期:2017-05-01 00:00:00

  • Systematic evidence review of newborn screening and treatment of severe combined immunodeficiency.

    abstract:CONTEXT:Severe combined immunodeficiency (SCID) is a group of disorders that leads to early childhood death as a result of severe infections. Recent research has addressed potential newborn screening for SCID. OBJECTIVE:To conduct a systematic review of the evidence for newborn screening for SCID, including test chara...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2009-1567

    authors: Lipstein EA,Vorono S,Browning MF,Green NS,Kemper AR,Knapp AA,Prosser LA,Perrin JM

    更新日期:2010-05-01 00:00:00

  • Severe fatigue in adolescents: a common phenomenon?

    abstract:OBJECTIVE:The purpose of this study was to determine the prevalence of severe fatigue in adolescent boys and girls, to explore the role of lifestyle factors in fatigue, and to investigate whether severe fatigue in a healthy population is associated with depression, anxiety, and comorbid factors also observed in chronic...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2575

    authors: ter Wolbeek M,van Doornen LJ,Kavelaars A,Heijnen CJ

    更新日期:2006-06-01 00:00:00

  • Delayed recognition of human immunodeficiency virus infection in preadolescent children.

    abstract::Thirty-two (18%) of 181 children cared for at our institution who were infected with the human immunodeficiency virus type 1 (HIV-1) were first seen, and HIV was diagnosed, when they were 4 years of age and older. Initial complaints or diagnoses for these children included the following: hematologic disorders (5) (3 i...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Persaud D,Chandwani S,Rigaud M,Leibovitz E,Kaul A,Lawrence R,Pollack H,DiJohn D,Krasinski K,Borkowsky W

    更新日期:1992-11-01 00:00:00

  • Simulation in Pediatric Emergency Medicine Fellowships.

    abstract:BACKGROUND AND OBJECTIVES:Graduate medical education faces challenges as programs transition to the next accreditation system. Evidence supports the effectiveness of simulation for training and assessment. This study aims to describe the current use of simulation and barriers to its implementation in pediatric emergenc...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-4158

    authors: Doughty CB,Kessler DO,Zuckerbraun NS,Stone KP,Reid JR,Kennedy CS,Nypaver MM,Auerbach MA

    更新日期:2015-07-01 00:00:00

  • Rapid elimination of quinidine in pediatric patients.

    abstract::The oral absorption and elimination of quinidine in pediatric patients was studied. Single oral doses of quinidine sulfate were administered to 13 patients ranging in age from 4 to 22 years of age. Serum quinidine concentration reached a peak within 30 minutes to two hours after drug administration. The serum half-lif...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Szefler SJ,Pieroni DR,Gingell RL,Shen DD

    更新日期:1982-09-01 00:00:00

  • Treatment of congenital generalized lymphangiectasia with propranolol in a preterm infant.

    abstract::Generalized lymphangiectasia is a rare congenital disorder characterized by dilated lymphatic vessels with a fatal prognosis, especially in cases with thoracic involvement. We describe the use of propranolol in the therapy of generalized lymphangiectasia in a preterm infant with hydrops fetalis. Propranolol was well t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-2087

    authors: Poralla C,Specht S,Born M,Müller A,Bartmann P,Müller A

    更新日期:2014-02-01 00:00:00

  • Attitudes toward neonatal intensive care treatment of preterm infants with a high risk of developing long-term disabilities.

    abstract:OBJECTIVES:To assess (1) the differences in attitudes toward disabilities of 3 groups of subjects involved in neonatal care decision-making: health care workers, mothers of term infants, and parents of preterm infants, and (2) the impact of subject characteristics on these attitudes including parental education level, ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2061

    authors: Lam HS,Wong SP,Liu FY,Wong HL,Fok TF,Ng PC

    更新日期:2009-06-01 00:00:00

  • Esophageal spasm associated with apnea and bradycardia in an infant.

    abstract::A newborn infant was found to have diffuse esophageal spasm in association with apnea and bradycardia. This association has not been physiologically documented before. The infant's condition improved after the administration of glycopyrrolate, an anticholinergic agent. It is speculated that the association of esophage...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Fontán JP,Heldt GP,Heyman MB,Marin MS,Tooley WH

    更新日期:1984-01-01 00:00:00

  • The effect of maternal antibody on the serologic response and the incidence of adverse reactions after primary immunization with acellular and whole-cell pertussis vaccines combined with diphtheria and tetanus toxoids.

    abstract:OBJECTIVE:To evaluate the effect of maternally derived antibody on the immunogenicity and reactogenicity of acellular (DTaP) or whole-cell (DTP) pertussis vaccine with diphtheria and tetanus toxoids combined. METHODS:A total of 2342 infants were randomized to receive one of 13 DTaP or 2 DTP vaccines at 2, 4, and 6 mon...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Englund JA,Anderson EL,Reed GF,Decker MD,Edwards KM,Pichichero ME,Steinhoff MC,Rennels MB,Deforest A,Meade BD

    更新日期:1995-09-01 00:00:00

  • Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. The Children's Leukemia Cooperative Group of the European Organization of Research and Treatment of Cancer (EORTC).

    abstract:OBJECTIVE:Skin involvement in children with acute monocytic leukemia or CD30-positive anaplastic large-cell lymphoma is well-known. In contrast, very little is known about the malignant cutaneous infiltrates in children with acute lymphoblatic leukemia (ALL) or lymphoblastic lymphoma (LBL). This study was designed to d...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.100.1.60

    authors: Millot F,Robert A,Bertrand Y,Mechinaud F,Laureys G,Ferster A,Brock P,Rohrlich P,Mazingue F,Plantaz D,Plouvier E,Pacquement H,Behar C,Rialland X,Chantraine JM,Guilhot F,Otten J

    更新日期:1997-07-01 00:00:00

  • Risk Stratification to Decrease Unnecessary Diagnostic Imaging for Acute Appendicitis.

    abstract:BACKGROUND:There has been an increase in the use of imaging modalities to diagnose appendicitis despite evidence that can help identify children at especially high or low risk of appendicitis who may not benefit. We hypothesized that the passive diffusion of a standardized care pathway (including diagnostic imaging rec...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.2015-4031

    authors: Depinet H,von Allmen D,Towbin A,Hornung R,Ho M,Alessandrini E

    更新日期:2016-09-01 00:00:00

  • Relative efficacy of an incubator and an open warmer in producing thermoneutrality for the small premature infant.

    abstract::To determine which warming system more closely approximates a neutral thermal environment, the oxygen consumption of 16 premature babies, weighing less than 1,500 gm each, was measured in a convectively heated incubator and under an open radiant warmer. Both systems were controlled to maintain a skin temperature of 36...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: LeBlanc MH

    更新日期:1982-04-01 00:00:00

  • Using registries to identify adverse events in rheumatic diseases.

    abstract::The proven effectiveness of biologics and other immunomodulatory products in inflammatory rheumatic diseases has resulted in their widespread use as well as reports of potential short- and long-term complications such as infection and malignancy. These complications are especially worrisome in children who often have ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2013-0755

    authors: Lionetti G,Kimura Y,Schanberg LE,Beukelman T,Wallace CA,Ilowite NT,Winsor J,Fox K,Natter M,Sundy JS,Brodsky E,Curtis JR,Del Gaizo V,Iyasu S,Jahreis A,Meeker-O'Connell A,Mittleman BB,Murphy BM,Peterson ED,Raymond SC

    更新日期:2013-11-01 00:00:00

  • Early dexamethasone therapy in preterm infants: a follow-up study.

    abstract:OBJECTIVES:To study the outcome at 2-year corrected age of infants who participated in a double-blind controlled trial of early (<12 hours) dexamethasone therapy for the prevention of chronic lung disease (CLD). METHODS AND MATERIALS:A total of 133 children (70 in the control group, 63 in the dexamethasone-treated gro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.5.e7

    authors: Yeh TF,Lin YJ,Huang CC,Chen YJ,Lin CH,Lin HC,Hsieh WS,Lien YJ

    更新日期:1998-05-01 00:00:00

  • Quality of life for children with functional abdominal pain: a comparison study of patients' and parents' perceptions.

    abstract:OBJECTIVE:Children with chronic abdominal pain of nonorganic origin, termed functional abdominal pain (FAP), experience school absences and social withdrawal and report impaired physical ability. The aim of this study was to assess patients' and parents' perceptions of health-related quality of life (QoL) for children ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0114

    authors: Youssef NN,Murphy TG,Langseder AL,Rosh JR

    更新日期:2006-01-01 00:00:00

  • The psychological consequences of Turner syndrome and review of the National Cooperative Growth Study psychological substudy.

    abstract:OBJECTIVE:To present longitudinal data on the psychological profile of a cohort of girls with and without Turner syndrome (TS) treated for 3 years with growth hormone (GH). METHODS:Among a sample of 283 children with short stature, 37 girls with TS were recruited at 27 US medical centers. Of the original cohort, 22 gi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Siegel PT,Clopper R,Stabler B

    更新日期:1998-08-01 00:00:00