Respiratory syncytial virus immune globulin treatment of RSV lower respiratory tract infection in previously healthy children.

Abstract:

OBJECTIVE:To evaluate the efficacy of high titer respiratory syncytial virus (RSV) immune globulin (RSVIG) in the treatment of previously healthy children hospitalized with proven RSV lower tract infection (LRI). METHOD:Infants and young children /=2. 5 were enrolled. RESULTS:One hundred and one previously healthy children hospitalized with RSV LRI received either 1500 mg/kg of RSVIG (RespiGam, MedImmune Inc, Gaithersburg, MD) or albumin placebo in a randomized, double-blind, placebo-controlled trial. Forty-six RSVIG and 52 recipients of placebo met all eligibility criteria. Demographic characteristics of the two groups were similar. More RSVIG recipients (46% vs 29%) had an SaO2 /=3.0) had 1.6 fewer hospital days and 2.7 days less ICU stays. CONCLUSION:RSVIG infusions seemed safe and generally well tolerated. Although some beneficial effect trends were seen for those with more severe disease who were treated there was no evidence that treatment with RSVIG resulted in reduced hospitalization and reduced ICU stays in all children with RSV disease.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Rodriguez WJ,Gruber WC,Groothuis JR,Simoes EA,Rosas AJ,Lepow M,Kramer A,Hemming V

doi

10.1542/peds.100.6.937

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

937-42

issue

6

eissn

0031-4005

issn

1098-4275

journal_volume

100

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Pomerantz WJ,Timm NL,Gittelman MA

    更新日期:2010-04-01 00:00:00

  • Pediatric Mental Health Boarding.

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    journal_title:Pediatrics

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    authors: McEnany FB,Ojugbele O,Doherty JR,McLaren JL,Leyenaar JK

    更新日期:2020-10-01 00:00:00

  • Developmental Outcomes of Preterm Infants With Neonatal Hypoglycemia.

    abstract:BACKGROUND AND OBJECTIVES:Neonatal hypoglycemia has been associated with abnormalities on brain imaging and a spectrum of developmental delays, although historical and recent studies show conflicting results. We compared the cognitive, academic, and behavioral outcomes of preterm infants with neonatal hypoglycemia with...

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    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2016-1424

    authors: Goode RH,Rettiganti M,Li J,Lyle RE,Whiteside-Mansell L,Barrett KW,Casey PH

    更新日期:2016-12-01 00:00:00

  • Blood pressure fluctuation and intraventricular hemorrhage in the preterm infant of less than 31 weeks' gestation.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Miall-Allen VM,de Vries LS,Dubowitz LM,Whitelaw AG

    更新日期:1989-05-01 00:00:00

  • Nurse Home Visiting and Maternal Mental Health: 3-Year Follow-Up of a Randomized Trial.

    abstract:BACKGROUND:Poor mental health is recognized as one of the greatest global burdens of disease. Maternal mental health is crucial for the optimal health of mothers and their children. We examined the effects of an Australian Nurse Home Visiting (NHV) program (right@home), offered to pregnant women experiencing adversity,...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-025361

    authors: Goldfeld S,Bryson H,Mensah F,Gold L,Orsini F,Perlen S,Price A,Hiscock H,Grobler A,Dakin P,Bruce T,Harris D,Kemp L

    更新日期:2021-02-01 00:00:00

  • Minoxidil for control of acute blood pressure elevation in chronically hypertensive children.

    abstract::Twenty-three episodes of acute elevation of BP related to renal disease in 13 chronically hypertensive children 2 to 18 years of age were treated with a single oral dose of minoxidil. All except one patient were receiving a diuretic and all but one a beta-blocking agent at the time of minoxidil treatment. The goal of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Strife CF,Quinlan M,Waldo FB,Fryer CJ,Jackson EC,Welch TR,McEnery PT,West CD

    更新日期:1986-11-01 00:00:00

  • Incidence and outcomes of symptomatic neonatal arterial ischemic stroke.

    abstract:BACKGROUND AND OBJECTIVES:Neonatal arterial ischemic stroke (NAIS) is associated with considerable lifetime burdens such as cerebral palsy, epilepsy, and cognitive impairment. Prospective epidemiologic studies that include outcome assessments are scarce. This study aimed to provide information on the epidemiology, clin...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-1520

    authors: Grunt S,Mazenauer L,Buerki SE,Boltshauser E,Mori AC,Datta AN,Fluss J,Mercati D,Keller E,Maier O,Poloni C,Ramelli GP,Schmitt-Mechelke T,Steinlin M

    更新日期:2015-05-01 00:00:00

  • Left atrial myxoma: association with acute coronary embolization in an 11-year-old boy.

    abstract::An 11-year-old boy had clinical signs of an acute inferior wall myocardial infarction. On echocardiography, a left atrial myxoma was demonstrated. Coronary artery embolization from myxoma was confirmed by selective coronary arteriography. The tumor was removed 12 days after acute coronary embolization. The clinical va...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Tanabe J,Williams RL,Diethrich EB

    更新日期:1979-05-01 00:00:00

  • Preventing neonatal group B streptococcal disease: cost-effectiveness in a health maintenance organization and the impact of delayed hospital discharge for newborns who received intrapartum antibiotics.

    abstract:OBJECTIVES:To estimate the cost and health benefits of implementing a risk factor-based prevention strategy for early-onset neonatal group B streptococcal (GBS) disease, using baseline assumptions and costs from a health maintenance organization. With the risk factor-based strategy, intrapartum antibiotics (IPAs) would...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.4.703

    authors: Mohle-Boetani JC,Lieu TA,Ray GT,Escobar G

    更新日期:1999-04-01 00:00:00

  • Policy statement—Professional liability insurance and medicolegal education for pediatric residents and fellows.

    abstract::The American Academy of Pediatrics believes that pediatric residents and fellows should be fully informed of the scope and limitations of their professional liability insurance coverage while in training. The academy states that residents and fellows should be educated by their training institutions on matters relatin...

    journal_title:Pediatrics

    pub_type: 共识发展会议,杂志文章

    doi:10.1542/peds.2011-1025

    authors: Committee on Medical Liability and Risk Management.,Gonzalez JL

    更新日期:2011-09-01 00:00:00

  • Digital Media and Sleep in Childhood and Adolescence.

    abstract::Given the pervasive use of screen-based media and the high prevalence of insufficient sleep among American youth and teenagers, this brief report summarizes the literature on electronic media and sleep and provides research recommendations. Recent systematic reviews of the literature reveal that the vast majority of s...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2016-1758J

    authors: LeBourgeois MK,Hale L,Chang AM,Akacem LD,Montgomery-Downs HE,Buxton OM

    更新日期:2017-11-01 00:00:00

  • Gypsies and acute medical intervention.

    abstract::Recently, a 7-month-old, terminally ill Gypsy infant was admitted to a pediatric intensive care unit. Treating this child and her extended family was a challenging experience during which numerous culture-related problems were encountered. The Gypsy approach to acute medical care consisted of the presence of a large e...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Wetzel RC,Dean JM,Rogers MC

    更新日期:1983-11-01 00:00:00

  • Reducing violent injuries: priorities for pediatrician advocacy.

    abstract::A basic framework for developing an advocacy plan must systematically break down the large task of policy development implementation into manageable components. The basic framework described in detail in this paper includes three steps: Setting policy objectives by narrowing the scope of policy, by reviewing policy op...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Dolins JC,Christoffel KK

    更新日期:1994-10-01 00:00:00

  • Rapid, needle-free delivery of lidocaine for reducing the pain of venipuncture among pediatric subjects.

    abstract:OBJECTIVES:The purpose of this study was to determine the optimal configuration of an investigational, single-use, needle-free, drug system (ALGRX 3268) that delivers powdered lidocaine into the epidermis for the rapid production of local anesthesia among pediatric subjects undergoing venipuncture. METHODS:Children 3 ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.2004-0656

    authors: Migdal M,Chudzynska-Pomianowska E,Vause E,Henry E,Lazar J

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.4.800

    authors: Ohyama M,Itani Y,Yamanaka M,Goto A,Kato K,Ijiri R,Tanaka Y

    更新日期:2004-04-01 00:00:00

  • Insulin receptors in cystic fibrosis: increased receptor number and altered affinity.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lippe BM,Kaplan SA,Neufeld ND,Smith A,Scott M

    更新日期:1980-05-01 00:00:00

  • Preschool child care participation and obesity at the start of kindergarten.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2233

    authors: Maher EJ,Li G,Carter L,Johnson DB

    更新日期:2008-08-01 00:00:00

  • Quality health care for children and the Affordable Care Act: a voltage drop checklist.

    abstract::The Affordable Care Act (ACA) introduces enormous policy changes to the health care system with several anticipated benefits and a growing number of unanticipated challenges for child and adolescent health. Because the ACA gives each state and their payers substantial autonomy and discretion on implementation, underst...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2014-0881

    authors: Cheng TL,Wise PH,Halfon N

    更新日期:2014-10-01 00:00:00

  • Informed Consent in Decision-Making in Pediatric Practice.

    abstract::Informed consent should be seen as an essential part of health care practice; parental permission and childhood assent is an active process that engages patients, both adults and children, in their health care. Pediatric practice is unique in that developmental maturation allows, over time, for increasing inclusion of...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-1485

    authors: Katz AL,Webb SA,COMMITTEE ON BIOETHICS.

    更新日期:2016-08-01 00:00:00

  • Breast Milk Consumption in Preterm Neonates and Cardiac Shape in Adulthood.

    abstract:BACKGROUND AND OBJECTIVES:Preterm birth relates to long-term alterations in cardiac morphology and function. Understanding whether preterm postnatal life is a tractable period of cardiovascular development that can be positively altered by nutrition is relevant to long-term outcomes. We hypothesized that being fed huma...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2016-0050

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  • Summary of workgroup meeting on use of family history information in pediatric primary care and public health.

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    journal_title:Pediatrics

    pub_type:

    doi:10.1542/peds.2007-1010H

    authors: Green RF

    更新日期:2007-09-01 00:00:00

  • Prepregnant overweight and obesity diminish the prolactin response to suckling in the first week postpartum.

    abstract:OBJECTIVE:The population subgroups with the highest proportion of overweight and obese women often are characterized by the lowest rates of initiation and shortest durations of breastfeeding. We previously documented that these 2 population-level trends may be related. In a population of white women who lived in a rura...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.5.e465

    authors: Rasmussen KM,Kjolhede CL

    更新日期:2004-05-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-0558

    authors: Duvall SW,Lindly O,Zuckerman K,Msall ME,Weddle M

    更新日期:2019-02-01 00:00:00

  • First Use of a Serogroup B Meningococcal Vaccine in the US in Response to a University Outbreak.

    abstract:BACKGROUND:In 2013-2014, an outbreak of serogroup B meningococcal disease occurred among persons linked to a New Jersey university (University A). In the absence of a licensed serogroup B meningococcal (MenB) vaccine in the United States, the Food and Drug Administration authorized use of an investigational MenB vaccin...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-4015

    authors: McNamara LA,Shumate AM,Johnsen P,MacNeil JR,Patel M,Bhavsar T,Cohn AC,Dinitz-Sklar J,Duffy J,Finnie J,Garon D,Hary R,Hu F,Kamiya H,Kim HJ,Kolligian J Jr,Neglia J,Oakley J,Wagner J,Wagner K,Wang X,Yu Y,Montana

    更新日期:2015-05-01 00:00:00

  • Pharmacokinetic comparison of intravenous and oral chloramphenicol in patients with Haemophilus influenzae meningitis.

    abstract::The pharmacokinetics of chloramphenicol following intravenous and oral administration were studied in 14 infants with Haemophilus influenzae meningitis. Following five days of treatment with intravenous chloramphenicol (100 mg/kg/day every six hours), oral chloramphenicol was substituted at the same dose. Multiple ser...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Yogev R,Kolling WM,Williams T

    更新日期:1981-05-01 00:00:00

  • Explaining the low risk of preterm birth among arab americans in the United States: an analysis of 617451 births.

    abstract:OBJECTIVES:Arab Americans have a lower risk for preterm birth than white Americans. We assessed factors that may contribute to the association between ethnicity and preterm birth risk in Michigan, the state with the largest concentration of Arab Americans in the United States. Factors assessed as potential contributors...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-1634

    authors: El-Sayed AM,Galea S

    更新日期:2009-03-01 00:00:00

  • Superior vena cava syndrome in childhood: report of ten cases and review of the literature.

    abstract::Experience with ten children with superior vena cava obstruction is reported. Five patients had non-Hodgkin's lymphoma, two had Hodgkin's disease, two had benign lesions, and one patient was suspected on clinical and radiologic basis to have a lymphoma. The clinical situation at presentation was often critical and req...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Issa PY,Brihi ER,Janin Y,Slim MS

    更新日期:1983-03-01 00:00:00

  • Multicenter trial of cryotherapy for retinopathy of prematurity: preliminary results. Cryotherapy for Retinopathy of Prematurity Cooperative Group.

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    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors:

    更新日期:1988-05-01 00:00:00

  • Hypothyroxinemia in mechanically ventilated term infants is associated with increased use of rescue therapies.

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    pub_type: 杂志文章

    doi:10.1542/peds.2004-0192

    authors: Lim DJ,Herring MK,Leef KH,Getchell J,Bartoshesky LE,Paul DA

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    pub_type: 杂志文章

    doi:

    authors: Walther FJ,Wu PY,Siassi B

    更新日期:1985-12-01 00:00:00