Abstract:
:: media-1vid110.1542/5849572227001PEDS-VA_2018-2516Video Abstract OBJECTIVES: For decades, infants with Duarte galactosemia (DG) have been identified by newborn screening (NBS), but whether they should be treated with dietary restrictions of galactose has remained unknown. To clarify, we conducted a study of dietary and developmental outcomes in 206 children with DG (case patients) and 144 controls, all of whom were 6 to 12 years old. METHODS:We recruited case patients from states where they were identified by NBS; unaffected siblings served as controls. Diet in infancy was ascertained by retrospective parent surveys; developmental outcomes were assessed in 5 domains, yielding 73 outcome measures for each child. We divided subjects randomly into independent discovery (n = 87) and validation (n = 263) sets. We tested the discovery set to order the 73 outcome measures by ascending P values and tested the 10 outcomes with the lowest P values for possible association with DG in the validation set. We also tested these same 10 outcomes for possible association with milk exposure in infancy among case patients in the validation set. RESULTS:None of the 73 outcomes tested in the discovery set revealed significant association with DG, and none of the 10 outcomes tested in the validation set revealed either significant association with DG or significant association with milk exposure among children with DG. CONCLUSIONS:Through our results, we demonstrated that there were no significant differences in outcomes tested between case patients and controls or among case patients as a function of milk exposure in infancy. In this study, we provide a long-needed foundation of knowledge for health care providers, families, and NBS professionals seeking to make evidence-based decisions about DG.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Carlock G,Fischer ST,Lynch ME,Potter NL,Coles CD,Epstein MP,Mulle JG,Kable JA,Barrett CE,Edwards SM,Wilson E,Fridovich-Keil JLdoi
10.1542/peds.2018-2516subject
Has Abstractpub_date
2019-01-01 00:00:00issue
1eissn
0031-4005issn
1098-4275pii
peds.2018-2516journal_volume
143pub_type
杂志文章,多中心研究相关文献
PEDIATRICS文献大全abstract:BACKGROUND:Little is known about the impact of providing health insurance to uninsured children who have asthma or other chronic diseases. OBJECTIVES:To evaluate the association between health insurance and the utilization of health care and the quality of care among children who have asthma. DESIGN:Before-and-during...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:CONTEXT:Disparities in child health are a major public health concern. However, it is unclear whether these are predominantly the result of low income, race, or other social risk factors that may contribute to their health disadvantage. Although others have examined the effects of the accumulation of risk factors, this...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1647
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:The goal was to determine whether home asthma telemonitoring with store-and-forward technology improved outcomes, compared with in-person, office-based visits. METHODS:A total of 120 patients, 6 to 17 years of age, with persistent asthma were assigned randomly to the office-based or virtual group. The 2 grou...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2006-1884
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:For asthma, attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD), the objectives were to (1) describe the percent increases in prevalence and comorbidity and how these vary by poverty status, and (2) examine the extent to which poverty status is a predictor of higher than avera...
journal_title:Pediatrics
pub_type: 杂志文章,收录出版
doi:10.1542/peds.2016-2539
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of in utero and lactational exposure to polychlorinated biphenyls (PCBs) and dioxins on the mental and psychomotor development of infants. DESIGN:Prenatal PCB exposure was estimated from the levels in maternal plasma during the last month of pregnancy. Postnatal PCB and dioxin exposur...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of maternally derived antibody on the immunogenicity and reactogenicity of acellular (DTaP) or whole-cell (DTP) pertussis vaccine with diphtheria and tetanus toxoids combined. METHODS:A total of 2342 infants were randomized to receive one of 13 DTaP or 2 DTP vaccines at 2, 4, and 6 mon...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this work was to describe levels of maternal anxiety, depressive symptoms, and perceptions of infant vulnerability associated with newborn genetic screening for susceptibility to type 1 diabetes. PATIENTS AND METHODS:Mothers of infants tested at birth for genetic susceptibility to type 1 diabe...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2006-1381
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:Previous analyses have suggested center volume is associated with outcome in children undergoing heart surgery. However, data are limited regarding potential mediating factors, including the relationship of center volume with postoperative complications and mortality in those who suffer a complication. We exa...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2011-1188
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:We assessed the effects of very preterm birth (gestational age <32 weeks or birth weight <1501 g) and prematurity-related morbidities on health care costs during the fifth year of life. METHODS:The study population consisted of 588 very preterm children and 176 term control subjects born in 2001-2002. Costs ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-2882
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:Many organizations make efforts to identify future pediatric leaders, often focusing on chief residents (CRs). Identifying future leaders is an issue of great importance not only to the ultimate success of the organization but also to the profession. Because little is known regarding whether completing a CR p...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:β blockers are widely used in the treatment of hypertensive disorders during pregnancy. These medications cross the placenta and may cause physiologic changes in neonates exposed in utero. We sought to define the risks of neonatal hypoglycemia and bradycardia associated with maternal exposure ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-0731
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:More rapid infant weight gain may be associated with better neurodevelopment but also with higher blood pressure (BP). The objective of this study was to determine the extent to which infant weight gain is associated with systolic BP (SBP) and IQ at school age in former preterm, low birth weight infants. ME...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-2746
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:The goals of this study were to: (1) determine if management according to a standardized clinical management pathway/algorithm (compared with usual treatment) improves clinical outcomes by 6 weeks; and (2) assess the reliability and validity of a standardized clinical management pathway for chronic cough in ...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2012-3318
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:Does predictive power for outcomes of neonatal intensive care unit (NICU) patients get better with time? Or does it get worse? We determined the predictive power of Score for Neonatal Acute Physiology (SNAP) scores and clinical intuitions as a function of day of life (DOL) for newborn infants admitted to our...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.109.5.878
更新日期:2002-05-01 00:00:00
abstract::In the last 20 years, two thirds of all new vaccines provided worldwide have been produced by a US network of independent industrial, governmental, and academic partners engaged in vaccine research and development. Vaccines are complex products and the science of vaccinology is difficult. To achieve the full promise o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.100.6.1015
更新日期:1997-12-01 00:00:00
abstract::Three infants with infant botulism are presented to illustrate how atypical, early, and severe features may obscure or delay diagnosis. Two boys aged 6 weeks and 20 days, respectively, presented with rapid deterioration after brief periods of poor feeding, one with an apparent life-threatening event at home and the ot...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-0297
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Blood transfusions in the neonatal patient population are common, but there are no established guidelines regarding transfusion thresholds. Little is known about postoperative outcomes in neonates who receive preoperative blood transfusions (PBTs). METHODS:Using the American College of Surgeons National Sur...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-3718
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To identify evidence-based pediatric guidelines and to assess their quality. METHODS:We searched Medline, Embase, and relevant Web sites of guideline development programs and national pediatric societies to identify evidence-based pediatric guidelines. A list with titles of identified guidelines was sent to ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-0575
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to characterize noise and light levels for extremely low birth weight newborns throughout their stay in the NICU, evaluate factors influencing noise and light levels, and determine whether exposures meet recommendations from the American Academy of Pediatrics. METHODS:Sound...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-3418
更新日期:2009-02-01 00:00:00
abstract::Cat scratch disease is a benign, self-limited illness characterized by regional lymphadenopathy that usually occurs in association with a history of contact with a cat. Cases of cat scratch disease with skin manifestations that included erythema nodosum; erythema multiforme; erythema marginatum; and non-specific macul...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Adolescent obesity is a strong predictor of adult obesity, and adult obesity has been associated with depression, especially in women. Studies have also suggested an association between depression in adolescence and higher body mass index (BMI) in adulthood. Whether depression leads to obesity or obesity cau...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.110.3.497
更新日期:2002-09-01 00:00:00
abstract::An overview is presented of the major methods of contraception available to the sexually active adolescent. Emphasis is given to the combined birth control pill, while the literature describing absolute and relative contraindications to oral contraception is reviewed. It is noted that adolescents with chronic illness ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Infant mortality is an indicator of overall societal health, and a significant proportion of infant deaths occur in NICUs. The objectives were to identify causes of death and to define potentially preventable factors associated with death as areas for quality improvement efforts in the NICU. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-2967
更新日期:2015-01-01 00:00:00
abstract::The interests of the public and both the medical and legal professions are best served when scientifically sound and unbiased expert witness testimony is readily available in civil and criminal proceedings. As members of the medical community, patient advocates, and private citizens, pediatricians have ethical and pro...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-1132
更新日期:2009-07-01 00:00:00
abstract::Simultaneous serum concentrations of dehydroepiandrosterone sulfate (DHEA-S) and 17-hydroxyprogesterone (17-OHP) were compared with urinary 17-ketosteroid (17-KS) and pregnanetriol (PT) excretion during therapy in 18 prepubertal patients with the 21-hydroxylase deficiency form of congenital adrenal hyperplasia (CAH). ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-06-01 00:00:00
abstract::Kwashiorkor, with typical edema and skin rash is occasionally seen in affluent countries as a result of severe protein restriction. Treatment is with a lactose-free formula after rehydration and sometimes after a period of parenteral alimentation. Complications of therapy included: diarrhea, congestive heart failure, ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1980-12-01 00:00:00
abstract:OBJECTIVE:The objective for this study was to characterize the impact and the safety of transporting neonates with known or suspected cardiac abnormalities. METHODS:We reviewed retrospectively the charts and computerized records of 192 admissions to a cardiac ICU in 2002. Patients were included when they were < 28 day...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0719
更新日期:2006-09-01 00:00:00
abstract::A rare complication of infection with the Epstein-Barr virus is the development of hemophagocytic lymphohistiocytosis. Although most cases of Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis develop in immunocompetent individuals, the rare immunodeficiency X-linked lymphoproliferative disease is often unm...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1534
更新日期:2007-05-01 00:00:00
abstract::Successful intervention for inborn errors of metabolism (IEMs) is a triumph of modern medicine. For many of these conditions, medical foods are the cornerstone of therapy and the only effective interventions preventing disability or death. Medical foods are designed for patients with limited or impaired capacity to in...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-2261
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:We sought to document gender differences in lymphocyte subsets and plasma RNA levels in a pediatric cohort with presumed minimal hormonal differences (on the basis of age). METHODS:Blood samples from antiretroviral therapy-treated, HIV-infected children (n = 158) and HIV-uninfected children (n = 1801) who we...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2005-0294
更新日期:2006-07-01 00:00:00