Insulin receptors in cystic fibrosis: increased receptor number and altered affinity.

Abstract:

:Patients with cystic fibrosis are known to have pancreatic disorganization with associated pancreatic exocrine insufficiency. Endocrine hormonal secretion is also affected but diminution in insulin secretion is rarely accompanied by overt diabetes. We studied seven patients with cystic fibrosis to determine their carbohydrate tolerance and the status of peripheral monocyte insulin receptors. Oral glucose tolerance tests showed the presence of mild hyperglycemia and diminished insulin secretion. Mean insulin receptor sites per cell were markedly increased above controls, 25,000 vs 13,100 sites per cell while receptor affinity was diminished. The increase in receptor number could be a consequence of the insulinopenia and/or the decreased body weight of the patients and serve as a compensatory mechanism maintaining a degree of relative insulin sensitivity. Ultimate carbohydrate tolerance may be a function of the patient's ability to maintain increased receptor numbers in the face of hypoinsulinemia and impaired receptor affinity.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Lippe BM,Kaplan SA,Neufeld ND,Smith A,Scott M

subject

Has Abstract

pub_date

1980-05-01 00:00:00

pages

1018-22

issue

5

eissn

0031-4005

issn

1098-4275

journal_volume

65

pub_type

杂志文章
  • A rose by any other name? Objective knowledge, perceived knowledge, and adolescent male condom use.

    abstract:OBJECTIVE:To investigate the role of objective and perceived knowledge about condoms in adolescent males' condom use at first intercourse. METHODS:A longitudinal analysis was conducted of data from a nationally representative sample of 404 virgin male adolescents who were aged 15 to 17 years at wave 1 and reported bec...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-0139

    authors: Rock EM,Ireland M,Resnick MD,McNeely CA

    更新日期:2005-03-01 00:00:00

  • Pediatrician identification of Latino children at risk for autism spectrum disorder.

    abstract:BACKGROUND AND OBJECTIVES:Latino-white disparities in age at autism spectrum disorder (ASD) diagnosis may be modified by primary care pediatrician (PCP) practices and beliefs. The objectives of this study were to assess ASD and developmental screening practices, attitudes toward ASD identification in Latino children, a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0383

    authors: Zuckerman KE,Mattox K,Donelan K,Batbayar O,Baghaee A,Bethell C

    更新日期:2013-09-01 00:00:00

  • Maternal practices that influence Hispanic infants' health and cognitive growth.

    abstract:OBJECTIVES:Infants born to immigrant mothers, including Hispanic mothers, display birth weight and mortality advantages, compared with other disadvantaged groups. We examined prenatal biological factors and maternal practices that account for this advantage. Then we estimated the extent to which healthy birth outcomes,...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-0496

    authors: Fuller B,Bein E,Bridges M,Halfon N,Jung S,Rabe-Hesketh S,Kuo A

    更新日期:2010-02-01 00:00:00

  • The infant development, environment, and lifestyle study: effects of prenatal methamphetamine exposure, polydrug exposure, and poverty on intrauterine growth.

    abstract:OBJECTIVE:Methamphetamine use among pregnant women is an increasing problem in the United States. Effects of methamphetamine use during pregnancy on fetal growth have not been reported in large, prospective studies. We examined the neonatal growth effects of prenatal methamphetamine exposure in the multicenter, longitu...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2005-2564

    authors: Smith LM,LaGasse LL,Derauf C,Grant P,Shah R,Arria A,Huestis M,Haning W,Strauss A,Della Grotta S,Liu J,Lester BM

    更新日期:2006-09-01 00:00:00

  • Acute Tc-99m DMSA scan for identifying dilating vesicoureteral reflux in children: a meta-analysis.

    abstract::Controversy exists regarding the type and/or sequence of imaging studies needed during the first febrile urinary tract infection (UTI) in young children. Several investigators have claimed that because acute-phase Tc-99m dimercaptosuccinic acid (DMSA) renal-scan results are abnormal in the presence of dilating vesicou...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.2010-3460

    authors: Mantadakis E,Vouloumanou EK,Georgantzi GG,Tsalkidis A,Chatzimichael A,Falagas ME

    更新日期:2011-07-01 00:00:00

  • Adverse reactions and serologic response to a booster dose of acellular pertussis vaccine in children immunized with acellular or whole-cell vaccine as infants.

    abstract::Adverse reactions and antibody response to pertussis toxin, ie, antitoxin, after a booster injection of an acellular pertussis vaccine were studied in 2-year-old children. A majority (212/241) of the children had previously been immunized with either two or three doses of the acellular vaccine at the ages of 6, 7, and...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Blennow M,Granström M

    更新日期:1989-07-01 00:00:00

  • Complete DiGeorge anomaly in the absence of neonatal hypocalcemia and velofacial and cardiac defects.

    abstract::We report an atypical case of complete DiGeorge (DG) anomaly that presented initially exclusively as severe combined immunodeficiency (SCID). The child had severe infections at diagnosis, in keeping with the SCID phenotype; however, normal lymphocyte counts and immunoglobulin levels were noted at admission, which dela...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0371

    authors: Al-Tamemi S,Mazer B,Mitchell D,Albuquerque P,Duncan AM,McCusker C,Jabado N

    更新日期:2005-09-01 00:00:00

  • Cognitive delay and behavior problems prior to school age.

    abstract:OBJECTIVE:To investigate the relationship between cognitive delay (CD) and behavior problems between ages 9 months and 5 years, while adjusting for covariates related to CD. METHODS:Data were from 4 waves of the Early Childhood Longitudinal Study, Birth Cohort (n = 8000). Children were classified as typically developi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-0259

    authors: Cheng ER,Palta M,Kotelchuck M,Poehlmann J,Witt WP

    更新日期:2014-09-01 00:00:00

  • Outcomes for children hospitalized with abusive versus noninflicted abdominal trauma.

    abstract:BACKGROUND:Abusive abdominal trauma (AAT) is the second leading cause of child abuse mortality. Previous outcome studies have been limited to data from trauma centers. OBJECTIVES:The goals of this study were (1) to examine mortality, length of hospitalization, and hospital charges among a national sample of children h...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-2096

    authors: Lane WG,Lotwin I,Dubowitz H,Langenberg P,Dischinger P

    更新日期:2011-06-01 00:00:00

  • C-reactive protein in the diagnosis, management, and prognosis of neonatal necrotizing enterocolitis.

    abstract:OBJECTIVE:In this prospective, observational study, we determined whether serum C-reactive protein (CRP) correlated with necrotizing enterocolitis (NEC) stages II and III. We hypothesized that serial CRP measurement if used as an adjunct to abdominal radiographs would improve the identification of infants with NEC. ME...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-1806

    authors: Pourcyrous M,Korones SB,Yang W,Boulden TF,Bada HS

    更新日期:2005-11-01 00:00:00

  • Conclusion: The Equity Project.

    abstract::As a result of the work completed during the meeting and summarized at the last session, 4 implementation groups have been established as the organizational framework for the American Academy of Pediatrics (AAP)-Royal College of Paediatrics and Child Health (RCPCH) Equity Project. This project will be the mechanism by...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Goldhagen J,Waterston T

    更新日期:2003-09-01 00:00:00

  • Clinical value of immunoglobulin A antitransglutaminase assay in the diagnosis of celiac disease.

    abstract:OBJECTIVES:Our goal was to evaluate the possible correspondence between antitissue transglutaminase of immunoglobulin A class levels and stage of mucosal damage in patients affected by celiac disease. In addition, we assessed clinical use of antitissue transglutaminase values to predict biopsy results. METHODS:One tho...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0604

    authors: Diamanti A,Colistro F,Calce A,Devito R,Ferretti F,Minozzi A,Santoni A,Castro M

    更新日期:2006-12-01 00:00:00

  • The Dilemma of Predicting Violent Radicalization.

    abstract::Parents, educators, law enforcement officials, and health professionals are all concerned about the violent radicalization of adolescents. Health professionals may be called on to assess teenagers regarding the risk that they will become dangerous. We present a case in which a psychiatrist is asked to do a forensic ev...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-0685

    authors: Rousseau C,Ellis BH,Lantos JD

    更新日期:2017-10-01 00:00:00

  • Report of colloquium II: the theory and practice of graduate medical education--how do we know when we have made a "good doctor"?

    abstract::Participants of the second colloquium of the Residency Review and Redesign in Pediatrics (R(3)P) Project considered 3 primary questions: What is a "good doctor"? How do we make one? and How do we know when we have made one? Experts from other countries and other medical specialties helped participants wrestle with the...

    journal_title:Pediatrics

    pub_type:

    doi:10.1542/peds.2008-1578F

    authors: Carraccio C,Sectish TC

    更新日期:2009-01-01 00:00:00

  • Pediatric chest pain: a prospective study.

    abstract::Previous studies of childhood chest pain have been retrospective or considered only limited age groups or referred patients. In this study, all children who were admitted to the emergency department with chest pain were evaluated prospectively. Patients with ill-defined chest pain had ECGs and echocardiograms performe...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Selbst SM,Ruddy RM,Clark BJ,Henretig FM,Santulli T Jr

    更新日期:1988-09-01 00:00:00

  • A case of protein-losing enteropathy caused by intestinal lymphangiectasia in a preterm infant.

    abstract::Intestinal lymphangiectasia is characterized by obstruction of lymph drainage from the small intestine and lacteal dilation that distorts the villus architecture. Lymphatic vessel obstruction and elevated intestinal lymphatic pressure in turn cause lymphatic leakage into the intestinal lumen, thus resulting in malabso...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.2.416

    authors: Salvia G,Cascioli CF,Ciccimarra F,Terrin G,Cucchiara S

    更新日期:2001-02-01 00:00:00

  • A Framework for Evaluation of the Higher-Risk Infant After a Brief Resolved Unexplained Event.

    abstract::In 2016, the American Academy of Pediatrics published a clinical practice guideline that more specifically defined apparent life-threatening events as brief resolved unexplained events (BRUEs) and provided evidence-based recommendations for the evaluation of infants who meet lower-risk criteria for a subsequent event ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-4101

    authors: Merritt JL 2nd,Quinonez RA,Bonkowsky JL,Franklin WH,Gremse DA,Herman BE,Jenny C,Katz ES,Krilov LR,Norlin C,Sapién RE,Tieder JS

    更新日期:2019-08-01 00:00:00

  • Pacifier use and morbidity in the first six months of life.

    abstract:OBJECTIVE:To assess the prevalence of pacifier use and whether this habit adversely affects the health of 6-month-old infants. DESIGN:Data collected via self-completion questionnaires from mothers forming part of the prospective, population-based Avon Longitudinal Study of Pregnancy and Childhood. METHODS:The mothers...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.3.e34

    authors: North K,Fleming P,Golding J

    更新日期:1999-03-01 00:00:00

  • Developmental Outcomes in Duarte Galactosemia.

    abstract::: media-1vid110.1542/5849572227001PEDS-VA_2018-2516Video Abstract OBJECTIVES: For decades, infants with Duarte galactosemia (DG) have been identified by newborn screening (NBS), but whether they should be treated with dietary restrictions of galactose has remained unknown. To clarify, we conducted a study of dietary a...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-2516

    authors: Carlock G,Fischer ST,Lynch ME,Potter NL,Coles CD,Epstein MP,Mulle JG,Kable JA,Barrett CE,Edwards SM,Wilson E,Fridovich-Keil JL

    更新日期:2019-01-01 00:00:00

  • Increased risk of precocious puberty in internationally adopted children in Denmark.

    abstract:BACKGROUND:Studies have indicated that internationally adopted children have an increased risk of developing precocious puberty, but no epidemiologic risk estimates have previously been calculated. We aimed to assess the risk of developing precocious puberty in intercountry adoptees, children immigrating with their fam...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2939

    authors: Teilmann G,Pedersen CB,Skakkebaek NE,Jensen TK

    更新日期:2006-08-01 00:00:00

  • Diagnosis of HIV-1 infection in children younger than 18 months in the United States.

    abstract::The objectives of this technical report are to describe methods of diagnosis of HIV-1 infection in children younger than 18 months in the United States and to review important issues that must be considered by clinicians who care for infants and young children born to HIV-1-infected women. Appropriate HIV-1 diagnostic...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2007-2951

    authors: Read JS,Committee on Pediatric AIDS, American Academy of Pediatrics.

    更新日期:2007-12-01 00:00:00

  • Adolescent participation in tobacco promotions: the role of psychosocial factors.

    abstract:OBJECTIVES:To identify psychosocial factors that place adolescents at risk for participation in tobacco promotions, and to further investigate the hypothesis that psychosocial vulnerabilities have an indirect effect on smoking initiation among youth by way of involvement with tobacco promotions. METHODS:Data were from...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.2.402

    authors: Albers AB,Biener L

    更新日期:2003-02-01 00:00:00

  • Children's access to primary care: differences by race, income, and insurance status.

    abstract:OBJECTIVE:Congressional initiatives to reduce spending under major public programs designed to improve access to health care have brought renewed attention to the health care needs of traditionally disadvantaged populations. The objective of this study was to assess access to and use of primary care services for poor, ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Newacheck PW,Hughes DC,Stoddard JJ

    更新日期:1996-01-01 00:00:00

  • Navajo perceptions of asthma and asthma medications: clinical implications.

    abstract:BACKGROUND:Despite the large number of asthma patients, relatively little is known about the beliefs of asthmatic children and their parent(s), or the extent to which these beliefs influence management of the disease. OBJECTIVE:The purpose of this study was to examine how medication-taking and the use of health care s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.1.e11

    authors: Van Sickle D,Wright AL

    更新日期:2001-07-01 00:00:00

  • Long-term follow-up study of serum immunoglobulin G and immunoglobulin A antibodies after Helicobacter pylori eradication.

    abstract:OBJECTIVE:There have been few studies concerning serum titers of anti-Helicobacter pylori immunoglobulin G (IgG) antibody >12 months after eradication of the original infection. Moreover, clinical usefulness of immunoglobulin A (IgA) antibody levels remains to be established. The purpose of this study was to investigat...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.104.2.e22

    authors: Kato S,Furuyama N,Ozawa K,Ohnuma K,Iinuma K

    更新日期:1999-08-01 00:00:00

  • Pilot interferon-beta trial in children with chronic hepatitis B who had previously not responded to interferon-alpha therapy.

    abstract:BACKGROUND:Recombinant interferon alpha (IFN-alpha) treatment is useful in 40% of children with chronic hepatitis B. However, nonresponder children continue to have viral replication and a progressive disease. OBJECTIVE:To administer natural IFN-beta to hepatitis B virus chronic carrier children who had not responded ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.99.2.222

    authors: Ruíz-Moreno M,Fernández P,Leal A,Bartolomé J,Castillo I,Oliva H,Carreño V

    更新日期:1997-02-01 00:00:00

  • Missed insulin meal boluses and elevated hemoglobin A1c levels in children receiving insulin pump therapy.

    abstract:OBJECTIVE:To identify possible causes of suboptimal glycemic control (ascertained by hemoglobin A1c [HbA1c] level) in youths using insulin pump therapy. METHODS:Forty-eight youths who were receiving insulin pump therapy for > or =6 months, and who were using insulin pumps and blood glucose meters with data that could ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.3.e221

    authors: Burdick J,Chase HP,Slover RH,Knievel K,Scrimgeour L,Maniatis AK,Klingensmith GJ

    更新日期:2004-03-01 00:00:00

  • Stable prevalence but changing risk factors for sudden infant death syndrome in child care settings in 2001.

    abstract:OBJECTIVE:A total of 20% of sudden infant death syndrome (SIDS) cases in the 1990s occurred in child care settings. This is much higher than the 8% expected from Census Bureau data. Factors that were associated with child care SIDS included older age; white race; older, more educated mothers; and unaccustomed prone pos...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0924

    authors: Moon RY,Sprague BM,Patel KM

    更新日期:2005-10-01 00:00:00

  • The clinical phenotype of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutyric aciduria): case reports of 23 new patients.

    abstract:OBJECTIVES:To further define the clinical spectrum of the disease for pediatric and metabolic specialists, and to suggest that the general pediatrician and pediatric neurologist consider succinic semialdehyde dehydrogenase (SSADH) deficiency in the differential diagnosis of patients with (idiopathic) mental retardation...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.99.4.567

    authors: Gibson KM,Christensen E,Jakobs C,Fowler B,Clarke MA,Hammersen G,Raab K,Kobori J,Moosa A,Vollmer B,Rossier E,Iafolla AK,Matern D,Brouwer OF,Finkelstein J,Aksu F,Weber HP,Bakkeren JA,Gabreels FJ,Bluestone D,Barron T

    更新日期:1997-04-01 00:00:00

  • Intentions to use violence among young adolescents.

    abstract:OBJECTIVE:Frequent violent behavior among adolescents has been found to be associated with previous exposure to violence, personal victimization, depression, hopelessness, and older age. Although young adolescents engage in less severe violent behavior than older adolescents, their perceived normative expectations to u...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: DuRant RH,Treiber F,Goodman E,Woods ER

    更新日期:1996-12-01 00:00:00