Birthweight of children with phenylketonuria.

Abstract:

:The assumption that children with phenylketonuria (PKU) develop normally until birth was brought into question by the recent report that PKU children weigh several hundred grams less at birth than their unaffected siblings. We have examined intrafamily differences in birthweight in 40 sibships with at least one affected and one unaffected child. The difference in mean birthweights computed by taking a weighted average of the intrafamily differences was 69 gm, and the adjusted estimate of the birthweight difference between children with PKU and their siblings, obtained from a fitted multiple regression function, is -51 gm. The findings are not consistent with the large difference in birthweight reported previously and are compatible with the assumption that the intrauterine physical growth of children with classical PKU is not adversely affected.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Rothman KJ,Pueschel SN

subject

Has Abstract

pub_date

1976-12-01 00:00:00

pages

842-4

issue

6

eissn

0031-4005

issn

1098-4275

journal_volume

58

pub_type

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