Persistent pulmonary hypertension of the newborn treated with magnesium sulfate in premature neonates.


OBJECTIVE:To evaluate the clinical effects of magnesium sulfate (MgSO4) in the treatment of persistent pulmonary hypertension of the newborn (PPHN) in premature infants. METHODS:This was a prospective, nonrandomized, clinical study. Seven premature neonates with PPHN were treated with MgSO4 as soon as documentation of an interatrial right-to-left shunt was made. A loading dose of 200 mg/kg was infused over 30 minutes, followed by a maintenance dose of 20 to 50 mg/kg/h. Alveolar-arterial oxygen tension difference (AaDO2) and oxygenation index were followed up sequentially as the primary outcome measures. Blood pressures and serum electrolytes were also monitored. RESULTS:Six cases responded clinically. The decrease of AaDO2 reached significance at 36 hours, but the decrease of oxygenation index was not significant over 72 hours. Four infants survived. No significant side effects were encountered. CONCLUSION:Our results suggest that MgSO4 may be considered as an alternative treatment of PPHN in premature infants.






Wu TJ,Teng RJ,Tsou KI


Has Abstract


1995-09-01 00:00:00




3 Pt 1








  • Incidence and outcomes of symptomatic neonatal arterial ischemic stroke.

    abstract:BACKGROUND AND OBJECTIVES:Neonatal arterial ischemic stroke (NAIS) is associated with considerable lifetime burdens such as cerebral palsy, epilepsy, and cognitive impairment. Prospective epidemiologic studies that include outcome assessments are scarce. This study aimed to provide information on the epidemiology, clin...


    pub_type: 杂志文章


    authors: Grunt S,Mazenauer L,Buerki SE,Boltshauser E,Mori AC,Datta AN,Fluss J,Mercati D,Keller E,Maier O,Poloni C,Ramelli GP,Schmitt-Mechelke T,Steinlin M

    更新日期:2015-05-01 00:00:00

  • Screening for congenital adrenal hyperplasia: the Delfia Screening Test overestimates serum 17-hydroxyprogesterone in preterm infants.

    abstract:OBJECTIVE:To compare 17-hydroxyprogesterone (17-OHP) levels measured by quantitative serum radioimmunoassay (RIA), including an extraction step, and by screening fluoroimmunoassay (FIA) on blood spots in preterm infants. METHODS:Subjects were 39 healthy infants born at less than 31 weeks' gestational age. Each infant ...


    pub_type: 临床试验,杂志文章


    authors: al Saedi S,Dean H,Dent W,Stockl E,Cronin C

    更新日期:1996-01-01 00:00:00

  • Pulmonary paragonimiasis in Laotian refugee children.

    abstract::Three Laotian refugee children with chronic pulmonary complaints and findings were found to have pulmonary paragonimiasis during a one-year period in Chicago. These patients ranged from 8 to 11 years of age and the diagnosis was delayed five to six months in two children because of the unfamiliarity of American physic...


    pub_type: 杂志文章


    authors: Burton K,Yogev R,London N,Boyer K,Shulman ST

    更新日期:1982-08-01 00:00:00

  • Identifying and treating a substandard housing cluster using a medical-legal partnership.

    abstract:BACKGROUND AND OBJECTIVE:There is a documented connection between the home environment and health. Medical-legal partnerships (MLPs) can address social and environmental determinants of health. Our objective was to describe a cluster of substandard housing identified and treated by an MLP based in a pediatric primary c...


    pub_type: 杂志文章


    authors: Beck AF,Klein MD,Schaffzin JK,Tallent V,Gillam M,Kahn RS

    更新日期:2012-11-01 00:00:00

  • Teleintervention for infants and young children who are deaf or hard-of-hearing.

    abstract::Advancements in videoconferencing equipment and Internet-based tools for sharing information have resulted in widespread use of telemedicine for providing health care to people who live in remote areas. Given the limited supply of people trained to provide early-intervention services to infants and young children who ...


    pub_type: 杂志文章


    authors: McCarthy M,Muñoz K,White KR

    更新日期:2010-08-01 00:00:00

  • Using a preprinted order sheet to reduce prescription errors in a pediatric emergency department: a randomized, controlled trial.

    abstract:OBJECTIVE:Medication errors are common among pediatric patients and in emergency departments (EDs). Such errors may lead to prolonged hospitalization, unnecessary diagnostic tests and treatments, and death. The objective of this study was to determine whether the use of a structured order sheet reduces the incidence of...


    pub_type: 杂志文章,随机对照试验


    authors: Kozer E,Scolnik D,MacPherson A,Rauchwerger D,Koren G

    更新日期:2005-12-01 00:00:00

  • Prevention of neonatal respiratory distress syndrome by tracheal instillation of surfactant: a randomized clinical trial.

    abstract::With a randomized clinical trial, the possibility was assessed that a tracheal instillation of pulmonary surfactant prior to the first breath might prevent the development of some of the signs of neonatal respiratory distress syndrome. Of the 72 infants in the trial, all born at a gestational age of less than 30 weeks...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Enhorning G,Shennan A,Possmayer F,Dunn M,Chen CP,Milligan J

    更新日期:1985-08-01 00:00:00

  • Eosinophilic hepatitis in an adolescent during lisdexamfetamine dimesylate treatment for ADHD.

    abstract::We describe here the case of an adolescent who developed eosinophilic hepatitis during treatment for attention-deficit/hyperactivity disorder with lisdexamfetamine dimesylate (Vyvanse [Shire US Inc, Wayne, PA]). A 14-year-old boy presented to his primary care provider with abdominal pain and worsening jaundice. A diag...


    pub_type: 杂志文章


    authors: Hood B,Nowicki MJ

    更新日期:2010-06-01 00:00:00

  • Promoting best-care practices in childhood asthma: quality improvement in community health centers.

    abstract:OBJECTIVE:Outpatient asthma management remains suboptimal. We previously reported significant improvements in asthma guideline adherence and outcomes in children by using quality-improvement processes and community health workers. We hypothesized that a larger project could achieve comparable outcome improvements with ...


    pub_type: 杂志文章,多中心研究


    authors: Lob SH,Boer JH,Porter PG,Núñez D,Fox P

    更新日期:2011-07-01 00:00:00

  • Do parent perceptions predict continuity of publicly funded care for attention-deficit/hyperactivity disorder?

    abstract:OBJECTIVE:To examine whether parent perceptions about care (barriers, disorder knowledge, treatment willingness) vary among children who drop out of or stay in publicly funded care for attention-deficit/hyperactivity disorder (ADHD) and to explore whether parent perceptions are predictive of staying in care over time. ...


    pub_type: 杂志文章


    authors: Zima BT,Bussing R,Tang L,Zhang L

    更新日期:2013-03-01 00:00:00

  • A Multifaceted Approach to Improving Outcomes in the NICU: The Pediatrix 100 000 Babies Campaign.

    abstract:BACKGROUND AND OBJECTIVE:Despite advances in neonatal medicine, infants requiring neonatal intensive care continue to experience substantial morbidity and mortality. The purpose of this initiative was to generate large-scale simultaneous improvements in multiple domains of care in a large neonatal network through a pro...


    pub_type: 杂志文章


    authors: Ellsbury DL,Clark RH,Ursprung R,Handler DL,Dodd ED,Spitzer AR

    更新日期:2016-04-01 00:00:00

  • Substantial reduction in severe diarrheal morbidity by daily zinc supplementation in young north Indian children.

    abstract:OBJECTIVE:To evaluate the impact of 4 months of daily zinc supplementation on the incidence of severe and recurrent diarrhea in children 6 to 30 months of age. METHODS:A double-blind, randomized, placebo-controlled trial was conducted on children who were identified by a door-to-door survey to be aged 6 to 30 months a...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bhandari N,Bahl R,Taneja S,Strand T,Mølbak K,Ulvik RJ,Sommerfelt H,Bhan MK

    更新日期:2002-06-01 00:00:00

  • Blood pressure fluctuation and intraventricular hemorrhage in the preterm infant of less than 31 weeks' gestation.

    abstract::A total of 22 infants of less than 31 weeks' gestation who were mechanically ventilated for a minimum of 12 hours for respiratory distress syndrome were studied. The coefficient of variation of direct systolic pressure was measured each minute from six to 36 hours of age and averaged per hour after birth with a microc...


    pub_type: 杂志文章


    authors: Miall-Allen VM,de Vries LS,Dubowitz LM,Whitelaw AG

    更新日期:1989-05-01 00:00:00

  • Congenital Trismus From Brainstem Dysgenesis: Case Report and Review of Literature.

    abstract::Trismus refers to any condition inducing limited mouth opening and may present as a result of acquired or congenital pathology. We present the case of a newborn who presented with severe, congenital trismus due to brainstem dysgenesis. We describe the course of his investigations, and a multidisciplinary approach to t...


    pub_type: 杂志文章,评审


    authors: Hong CJ,Caulley L,Kohlert S,Graham GE,McMillan HJ,Michaud J,Vaccani JP

    更新日期:2016-07-01 00:00:00

  • Lithium in the Acute Treatment of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Study.

    abstract:BACKGROUND:Lithium is a benchmark treatment for bipolar disorder in adults. Definitive studies of lithium in pediatric bipolar I disorder (BP-I) are lacking. METHODS:This multicenter, randomized, double-blind, placebo-controlled study of pediatric participants (ages 7-17 years) with BP-I/manic or mixed episodes compar...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Findling RL,Robb A,McNamara NK,Pavuluri MN,Kafantaris V,Scheffer R,Frazier JA,Rynn M,DelBello M,Kowatch RA,Rowles BM,Lingler J,Martz K,Anand R,Clemons TE,Taylor-Zapata P

    更新日期:2015-11-01 00:00:00

  • Adult patient visits to children's hospital emergency departments.

    abstract:BACKGROUND:Adults frequently seek medical services in children's hospital emergency departments (CHEDs), and are required to be admitted to CHEDs under the provisions of the Emergency Medical Transfer and Active Labor Act (EMTALA), which requires medical evaluation and stabilization of every patient who presents to an ...


    pub_type: 杂志文章


    authors: Bourgeois FT,Shannon MW

    更新日期:2003-06-01 00:00:00

  • Food protein-induced enterocolitis syndrome caused by solid food proteins.

    abstract:BACKGROUND:Infantile food protein-induced enterocolitis syndrome (FPIES) is a severe, cell-mediated gastrointestinal food hypersensitivity typically provoked by cow's milk or soy. Solid foods are rarely considered a cause. OBJECTIVE:To describe the clinical characteristics and natural history of FPIES provoked by soli...


    pub_type: 杂志文章,多中心研究


    authors: Nowak-Wegrzyn A,Sampson HA,Wood RA,Sicherer SH

    更新日期:2003-04-01 00:00:00

  • Adolescents' beliefs about the risks involved in smoking "light" cigarettes.

    abstract:BACKGROUND:Light cigarettes have been marketed by the tobacco industry as being a healthier smoking choice, a safe alternative to cessation, and a first step toward quitting smoking altogether. Research, however, has failed to show a reduction in smoking-related health risks, an increase in rates of smoking cessation, ...


    pub_type: 杂志文章


    authors: Kropp RY,Halpern-Felsher BL

    更新日期:2004-10-01 00:00:00

  • Health of children born as a result of in vitro fertilization.

    abstract:OBJECTIVE:The purpose of this study was to use nationwide registries to examine the health of children up to 4 years of age who were born as a result of in vitro fertilization. METHODS:Children born after in vitro fertilization (N = 4559) from 1996 to 1999 were monitored until 2003. Two control groups were selected fr...


    pub_type: 杂志文章


    authors: Klemetti R,Sevón T,Gissler M,Hemminki E

    更新日期:2006-11-01 00:00:00

  • Comprehensive evaluation of the child with intellectual disability or global developmental delays.

    abstract::Global developmental delay and intellectual disability are relatively common pediatric conditions. This report describes the recommended clinical genetics diagnostic approach. The report is based on a review of published reports, most consisting of medium to large case series of diagnostic tests used, and the proporti...


    pub_type: 杂志文章,评审


    authors: Moeschler JB,Shevell M,Committee on Genetics.

    更新日期:2014-09-01 00:00:00

  • Population-based impact of pneumococcal conjugate vaccine in young children.

    abstract:OBJECTIVE:To determine the population impact of pneumococcal conjugate vaccine (PCV) on pneumococcal-related diseases, including pneumonia and otitis media. METHODS:Using administrative data from Tennessee Medicaid and 3 commercial insurance plans in upstate New York, we measured annual rates of medical visits for pne...


    pub_type: 杂志文章


    authors: Poehling KA,Lafleur BJ,Szilagyi PG,Edwards KM,Mitchel E,Barth R,Schwartz B,Griffin MR

    更新日期:2004-09-01 00:00:00

  • Sensitization to silk and childhood asthma in rural China.

    abstract:OBJECTIVE:Sensitization to perennial aeroallergens is associated with asthma in industrialized countries with a Western lifestyle. Because silk products are commonly used in Chinese society, we were interested in examining the relation between sensitization to silk and asthma. DESIGN:Cross-sectional study of 871 child...


    pub_type: 杂志文章


    authors: Celedón JC,Palmer LJ,Xu X,Wang B,Fang Z,Weiss ST

    更新日期:2001-05-01 00:00:00

  • Lay Field-worker-Led School Health Program for Primary Schools in Low- and Middle-Income Countries.

    abstract:BACKGROUND AND OBJECTIVES:School health programs are frequently attempted in low- and/or middle-income countries; however, programmatic scope and reach is limited by human resource constraints. We sought to determine if trained community members could implement a school health program that improved outcomes in rural pr...


    pub_type: 杂志文章,多中心研究


    authors: Matergia M,Ferrarone P,Khan Y,Matergia DW,Giri P,Thapa S,Simões EAF

    更新日期:2019-04-01 00:00:00

  • Effects of therapeutic irradiation delivered in early childhood upon subsequent lung function.

    abstract::To determine the long-term effects of therapeutic pulmonary irradiation and treatment with actinomycin D during a period of lung growth, 12 patients treated for Wilms' tumor metastatic to the lung and 8 patients treated for Wilms' tumor with no evidence of pulmonary metastases were studied 7 to 14 years after their in...


    pub_type: 杂志文章


    authors: Wohl ME,Griscom NT,Traggis DG,Jaffe N

    更新日期:1975-04-01 00:00:00

  • Quality of evidence-based pediatric guidelines.

    abstract:OBJECTIVE:To identify evidence-based pediatric guidelines and to assess their quality. METHODS:We searched Medline, Embase, and relevant Web sites of guideline development programs and national pediatric societies to identify evidence-based pediatric guidelines. A list with titles of identified guidelines was sent to ...


    pub_type: 杂志文章


    authors: Boluyt N,Lincke CR,Offringa M

    更新日期:2005-05-01 00:00:00

  • Successful direct extubation of very low birth weight infants from low intermittent mandatory ventilation rate.

    abstract::It is common practice to use endotracheal continuous positive airway pressure for various time periods up to 24 hours before attempting extubation in infants who are mechanically ventilated. A few studies in newborns have indicated that airway resistance is increased through small endotracheal tubes. This increases th...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kim EH,Boutwell WC

    更新日期:1987-09-01 00:00:00

  • Exclusive breastfeeding protects against bacterial colonization and day care exposure to otitis media.

    abstract:OBJECTIVE:We followed a cohort (N = 306) of infants at well-baby visits in two suburban pediatric practices to assess the relation of exclusive breastfeeding, and other environmental exposures, to episodes of acute otitis media (AOM) and otitis media with effusion (OME). METHODS:Detailed prospective information about ...


    pub_type: 杂志文章


    authors: Duffy LC,Faden H,Wasielewski R,Wolf J,Krystofik D

    更新日期:1997-10-01 00:00:00

  • Just a click away: recreational drug Web sites on the Internet.

    abstract::The explosive growth of the Internet in recent years has provided a revolutionary new means of interpersonal communication and connectivity. Information on recreational drugs-once limited to bookstores, libraries, mass media, and personal contacts-is now readily available to just about anyone with Internet access. Not...


    pub_type: 杂志文章


    authors: Wax PM

    更新日期:2002-06-01 00:00:00

  • Visual System Assessment in Infants, Children, and Young Adults by Pediatricians

    abstract::Appropriate visual assessments help identify children who may benefit from early interventions to correct or improve vision. Examination of the eyes and visual system should begin in the nursery and continue throughout both childhood and adolescence during routine well-child visits in the medical home. Newborn infants...


    pub_type: 杂志文章


    authors: Donahue SP,Nixon CN,Section on Opthamology, American Academy of Pediatrics.,Committee on Practice and Ambulatory Medicine, American Academy of Pediatrics.,American Academy of Ophthalmology.,American Association for Pediatric Ophthalmology and

    更新日期:2016-01-01 00:00:00

  • Reflex sympathetic dystrophy in children.

    abstract::Two pediatric patients had reflex sympathetic dystrophy, which has been well described in adults but is rarely recognized in children. The syndrome consists of continuous pain, hyperesthesia, and autonomic symptoms occurring in an extremity, usually following trauma. The various types of presentation, differential dia...


    pub_type: 杂志文章


    authors: Fermaglich DR

    更新日期:1977-12-01 00:00:00