Safety of a higher loading dose of phenobarbital in the term newborn.

Abstract:

:The conventional loading dose of phenobarbital for newborn infants with hypoxic-ischemic seizures, 20 mg/kg, often fails to control convulsive activity. To determine the safety of a higher loading dose and to establish the pharmacokinetic parameters of a higher loading dose, ten severely asphyxiated term newborns were given 30 mg/kg of phenobarbital intravenously over 15 minutes. The mean serum concentration of phenobarbital two hours after loading was 30.0 +/- 3.2 micrograms/mL, the apparent volume of distribution was 0.97 +/- 0.18 L/kg, total clearance was 0.08 +/- 0.03 mL/min/kg, and mean serum half-life was 148 +/- 55 hours. The higher loading dose was not associated with any short-term adverse effects on cardiorespiratory function, even in spontaneously breathing infants.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Donn SM,Grasela TH,Goldstein GW

subject

Has Abstract

pub_date

1985-06-01 00:00:00

pages

1061-4

issue

6

eissn

0031-4005

issn

1098-4275

journal_volume

75

pub_type

杂志文章
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    authors: Sullivan DW,Purdy LJ,Billingham M,Glader BE

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    authors: Greydanus DE,McAnarney ER

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    pub_type: 杂志文章

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    authors: Jiang X,Srinivasan SR,Radhakrishnamurthy B,Dalferes ER,Berenson GS

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    journal_title:Pediatrics

    pub_type: 杂志文章

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