The effect of maternal antibody on the serologic response and the incidence of adverse reactions after primary immunization with acellular and whole-cell pertussis vaccines combined with diphtheria and tetanus toxoids.

Abstract:

OBJECTIVE:To evaluate the effect of maternally derived antibody on the immunogenicity and reactogenicity of acellular (DTaP) or whole-cell (DTP) pertussis vaccine with diphtheria and tetanus toxoids combined. METHODS:A total of 2342 infants were randomized to receive one of 13 DTaP or 2 DTP vaccines at 2, 4, and 6 months of age. The correlation between preimmunization and postimmunization antibody after three doses of vaccine and the relation between preimmunization antibody and adverse reactions after the first immunization were modeled by linear regression. RESULTS:After DTP but not DTaP, higher levels of preexisting antibody were associated with substantial (28% to 56%) reductions in the subsequent antibody response to pertussis toxin (PT). For other pertussis antibodies, modest inverse correlations were seen between preexisting antibody concentrations and most postimmunization antibody responses (resulting in 8% to 18% reductions in postimmunization antibody) for both DTP and DTaP. There was no consistent association in any DTP or DTaP group between adverse reactions and preimmunization antibody levels. CONCLUSION:The PT antibody response to DTaP, unlike DTP, is not adversely affected by preexisting antibody to PT. Inhibitory effects with respect to other antibodies, seen with both DTP and DTaP, were relatively modest. Our data suggest that the use of acellular pertussis vaccines in adults, which could confer higher levels of antibody in women before pregnancy, would be unlikely to adversely affect pertussis antibody responses after DTaP among infants born to mothers with high antibody levels.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Englund JA,Anderson EL,Reed GF,Decker MD,Edwards KM,Pichichero ME,Steinhoff MC,Rennels MB,Deforest A,Meade BD

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

580-4

issue

3 Pt 2

eissn

0031-4005

issn

1098-4275

journal_volume

96

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    abstract:OBJECTIVE:To evaluate the clinical effects of magnesium sulfate (MgSO4) in the treatment of persistent pulmonary hypertension of the newborn (PPHN) in premature infants. METHODS:This was a prospective, nonrandomized, clinical study. Seven premature neonates with PPHN were treated with MgSO4 as soon as documentation of...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Wu TJ,Teng RJ,Tsou KI

    更新日期:1995-09-01 00:00:00

  • Pulmonary paragonimiasis in Laotian refugee children.

    abstract::Three Laotian refugee children with chronic pulmonary complaints and findings were found to have pulmonary paragonimiasis during a one-year period in Chicago. These patients ranged from 8 to 11 years of age and the diagnosis was delayed five to six months in two children because of the unfamiliarity of American physic...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Burton K,Yogev R,London N,Boyer K,Shulman ST

    更新日期:1982-08-01 00:00:00

  • Adolescents with cystic fibrosis: family reports of adolescent health-related quality of life and forced expiratory volume in one second.

    abstract:PURPOSE:To assess the relationship between adolescent and parent reports of adolescent health-related quality of life (HRQL) and between adolescent pulmonary function (forced expiratory volume in 1 second as percent of predicted) and reporter perceptions of adolescent health. METHODS:Twenty-four adolescents with cysti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.5.e70

    authors: Powers PM,Gerstle R,Lapey A

    更新日期:2001-05-01 00:00:00

  • Tight glycemic control with insulin in hyperglycemic preterm babies: a randomized controlled trial.

    abstract:OBJECTIVE:The optimal treatment of neonatal hyperglycemia is unclear. The aim of this trial was to determine whether tight glycemic control with insulin improves growth in hyperglycemic preterm infants, without increasing the incidence of hypoglycemia. METHODS:Randomized, controlled, nonblinded trial of 88 infants bor...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2011-2470

    authors: Alsweiler JM,Harding JE,Bloomfield FH

    更新日期:2012-04-01 00:00:00

  • Varicella zoster virus meningitis in a previously immunized child.

    abstract::We are reporting a previously well 5-year-old child with varicella-zoster meningitis who had a history of a previous immunization against varicella. This child also developed a transient sensorineural hearing loss. The child was treated with acyclovir and made a full recovery. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.114.2.e273

    authors: Schwab J,Ryan M

    更新日期:2004-08-01 00:00:00

  • Adolescent mothers and their infants.

    abstract::It is unclear why children of adolescent mothers experience more developmental problems than children of adult mothers. There has been minimal systematic investigation of whether there is a relationship between the young age of the mother and her mothering behaviors. Our data fail to demonstrate any relationship betwe...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: McAnarney ER,Lawrence RA,Aten MJ,Iker HP

    更新日期:1984-03-01 00:00:00

  • Life-threatening sepsis caused by Burkholderia cepacia from contaminated intravenous flush solutions prepared by a compounding pharmacy in another state.

    abstract::We report 2 life-threatening cases of Burkholderia cepacia sepsis caused by infusate contamination during compounding. Bacterial isolates from the patients' blood cultures and the infusate were indistinguishable by pulsed-field gel electrophoresis. Proper quality controls at a local and national level are important fo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2617

    authors: Held MR,Begier EM,Beardsley DS,Browne FA,Martinello RA,Baltimore RS,McDonald LC,Jensen B,Hadler JL,Dembry LM

    更新日期:2006-07-01 00:00:00

  • Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial.

    abstract:OBJECTIVE:To investigate the effect of vitamin D3 supplementation on the incidence and risk for first and recurrent diarrheal illnesses among children in Kabul, Afghanistan. METHODS:This double-blind placebo-controlled trial randomized 3046 high-risk 1- to 11-month-old infants to receive 6 quarterly doses of oral vita...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2012-3986

    authors: Aluisio AR,Maroof Z,Chandramohan D,Bruce J,Mughal MZ,Bhutta Z,Walraven G,Masher MI,Ensink JH,Manaseki-Holland S

    更新日期:2013-10-01 00:00:00

  • Lupus nephritis: prognostic factors in children.

    abstract::As newer treatment modalities become available for patients with severe lupus nephritis, it becomes increasingly important to identify patients at risk for renal failure. In this study, the records of 90 children presenting with systemic lupus erythematosus over a 13-year period were reviewed. Nineteen were lost to fo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: McCurdy DK,Lehman TJ,Bernstein B,Hanson V,King KK,Nadorra R,Landing BH

    更新日期:1992-02-01 00:00:00

  • Neurologic manifestations in children with Lyme disease.

    abstract:OBJECTIVE:Lyme disease (LD) is a tick-borne spirochetal infection with a wide range of neurologic and non-neurologic manifestations. The clinical diversity of LD and limitations in serologic diagnosis often make it difficult to document the diagnosis of neuroborreliosis with certainty. METHODS:We reviewed clinical man...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bingham PM,Galetta SL,Athreya B,Sladky J

    更新日期:1995-12-01 00:00:00

  • Renal ultrasound evaluation of urinary tract infections in children.

    abstract::Ultrasonography of the kidney may replace the intravenous pyelogram as the study of choice in identifying treatable abnormalities in children with urinary tract infection. In a series of 64 consecutive children with urinary tract infection in whom an intravenous pyelogram, renal ultrasound, and voiding cystogram were ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Johnson CE,DeBaz BP,Shurin PA,DeBartolomeo R

    更新日期:1986-11-01 00:00:00

  • Medical conditions affecting sports participation.

    abstract::Children and adolescents with medical conditions present special issues with respect to participation in athletic activities. The pediatrician can play an important role in determining whether a child with a health condition should participate in certain sports by assessing the child's health status, suggesting approp...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2008-0080

    authors: Rice SG,American Academy of Pediatrics Council on Sports Medicine and Fitness.

    更新日期:2008-04-01 00:00:00

  • Health supervision for children with fragile X syndrome.

    abstract::Fragile X syndrome (an FMR1-related disorder) is the most commonly inherited form of mental retardation. Early physical recognition is difficult, so boys with developmental delay should be strongly considered for molecular testing. The characteristic adult phenotype usually does not develop until the second decade of ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2010-3500

    authors: Hersh JH,Saul RA,Committee on Genetics.

    更新日期:2011-05-01 00:00:00

  • Chloral hydrate and the carbon dioxide chemoreceptor response: a study of puppies and infants.

    abstract::CO2 chemoreceptor function was assessed during natural sleep and following the administration of 100 mg/kg of chloral hydrate to 26 puppies. With chloral hydrate-induced sleep, there were no significant changes in ventilation or in CO2 chemoreceptor response. The ventilation and CO2 chemoreceptor response of a group o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lees MH,Olsen GD,McGilliard KL,Newcomb JD,Sunderland CO

    更新日期:1982-09-01 00:00:00

  • Asymptomatic Kawasaki Disease in a 3-Month-Old Infant.

    abstract::Kawasaki disease (KD) is the leading cause of acquired heart disease in children in the United States. It is a systemic vasculitis characterized by diffuse inflammation of medium and small blood vessels. If untreated it can lead to myocardial infarction, ischemic heart disease, or sudden death. Early recognition and t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-3936

    authors: Pinches H,Dobbins K,Cantrell S,May J,Lopreiato J

    更新日期:2016-08-01 00:00:00

  • Clinical comparison of localized intestinal perforation and necrotizing enterocolitis in neonates.

    abstract:OBJECTIVE:To better define the prognosis of neonates with gastrointestinal perforation and improve their management. METHODS:We reviewed the results of physical examinations, laboratory results, and radiographic tests of 42 patients in whom gastrointestinal perforation was diagnosed in our neonatal intensive care unit...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Buchheit JQ,Stewart DL

    更新日期:1994-01-01 00:00:00

  • Identification of Extremely Premature Infants at Low Risk for Early-Onset Sepsis.

    abstract:BACKGROUND:Premature infants are at high risk of early-onset sepsis (EOS) relative to term infants, and most are administered empirical antibiotics after birth. We aimed to determine if factors evident at birth could be used to identify premature infants at lower risk of EOS. METHODS:Study infants were born at 22 to 2...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2017-0925

    authors: Puopolo KM,Mukhopadhyay S,Hansen NI,Cotten CM,Stoll BJ,Sanchez PJ,Bell EF,Das A,Hensman AM,Van Meurs KP,Wyckoff MH,NICHD Neonatal Research Network.

    更新日期:2017-11-01 00:00:00

  • Mother-to-child transmission of human immunodeficiency virus type 1: risk of infection and correlates of transmission.

    abstract::One thousand eight hundred eighty-seven children born to human immunodeficiency virus type 1 (HIV-1) seropositive mothers, including 1045 infants prospectively followed up from birth, were studied. Intravenous drug use was the most frequent maternal risk factor, although the percentage of women infected by sexual cont...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gabiano C,Tovo PA,de Martino M,Galli L,Giaquinto C,Loy A,Schoeller MC,Giovannini M,Ferranti G,Rancilio L

    更新日期:1992-09-01 00:00:00

  • Exposure to smoking in internationally distributed American movies and youth smoking in Germany: a cross-cultural cohort study.

    abstract:OBJECTIVE:Studies of US adolescents have linked exposure to movie smoking with smoking behavior. It is unclear whether European adolescents are also responsive to movie tobacco imagery. METHODS:A longitudinal study was conducted to assess exposure to movie smoking in 2711 German never-smokers (aged 10 to 16 years). Mo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-1201

    authors: Hanewinkel R,Sargent JD

    更新日期:2008-01-01 00:00:00

  • The effects of stimulant medication on the growth of hyperkinetic children.

    abstract::This article reviews the literature on possible growth-suppressing effects of stimulant medications in the long-term treatment of children with the hyperkinetic behavior syndrome. The evidence clearly indicates a temporary retardation in the rate of growth in weight and suggests a temporary slowing of growth in statur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Roche AF,Lipman RS,Overall JE,Hung W

    更新日期:1979-06-01 00:00:00

  • Quality-of-life concerns differ among patients, parents, and medical providers in children and adolescents with congenital and acquired heart disease.

    abstract:OBJECTIVES:Mortality rates in pediatric patients with heart disease have decreased dramatically in recent decades, resulting in an increasing number of survivors with morbidities that impact quality of life. The purpose of this study was to assess and compare how heart disease affects the quality of life of the pediatr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2572

    authors: Marino BS,Tomlinson RS,Drotar D,Claybon ES,Aguirre A,Ittenbach R,Welkom JS,Helfaer MA,Wernovsky G,Shea JA

    更新日期:2009-04-01 00:00:00

  • Black-white differences in health care utilization among US children with frequent ear infections.

    abstract:OBJECTIVE:To examine differences in patterns of and barriers to health care utilization between black and white children who have frequent ear infections (FEI). METHODS:Analysis was conducted using the 1997 and 1998 National Health Interview Survey-Sample Child Files. Data on 25 497 children under 18 years of age and ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.5.e84

    authors: Park CH,Kogan MD,Overpeck MD,Casselbrant ML

    更新日期:2002-05-01 00:00:00

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    abstract:OBJECTIVE:As newborn screening (NBS) programs expand to include conditions that challenge traditional public health criteria, little is known about what influences physicians' attitudes toward screening. We examined the effect of state policy and perceived state policy on pediatricians' attitudes toward screening. MET...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1990

    authors: Koopmans J,Ross LF

    更新日期:2006-05-01 00:00:00

  • Ten-Year Trends in Bullying and Related Attitudes Among 4th- to 12th-Graders.

    abstract:BACKGROUND AND OBJECTIVES:Bullying is a significant public health concern, and it has received considerable attention from the media and policymakers over the past decade, which has led some to believe that it is increasing. However, there are limited surveillance data on bullying to inform our understanding of such tr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-2615

    authors: Waasdorp TE,Pas ET,Zablotsky B,Bradshaw CP

    更新日期:2017-06-01 00:00:00

  • Subacute Neuropsychiatric Syndrome in Girls With SHANK3 Mutations Responds to Immunomodulation.

    abstract::Phenotypic and biological characterization of rare monogenic disorders represents 1 of the most important avenues toward understanding the mechanisms of human disease. Among patients with SH3 and multiple ankyrin repeat domains 3 (SHANK3) mutations, a subset will manifest neurologic regression, psychosis, and mood dis...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2019-1490

    authors: Bey AL,Gorman MP,Gallentine W,Kohlenberg TM,Frankovich J,Jiang YH,Van Haren K

    更新日期:2020-02-01 00:00:00

  • Maternal Intellectual or Developmental Disability and Newborn Discharge to Protective Services.

    abstract:BACKGROUND:Approximately half of women with intellectual and developmental disabilities (IDDs) lose custody of their children at some point in their child's development, but their rates of and risk factors for newborn discharge to child protective services from the birth hospitalization are relatively unknown. METHODS...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-1416

    authors: Brown HK,Potvin LA,Lunsky Y,Vigod SN

    更新日期:2018-12-01 00:00:00

  • Serum luteinizing hormone rises within minutes after depot leuprolide injection: implications for monitoring therapy.

    abstract:OBJECTIVE:To find the time of the serum gonadotropin peak after depot leuprolide injection in children and to show that depot leuprolide therapy can be monitored by measuring serum luteinizing hormone (LH) immediately after injections. STUDY DESIGN:We measured concentrations of leuprolide, LH, and follicle-stimulating...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.2.e30

    authors: Bhatia S,Neely EK,Wilson DM

    更新日期:2002-02-01 00:00:00

  • The value of pulsus paradoxus in assessing the child with status asthmaticus.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Galant SP,Groncy CE,Shaw KC

    更新日期:1978-01-01 00:00:00

  • Family history of asthma and atopy: in-depth analyses of the impact on asthma and wheeze in 7- to 8-year-old children.

    abstract:OBJECTIVES:Development of asthma in children is influenced by interactions between genetic and environmental factors. It is unclear whether paternal or maternal histories of disease confer different risks. Previous population-based studies have not stratified analyses by child gender and sensitization status. Our aim w...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3742

    authors: Bjerg A,Hedman L,Perzanowski MS,Platts-Mills T,Lundbäck B,Rönmark E

    更新日期:2007-10-01 00:00:00

  • Coarctation of the abdominal aorta and renal artery stenosis related to an umbilical artery catheter placement in a neonate.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.3.e36

    authors: Adelman RD,Morrell RE

    更新日期:2000-09-01 00:00:00