Epigenetics and primary care.

Abstract:

:Epigenetics, the study of functionally relevant chemical modifications to DNA that do not involve a change in the DNA nucleotide sequence, is at the interface between research and clinical medicine. Research on epigenetic marks, which regulate gene expression independently of the underlying genetic code, has dramatically changed our understanding of the interplay between genes and the environment. This interplay alters human biology and developmental trajectories, and can lead to programmed human disease years after the environmental exposure. In addition, epigenetic marks are potentially heritable. In this article, we discuss the underlying concepts of epigenetics and address its current and potential applicability for primary care providers.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Wright R,Saul RA

doi

10.1542/peds.2013-1032F

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

S216-23

issue

Suppl 3

eissn

0031-4005

issn

1098-4275

pii

peds.2013-1032F

journal_volume

132

pub_type

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