Pilot interferon-beta trial in children with chronic hepatitis B who had previously not responded to interferon-alpha therapy.

Abstract:

BACKGROUND:Recombinant interferon alpha (IFN-alpha) treatment is useful in 40% of children with chronic hepatitis B. However, nonresponder children continue to have viral replication and a progressive disease. OBJECTIVE:To administer natural IFN-beta to hepatitis B virus chronic carrier children who had not responded to a previous IFN-alpha cycle. METHODS:Twenty-two children with chronic hepatitis B, nonresponders to a previous IFN-alpha cycle, were retreated with 5 MU/m2 of body surface of natural IFN-beta, administered intramuscularly, three times per week for 24 weeks. RESULTS:At the end of treatment, 9 (41%) of 22 children became hepatitis B virus DNA negative. Hepatitis B e antibodies (anti-HBe) developed in 5 of these children, and 6 had normal alanine aminotransferase values. At the end of the posttreatment follow-up (21 months from the beginning of the study), 10 (45%) of 22 children were viral DNA negative, 7 (32%) of 22 were anti-HBe positive (none of them had viral DNA in serum), and 11 (50%) of 22 had normal alanine aminotransferase levels (10 without detectable viral DNA and 7 anti-HBe positive). CONCLUSION:IFN-beta seems to be an effective retreatment therapy for children with chronic hepatitis B who are nonresponders to a first IFN-alpha cycle; however, a controlled study should be performed to confirm these results.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Ruíz-Moreno M,Fernández P,Leal A,Bartolomé J,Castillo I,Oliva H,Carreño V

doi

10.1542/peds.99.2.222

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

222-5

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

99

pub_type

杂志文章
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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0400

    authors: Dempsey AF,Schaffer S,Singer D,Butchart A,Davis M,Freed GL

    更新日期:2011-11-01 00:00:00

  • A Multifaceted Approach to Improving Outcomes in the NICU: The Pediatrix 100 000 Babies Campaign.

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    authors: Ellsbury DL,Clark RH,Ursprung R,Handler DL,Dodd ED,Spitzer AR

    更新日期:2016-04-01 00:00:00

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    abstract::The possibility that arterial oxygen saturation (SaO2) decreases during sleep in children with chronic bronchial asthma was investigated. The relationship between decreases in sleep SaO2 and airflow obstruction and ventilatory drives, as characterized by ventilatory and inspiratory muscle activity responses to hypoxia...

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    authors: Smith TF,Hudgel DW

    更新日期:1980-11-01 00:00:00

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    authors: Hutchins SS,Escolan J,Markowitz LE,Hawkins C,Kimbler A,Morgan RA,Preblud SR,Orenstein WA

    更新日期:1989-03-01 00:00:00

  • Relative effects of drugs and diet on hyperactive behaviors: an experimental study.

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    doi:

    authors: Williams JI,Cram DM,Tausig FT,Webster E

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  • Associations of executive function with sleepiness and sleep duration in adolescents.

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    doi:10.1542/peds.2008-1182

    authors: Anderson B,Storfer-Isser A,Taylor HG,Rosen CL,Redline S

    更新日期:2009-04-01 00:00:00

  • Maternal Depression in Early Childhood and Developmental Vulnerability at School Entry.

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    doi:10.1542/peds.2020-0794

    authors: Wall-Wieler E,Roos LL,Gotlib IH

    更新日期:2020-09-01 00:00:00

  • Cost-effectiveness analysis of bicycle helmet subsidies in a defined population.

    abstract:OBJECTIVE:To examine the potential effects of bicycle safety helmet cost subsidy on bicycle head injury rates and costs. DESIGN:Using empiric data on the incidence and costs of bicycle injuries to children, we examined the hypothetical effects of various bicycle helmet subsidies in a cost-effectiveness analysis. A hyp...

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    pub_type: 杂志文章

    doi:

    authors: Thompson RS,Thompson DC,Rivara FP,Salazar AA

    更新日期:1993-05-01 00:00:00

  • Infection prevention and control in pediatric ambulatory settings.

    abstract::Since the American Academy of Pediatrics published a statement titled "Infection Control in Physicians' Offices" (Pediatrics. 2000;105[6]:1361-1369), there have been significant changes that prompted this updated statement. Infection prevention and control is an integral part of pediatric practice in ambulatory medica...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2007-1734

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    更新日期:2007-09-01 00:00:00

  • The misuse of antibiotics for treatment of upper respiratory tract infections in children.

    abstract::Antibiotic therapy has been shown to be of no value in the treatment of the URI--either in shortening the course of the acute illness or in preventing the development of secondary bacterial infections. Patient expense, as well as the threat of adverse reactions, should prohibit the present practice by some of routinel...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Soyka LF,Robinson DS,Lachant N,Monaco J

    更新日期:1975-04-01 00:00:00

  • Ketonic diet in the management of pyruvate dehydrogenase deficiency.

    abstract::Two brothers, aged 11 years 6 months and 2 years 3 months, with psychomotor and growth retardation, episodes of weakness, ataxia, ophthalmoplegia, and elevated levels of blood pyruvate were shown to have a deficiency in the pyruvate dehydrogenase complex (PDH). When they ate a diet high enough in fats to cause ketonem...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Falk RE,Cederbaum SD,Blass JP,Gibson GE,Kark RA,Carrel RE

    更新日期:1976-11-01 00:00:00

  • Intrahepatic cholestasis associated with parenteral nutrition in premature infants.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Beale EF,Nelson RM,Bucciarelli RL,Donnelly WH,Eitzman DV

    更新日期:1979-09-01 00:00:00

  • Environmental Enteric Dysfunction and Growth Failure/Stunting in Global Child Health.

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    doi:10.1542/peds.2016-0641

    authors: Owino V,Ahmed T,Freemark M,Kelly P,Loy A,Manary M,Loechl C

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    pub_type: 杂志文章

    doi:10.1542/peds.2009-1835

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    更新日期:2010-06-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1542/peds.113.1.e73

    authors: Yeh EA,Collins A,Cohen ME,Duffner PK,Faden H

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  • Emergency medical services system changes reduce pediatric epinephrine dosing errors in the prehospital setting.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0854

    authors: Kaji AH,Gausche-Hill M,Conrad H,Young KD,Koenig WJ,Dorsey E,Lewis RJ

    更新日期:2006-10-01 00:00:00

  • Developing circadian rhythmicity in infants.

    abstract::Circadian rhythms are endogenously generated rhythms with a period length of approximately 24 hours. Evidence gathered during the past decade indicates that the circadian timing system develops prenatally and the suprachiasmatic nuclei, the site of a circadian clock, is present by midgestation in primates. Recent evid...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.112.2.373

    authors: Rivkees SA

    更新日期:2003-08-01 00:00:00

  • Temperament and behavior of preterm infants: a six-year follow-up.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Oberklaid F,Sewell J,Sanson A,Prior M

    更新日期:1991-06-01 00:00:00

  • Community asthma initiative: evaluation of a quality improvement program for comprehensive asthma care.

    abstract:OBJECTIVES:The objective of this study was to assess the cost-effectiveness of a quality improvement (QI) program in reducing asthma emergency department (ED) visits, hospitalizations, limitation of physical activity, patient missed school, and parent missed work. METHODS:Urban, low-income patients with asthma from 4 ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-3472

    authors: Woods ER,Bhaumik U,Sommer SJ,Ziniel SI,Kessler AJ,Chan E,Wilkinson RB,Sesma MN,Burack AB,Klements EM,Queenin LM,Dickerson DU,Nethersole S

    更新日期:2012-03-01 00:00:00

  • Metopic craniostenosis as a consequence of fetal head constraint: two interesting experiments of nature.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Graham JM Jr,Smith DW

    更新日期:1980-05-01 00:00:00

  • Cardiac output changes in newborns with hyperbilirubinemia treated with phototherapy.

    abstract::Phototherapy is known to increase peripheral blood flow in neonates, but information on the associated cardiovascular effects is not available. Using pulsed Doppler echocardiography we evaluated cardiac output and stroke volume in 12 preterm and 13 term neonates during and after phototherapy. We concomitantly measured...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Walther FJ,Wu PY,Siassi B

    更新日期:1985-12-01 00:00:00

  • Unexplained reduced microbiological efficacy of intramuscular benzathine penicillin G and of oral penicillin V in eradication of group a streptococci from children with acute pharyngitis.

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    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.108.5.1180

    authors: Kaplan EL,Johnson DR

    更新日期:2001-11-01 00:00:00

  • Maternal employment and the quality of young children's diets: empirical evidence based on the 1987-1988 Nationwide Food Consumption Survey.

    abstract::Data from 442 children, aged 2 to 5, who were participants in the 1987-1988 Nationwide Food Consumption Survey, were examined to determine the effect of maternal employment on the quality of their diets. Diet quality was assessed by examining nutrient adequacy and nutrient overconsumption using the 3-day average of on...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

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    更新日期:1992-08-01 00:00:00

  • Acute disseminated encephalomyelitis in children.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.2.e21

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    更新日期:2002-08-01 00:00:00

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    journal_title:Pediatrics

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    pub_type: 杂志文章

    doi:10.1542/peds.2010-3229

    authors: Mastropietro CW,Valentine K

    更新日期:2011-06-01 00:00:00

  • Trampoline Park and Home Trampoline Injuries.

    abstract:BACKGROUND AND OBJECTIVE:Trampoline parks, indoor recreational facilities with wall-to-wall trampolines, are increasing in number and popularity. The objective was to identify trends in emergency department visits for trampoline park injuries (TPIs) and compare TPI characteristics with home trampoline injuries (HTIs). ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-1236

    authors: Kasmire KE,Rogers SC,Sturm JJ

    更新日期:2016-09-01 00:00:00

  • Detection of Kingella kingae osteoarticular infections in children by oropharyngeal swab PCR.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0810

    authors: Ceroni D,Dubois-Ferriere V,Cherkaoui A,Gesuele R,Combescure C,Lamah L,Manzano S,Hibbs J,Schrenzel J

    更新日期:2013-01-01 00:00:00

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    doi:

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