Abstract:
OBJECTIVE:To describe the epidemiologic, clinical, neuroimaging, and laboratory features; treatment; and outcome in a cohort of children with acute disseminated encephalomyelitis (ADEM). METHODS:A 6-year retrospective chart review of children with the diagnosis of ADEM was conducted. RESULTS:Eighteen cases were identified. Sixteen patients (88%) presented in either winter or spring. Thirteen children (72%) had a recent upper respiratory tract illness. Patients presented most often with motor deficits (77%) and secondly with altered consciousness (45%). Spinal fluid abnormalities occurred in 70%. Despite rigorous microbiologic testing, a definite microbiologic diagnosis was established only in 1 child with Epstein-Barr virus disease and probable or possible diagnoses in 3 children with Bartonella henselae, Mycoplasma pneumoniae, or rotavirus disease. Brain magnetic resonance imaging identified lesions in the cerebral cortex in 80%, in subcortical white matter in 93%, in periventricular white matter in 60%, in deep gray matter in 47%, and in brainstem in 47% of patients. Eleven patients (61%) were treated with corticosteroids, and 2 were treated with intravenous immunoglobulins. All patients survived. Three patients (17%) had long-term neurologic sequelae. CONCLUSIONS:Epidemiologic evidence from this study suggests an infectious cause for ADEM. The agent is most likely a difficult-to-diagnose winter/spring respiratory virus. Magnetic resonance imaging was the neuroimaging study of choice for establishing the diagnosis and for following the course of the disease. Prognosis for survival and outcome was excellent. Recurrent episodes of ADEM must be differentiated from multiple sclerosis.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Murthy SN,Faden HS,Cohen ME,Bakshi Rdoi
10.1542/peds.110.2.e21subject
Has Abstractpub_date
2002-08-01 00:00:00pages
e21issue
2 Pt 1eissn
0031-4005issn
1098-4275journal_volume
110pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:Despite new treatments, congenital diaphragmatic hernia (CDH) still has high mortality. The aim of this study was to identify echocardiographic predictors of outcome in newborns with an isolated CDH. METHODS:We reviewed medical charts and echocardiograms of 40 newborns who presented with CDH in the first 24 ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.105.5.1106
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:To determine if the incidence of empyema among children in the United States has changed since the introduction of the pneumococcal conjugate vaccine in 2000. METHODS:We used the nationally representative Kids' Inpatient Database to estimate the annual total number of hospitalizations of children < or = 18 y...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-0184
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:In experimental models of ischemic-anoxic brain injury, changes in body temperature after the insult have a profound influence on neurologic outcome. Specifically, hypothermia ameliorates whereas hyperthermia exacerbates neurologic injury. Accordingly, we sought to determine the temperature changes occurring ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.1.118
更新日期:2000-07-01 00:00:00
abstract::Fertility preservation in prepubertal and young adolescent girls scheduled for chemotherapy is a demanding situation. Despite the recent impressive improvements of ovarian cortex cryopreservation, significant limitations persist. The technique remains experimental, it exposes the girl to the risks of surgery and to an...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-0291
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the roles of production and conjugation of bilirubin, individually and in combination, in the mechanism of neonatal jaundice. METHODS:A cohort of healthy, term male newborns was sampled on the third day of life, coincident with routine metabolic screening, for bloo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.110.4.e47
更新日期:2002-10-01 00:00:00
abstract::A total of 36 toddlers and preschool children exhibiting bedtime tantrum activity were randomly assigned to one of three groups: positive routines, graduated extinction, or control. Positive routines involved changing the child's bedtime to coincide with when he naturally fell asleep, as well as parent and child engag...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:Intrapartum antibiotic prophylaxis (IAP) in mothers with group B streptococcus (GBS) colonization presents difficult neonatal management decisions. IAP was instituted in response to an increased incidence of early-onset GBS sepsis (EOGBSS), and a study was conducted to evaluate the outcome of these newborns. ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:There is a common belief that children are not getting enough sleep and that children's total sleep time has been declining. Over the century, many authors have proposed sleep recommendations. The aim of this study was to describe historical trends in recommended and actual sleep durations for ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2011-2039
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of fiber-optic phototherapy using the standard Ohmeda Biliblanket, a large version, double standard Biliblankets, and conventional phototherapy using daylight fluorescent lamps in full-term, healthy infants with nonhemolytic hyperbilirubinemia. METHODS:Full-term, healthy infants with...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.99.5.e13
更新日期:1997-05-01 00:00:00
abstract::Photoisomerization of native bilirubin to more polar configurational isomers (Z,E-bilirubin) and structural isomers (lumirubin) was studied in 20 premature infants with physiologic jaundice to determine the effect of low-dose (6 microW/cm2/nm) v high-dose (12 microW/cm2/nm) phototherapy. Patients were assigned prospec...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Polysomnography defines the pathophysiology of obstructive sleep apnea syndrome (OSAS) but does not predict some important comorbidities or their response to adenotonsillectomy. We assessed whether OSAS symptoms, as reflected on the Sleep-Related Breathing Disorders Scale of the Pediatric Slee...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2014-3099
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:This qualitative study aimed at understanding the experiences of fathers of very ill neonates in the NICU. METHODS:Sixteen fathers of very ill and/or very preterm infants who had been in the NICU for >30 days were interviewed by a male physician. Fathers were asked about their level of comfort with or concer...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1005
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:A total of 20% of sudden infant death syndrome (SIDS) cases in the 1990s occurred in child care settings. This is much higher than the 8% expected from Census Bureau data. Factors that were associated with child care SIDS included older age; white race; older, more educated mothers; and unaccustomed prone pos...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-0924
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVES:Our goals were to highlight an increasing trend in orthopedic injuries in children as a result of "heeling" or "street gliding," to describe injuries sustained by children using Heelys (HSL, Carrollton, TX) and Street Gliders (Glowgadgets Ltd, Bristol, United Kingdom), and to increase public awareness and pr...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-2882
更新日期:2007-06-01 00:00:00
abstract::Lysosomal storage disorders are rare inborn errors of metabolism, with a combined incidence of 1 in 1500 to 7000 live births. These relatively rare disorders are seldom considered when evaluating a sick newborn. A significant number of the >50 different lysosomal storage disorders, however, do manifest in the neonatal...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2008-0635
更新日期:2009-04-01 00:00:00
abstract::This report describes an attempt to evaluate the effectiveness of "trained mother" interviews early in the medical school curriculum. As an adjunct to a first-year course that teaches interviewing techniques, half of the students were exposed to an interview with one of three trained mothers early in the course. This ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-08-01 00:00:00
abstract:OBJECTIVE:Despite marked growth in neonatal intensive care during the past 30 years, it is not known if neonatologists and beds are preferentially located in regions with greater newborn risk. This study reports the relationship between regional measures of intensive care capacity and low birth weight infants using new...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.2.426
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:To examine the perspectives of low-income parents on redesigning well-child care (WCC) for children aged 0 to 3 years, focusing on possible changes in 3 major domains: providers, locations, and formats. METHODS:Eight focus groups (4 English and 4 Spanish) were conducted with 56 parents of children aged 6 mon...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-2608
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Latino-white disparities in age at autism spectrum disorder (ASD) diagnosis may be modified by primary care pediatrician (PCP) practices and beliefs. The objectives of this study were to assess ASD and developmental screening practices, attitudes toward ASD identification in Latino children, a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-0383
更新日期:2013-09-01 00:00:00
abstract::Neonatal necrotizing enterocolitis (NEC) remains an important cause of morbidity and mortality among very low birth weight infants. It has long been suspected that intestinal microbes contribute to the pathogenesis of NEC, but the details of this relationship remain poorly understood. Recent advances in molecular biol...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2009-3149
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Posterior fossa hemorrhages may be underdiagnosed in surviving neonates, with cerebellar hemorrhage discovered in 10% to 25% of autopsy specimens from very low birth weight infants. Posterior fossa lesions have been difficult to visualize by the traditional ultrasonography approach through the anterior fontan...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.6.e62
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:Infants born to immigrant mothers, including Hispanic mothers, display birth weight and mortality advantages, compared with other disadvantaged groups. We examined prenatal biological factors and maternal practices that account for this advantage. Then we estimated the extent to which healthy birth outcomes,...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-0496
更新日期:2010-02-01 00:00:00
abstract::During and after respiratory tract infections in 29 hospitalized infants, 12 cardiorespiratory measurements were performed on 24-hour recordings of ECG and respiratory activity. These measurements were compared with similar data obtained from 110 age-matched control infants without infection. Respiratory and heart rat...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract::A cytogenetic test was developed to enable the diagnostic differentiation between Fanconi anemia and the group of disorders classified as "idiopathic" aplastic anemia. The method is based on the effect of the bifunctional alkylating agent mitomycin C (MMC) on chromosomes of peripheral lymphocytes in culture 92 to 96 h...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVES:To determine whether maternal report of infant behavioral dysregulation at 6 months is associated with a higher prevalence of behavioral concerns at 5, 14, and 21 years of age; and to assess the extent to which maternal and social factors may affect reported child behavior outcomes. METHODS:From the Mater-U...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-3517
更新日期:2012-11-01 00:00:00
abstract::Global developmental delay and intellectual disability are relatively common pediatric conditions. This report describes the recommended clinical genetics diagnostic approach. The report is based on a review of published reports, most consisting of medium to large case series of diagnostic tests used, and the proporti...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2014-1839
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:This is an investigation into the longitudinal patterns of bed sharing, the characteristics associated with those patterns, and the relationship with breastfeeding. METHODS:The study used prospective, population-based data from the United Kingdom to investigate nocturnal bed sharing at 5 time points from bi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-1277
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:With this study we aimed to compare survival rates for children with Down syndrome in 2 time periods, 1 before prenatal screening (1988-1990) and 1 contemporaneous with screening (1998-2000), and to examine the frequency of comorbidities and their influence on survival rates. METHODS:Record-linkage was perf...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-2840
更新日期:2009-01-01 00:00:00
abstract::: media-1vid110.1542/5972296741001PEDS-VA_2018-2373Video Abstract BACKGROUND: Studies have revealed an association between positional plagiocephaly and/or brachycephaly (PPB) and development, although little is known about long-term outcomes. We examined cognition and academic achievement in children with and without ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-2373
更新日期:2019-02-01 00:00:00
abstract::We report on 6 infants who underwent elective surgery and developed postoperative encephalopathy, which had features most consistent with intraoperative cerebral hypoperfusion. All infants were <48 weeks' postmenstrual age and underwent procedures lasting 120 to 185 minutes. Intraoperative records revealed that most o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-0973
更新日期:2014-03-01 00:00:00