The effect of maternal antibody on the serologic response and the incidence of adverse reactions after primary immunization with acellular and whole-cell pertussis vaccines combined with diphtheria and tetanus toxoids.


OBJECTIVE:To evaluate the effect of maternally derived antibody on the immunogenicity and reactogenicity of acellular (DTaP) or whole-cell (DTP) pertussis vaccine with diphtheria and tetanus toxoids combined. METHODS:A total of 2342 infants were randomized to receive one of 13 DTaP or 2 DTP vaccines at 2, 4, and 6 months of age. The correlation between preimmunization and postimmunization antibody after three doses of vaccine and the relation between preimmunization antibody and adverse reactions after the first immunization were modeled by linear regression. RESULTS:After DTP but not DTaP, higher levels of preexisting antibody were associated with substantial (28% to 56%) reductions in the subsequent antibody response to pertussis toxin (PT). For other pertussis antibodies, modest inverse correlations were seen between preexisting antibody concentrations and most postimmunization antibody responses (resulting in 8% to 18% reductions in postimmunization antibody) for both DTP and DTaP. There was no consistent association in any DTP or DTaP group between adverse reactions and preimmunization antibody levels. CONCLUSION:The PT antibody response to DTaP, unlike DTP, is not adversely affected by preexisting antibody to PT. Inhibitory effects with respect to other antibodies, seen with both DTP and DTaP, were relatively modest. Our data suggest that the use of acellular pertussis vaccines in adults, which could confer higher levels of antibody in women before pregnancy, would be unlikely to adversely affect pertussis antibody responses after DTaP among infants born to mothers with high antibody levels.






Englund JA,Anderson EL,Reed GF,Decker MD,Edwards KM,Pichichero ME,Steinhoff MC,Rennels MB,Deforest A,Meade BD


Has Abstract


1995-09-01 00:00:00




3 Pt 2








  • Randomized, controlled trial comparing synchronized intermittent mandatory ventilation and synchronized intermittent mandatory ventilation plus pressure support in preterm infants.

    abstract:BACKGROUND:Prolonged mechanical ventilation is associated with lung injury in preterm infants. In these infants, weaning from synchronized intermittent mandatory ventilation may be delayed by their inability to cope with increased respiratory loads. The addition of pressure support to synchronized intermittent mandator...


    pub_type: 杂志文章,随机对照试验


    authors: Reyes ZC,Claure N,Tauscher MK,D'Ugard C,Vanbuskirk S,Bancalari E

    更新日期:2006-10-01 00:00:00

  • Variability in head circumference growth rate during the first 2 years of life.

    abstract::The head circumference (HC) curves were plotted for a group of 415 healthy full-term babies over the first 2 years of life. Two hundred ten (51%) of the cohort demonstrated HC variability, defined as an HC acceleration or deceleration of at least 1 centile curve for at least 2 months. Of these, the deceleration patter...


    pub_type: 杂志文章


    authors: Jaffe M,Tal Y,Hadad B,Tirosh E,Tamir A

    更新日期:1992-08-01 00:00:00

  • Unscheduled Referrals and Unattended Appointments After Pediatric Subspecialty Referral.

    abstract:OBJECTIVES:Incomplete subspecialty referrals, whether unscheduled or unattended, represent unmet patient needs and an opportunity to improve patient safety and experiences. Our objectives were to describe the rates of appointment scheduling and visit attendance after pediatric subspecialty referral and to examine patie...


    pub_type: 杂志文章


    authors: Bohnhoff JC,Taormina JM,Ferrante L,Wolfson D,Ray KN

    更新日期:2019-12-01 00:00:00

  • The misuse of antibiotics for treatment of upper respiratory tract infections in children.

    abstract::Antibiotic therapy has been shown to be of no value in the treatment of the URI--either in shortening the course of the acute illness or in preventing the development of secondary bacterial infections. Patient expense, as well as the threat of adverse reactions, should prohibit the present practice by some of routinel...


    pub_type: 杂志文章


    authors: Soyka LF,Robinson DS,Lachant N,Monaco J

    更新日期:1975-04-01 00:00:00

  • Severe methemoglobinemia complicating topical benzocaine use during endoscopy in a toddler: a case report and review of the literature.

    abstract::Severe methemoglobinemia resulting from the use of topical benzocaine has been reported in adults as a rare complication. Here we report a case of severe acquired methemoglobinemia resulting from topical use of benzocaine spray during diagnostic upper gastrointestinal endoscopy in a 3-year-old boy with repeated episod...


    pub_type: 杂志文章,评审


    authors: Dahshan A,Donovan GK

    更新日期:2006-04-01 00:00:00

  • Idiopathic disseminated bacillus Calmette-Guérin infection: a French national retrospective study.

    abstract:OBJECTIVE:Disseminated bacillus Calmette-Guérin (BCG) infection after inoculation of live vaccine is considered to result from impaired immunity of the child. However, in half of the cases, regarded as idiopathic, no well-defined immunodeficiency condition can account for the infection. The objective of the present stu...


    pub_type: 杂志文章


    authors: Casanova JL,Blanche S,Emile JF,Jouanguy E,Lamhamedi S,Altare F,Stéphan JL,Bernaudin F,Bordigoni P,Turck D,Lachaux A,Albertini M,Bourrillon A,Dommergues JP,Pocidalo MA,Le Deist F,Gaillard JL,Griscelli C,Fischer A

    更新日期:1996-10-01 00:00:00

  • Translating child abuse research into action.

    abstract::The Child Abuse Recognition Experience Study revealed that primary care clinicians did not always follow the legal mandate to report suspected child abuse to child protective services. National child abuse experts representing different disciplines met in a 2-day conference in January 2007 to discuss and develop new s...


    pub_type: 杂志文章


    authors: Flaherty EG,Sege RD,Hurley TP

    更新日期:2008-09-01 00:00:00

  • Effects of upgraded child restraint law designed to increase booster seat use in New York.

    abstract:OBJECTIVE:The goal was to examine the association between the New York State (NYS) upgraded child restraint law (UCRL) implemented in 2005 and the traffic injury rate among 4- to 6-year-old children in New York State. METHODS:A before/after comparison study of population-based, traffic injury rates for 4- to 6-year-ol...


    pub_type: 杂志文章


    authors: Sun K,Bauer MJ,Hardman S

    更新日期:2010-09-01 00:00:00

  • An Extravagant Gift From a Grateful Patient.

    abstract::media-1vid110.1542/5787668327001PEDS-VA_2017-2837Video AbstractGift giving is psychologically and culturally complex. In any context, a gift can have multiple meanings. In the context of the doctor-patient relationship, the giving of gifts and decisions about whether to accept gifts raise complex ethical issues. In th...


    pub_type: 杂志文章


    authors: Sharma A,Johnson LM,Caruso Brown A,Unguru Y,Lantos JD

    更新日期:2018-06-01 00:00:00

  • Diagnosis of HIV-1 infection in children younger than 18 months in the United States.

    abstract::The objectives of this technical report are to describe methods of diagnosis of HIV-1 infection in children younger than 18 months in the United States and to review important issues that must be considered by clinicians who care for infants and young children born to HIV-1-infected women. Appropriate HIV-1 diagnostic...


    pub_type: 杂志文章,评审


    authors: Read JS,Committee on Pediatric AIDS, American Academy of Pediatrics.

    更新日期:2007-12-01 00:00:00

  • Is zero central line-associated bloodstream infection rate sustainable? A 5-year perspective.

    abstract:BACKGROUND AND OBJECTIVE:Adoption and implementation of evidence-based measures for catheter care leads to reductions in central line-associated bloodstream infection (CLABSI) rates in the NICU. The purpose of this study is to evaluate whether this rate reduction is sustainable for at least 1 year and to identify key d...


    pub_type: 杂志文章


    authors: Erdei C,McAvoy LL,Gupta M,Pereira S,McGowan EC

    更新日期:2015-06-01 00:00:00

  • Intrauterine rubella, head size, and intellect.

    abstract::The assumption that congenital rubella is commonly associated with microcephaly and mental retardation was examined. Among a rubella clinic population of 111 children, 92 children had vision sufficient to allow testing by the Leiter International Scale. The mean IQ for this group was 99.46 (SD, 19.5). Head circumferen...


    pub_type: 杂志文章


    authors: Macfarlane DW,Boyd RD,Dodrill CB,Tufts E

    更新日期:1975-06-01 00:00:00

  • Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates.

    abstract::Therapeutic moderate hypothermia in newborns with hypoxic-ischemic encephalopathy is rapidly becoming standard clinical practice. We report here 12 cases of subcutaneous fat necrosis among 1239 cases registered with a national registry of newborns treated with moderate whole-body hypothermia. All the infants suffered ...


    pub_type: 杂志文章


    authors: Strohm B,Hobson A,Brocklehurst P,Edwards AD,Azzopardi D,UK TOBY Cooling Register.

    更新日期:2011-08-01 00:00:00

  • Campylobacter jejuni-associated hemolytic-uremic syndrome in a mother and daughter.

    abstract::A mother and daughter with Campylobacter jejuni-associated hemolytic-uremic syndrome (HUS) are discussed. The mother was hospitalized with bloody diarrhea and HUS; C jejuni was isolated from her stool. The 2-year-old daughter had been admitted five days prior to her mother with HUS following a three-day prodrome of vo...


    pub_type: 杂志文章


    authors: Chamovitz BN,Hartstein AI,Alexander SR,Terry AB,Short P,Katon R

    更新日期:1983-02-01 00:00:00

  • Validity of Newborn Clinical Assessment to Determine Gestational Age in Bangladesh.

    abstract:BACKGROUND:Gestational age (GA) is frequently unknown or inaccurate in pregnancies in low-income countries. Early identification of preterm infants may help link them to potentially life-saving interventions. METHODS:We conducted a validation study in a community-based birth cohort in rural Bangladesh. GA was determin...


    pub_type: 杂志文章


    authors: Lee AC,Mullany LC,Ladhani K,Uddin J,Mitra D,Ahmed P,Christian P,Labrique A,DasGupta SK,Lokken RP,Quaiyum M,Baqui AH,Projahnmo Study Group.

    更新日期:2016-07-01 00:00:00

  • Recurrent pneumonia in children and its relationship to bronchial hyperreactivity.

    abstract::To determine what conditions are most likely to cause persistent or recurrent pneumonia (PRP) in children, the records of 81 children referred to James Whitcomb Riley Hospital for Children for evaluation of PRP were reviewed. Twenty patients had an apparent underlying cause that predisposed them to PRP. Of the 61 rema...


    pub_type: 杂志文章


    authors: Eigen H,Laughlin JJ,Homrighausen J

    更新日期:1982-11-01 00:00:00

  • Flunisolide aerosol for treatment of severe, chronic asthma in steroid-independent children.

    abstract::The efficacy and safety of flunisolide aerosol were studied in 46 steroid-independent children with asthma inadequately controlled by nonsteroid drugs. This was a double-blind, placebo-controlled, parallel study lasting eight weeks. Patients were randomly assigned either flunisolide by inhalation, 0.5 mg twice a day, ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Meltzer EO,Kemp JP,Orgel HA,Izu AE

    更新日期:1982-03-01 00:00:00

  • Air pollution and infant death in southern California, 1989-2000.

    abstract:OBJECTIVE:We evaluated the influence of outdoor air pollution on infant death in the South Coast Air Basin of California, an area characterized by some of the worst air quality in the United States. METHODS:Linking birth and death certificates for infants who died between 1989 and 2000, we identified all infant deaths...


    pub_type: 杂志文章


    authors: Ritz B,Wilhelm M,Zhao Y

    更新日期:2006-08-01 00:00:00

  • Early treatment of premature infants with recombinant human erythropoietin.

    abstract:OBJECTIVES:The specific objectives of this study were (1) to assess the safety and efficacy of recombinant human erythropoietin (rhEPO) in reducing postnatal hemoglobin decline in premature infants of less than 33 weeks' gestation, and thus reducing the need for transfusion; and (2) to determine the optimal dosage of r...


    pub_type: 临床试验,杂志文章


    authors: Messer J,Haddad J,Donato L,Astruc D,Matis J

    更新日期:1993-10-01 00:00:00

  • Prevalence of abusive injuries in siblings and household contacts of physically abused children.

    abstract:OBJECTIVE:Siblings and other children who share a home with a physically abused child are thought to be at high risk for abuse, but rates of injury in these contact children are unknown and screening of contacts is highly variable. Our objective was to determine the prevalence of abusive injuries identified by a common...


    pub_type: 杂志文章


    authors: Lindberg DM,Shapiro RA,Laskey AL,Pallin DJ,Blood EA,Berger RP,ExSTRA Investigators.

    更新日期:2012-08-01 00:00:00

  • Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection.

    abstract::Initial reports of congenital Zika virus (ZIKV) infection focused on microcephaly at birth with severe brain anomalies; the phenotype has broadened to include microcephaly that develops after birth and neurodevelopmental sequelae. In this narrative review, we summarize medical literature describing motor abnormalities...


    pub_type: 杂志文章,评审


    authors: Pessoa A,van der Linden V,Yeargin-Allsopp M,Carvalho MDCG,Ribeiro EM,Van Naarden Braun K,Durkin MS,Pastula DM,Moore JT,Moore CA

    更新日期:2018-02-01 00:00:00

  • Respiratory failure and hypercoagulability in a toddler with Lemierre's syndrome.

    abstract::A 3.5-year-old healthy boy with 4 days of fever was referred to the emergency department for respiratory distress. The physical examination was remarkable for stupor, tachycardia, tachypnea, and dyspnea. Initial blood tests showed pancytopenia. He rapidly developed torticollis. Computerized tomography of the neck reve...


    pub_type: 杂志文章


    authors: Schmid T,Miskin H,Schlesinger Y,Argaman Z,Kleid D

    更新日期:2005-05-01 00:00:00

  • Rumination syndrome in children and adolescents: diagnosis, treatment, and prognosis.

    abstract:OBJECTIVES:To characterize the clinical features, results of diagnostic testing, and treatment outcomes for children and adolescents with rumination syndrome. METHODS:Review of the medical records for all 147 patients ages 5 to 20 diagnosed with rumination syndrome at our institution between 1975 and 2000. Data are pr...


    pub_type: 杂志文章


    authors: Chial HJ,Camilleri M,Williams DE,Litzinger K,Perrault J

    更新日期:2003-01-01 00:00:00

  • Iron deficiency in early childhood in the United States: risk factors and racial/ethnic disparities.

    abstract:BACKGROUND:Iron deficiency affects 2.4 million US children, and childhood iron-deficiency anemia is associated with behavioral and cognitive delays. Given the detrimental long-term effects and high prevalence of iron deficiency, its prevention in early childhood is an important public health issue. OBJECTIVES:The stud...


    pub_type: 杂志文章


    authors: Brotanek JM,Gosz J,Weitzman M,Flores G

    更新日期:2007-09-01 00:00:00

  • Variation in Family Experience of Pediatric Inpatient Care As Measured by Child HCAHPS.

    abstract:BACKGROUND:Making national comparisons of family experience of inpatient pediatric care has been limited by the lack of a publicly available survey. The Agency for Healthcare Research and Quality and Centers for Medicare & Medicaid Services commissioned development of the Child Hospital Consumer Assessment of Healthcar...


    pub_type: 杂志文章


    authors: Toomey SL,Elliott MN,Zaslavsky AM,Klein DJ,Ndon S,Hardy S,Wu M,Schuster MA

    更新日期:2017-04-01 00:00:00

  • Comparison of rifampin and ampicillin in day care center contacts of Haemophilus influenzae type b disease.

    abstract::A prospective, randomized, crossover trial was conducted comparing therapy with rifampin to therapy with ampicillin in eradicating Haemophilus influenzae type b carriage. Twenty-eight carriers were identified in a day care center following exposure to a patient with H influenzae type b meningitis; 26 children were ran...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gessert C,Granoff DM,Gilsdorf J

    更新日期:1980-07-01 00:00:00

  • Egg Freezing in Childhood and Young Adult Cancer Survivors.

    abstract::Fertility preservation in prepubertal and young adolescent girls scheduled for chemotherapy is a demanding situation. Despite the recent impressive improvements of ovarian cortex cryopreservation, significant limitations persist. The technique remains experimental, it exposes the girl to the risks of surgery and to an...


    pub_type: 杂志文章


    authors: Filippi F,Meazza C,Paffoni A,Raspagliesi F,Terenziani M,Somigliana E

    更新日期:2016-10-01 00:00:00

  • Executive functioning of 4 children with hyperphenylalaninemia from childhood to adolescence.

    abstract::Hyperphenylalaninemia is a variant of phenylketonuria, and debate remains as to what, if any, active management of this condition is required to preserve cognitive function and psychological well-being. This study is the first to examine longitudinally the executive function (EF) in adolescents with hyperphenylalanine...


    pub_type: 杂志文章


    authors: Sharman R,Sullivan KA,Jones T,Young RM,McGill J

    更新日期:2015-04-01 00:00:00

  • Heterogeneity of diagnoses presenting as cyclic vomiting.

    abstract:OBJECTIVE:To establish the diagnostic profile in children who present with cyclic vomiting. METHODS:We studied 225 children < 18 years of age who presented to our pediatric gastroenterology service from 1986 to 1997 with at least three discrete episodes of vomiting between which they were well. To determine the diagno...


    pub_type: 杂志文章


    authors: Li BU,Murray RD,Heitlinger LA,Robbins JL,Hayes JR

    更新日期:1998-09-01 00:00:00

  • Lupus nephritis: prognostic factors in children.

    abstract::As newer treatment modalities become available for patients with severe lupus nephritis, it becomes increasingly important to identify patients at risk for renal failure. In this study, the records of 90 children presenting with systemic lupus erythematosus over a 13-year period were reviewed. Nineteen were lost to fo...


    pub_type: 杂志文章


    authors: McCurdy DK,Lehman TJ,Bernstein B,Hanson V,King KK,Nadorra R,Landing BH

    更新日期:1992-02-01 00:00:00