Persistent pulmonary hypertension of the newborn treated with magnesium sulfate in premature neonates.


OBJECTIVE:To evaluate the clinical effects of magnesium sulfate (MgSO4) in the treatment of persistent pulmonary hypertension of the newborn (PPHN) in premature infants. METHODS:This was a prospective, nonrandomized, clinical study. Seven premature neonates with PPHN were treated with MgSO4 as soon as documentation of an interatrial right-to-left shunt was made. A loading dose of 200 mg/kg was infused over 30 minutes, followed by a maintenance dose of 20 to 50 mg/kg/h. Alveolar-arterial oxygen tension difference (AaDO2) and oxygenation index were followed up sequentially as the primary outcome measures. Blood pressures and serum electrolytes were also monitored. RESULTS:Six cases responded clinically. The decrease of AaDO2 reached significance at 36 hours, but the decrease of oxygenation index was not significant over 72 hours. Four infants survived. No significant side effects were encountered. CONCLUSION:Our results suggest that MgSO4 may be considered as an alternative treatment of PPHN in premature infants.






Wu TJ,Teng RJ,Tsou KI


Has Abstract


1995-09-01 00:00:00




3 Pt 1








  • Modeling the impact of formal and informal supports for young children with disabilities and their families.

    abstract:OBJECTIVE:The purpose of this work was to examine factors related to perceived impact of early intervention on children with disabilities and their families. METHODS:A nationally representative sample of approximately 2100 parents completed a 40-minute telephone interview near their child's third birthday. Structural ...


    pub_type: 杂志文章


    authors: Bailey DB Jr,Nelson L,Hebbeler K,Spiker D

    更新日期:2007-10-01 00:00:00

  • Acute confusional migraine in an adolescent: response to intravenous valproate.

    abstract::Acute confusional migraine (ACM) is a dramatic, rare manifestation of migraine described mostly for children and adolescents. There are few data on the treatment of an ACM attack. Prochlorperazine has been suggested as an effective drug. The authors of some reports have suggested that valproic acid may play a role in ...


    pub_type: 杂志文章


    authors: Avraham SB,Har-Gil M,Watemberg N

    更新日期:2010-04-01 00:00:00

  • Early-Onset Sepsis Risk Calculator Integration Into an Electronic Health Record in the Nursery.

    abstract:BACKGROUND AND OBJECTIVES:An early-onset sepsis (EOS) risk calculator tool to guide evaluation and treatment of infants at risk for sepsis has reduced antibiotic use without increased adverse outcomes. We performed an electronic health record (EHR)-driven quality improvement intervention to increase calculator use for ...


    pub_type: 杂志文章


    authors: Stipelman CH,Smith ER,Diaz-Ochu M,Spackman J,Stoddard G,Kawamoto K,Shakib JH

    更新日期:2019-08-01 00:00:00

  • Screen Violence and Youth Behavior.

    abstract::Violence in screen entertainment media (ie, television, film, video games, and the Internet), defined as depictions of characters (or players) trying to physically harm other characters (or players), is ubiquitous. The Workgroup on Media Violence and Violent Video Games reviewed numerous meta-analyses and other releva...


    pub_type: 杂志文章,评审


    authors: Anderson CA,Bushman BJ,Bartholow BD,Cantor J,Christakis D,Coyne SM,Donnerstein E,Brockmyer JF,Gentile DA,Green CS,Huesmann R,Hummer T,Krahé B,Strasburger VC,Warburton W,Wilson BJ,Ybarra M

    更新日期:2017-11-01 00:00:00

  • Successful treatment of type 1 diabetes and seizures with combined ketogenic diet and insulin.

    abstract::Diabetic ketoacidosis (DKA) is a life-threatening condition and a major cause of morbidity and mortality in children with type 1 diabetes mellitus. The deficiency of insulin leads to metabolic decompensation, causing hyperglycemia and ketosis that resolves with the administration of insulin and fluids. However, an ind...


    pub_type: 杂志文章


    authors: Aguirre Castaneda RL,Mack KJ,Lteif A

    更新日期:2012-02-01 00:00:00

  • Transmission of hepatitis B virus infection by asymptomatic chronic HBsAg carrier mothers.

    abstract::The courses of 18 children born to 13 chronic hepatitis B surface antigen (HBsAg) carrier mothers were followed prospectively for serological and biochemical evidence of type B hepatitis. Three children developed transient HBsAg positivity accompanied by the appearance of antibody to the hepatitis B core antigen. Two ...


    pub_type: 杂志文章


    authors: Papaevangelou G,Hoofnagle JH

    更新日期:1979-04-01 00:00:00

  • Oxygen Saturation Targets in Preterm Infants and Outcomes at 18-24 Months: A Systematic Review.

    abstract:CONTEXT:The optimal oxygen saturation target for extremely preterm infants remains unclear. OBJECTIVE:To systematically review evidence evaluating the effect of lower (85%-89%) versus higher (91%-95%) pulse oxygen saturation (Spo2) target on mortality and neurodevelopmental impairment (NDI) at 18 to 24 months. DATA S...


    pub_type: 杂志文章,评审


    authors: Manja V,Saugstad OD,Lakshminrusimha S

    更新日期:2017-01-01 00:00:00

  • Pulmonary vein stenosis: prematurity and associated conditions.

    abstract:OBJECTIVE:Pulmonary vein stenosis is a rare, although often lethal, anomaly. Risk factors for the diagnosis of pulmonary vein stenosis are poorly characterized. In this study we sought to identify factors associated with pulmonary vein stenosis, paying particular attention to preterm birth. METHODS:By review of the ca...


    pub_type: 杂志文章


    authors: Drossner DM,Kim DW,Maher KO,Mahle WT

    更新日期:2008-09-01 00:00:00

  • Self-reported quality of life of young children with conditions from early infancy: a systematic review.

    abstract:CONTEXT:There is little consistency in the use of instruments for measuring self-reported quality of life (QoL) in young children. OBJECTIVE:To systematically review studies of self-reported QoL in children aged <12 years with congenital health conditions, and to examine the agreement between self- and proxy-reports. ...


    pub_type: 杂志文章,评审


    authors: Jardine J,Glinianaia SV,McConachie H,Embleton ND,Rankin J

    更新日期:2014-10-01 00:00:00

  • Range of neurologic disorders in patients with celiac disease.

    abstract:OBJECTIVE:During the past 2 decades, celiac disease (CD) has been recognized as a multisystem autoimmune disorder. A growing body of distinct neurologic conditions such as cerebellar ataxia, epilepsy, myoclonic ataxia, chronic neuropathies, and dementia have been reported, mainly in middle-aged adults. There still are ...


    pub_type: 杂志文章


    authors: Zelnik N,Pacht A,Obeid R,Lerner A

    更新日期:2004-06-01 00:00:00

  • Effectiveness of a regional poison center in reducing excess emergency room visits for children's poisonings.

    abstract::A study was done to assess the necessity of hospital care for poisoning episodes in children less than 5 years old and to evaluate the impact of a regional poison center on the use of emergency rooms for pediatric poisonings. Of the pediatric patients seen in emergency rooms for acute poisonings, 63% did not require t...


    pub_type: 杂志文章


    authors: Chafee-Bahamon C,Lovejoy FH Jr

    更新日期:1983-08-01 00:00:00

  • Symptomatic liver involvement in neonatal hereditary hemorrhagic telangiectasia.

    abstract::High-flow hepatic vascular anomalies with arteriovenous shunting commonly manifest during the neonatal period with signs and symptoms of congestive heart failure, but to our knowledge, they have never been described in patients with hereditary hemorrhagic telangiectasia (HHT). We report here our experience with 3 pati...


    pub_type: 杂志文章


    authors: Al-Saleh S,John PR,Letarte M,Faughnan ME,Belik J,Ratjen F

    更新日期:2011-06-01 00:00:00

  • Securing central lines in rambunctious toddlers.

    abstract::Central line dislodgment in toddlers continues to be a problem. The deployment of a spandex/nylon bodysuit has resulted in eliminating this problem in two overactive toddlers. We highly recommend using this type of garment in appropriate clinical situations. ...


    pub_type: 杂志文章


    authors: Janik JP,Wayne ER,Janik JS

    更新日期:1995-09-01 00:00:00

  • Annual summary of vital statistics--1980.

    abstract::Data for this article, as in previous reports, are drawn principally from the Monthly Vital Statistics Report, published by the National Center for Health Statistics. The international data come from the Demographic Yearbook and the quarterly Population and Vital Statistics Report, both published by the Statistical Of...


    pub_type: 杂志文章


    authors: Wegman ME

    更新日期:1981-12-01 00:00:00

  • Rape prevention through empowerment of adolescent girls.

    abstract:BACKGROUND AND OBJECTIVE:Sexual assault is a major cause of injury, unplanned pregnancy, HIV infection, and mental health problems worldwide. In parts of sub-Saharan Africa, sexual assault has reached epidemic proportions. This study evaluated the efficacy of an empowerment and self-defense intervention for adolescent ...


    pub_type: 杂志文章,随机对照试验


    authors: Sarnquist C,Omondi B,Sinclair J,Gitau C,Paiva L,Mulinge M,Cornfield DN,Maldonado Y

    更新日期:2014-05-01 00:00:00

  • Management of Neonates Born to Mothers With Graves' Disease.

    abstract::Neonates born to mothers with Graves' disease are at risk for significant morbidity and mortality and need to be appropriately identified and managed. Because no consensus guidelines regarding the treatment of these newborns exist, we sought to generate a literature-based management algorithm. The suggestions include ...


    pub_type: 杂志文章,评审


    authors: van der Kaay DC,Wasserman JD,Palmert MR

    更新日期:2016-04-01 00:00:00

  • Screening for congenital adrenal hyperplasia: the Delfia Screening Test overestimates serum 17-hydroxyprogesterone in preterm infants.

    abstract:OBJECTIVE:To compare 17-hydroxyprogesterone (17-OHP) levels measured by quantitative serum radioimmunoassay (RIA), including an extraction step, and by screening fluoroimmunoassay (FIA) on blood spots in preterm infants. METHODS:Subjects were 39 healthy infants born at less than 31 weeks' gestational age. Each infant ...


    pub_type: 临床试验,杂志文章


    authors: al Saedi S,Dean H,Dent W,Stockl E,Cronin C

    更新日期:1996-01-01 00:00:00

  • Electronic prescribing in pediatrics: toward safer and more effective medication management.

    abstract::This policy statement identifies the potential value of electronic prescribing (e-prescribing) systems in improving quality and reducing harm in pediatric health care. On the basis of limited but positive pediatric data and on the basis of federal statutes that provide incentives for the use of e-prescribing systems, ...


    pub_type: 杂志文章,实务指引


    authors: American Academy of Pediatrics Council on Clinical Information Technology Executive Committee, 2011–2012.

    更新日期:2013-04-01 00:00:00

  • Ethics Rounds: Death After Pediatric Dental Anesthesia: An Avoidable Tragedy?

    abstract::Early childhood caries (ECC) is the single most common chronic childhood disease. In the treatment of ECC, children are often given moderate sedation or general anesthesia. An estimated 100 000 to 250 000 pediatric dental sedations are performed annually in the United States. The most common medications are benzodiaze...


    pub_type: 杂志文章


    authors: Lee H,Milgrom P,Huebner CE,Weinstein P,Burke W,Blacksher E,Lantos JD

    更新日期:2017-12-01 00:00:00

  • Which children benefit the most from early intervention?

    abstract::Recent findings from three separate studies support and extend a large and growing body of early-intervention research literature spanning 30 years. The literature is consistent in demonstrating positive developmental outcomes as a result of intensive early intervention for children of low-income and undereducated fam...


    pub_type: 杂志文章


    authors: Ramey CT,Ramey SL

    更新日期:1994-12-01 00:00:00

  • Exclusive Breastfeeding and Risk of Dental Malocclusion.

    abstract:OBJECTIVES:The distinct effect of exclusive and predominant breastfeeding on primary dentition malocclusions is still unclear. We hypothesized that exclusive breastfeeding presents a higher protective effect against malocclusions than predominant breastfeeding and that the use of a pacifier modifies the association bet...


    pub_type: 杂志文章


    authors: Peres KG,Cascaes AM,Peres MA,Demarco FF,Santos IS,Matijasevich A,Barros AJ

    更新日期:2015-07-01 00:00:00

  • Neurodevelopmental outcomes of extremely low birth weight infants

    abstract:OBJECTIVE:This study evaluated the impact of changes in perinatal management on neurodevelopmental impairment (NDI) at 18 to 22 months' corrected age of low gestation (22-26 weeks) and higher gestation (27-32 weeks) extremely low birth weight infants (401-1000 g birth weight) who were cared for in the National Institut...


    pub_type: 杂志文章


    authors: Vohr BR,Wright LL,Poole WK,McDonald SA

    更新日期:2005-09-01 00:00:00

  • Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial.

    abstract:OBJECTIVE:Live probiotic bacteria and dietary prebiotic oligosaccharides (together termed synbiotics) increasingly are being used in infancy, but evidence of long-term safety is lacking. In a randomized, placebo-controlled, double-blind trial, we studied the safety and long-term effects of feeding synbiotics to newborn...


    pub_type: 杂志文章,随机对照试验


    authors: Kukkonen K,Savilahti E,Haahtela T,Juntunen-Backman K,Korpela R,Poussa T,Tuure T,Kuitunen M

    更新日期:2008-07-01 00:00:00

  • INSIGHT Responsive Parenting Intervention and Infant Sleep.

    abstract:OBJECTIVES:Inadequate sleep during infancy is associated with adverse outcomes for infants and families. We sought to improve sleep behaviors and duration through a responsive parenting (RP) intervention designed for obesity prevention. METHODS:The Intervention Nurses Start Infants Growing on Healthy Trajectories (INS...


    pub_type: 杂志文章,随机对照试验


    authors: Paul IM,Savage JS,Anzman-Frasca S,Marini ME,Mindell JA,Birch LL

    更新日期:2016-07-01 00:00:00

  • Invasive Bacterial Infections in Afebrile Infants Diagnosed With Acute Otitis Media.

    abstract:OBJECTIVES:To determine the prevalence of invasive bacterial infections (IBIs) and adverse events in afebrile infants with acute otitis media (AOM). METHODS:We conducted a 33-site cross-sectional study of afebrile infants ≤90 days of age with AOM seen in emergency departments from 2007 to 2017. Eligible infants were i...


    pub_type: 杂志文章


    authors: McLaren SH,Cruz AT,Yen K,Lipshaw MJ,Bergmann KR,Mistry RD,Gutman CK,Ahmad FA,Pruitt CM,Thompson GC,Steimle MD,Zhao X,Schuh AM,Thompson AD,Hanson HR,Ulrich SL,Meltzer JA,Dunnick J,Schmidt SM,Nigrovic LE,Waseem M,

    更新日期:2021-01-01 00:00:00

  • Stunting of growth as a major feature of anorexia nervosa in male adolescents.

    abstract:OBJECTIVE:To assess growth retardation in male adolescent patients who have a diagnosis of anorexia nervosa (AN) and the effect of weight restoration on catch-up growth. METHODS:Medical charts of all male adolescent AN patients (n = 12) who were admitted to the Pediatric Psychosomatic Department at the Sheba Medical C...


    pub_type: 杂志文章


    authors: Modan-Moses D,Yaroslavsky A,Novikov I,Segev S,Toledano A,Miterany E,Stein D

    更新日期:2003-02-01 00:00:00

  • Long-term effectiveness of varicella vaccine: a 14-Year, prospective cohort study.

    abstract:BACKGROUND:Varicella vaccine was licensed in the United States in 1995 for individuals ≥12 months of age. A second dose was recommended in the United States in June 2006. Varicella incidence and vaccine effectiveness were assessed in a 14-year prospective study conducted at Kaiser Permanente Northern California. METHO...


    pub_type: 杂志文章,多中心研究


    authors: Baxter R,Ray P,Tran TN,Black S,Shinefield HR,Coplan PM,Lewis E,Fireman B,Saddier P

    更新日期:2013-05-01 00:00:00

  • Standardizing the Evaluation of Nonaccidental Trauma in a Large Pediatric Emergency Department.

    abstract:BACKGROUND AND OBJECTIVES:Variability exists in the evaluation of nonaccidental trauma (NAT) in the pediatric emergency department because of misconceptions and individual bias of clinicians. Further maltreatment, injury, and death can ensue if these children are not evaluated appropriately. The implementation of guide...


    pub_type: 杂志文章


    authors: Riney LC,Frey TM,Fain ET,Duma EM,Bennett BL,Murtagh Kurowski E

    更新日期:2018-01-01 00:00:00

  • Eosinophilic Pneumonia and Lymphadenopathy Associated With Vaping and Tetrahydrocannabinol Use.

    abstract::Idiopathic acute eosinophilic pneumonia is a rare and potentially life-threatening condition that is defined by bilateral pulmonary infiltrates and fever in the presence of pulmonary eosinophilia. It often presents acutely in previously healthy individuals and can be difficult to distinguish from infectious pneumonia....


    pub_type: 杂志文章


    authors: Mull ES,Erdem G,Nicol K,Adler B,Shell R

    更新日期:2020-04-01 00:00:00

  • Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial.

    abstract:OBJECTIVE:To investigate the effect of vitamin D3 supplementation on the incidence and risk for first and recurrent diarrheal illnesses among children in Kabul, Afghanistan. METHODS:This double-blind placebo-controlled trial randomized 3046 high-risk 1- to 11-month-old infants to receive 6 quarterly doses of oral vita...


    pub_type: 杂志文章,随机对照试验


    authors: Aluisio AR,Maroof Z,Chandramohan D,Bruce J,Mughal MZ,Bhutta Z,Walraven G,Masher MI,Ensink JH,Manaseki-Holland S

    更新日期:2013-10-01 00:00:00