Surfactant replacement therapy for severe neonatal respiratory distress syndrome: an international randomized clinical trial. Collaborative European Multicenter Study Group.

Abstract:

:In a randomized multicenter trial, involving the collaboration of eight European neonatal intensive care units, the efficacy of replacement therapy with a new surfactant preparation (Curosurf) was tested in 146 patients with severe neonatal respiratory distress syndrome. Criteria for entry included birth weight 700 to 2,000 g, age when treated two to 15 hours, and requirement of artificial ventilation with FiO2 greater than or equal to 0.6. The babies were treated with a single large dose of surfactant (200 mg/kg) at a median age of nine hours (range two to 15 hours). Average FiO2 before treatment was the same (0.80) for both surfactant-treated patients and control patients. Babies receiving surfactant showed, within five minutes, a dramatic improvement of oxygenation as reflected by a nearly threefold increase of the PaO2/FiO2 ratio. Six hours after randomization, the PaO2/FiO2 ratio still showed a 98% improvement in surfactant-treated patients compared with controls (P less than .001), and statistically significant differences in favor of the treated babies persisted until 48 hours after randomization, when surviving control infants began to recover. Treatment with surfactant decreased neonatal (less than or equal to 28 days) mortality from 51% to 31% (P less than .05). Compared with control babies, the surfactant-treated group also had a decreased incidence of pulmonary interstitial emphysema (23% v 39%; P less than .05) and pneumothorax (18% v 35%; P less than .05). The percentage of survivors without bronchopulmonary dysplasia in the treated group was more than twice that of the control group (55% v 26%; P less than .001).(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Pediatrics

journal_title

Pediatrics

authors

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

683-91

issue

5

eissn

0031-4005

issn

1098-4275

journal_volume

82

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    authors: Decker MR,Silverman JG,Raj A

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    authors: Cowen L,Mok J,Corey M,MacMillan H,Simmons R,Levison H

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    abstract:OBJECTIVES:Coronaviruses cause upper respiratory illness and occasionally lower tract disease in susceptible populations. In this study we examined the prevalence of 4 human coronaviruses, including subtypes OC43, 229E, and the recently described NL63 and HKU1 in a pediatric population presenting to a children's hospit...

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    更新日期:2007-01-01 00:00:00

  • Trends in Referrals to a Pediatric Transgender Clinic.

    abstract:OBJECTIVES:We characterized referral trends over time at a transgender clinic within an integrated health system in Northern California. We identified the transition-related requests of pediatric transgender and gender-nonconforming patients and evaluated differences in referrals by age group. METHODS:Medical records ...

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    更新日期:2009-03-01 00:00:00

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    doi:

    authors: Butler KM,Venzon D,Henry N,Husson RN,Mueller BU,Balis FM,Jacobsen F,Lewis LL,Pizzo PA

    更新日期:1993-04-01 00:00:00

  • Involving Youth With a Chronic Illness in Decision-making: Highlighting the Role of Providers.

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    pub_type: 杂志文章

    doi:10.1542/peds.2015-3500

    authors: Jimenez N,Symons RG,Wang J,Ebel BH,Vavilala MS,Buchwald D,Temkin N,Jaffe KM,Rivara FP

    更新日期:2016-06-01 00:00:00

  • Adverse events from cough and cold medications after a market withdrawal of products labeled for infants.

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    pub_type: 杂志文章

    doi:10.1542/peds.99.4.e5

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    更新日期:1997-04-01 00:00:00

  • Improvement methodology increases guideline recommended blood cultures in children with pneumonia.

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    pub_type: 杂志文章

    doi:10.1542/peds.2014-2077

    authors: Murtagh Kurowski E,Shah SS,Thomson J,Statile A,Sheehan B,Iyer S,White C,Ambroggio L

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  • Establishing New Norms for Developmental Milestones.

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

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    pub_type: 杂志文章

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    更新日期:1985-06-01 00:00:00

  • Sustained effects of cardiac rehabilitation in children with serious congenital heart disease.

    abstract:OBJECTIVE:Past studies have documented the acute benefits of cardiac rehabilitation in children with congenital heart disease. It is not known whether these benefits persist. PATIENTS AND METHODS:Fifteen patients, ages 8 to 17 years, with complex congenital heart disease, whose exercise function immediately after a 12...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.2006-0264

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    更新日期:2006-09-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Tabin R,Guignard JP,Gautier E,Dubrit M,Jeannet M,Golaz J,Moretta L

    更新日期:1983-01-01 00:00:00

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    pub_type: 指南,杂志文章

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    更新日期:1997-08-01 00:00:00

  • Developmental pattern of splenic dysfunction in sickle cell disorders.

    abstract::Splenic function in sickle hemoglobinopathy syndromes was assessed to determine the developmental pattern of splenic dysfunction. Nonvisualization of the spleen using technetium-99 metastable (99mTc) spleen scans correlated strongly with pocked (vesiculated) RBCs greater than or equal to 3.5%. Cross-sectional analysis...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Pearson HA,Gallagher D,Chilcote R,Sullivan E,Wilimas J,Espeland M,Ritchey AK

    更新日期:1985-09-01 00:00:00

  • Patient education for immunizations.

    abstract::Many physicians and parents consider immunizations routine; as a result, they fail to discuss this important aspect of health care. Parents should be educated about each vaccine and the role it plays in the well-being of their child. To ensure that parents will be able to give informed consent to have their child immu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Fulginiti VA

    更新日期:1984-11-01 00:00:00

  • Association of apolipoprotein E genotype and cerebral palsy in children.

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    pub_type: 杂志文章

    doi:10.1542/peds.101.4.597

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    doi:

    authors: Lopez JB,Gross P,Boggs TR

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