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Utility of symptoms to predict treatment outcomes in obstructive sleep apnea syndrome.

Abstract：

BACKGROUND AND OBJECTIVES:Polysomnography defines the pathophysiology of obstructive sleep apnea syndrome (OSAS) but does not predict some important comorbidities or their response to adenotonsillectomy. We assessed whether OSAS symptoms, as reflected on the Sleep-Related Breathing Disorders Scale of the Pediatric Sleep Questionnaire (PSQ), may offer clinical predictive value. METHODS:Baseline and 7-month follow-up data were analyzed from 185 participants (aged 5-9 years with polysomnographically confirmed OSAS) in the surgical treatment arm of the multicenter Childhood Adenotonsillectomy Trial. Associations were assessed between baseline PSQ or polysomnographic data and baseline morbidity (executive dysfunction, behavior, quality of life, sleepiness) or postsurgical improvement. RESULTS:At baseline, each 1-SD increase in baseline PSQ score was associated with an adjusted odds ratio that was ∼3 to 4 times higher for behavioral morbidity, 2 times higher for reduced global quality of life, 6 times higher for reduced disease-specific quality of life, and 2 times higher for sleepiness. Higher baseline PSQ scores (greater symptom burden) also predicted postsurgical improvement in parent ratings of executive functioning, behavior, quality of life, and sleepiness. In contrast, baseline polysomnographic data did not independently predict these morbidities or their postsurgical improvement. Neither PSQ nor polysomnographic data were associated with objectively assessed executive dysfunction or improvement at follow-up. CONCLUSIONS:PSQ symptom items, in contrast to polysomnographic results, reflect subjective measures of OSAS-related impairment of behavior, quality of life, and sleepiness and predict their improvement after adenotonsillectomy. Although objective polysomnography is needed to diagnose OSAS, the symptoms obtained during an office visit can offer adjunctive insight into important comorbidities and likely surgical responses.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Rosen CL,Wang R,Taylor HG,Marcus CL,Katz ES,Paruthi S,Arens R,Muzumdar H,Garetz SL,Mitchell RB,Jones D,Weng J,Ellenberg S,Redline S,Chervin RD

doi

10.1542/peds.2014-3099

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

e662-71

issue

eissn

0031-4005

issn

1098-4275

pii

peds.2014-3099

journal_volume

135

pub_type

杂志文章,多中心研究,随机对照试验

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Utility of symptoms to predict treatment outcomes in obstructive sleep apnea syndrome.