Relative effects of drugs and diet on hyperactive behaviors: an experimental study.

Abstract:

:In a test of Feingold's hypothesis that food additives trigger the hyperactive response, 26 hyperactive children were randomly assigned to treatment conditions whereby they were given active or placebo medications in combination with challenge cookies with artificial food colors or control cookies without the additives. The children were crossed over into each of the four treatment conditions and experimental procedures were employed, including double-blind assessments through the completion of behavior checklists, by teachers and parents. Stimulant medications were clearly more effective than diet in reducing hyperactive behavior. The parent ratings indicate strong drug effects and inconclusive diet effects. Drug effects are marked in teacher ratings as well. However, when the children were receiving placebos, their hyperactive behaviors in the classroom were greater when eating cookies with artificial colors than when eating cookies without artificial colors. According to the ratings, approximately seven children were no longer hyperactive. There is evidence to suggest that the behavior of three to eight children was diet-responsive, depending on the criteria used. There is evidence, particularly in teacher ratings, in support of Feingold's hypothesis if it is modified. Further research is required to specify which subtypes of hyperactive children respond to a diet free of artificial food colors.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Williams JI,Cram DM,Tausig FT,Webster E

subject

Has Abstract

pub_date

1978-06-01 00:00:00

pages

811-7

issue

6

eissn

0031-4005

issn

1098-4275

journal_volume

61

pub_type

临床试验,杂志文章,随机对照试验
  • Cardiovascular support for low birth weight infants and cerebral hemodynamics: a randomized, blinded, clinical trial.

    abstract:BACKGROUND:Maintaining adequate organ blood flow is the target of vasopressor treatment, but the impact of these measures on cerebral perfusion has not yet been evaluated systematically in a randomized, blinded, clinical trial. OBJECTIVES:To explore the effects on brain hemodynamics of 2 different inotropic agents use...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.2004-1396

    authors: Pellicer A,Valverde E,Elorza MD,Madero R,Gayá F,Quero J,Cabañas F

    更新日期:2005-06-01 00:00:00

  • Iatrogenic Cushing's Syndrome Due to Intranasal Usage of Ophthalmic Dexamethasone: A Case Report.

    abstract::Iatrogenic Cushing's syndrome (ICS) is caused by exogenous corticosteroid administration with suppression of the hypothalamic-pituitary-adrenal axis. It has been commonly described with oral and topical steroid use, but scarce reports have documented intranasal steroid usage as the etiology in infancy. In this article...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-3845

    authors: Orton S,Censani M

    更新日期:2016-05-01 00:00:00

  • The Use of Pyridostigmine in a Child With Chronic Intestinal Pseudo-Obstruction.

    abstract::Chronic intestinal pseudo-obstruction is a rare disorder that affects the motility of the gastrointestinal tract. It results in acute or subacute intestinal obstruction symptoms in the absence of mechanical lesion. It can lead to intestinal failure in children with significant strain on nutrition, growth, and developm...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-0007

    authors: Choudhury A,Rahyead A,Kammermeier J,Mutalib M

    更新日期:2018-04-01 00:00:00

  • Use and accuracy of diagnostic imaging by hospital type in pediatric appendicitis.

    abstract:OBJECTIVE:Accurate, timely diagnosis of pediatric appendicitis minimizes unnecessary operations and treatment delays. Preoperative abdominal-pelvic computed tomography (CT) scan is sensitive and specific for appendicitis; however, concerns regarding radiation exposure in children obligate scrutiny of CT use. Here, we c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1665

    authors: Saito JM,Yan Y,Evashwick TW,Warner BW,Tarr PI

    更新日期:2013-01-01 00:00:00

  • Prospective evaluation of postnatal steroid administration: a 1-year experience from the California Perinatal Quality Care Collaborative.

    abstract:OBJECTIVE:Postnatal steroids (PNSs) are used frequently to prevent or treat chronic lung disease (CLD) in the very low birth weight (VLBW) infant, and their use continues despite concerns regarding an increased incidence of longer-term neurodevelopmental abnormalities in such infants. More recently, there has been a su...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0796

    authors: Finer NN,Powers RJ,Ou CH,Durand D,Wirtschafter D,Gould JB,California Perinatal Quality Care Collaborative Executive Committee.

    更新日期:2006-03-01 00:00:00

  • Home care of children and youth with complex health care needs and technology dependencies.

    abstract::Children and youth with complex medical issues, especially those with technology dependencies, experience frequent and often lengthy hospitalizations. Hospital discharges for these children can be a complicated process that requires a deliberate, multistep approach. In addition to successful discharges to home, it is ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0606

    authors: Elias ER,Murphy NA,Council on Children with Disabilities.

    更新日期:2012-05-01 00:00:00

  • Diagnostic imaging and negative appendectomy rates in children: effects of age and gender.

    abstract:BACKGROUND AND OBJECTIVES:Diagnostic imaging is often used in the evaluation of children with possible appendicitis. The utility of imaging may vary according to a patient's age and gender. The objectives of this study were (1) to examine the use of computed tomography (CT) and ultrasound for age and gender subgroups o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-3375

    authors: Bachur RG,Hennelly K,Callahan MJ,Chen C,Monuteaux MC

    更新日期:2012-05-01 00:00:00

  • Congenital conductive hearing loss: the need for early identification and intervention.

    abstract::Pediatricians are familiar with conductive hearing loss, but to many it is synonymous with otitis media of some type. There is a group of children who have anatomic abnormalities of the external or middle ear causing their hearing losses. The records of 565 hearing-impaired children were reviewed, and 54 with non-otit...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Stewart JM,Downs MP

    更新日期:1993-02-01 00:00:00

  • Financial burden of raising CSHCN: association with state policy choices.

    abstract:OBJECTIVE:We examined the association between state Medicaid and State Children's Health Insurance Program (SCHIP) income eligibility and the financial burden reported by low-income families raising children with special health care needs (CSHCN). SAMPLE AND METHODS:Data on low-income CSHCN and their families were fro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-1255P

    authors: Parish SL,Shattuck PT,Rose RA

    更新日期:2009-12-01 00:00:00

  • Emergency Department and Hospital Use Among Adolescents With Justice System Involvement.

    abstract:OBJECTIVES:Adolescents with justice system involvement have high rates of physical and behavioral health disorders and are potentially high users of costly health care services. We examined emergency department (ED) and hospital use among a national sample of adolescents with various levels of justice involvement. MET...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-1144

    authors: Winkelman TNA,Genao I,Wildeman C,Wang EA

    更新日期:2017-11-01 00:00:00

  • A new framework for quality partnerships in Children's Hospitals.

    abstract::Children's hospitals and their affiliated departments of pediatrics often pursue separate programs in quality and safety; by integrating these programs, they can accelerate progress. Hospital executives and pediatric department chairs from 14 children's hospitals have been exploring practical approaches for integratin...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2010-1409

    authors: Levy FH,Brilli RJ,First LR,Hyman D,Kohrt AE,Ludwig S,Miles PV,Saffer M

    更新日期:2011-06-01 00:00:00

  • Survival and Impairment of Extremely Premature Infants: A Meta-analysis.

    abstract:CONTEXT:Survival of infants born at the limit of viability varies between high-income countries. OBJECTIVE:To summarize the prognosis of survival and risk of impairment for infants born at 22 + 0/7 weeks' to 27 + 6/7 weeks' gestational age (GA) in high-income countries. DATA SOURCES:We searched 9 databases for cohort...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.2018-0933

    authors: Myrhaug HT,Brurberg KG,Hov L,Markestad T

    更新日期:2019-02-01 00:00:00

  • A single dose of Sn-mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns.

    abstract:OBJECTIVES:Severe neonatal jaundice is a common clinical manifestation of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and the most difficult to manage; kernicterus is not an uncommon outcome. We assessed in healthy, direct Coombs test-negative Greek newborns of >/=38 weeks' gestational age 1) the current burd...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.1.25

    authors: Kappas A,Drummond GS,Valaes T

    更新日期:2001-07-01 00:00:00

  • Intravenous ribavirin treatment for severe adenovirus disease in immunocompromised children.

    abstract:BACKGROUND:Adenovirus is an important cause of morbidity and mortality in the immunocompromised host. The incidence of severe adenovirus disease in pediatrics is increasing in association with growing numbers of immunocompromised children, where case fatality rates as high as 50% to 80% have been reported. There are no...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.110.1.e9

    authors: Gavin PJ,Katz BZ

    更新日期:2002-07-01 00:00:00

  • Hypothyroxinemia in mechanically ventilated term infants is associated with increased use of rescue therapies.

    abstract:OBJECTIVE:Although common in preterm infants, transient hypothyroxinemia (TH) has not been investigated extensively in ill term infants. The objectives of this study were to investigate serum thyroxine (T4) and thyroid-stimulating hormone (TSH) in sick term infants and to determine whether there is any association betw...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-0192

    authors: Lim DJ,Herring MK,Leef KH,Getchell J,Bartoshesky LE,Paul DA

    更新日期:2005-02-01 00:00:00

  • Childhood urolithiasis: experiences and advances.

    abstract::Between June 1979 and June 1989, 54 children with urolithiasis were evaluated and treated at the Johns Hopkins Children's Center. The most common symptoms were flank or abdominal pain (58%) and gross hematuria (28%). In 46 children (86%), stones were secondary to a preexisting condition and in only 8 (14%) no apparent...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gearhart JP,Herzberg GZ,Jeffs RD

    更新日期:1991-04-01 00:00:00

  • Hyperphenylalaninemia due to dihydropteridine reductase deficiency: diagnosis by measurement of oxidized and reduced pterins in urine.

    abstract::Hyperphenylalaninemia due to dihydropteridine reductase deficiency results from the inability to maintain the aromatic amino acid hydroxylase cofactor, tetrahydrobiopterin, in its reduced or active form. Diagnosis of the disease is usually made by direct enzymatic assay on liver biopsies or in cultured skin fibroblast...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Milstien S,Kaufman S,Summer GK

    更新日期:1980-04-01 00:00:00

  • Parents' Perspectives Regarding Age Restrictions for Tackling in Youth Football.

    abstract:BACKGROUND:In ice hockey and soccer, age restrictions exist for body checking and heading because of injury risk. There are currently no age restrictions for tackling in youth football. METHODS:We surveyed a nationally representative sample of US parents regarding their support for age restrictions on tackling in foot...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-2402

    authors: Chrisman SPD,Whitlock KB,Kroshus E,Schwien C,Herring SA,Rivara FP

    更新日期:2019-05-01 00:00:00

  • Surfactant replacement therapy for severe neonatal respiratory distress syndrome: an international randomized clinical trial. Collaborative European Multicenter Study Group.

    abstract::In a randomized multicenter trial, involving the collaboration of eight European neonatal intensive care units, the efficacy of replacement therapy with a new surfactant preparation (Curosurf) was tested in 146 patients with severe neonatal respiratory distress syndrome. Criteria for entry included birth weight 700 to...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors:

    更新日期:1988-11-01 00:00:00

  • The changing composition of the pediatric medical subspecialty workforce.

    abstract:OBJECTIVES:To characterize the composition of the pediatric subspecialty workforce in terms of the distribution of women and international medical graduates (IMGs) across pediatric medical subspecialties and to determine whether the proportions of board-certified pediatric subspecialists who are women or IMGs differ be...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2446

    authors: Mayer ML,Preisser JS

    更新日期:2005-10-01 00:00:00

  • Does sensitization to contact allergens begin in infancy?

    abstract:OBJECTIVE:Because previous studies have found allergic contact sensitization common in children by 5 years of age, our aim was to determine the prevalence of positive epicutaneous test results in children <5 years of age and to determine whether sensitization to contact allergens was as common in infancy. METHODS:We r...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.105.1.e3

    authors: Bruckner AL,Weston WL,Morelli JG

    更新日期:2000-01-01 00:00:00

  • Can we identify a group of children at age 2 who are at high risk for the development of behavior or emotional problems in kindergarten and first grade?

    abstract::A group of 198 children were followed from age 2 through first grade to see how consistent their behavior was across time and across settings. Measures of child behavior in the home were obtained when the children were ages 2, 4, and 5. Classroom behavior was ascertained when the children were in nursery school, kinde...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Chamberlin RW

    更新日期:1977-06-01 00:00:00

  • Decline and change in seasonality of US rotavirus activity after the introduction of rotavirus vaccine.

    abstract:BACKGROUND:In 2006, routine immunization of US infants against rotavirus was initiated. We assessed national, regional, and local trends in rotavirus testing and detection before and after vaccine introduction. METHODS:We examined data for July 2000 through June 2008 from a national network of approximately 70 US labo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-3528

    authors: Tate JE,Panozzo CA,Payne DC,Patel MM,Cortese MM,Fowlkes AL,Parashar UD

    更新日期:2009-08-01 00:00:00

  • Translating child abuse research into action.

    abstract::The Child Abuse Recognition Experience Study revealed that primary care clinicians did not always follow the legal mandate to report suspected child abuse to child protective services. National child abuse experts representing different disciplines met in a 2-day conference in January 2007 to discuss and develop new s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-0715c

    authors: Flaherty EG,Sege RD,Hurley TP

    更新日期:2008-09-01 00:00:00

  • High-deductible health plans.

    abstract::High-deductible health plans (HDHPs) are insurance policies with higher deductibles than conventional plans. The Medicare Prescription Drug Improvement and Modernization Act of 2003 linked many HDHPs with tax-advantaged spending accounts. The 2010 Patient Protection and Affordable Care Act continues to provide for HDH...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-0555

    authors: Committee on Child Health Financing.

    更新日期:2014-05-01 00:00:00

  • Developmental Outcomes of Preterm Infants With Neonatal Hypoglycemia.

    abstract:BACKGROUND AND OBJECTIVES:Neonatal hypoglycemia has been associated with abnormalities on brain imaging and a spectrum of developmental delays, although historical and recent studies show conflicting results. We compared the cognitive, academic, and behavioral outcomes of preterm infants with neonatal hypoglycemia with...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2016-1424

    authors: Goode RH,Rettiganti M,Li J,Lyle RE,Whiteside-Mansell L,Barrett KW,Casey PH

    更新日期:2016-12-01 00:00:00

  • Mirrored symptoms in mother and child with chronic fatigue syndrome.

    abstract:OBJECTIVE:Our aim with this study was to assess the relation between chronic fatigue syndrome in adolescents and fatigue and associated symptoms in their fathers and mothers, more specifically the presence of chronic fatigue syndrome-like symptoms and psychologic distress. METHOD:In this cross-sectional study, 40 adol...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2307

    authors: van de Putte EM,van Doornen LJ,Engelbert RH,Kuis W,Kimpen JL,Uiterwaal CS

    更新日期:2006-06-01 00:00:00

  • Effect of botulinum toxin in the treatment of drooling: a controlled clinical trial.

    abstract:OBJECTIVE:To investigate the clinical effectiveness of botulinum neurotoxin type A (BoNT) to reduce drooling in children with cerebral palsy (CP). METHODS:A controlled clinical trial was performed in which the results of single-dose BoNT injections in the submandibular glands were compared with treatment with scopolam...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.2003-1104-L

    authors: Jongerius PH,van den Hoogen FJ,van Limbeek J,Gabreëls FJ,van Hulst K,Rotteveel JJ

    更新日期:2004-09-01 00:00:00

  • Clinical characteristics of peanut-allergic children: recent changes.

    abstract:OBJECTIVE:The goal was to determine whether patients seen in a referral clinic are experiencing initial allergic reactions to peanuts earlier, compared with a similar population profiled at a different medical center 10 years ago, and to investigate other changes in clinical characteristics of the patients between the ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0350

    authors: Green TD,LaBelle VS,Steele PH,Kim EH,Lee LA,Mankad VS,Williams LW,Anstrom KJ,Burks AW

    更新日期:2007-12-01 00:00:00

  • Advanced Ultrasound Techniques for Pediatric Imaging.

    abstract::Ultrasound has become a useful tool in the workup of pediatric patients because of the highly convenient, cost-effective, and safe nature of the examination. With rapid advancements in anatomic and functional ultrasound techniques over the recent years, the diagnostic and interventional utility of ultrasound has risen...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2018-2609

    authors: Hwang M,Piskunowicz M,Darge K

    更新日期:2019-03-01 00:00:00