Randomized, controlled trial of oros methylphenidate once a day in children with attention-deficit/hyperactivity disorder.

Abstract:

OBJECTIVE:A new once-a-day methylphenidate (MPH) formulation, Concerta (methylphenidate HCl) extended-release tablets (OROS MPH), has been developed. This study was conducted to determine the safety and efficacy of OROS MPH in a multicenter, randomized, clinical trial. METHODS:Children with attention-deficit/hyperactivity disorder (ADHD; n = 282), all subtypes, ages 6 to 12 years, were randomized to placebo (n = 90), immediate-release methylphenidate (IR MPH) 3 times a day (tid; dosed every 4 hours; n = 97), or OROS MPH once a day (qd; n = 95) in a double-blind, 28-day trial. Outcomes in multiple domains were assessed, and data were analyzed using analysis of variance and Kaplan Meier product limit estimates for time to study cessation. The primary time point for analysis was the last available patient visit using last observation carried forward. RESULTS:Children in the OROS and IR MPH groups showed significantly greater reductions in core ADHD symptoms than did children on placebo. This was true both at the end of week 1 and at the end of treatment on the basis of mean teacher and parent IOWA Conners ratings. IR MPH tid and OROS MPH qd did not differ significantly on any direct comparisons. Forty-eight percent of the placebo group discontinued early compared with 14% and 16% in the IR MPH and OROS MPH groups, respectively. CONCLUSIONS:For the treatment of core ADHD symptoms, OROS MPH dosed qd and IR MPH dosed tid were superior to placebo and were not significantly different from each other.attention-deficit/hyperactivity disorder, methylphenidate, OROS, Concerta.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Wolraich ML,Greenhill LL,Pelham W,Swanson J,Wilens T,Palumbo D,Atkins M,McBurnett K,Bukstein O,August G

doi

10.1542/peds.108.4.883

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

883-92

issue

4

eissn

0031-4005

issn

1098-4275

journal_volume

108

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Policy statement—Professional liability insurance and medicolegal education for pediatric residents and fellows.

    abstract::The American Academy of Pediatrics believes that pediatric residents and fellows should be fully informed of the scope and limitations of their professional liability insurance coverage while in training. The academy states that residents and fellows should be educated by their training institutions on matters relatin...

    journal_title:Pediatrics

    pub_type: 共识发展会议,杂志文章

    doi:10.1542/peds.2011-1025

    authors: Committee on Medical Liability and Risk Management.,Gonzalez JL

    更新日期:2011-09-01 00:00:00

  • The medical cost of abusive head trauma in the United States.

    abstract:OBJECTIVES:Health consequences of shaken baby syndrome, or pediatric abusive head trauma (AHT), can be severe and long-lasting. We aimed to estimate the multiyear medical cost attributable to AHT. METHODS:Using Truven Health MarketScan data, 2003-2011, we identified children 0 to 4 years old with commercial or Medicai...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-0117

    authors: Peterson C,Xu L,Florence C,Parks SE,Miller TR,Barr RG,Barr M,Steinbeigle R

    更新日期:2014-07-01 00:00:00

  • Pulmonary paragonimiasis in Laotian refugee children.

    abstract::Three Laotian refugee children with chronic pulmonary complaints and findings were found to have pulmonary paragonimiasis during a one-year period in Chicago. These patients ranged from 8 to 11 years of age and the diagnosis was delayed five to six months in two children because of the unfamiliarity of American physic...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Burton K,Yogev R,London N,Boyer K,Shulman ST

    更新日期:1982-08-01 00:00:00

  • Adolescent mothers and their infants.

    abstract::It is unclear why children of adolescent mothers experience more developmental problems than children of adult mothers. There has been minimal systematic investigation of whether there is a relationship between the young age of the mother and her mothering behaviors. Our data fail to demonstrate any relationship betwe...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: McAnarney ER,Lawrence RA,Aten MJ,Iker HP

    更新日期:1984-03-01 00:00:00

  • Epigenetics and primary care.

    abstract::Epigenetics, the study of functionally relevant chemical modifications to DNA that do not involve a change in the DNA nucleotide sequence, is at the interface between research and clinical medicine. Research on epigenetic marks, which regulate gene expression independently of the underlying genetic code, has dramatica...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2013-1032F

    authors: Wright R,Saul RA

    更新日期:2013-12-01 00:00:00

  • Prolonged retention of foreign bodies in the stomach.

    abstract::Two patients had prolonged retention of small round foreign bodies in the stomach. Both patients had a history of a pyloromyotomy. Radiographic examination revealed a prepyloric web in one patient and a deformed pylorus in the other. These findings were confirmed by surgery. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Mandell GA,Rosenberg HK,Schnaufer L

    更新日期:1977-10-01 00:00:00

  • Initiation of breastfeeding among mothers of very low birth weight infants.

    abstract:OBJECTIVE:To examine factors that predict the initiation of expressed milk feedings and the transition to direct breastfeedings among mothers of very low birth weight (VLBW) infants. METHODS:The sample consists of 361 mother-infant pairs enrolled in a follow-up study of children aged 6 to 8 years who were born weighin...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.111.6.1337

    authors: Smith MM,Durkin M,Hinton VJ,Bellinger D,Kuhn L

    更新日期:2003-06-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2010-1722H

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    更新日期:2011-05-01 00:00:00

  • Telemedicine for evaluation of retinopathy of prematurity.

    abstract::Retinopathy of prematurity (ROP) remains a significant threat to vision for extremely premature infants despite the availability of therapeutic modalities capable, in most cases, of managing this disorder. It has been shown in many controlled trials that application of therapies at the appropriate time is essential to...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2014-0978

    authors: Fierson WM,Capone A Jr,American Academy of Pediatrics Section on Ophthalmology.,American Academy of Ophthalmology, American Association of Certified Orthoptists.

    更新日期:2015-01-01 00:00:00

  • Comparison of urinary lactic dehydrogenase with antibody-coated bacteria in the urine sediment as means of localizing the site of urinary tract infection.

    abstract::Two noninvasive methods of localizing the site of urinary tract infection, urinary lactic dehydrogenase (LDH) isoenzymes and antibody coating of bacteria in the urinary sediment, have been prospectively compared with the bladder washout technique in a series of children with urinary tract infection. Fifteen children h...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lorentz WB Jr,Resnick MI

    更新日期:1979-11-01 00:00:00

  • Intrauterine effects of maternal prepregnancy overweight on child cognition and behavior in 2 cohorts.

    abstract:OBJECTIVE:Greater maternal prepregnancy adiposity has been associated with behavioral problems, such as attention-deficit/hyperactivity disorder, and lower intellectual function in offspring. However, few studies of humans have explored this, and it is unclear if intrauterine mechanisms or confounding factors drive the...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-0651

    authors: Brion MJ,Zeegers M,Jaddoe V,Verhulst F,Tiemeier H,Lawlor DA,Smith GD

    更新日期:2011-01-01 00:00:00

  • Should central venous catheters be removed as soon as candidemia is detected in neonates?

    abstract:BACKGROUND:Controversy exists regarding the most appropriate acute management of central venous catheters (CVCs) in neonates with candidemia, with up to two thirds of neonatologists preferring to attempt antifungal therapy without removing CVCs. OBJECTIVE:To determine whether CVCs should be removed as soon as candidem...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.5.e63

    authors: Karlowicz MG,Hashimoto LN,Kelly RE Jr,Buescher ES

    更新日期:2000-11-01 00:00:00

  • Iron-fortified formulas and gastrointestinal symptoms in infants: a controlled study, With the cooperation of The Syracuse Consortium for Pediatric Clinical Studies.

    abstract::In an attempt to determine whether iron-fortified infant formulas produced gastrointestinal symptoms in infants, we fed two similar formulas, one with and one without iron fortification, to a group of 93 term infants upon discharge from the nursery on the third day of life. Infants were fed the formulas for a period o...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors:

    更新日期:1980-08-01 00:00:00

  • Variability in head circumference growth rate during the first 2 years of life.

    abstract::The head circumference (HC) curves were plotted for a group of 415 healthy full-term babies over the first 2 years of life. Two hundred ten (51%) of the cohort demonstrated HC variability, defined as an HC acceleration or deceleration of at least 1 centile curve for at least 2 months. Of these, the deceleration patter...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Jaffe M,Tal Y,Hadad B,Tirosh E,Tamir A

    更新日期:1992-08-01 00:00:00

  • Evaluation of a clinical dehydration scale in children requiring intravenous rehydration.

    abstract:OBJECTIVES:To evaluate the reliability and validity of a previously derived clinical dehydration scale (CDS) in a cohort of children with gastroenteritis and evidence of dehydration. METHODS:Participants were 226 children older than 3 months who presented to a tertiary care emergency department and required intravenou...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-2985

    authors: Kinlin LM,Freedman SB

    更新日期:2012-05-01 00:00:00

  • Gross and fine motor development in 45,X and 47,XXX girls.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Salbenblatt JA,Meyers DC,Bender BG,Linden MG,Robinson A

    更新日期:1989-10-01 00:00:00

  • Cognitive function and brain structure in females with a history of adolescent-onset anorexia nervosa.

    abstract:OBJECTIVE:Abnormalities in cognitive function and brain structure have been reported in acutely ill adolescents with anorexia nervosa, but whether these abnormalities persist or are reversible in the context of weight restoration remains unclear. Brain structure and cognitive function in female subjects with adolescent...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-0170

    authors: Chui HT,Christensen BK,Zipursky RB,Richards BA,Hanratty MK,Kabani NJ,Mikulis DJ,Katzman DK

    更新日期:2008-08-01 00:00:00

  • Pneumococcal mastoiditis in children.

    abstract:OBJECTIVE:To determine the impact of antibiotic resistance on the frequency, clinical features, and management/outcome of mastoiditis attributable to Streptococcus pneumoniae. DESIGN:Retrospective review of the medical records of children with mastoiditis caused by S pneumoniae from September 1993 through December 199...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.106.4.695

    authors: Kaplan SL,Mason EO Jr,Wald ER,Kim KS,Givner LB,Bradley JS,Barson WJ,Tan TQ,Schutze GE,Yogev R

    更新日期:2000-10-01 00:00:00

  • Parental permission for pilot newborn screening research: guidelines from the NBSTRN.

    abstract::There is broad recognition of the need for population-based research to assess the safety and efficacy of newborn screening (NBS) for conditions that are not on current panels. However, prospective population-based research poses significant ethical, regulatory, and logistical challenges. In the context of NBS, there ...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2013-2271

    authors: Botkin JR,Lewis MH,Watson MS,Swoboda KJ,Anderson R,Berry SA,Bonhomme N,Brosco JP,Comeau AM,Goldenberg A,Goldman E,Therrell B,Levy-Fisch J,Tarini B,Wilfond B,Bioethics and Legal Work Group of the Newborn Screening Translatio

    更新日期:2014-02-01 00:00:00

  • Issues in estimating the prevalence of fetal alcohol syndrome: examination of 2 counties in New York State.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0610

    authors: Druschel CM,Fox DJ

    更新日期:2007-02-01 00:00:00

  • Evolution in the recognition of infantile hypertrophic pyloric stenosis.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.100.2.e9

    authors: Hulka F,Campbell TJ,Campbell JR,Harrison MW

    更新日期:1997-08-01 00:00:00

  • Neurodevelopment and in utero antiretroviral exposure of HIV-exposed uninfected infants.

    abstract:OBJECTIVE:Antiretroviral (ARV) drugs are routinely provided to HIV-infected pregnant women to prevent HIV mother-to-child transmission. Although ARV use has significantly reduced mother-to-child transmission to <2% in the United States, it remains crucial to monitor uninfected infants and children for adverse consequen...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-1112

    authors: Williams PL,Marino M,Malee K,Brogly S,Hughes MD,Mofenson LM,PACTG 219C Team.

    更新日期:2010-02-01 00:00:00

  • Stakeholder Perspectives on Research and Practice in Autism and Transition.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-4300F

    authors: Kuo AA,Crapnell T,Lau L,Anderson KA,Shattuck P

    更新日期:2018-04-01 00:00:00

  • Hyperphenylalaninemia due to dihydropteridine reductase deficiency: diagnosis by measurement of oxidized and reduced pterins in urine.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Milstien S,Kaufman S,Summer GK

    更新日期:1980-04-01 00:00:00

  • Early-Life Predictors of Fetal Alcohol Spectrum Disorders.

    abstract:BACKGROUND AND OBJECTIVES:Fetal alcohol spectrum disorders (FASD) comprise the continuum of disabilities associated with prenatal alcohol exposure. Although infancy remains the most effective time for initiation of intervention services, current diagnostic schemes demonstrate the greatest confidence, accuracy, and reli...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-2141

    authors: Kalberg WO,May PA,Buckley D,Hasken JM,Marais AS,De Vries MM,Bezuidenhout H,Manning MA,Robinson LK,Adam MP,Hoyme DB,Parry CDH,Seedat S,Elliott AJ,Hoyme HE

    更新日期:2019-12-01 00:00:00

  • Death in the intensive care nursery: physician practice of withdrawing and withholding life support.

    abstract:OBJECTIVE:To determine the frequency of selective nontreatment of extremely premature, critically ill, or malformed infants among all infant deaths in a level III intensive care nursery (ICN) and to determine the reasons documented by neonatologists for their decisions to withdraw or withhold life support. METHODS:Thi...

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    doi:10.1542/peds.99.1.64

    authors: Wall SN,Partridge JC

    更新日期:1997-01-01 00:00:00

  • First case of human infection caused by Pasteurella gallinarum causing infective endocarditis in an adolescent 10 years after surgical correction for truncus arteriosus.

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    doi:

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    更新日期:1995-06-01 00:00:00

  • Increasing breast milk production for premature infants with a relaxation/imagery audiotape.

    abstract::Many women whose premature infants are hospitalized in a newborn intensive care unit choose to express breast milk for their babies. Yet anxiety, fatigue, and emotional stress are powerful inhibitors of lactation. To facilitate the breast-feeding experience, intervention mothers were given a 20-minute audio cassette t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Feher SD,Berger LR,Johnson JD,Wilde JB

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  • Preterm Birth and Poor Fetal Growth as Risk Factors of Attention-Deficit/ Hyperactivity Disorder.

    abstract:BACKGROUND:Previous studies have shown an association between prematurity and attention- abstract deficit/hyperactivity disorder (ADHD). Results concerning late preterm infants are controversial, and studies examining fetal growth represented by weight for gestational age are scarce. Our objective was to examine the as...

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  • Outbreak of Mycoplasma pneumoniae-Associated Stevens-Johnson Syndrome.

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