Abstract:
OBJECTIVE:A voluntary market withdrawal of orally administered, over-the-counter, infant cough and cold medications (CCMs) was announced in October 2007. The goal of this study was to assess CCM-related adverse events (AEs) among children after the withdrawal. METHODS:Emergency department (ED) visits for CCM-related AEs among children <12 years of age were identified from a nationally representative, stratified, probability sample of 63 US EDs, for the 14 months before and after announcement of withdrawal. RESULTS:After withdrawal, the number and proportion of estimated ED visits for CCM-related AEs involving children <2 years of age were less than one-half of those in the prewithdrawal period (1248 visits [13.3%] vs 2790 visits [28.7%]; difference: -15.4% [95% confidence interval [CI]: -25.9% to -5.0%]), whereas the overall number of estimated ED visits for CCM-related AEs for children <12 years of age remained unchanged (9408 visits [95% CI: 6874-11 941 visits] vs 9727 visits [95% CI: 6649-12 805 visits]). During both periods, two-thirds of estimated ED visits involved unsupervised ingestions (ie, children finding and ingesting medications). CONCLUSIONS:ED visits for CCM-related AEs among children <2 years of age were substantially reduced after withdrawal of over-the-counter infant CCMs. Further reductions likely will require packaging improvements to reduce harm from unsupervised ingestions and continued education about avoiding CCM use for young children. Monitoring of CCM-related harm should continue because recommendations were updated in October 2008 to avoid the use of CCMs for children <4 years of age.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Shehab N,Schaefer MK,Kegler SR,Budnitz DSdoi
10.1542/peds.2010-1839subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1100-7issue
6eissn
0031-4005issn
1098-4275pii
peds.2010-1839journal_volume
126pub_type
杂志文章,多中心研究相关文献
PEDIATRICS文献大全abstract:OBJECTIVES:To develop and test an evidence-based model for reducing medication errors and harm in hospitalized children. METHODS:Prospective interrupted time series study evaluating the effectiveness of a multifaceted, staged intervention over 4 years in a major urban pediatric referral hospital. Guidelines for safe p...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-1902
更新日期:2012-05-01 00:00:00
abstract::The coexistence in two sisters, born to related parents, of a corticoresistant nephrotic syndrome, lymphopenia, an immune deficit, short stature, and photophobia is described. The immune deficit is mainly cellular; studies of lymphocyte markers demonstrate a pronounced deficiency of T lymphocytes and Fc-mu receptor-be...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:To assess the relationship between adolescent and parent reports of adolescent health-related quality of life (HRQL) and between adolescent pulmonary function (forced expiratory volume in 1 second as percent of predicted) and reporter perceptions of adolescent health. METHODS:Twenty-four adolescents with cysti...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.5.e70
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:International efforts have been focused on identifying children at low risk of clinically important traumatic brain injury in whom computed tomography (CT) neuroimaging can be avoided. We sought to determine if CT use for pediatric head trauma has decreased among US emergency departments (EDs)...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-0814
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular dysplasia. Most cases are caused by mutations in the endoglin gene on chromosome 9 (HHT type 1) or the activin receptor-like kinase 1 gene on chromosome 12 (HHT type 2), which leads to telangiectases and arteriovenous malformations ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.109.1.e12
更新日期:2002-01-01 00:00:00
abstract::A 46-month-old boy with juvenile chronic granulocytic leukemia was treated intensively with hydroxyurea, dimethyl myleran, cyclophosphamide, and total body irradiation. He then received a marrow transplant from an HL-A matched brother. Thirty-two months after the transplantation, he is hematologically normal and remai...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Controversy exists regarding the most appropriate acute management of central venous catheters (CVCs) in neonates with candidemia, with up to two thirds of neonatologists preferring to attempt antifungal therapy without removing CVCs. OBJECTIVE:To determine whether CVCs should be removed as soon as candidem...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.5.e63
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:Youth processed in the juvenile justice system are at great risk for early violent death. Groups at greatest risk, ie, racial/ethnic minorities, male youth, and urban youth, are overrepresented in the juvenile justice system. We compared mortality rates for delinquent youth with those for the general populati...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1459
更新日期:2005-06-01 00:00:00
abstract::Idiopathic acute eosinophilic pneumonia is a rare and potentially life-threatening condition that is defined by bilateral pulmonary infiltrates and fever in the presence of pulmonary eosinophilia. It often presents acutely in previously healthy individuals and can be difficult to distinguish from infectious pneumonia....
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-3007
更新日期:2020-04-01 00:00:00
abstract::To find out whether there is any relationship between the ventilatory response to hypoxia and the sudden infant death syndrome (SIDS), we studied the effects of mild induced hypoxia (PIO2, 120 mm Hg = 17% oxygen) in 16 infants aged 2 weeks to 6 months. Eight had recurrent apneic spells (apnea group) (five had aborted ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract::The validity of a mass blood pressure screening program carried out on Dallas high school students who were followed for at least 3 years is reported. Blood pressure results on initial screening in the tenth grade were related to outcome blood pressure status. The frequency of initial blood pressure elevation (systoli...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract::The purpose of this study was to determine the prevalence of persistent blood pressure elevations in an eighth-grade population composed of three ethnic groups, and to determine the feasibility of using school health facilities for hypertension screening. Blood pressure was recorded in 10,641 subjects (90% of the tota...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:Current federal regulations of potentially carcinogenic environmental chemicals are based on the assumption that risks for humans can be extrapolated from the effects of chronic high-dose exposure of rodents. It is assumed that all chemicals induce cancer by a genotoxic mechanism (direct interaction with DNA)...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:Our purpose with this work was to examine the relationship between negative comments about weight, shape, and eating and social adjustment, social support, self-esteem, and perceived childhood abuse and neglect. METHODS:A retrospective study was conducted with 455 college women with high weight and shape con...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1806
更新日期:2006-08-01 00:00:00
abstract::Primary type V hyperlipoproteinemia was identified in two preadolescent children. The propositus (kindred N) was a 10-year-old girl with severely creamy plasma, lipemia retinalis, hypertriglyceridemia (triglyceridelevel, 6,800 mg/100 ml), and ypercholesterolemia (cholesterol level, 490 mg/100 ml). Her parents and an 8...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract:OBJECTIVE:To examine factors that predict the initiation of expressed milk feedings and the transition to direct breastfeedings among mothers of very low birth weight (VLBW) infants. METHODS:The sample consists of 361 mother-infant pairs enrolled in a follow-up study of children aged 6 to 8 years who were born weighin...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.111.6.1337
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:This study was conducted to determine the prevalence of posterior fossae of the brain, arterial anomalies, cardiac anomalies, and eye anomalies (PHACE) in infants with large facial hemangiomas. The extracutaneous manifestations of PHACE may be associated with significant morbidity, and the prevalence of PHAC...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-3166
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:As newborn screening (NBS) programs expand to include conditions that challenge traditional public health criteria, little is known about what influences physicians' attitudes toward screening. We examined the effect of state policy and perceived state policy on pediatricians' attitudes toward screening. MET...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1990
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:Digital technologies offer new platforms for health promotion and disease management. Few studies have evaluated the use of digital technology among families receiving care in an urban pediatric primary care setting. METHODS:A self-administered survey was given to a convenience sample of caregivers bringing ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-0594
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Neonatal encephalopathy (NE) is a major predictor of death and long-term neurologic disability, but there are few studies of antecedents of NE. OBJECTIVES:To identify antecedents in a large registry of infants who had NE. METHODS:This was a maternal and infant record review of 4165 singleton neonates, gest...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-0714
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Gastric acidity is a major nonimmune defense mechanism against infections. The objective of this study was to investigate whether ranitidine treatment in very low birth weight (VLBW) infants is associated with an increased risk of infections, necrotizing enterocolitis (NEC), and fatal outcome....
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-0796
更新日期:2012-01-01 00:00:00
abstract::In recent years, next-generation sequencing technologies have revolutionized approaches to genetic studies. Whole-exome or whole-genome sequencing allows diagnoses in many patients who have complex phenotypes and unusual clinical presentations. As genomic and exomic testing expands in both the research and clinical se...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-3731C
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:CHARGE (coloboma, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, ear anomalies/deafness) syndrome and chromosome 22q11.2 deletion syndrome are known to have significant clinical overlap including cardiac anomalies, ear abnormalities, hearing loss, developmental delay, ren...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-3400
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:Legal and ethical standards require resuscitation when it is considered to be in the patient's best interest. We hypothesized that newborn infants might be dealt with according to different standards, compared with older patients. METHODS:An anonymous questionnaire describing 8 currently incompetent patients...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1520
更新日期:2008-05-01 00:00:00
abstract::A 4-year-old girl presented to a medical clinic with a painless right facial swelling. The treating physician ordered a radiograph of the sinuses and received a report of "maxillary sinusitis." After appropriate antibiotic treatment, the facial swelling increased, and the mother took the child to her community pediatr...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1940
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:Coronaviruses cause upper respiratory illness and occasionally lower tract disease in susceptible populations. In this study we examined the prevalence of 4 human coronaviruses, including subtypes OC43, 229E, and the recently described NL63 and HKU1 in a pediatric population presenting to a children's hospit...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1406
更新日期:2007-01-01 00:00:00
abstract::Cat scratch disease is a benign, self-limited illness characterized by regional lymphadenopathy that usually occurs in association with a history of contact with a cat. Cases of cat scratch disease with skin manifestations that included erythema nodosum; erythema multiforme; erythema marginatum; and non-specific macul...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Prolonged mechanical ventilation is associated with lung injury in preterm infants. In these infants, weaning from synchronized intermittent mandatory ventilation may be delayed by their inability to cope with increased respiratory loads. The addition of pressure support to synchronized intermittent mandator...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2005-2923
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVES:Trichophyton tonsurans is the single most common cause of pediatric dermatophytoses in North America and is observed with increasing frequency in other countries. This investigation was designed to gain insight into the natural course of T. tonsurans infection. PATIENTS AND METHODS:This 2-year prospective, ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-2065
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to examine whether selected genetic polymorphisms in the infant are associated with later-diagnosed cerebral palsy. METHODS:A population-based case-control study was conducted of 28 single-nucleotide polymorphisms measured in newborn screening blood spots. A total of 413 child...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-3758
更新日期:2008-11-01 00:00:00