Arterial oxygen desaturation during sleep in children with asthma and its relation to airway obstruction and ventilatory drive.

Abstract:

:The possibility that arterial oxygen saturation (SaO2) decreases during sleep in children with chronic bronchial asthma was investigated. The relationship between decreases in sleep SaO2 and airflow obstruction and ventilatory drives, as characterized by ventilatory and inspiratory muscle activity responses to hypoxia and hypercapnia was also examined. Sixteen asthmatics on suboptimal bronchodilator therapy and ten healthy children were studied. Both maximum decrease in SaO2 and number of desaturations (decrease in SaO2 greater than or equal to 4%) per hour during sleep were greater in the asthmatics than in the control subjects. Both maximum decrease in SaO2 and number of desaturations per hour asleep were correlated with change in FEV1 and FEF25%-75% over the sleep period. Changes in SaO2 were not related to awake measurements of ventilatory drive. Eight of the asthmatics also were studied when on a more optimal medication regimen. On this program they had less airflow obstruction before and after sleep, and the number and extent of decreases in SaO2 were not different from those of the control subjects. We conclude: (1) decreases in SaO2 occurred during sleep in suboptimally treated asthmatic children; (2) SaO2 changes during sleep were related to the amount of air-flow obstruction that developed during sleep; (3) SaO2 changes during sleep were not related to ventilatory drive measured during wakefulness; and (4) a good therapeutic regimen eliminated abnormal amounts of sleep hypoxemia by improving airflow limitation. However, as the results of this study indicate, when their pulmonary status is unstable, asthmatic children may develop clinically significant hypoxemia during sleep.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Smith TF,Hudgel DW

subject

Has Abstract

pub_date

1980-11-01 00:00:00

pages

746-51

issue

5

eissn

0031-4005

issn

1098-4275

journal_volume

66

pub_type

杂志文章
  • Unscheduled Referrals and Unattended Appointments After Pediatric Subspecialty Referral.

    abstract:OBJECTIVES:Incomplete subspecialty referrals, whether unscheduled or unattended, represent unmet patient needs and an opportunity to improve patient safety and experiences. Our objectives were to describe the rates of appointment scheduling and visit attendance after pediatric subspecialty referral and to examine patie...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-0545

    authors: Bohnhoff JC,Taormina JM,Ferrante L,Wolfson D,Ray KN

    更新日期:2019-12-01 00:00:00

  • Early Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research.

    abstract::This article reviews current evidence for autism spectrum disorder (ASD) interventions for children aged <3 years, based on peer-reviewed articles published up to December 2013. Several groups have adapted treatments initially designed for older, preschool-aged children with ASD, integrating best practice in behaviora...

    journal_title:Pediatrics

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1542/peds.2014-3667E

    authors: Zwaigenbaum L,Bauman ML,Choueiri R,Kasari C,Carter A,Granpeesheh D,Mailloux Z,Smith Roley S,Wagner S,Fein D,Pierce K,Buie T,Davis PA,Newschaffer C,Robins D,Wetherby A,Stone WL,Yirmiya N,Estes A,Hansen RL,McPartlan

    更新日期:2015-10-01 00:00:00

  • Legal, ethical, and financial dilemmas in electronic health record adoption and use.

    abstract::Electronic health records (EHRs) facilitate several innovations capable of reforming health care. Despite their promise, many currently unanswered legal, ethical, and financial questions threaten the widespread adoption and use of EHRs. Key legal dilemmas that must be addressed in the near-term pertain to the extent o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-2184

    authors: Sittig DF,Singh H

    更新日期:2011-04-01 00:00:00

  • Pancreatitis in human immunodeficiency virus-infected children receiving dideoxyinosine.

    abstract::To define predictive or contributory risk factors for pancreatitis in human immunodeficiency virus-infected children receiving dideoxyinosine (ddI), the authors evaluated 95 children, 3 months to 18 years of age, who had received ddI at 60 to 540 mg/m2 per day for a mean of 56 weeks. Pancreatitis developed in 7 patien...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Butler KM,Venzon D,Henry N,Husson RN,Mueller BU,Balis FM,Jacobsen F,Lewis LL,Pizzo PA

    更新日期:1993-04-01 00:00:00

  • Pediatric medication safety and the media: what does the public see?

    abstract:BACKGROUND:In the safety community, it is widely thought that a culture of safety is required to achieve high levels of safety. However, the press tends to report accidents, which are negative by their nature. Pediatric cases are often especially tragic. Relatively few data have been available on the role that the medi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2017

    authors: Stebbing C,Kaushal R,Bates DW

    更新日期:2006-06-01 00:00:00

  • Familial nonobstructive cardiomyopathy with endocardial fibroelastosis beyond infancy.

    abstract::A 10-year-old boy with congestive heart failure died in five months in spite of comprehensive medical treatment. Autopsy showed patchy areas of endocardial fibroelastosis of the left ventricle. The sister of this patient had followed a similar course at 13 years of age with death within six months of the onset of cong...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.61.3.410

    authors: Singh A,Doyle EF,Danilowicz DA,Finegold MJ

    更新日期:1978-03-01 00:00:00

  • Herpes simplex virus central nervous system relapse during treatment of infantile spasms with corticotropin.

    abstract::Here we report an infant who had herpes simplex virus (HSV) encephalitis and sustained severe bilateral damage to the posterior frontal lobes, postcentral gyri, and the thalami despite intravenous acyclovir treatment. At 7 months of age, the patient developed infantile spasms and was treated with corticotropin injecti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1867

    authors: Bonkowsky JL,Filloux FM,Byington CL

    更新日期:2006-05-01 00:00:00

  • Cigarette Tax Increase and Infant Mortality.

    abstract:BACKGROUND AND OBJECTIVE:Maternal smoking increases the risk for preterm birth, low birth weight, and sudden infant death syndrome, which are all causes of infant mortality. Our objective was to evaluate if changes in cigarette taxes and prices over time in the United States were associated with a decrease in infant mo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-2901

    authors: Patrick SW,Warner KE,Pordes E,Davis MM

    更新日期:2016-01-01 00:00:00

  • Global Climate Change and Children's Health.

    abstract::Rising global temperatures are causing major physical, chemical, and ecological changes in the planet. There is wide consensus among scientific organizations and climatologists that these broad effects, known as "climate change," are the result of contemporary human activity. Climate change poses threats to human heal...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章

    doi:10.1542/peds.2015-3232

    authors: COUNCIL ON ENVIRONMENTAL HEALTH.

    更新日期:2015-11-01 00:00:00

  • A prospective study of the role of depression in the development and persistence of adolescent obesity.

    abstract:BACKGROUND:Adolescent obesity is a strong predictor of adult obesity, and adult obesity has been associated with depression, especially in women. Studies have also suggested an association between depression in adolescence and higher body mass index (BMI) in adulthood. Whether depression leads to obesity or obesity cau...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.3.497

    authors: Goodman E,Whitaker RC

    更新日期:2002-09-01 00:00:00

  • Developmental care does not alter sleep and development of premature infants.

    abstract:OBJECTIVE:The Neonatal Individualized Developmental Care Program (NIDCAP) for very low birth weight (VLBW) preterm infants has been suggested by Als et al to improve several medical outcome variables such as time on ventilator, time to nipple feed, the duration of hospital stay, better behavioral performance on Assessm...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.100.6.e9

    authors: Ariagno RL,Thoman EB,Boeddiker MA,Kugener B,Constantinou JC,Mirmiran M,Baldwin RB

    更新日期:1997-12-01 00:00:00

  • Heliox therapy in bronchiolitis: phase III multicenter double-blind randomized controlled trial.

    abstract:BACKGROUND AND OBJECTIVE:Supportive care remains the mainstay of therapy in bronchiolitis. Earlier studies suggest that helium-oxygen therapy may be beneficial, but evidence is limited. We aimed to compare efficacy of 2 treatment gases, Heliox and Airox (21% oxygen + 79% helium or nitrogen, respectively), on length of ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2012-1317

    authors: Chowdhury MM,McKenzie SA,Pearson CC,Carr S,Pao C,Shah AR,Reus E,Eliahoo J,Gordon F,Bland H,Habibi P

    更新日期:2013-04-01 00:00:00

  • Detection of human immunodeficiency virus type 1 (HIV-1) DNA and p24 antigen in breast milk of HIV-1-infected Ugandan women and vertical transmission.

    abstract:OBJECTIVE:To determine the correlation between the detection of human immunodeficiency virus type 1 (HIV-1) in breast milk, the duration of breastfeeding, and vertical transmission of HIV-1 infection in Ugandan women. METHODS:A prospective study of HIV-1 infection in pregnant Ugandan women and their infants has been o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Guay LA,Hom DL,Mmiro F,Piwowar EM,Kabengera S,Parsons J,Ndugwa C,Marum L,Olness K,Kataaha P,Jackson JB

    更新日期:1996-09-01 00:00:00

  • Parental permission for pilot newborn screening research: guidelines from the NBSTRN.

    abstract::There is broad recognition of the need for population-based research to assess the safety and efficacy of newborn screening (NBS) for conditions that are not on current panels. However, prospective population-based research poses significant ethical, regulatory, and logistical challenges. In the context of NBS, there ...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2013-2271

    authors: Botkin JR,Lewis MH,Watson MS,Swoboda KJ,Anderson R,Berry SA,Bonhomme N,Brosco JP,Comeau AM,Goldenberg A,Goldman E,Therrell B,Levy-Fisch J,Tarini B,Wilfond B,Bioethics and Legal Work Group of the Newborn Screening Translatio

    更新日期:2014-02-01 00:00:00

  • Correlates of lactation in mothers of very low birth weight infants.

    abstract:OBJECTIVE:We sought to determine the correlates of intent to breastfeed and of successful lactation and nursing at the breast in mothers of very low birth weight (VLBW; <1.5 kg) infants. METHODS:We conducted a prospective observational study of 119 mothers of singleton VLBW infants (mean birth weight: 1056 g; mean ges...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.4.e57

    authors: Furman L,Minich N,Hack M

    更新日期:2002-04-01 00:00:00

  • Policy statement—Professional liability insurance and medicolegal education for pediatric residents and fellows.

    abstract::The American Academy of Pediatrics believes that pediatric residents and fellows should be fully informed of the scope and limitations of their professional liability insurance coverage while in training. The academy states that residents and fellows should be educated by their training institutions on matters relatin...

    journal_title:Pediatrics

    pub_type: 共识发展会议,杂志文章

    doi:10.1542/peds.2011-1025

    authors: Committee on Medical Liability and Risk Management.,Gonzalez JL

    更新日期:2011-09-01 00:00:00

  • Otoacoustic emissions as a screening test for hearing impairment in children recovering from acute bacterial meningitis.

    abstract:OBJECTIVES:To study the efficacy of otoacoustic emissions (OAEs) as a screening test for hearing impairment in children with acute bacterial meningitis. Hearing tests were performed before discharge from the hospital in an attempt to improve coverage and avoid delays in the diagnosis of postmeningitic hearing loss. ME...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.6.1364

    authors: Richardson MP,Williamson TJ,Reid A,Tarlow MJ,Rudd PT

    更新日期:1998-12-01 00:00:00

  • Infant dietary experience and acceptance of solid foods.

    abstract:OBJECTIVE:To examine the effects of dietary experience and milk feeding regimen on acceptance of their first vegetable by 4- to 6-month-old infants. DESIGN:Longitudinal study, of 26-days duration, observing infants aged 4 to 6 months at the start of the study. Random assignment to treatments, within-subject control. ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Sullivan SA,Birch LL

    更新日期:1994-02-01 00:00:00

  • Infant-feeding methods and childhood sleep-disordered breathing.

    abstract:OBJECTIVE:Childhood sleep-disordered breathing has an adverse impact on cognitive development, behavior, quality of life, and use of health care resources. Early viral infections and other immune-mediated responses may contribute to development of the chronic inflammation of the upper airway and hypertrophic upper airw...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0722

    authors: Montgomery-Downs HE,Crabtree VM,Sans Capdevila O,Gozal D

    更新日期:2007-11-01 00:00:00

  • Interpreters: telephonic, in-person interpretation and bilingual providers.

    abstract:CONTEXT:Language barriers affect health care interactions. Large, randomized studies of the relative efficacy of interpreter modalities have not been conducted. OBJECTIVE:To compare the efficacy of telephonic and in-person medical interpretation to visits with verified bilingual physicians. METHODS:This was a prospec...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2009-0769

    authors: Crossman KL,Wiener E,Roosevelt G,Bajaj L,Hampers LC

    更新日期:2010-03-01 00:00:00

  • Compliance with alarm limits for pulse oximetry in very preterm infants.

    abstract:OBJECTIVE:The objective of this study was to determine the rate of compliance with hospital guidelines for alarm limits for pulse oximetry in preterm infants on oxygen therapy. METHODS:All infants admitted to the nurseries at the Royal Women's Hospital, Melbourne, Australia, with gestational age <32 weeks or birth wei...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3099

    authors: Clucas L,Doyle LW,Dawson J,Donath S,Davis PG

    更新日期:2007-06-01 00:00:00

  • Cancer incidence among children and adolescents in the United States, 2001-2003.

    abstract:OBJECTIVE:Our goal was to describe current childhood cancer incidence in the United States and identify demographic and geographic variation among children and adolescents with cancer. METHODS:We examined data from 39 National Program of Cancer Registries and 5 Surveillance, Epidemiology, and End Results statewide reg...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2964

    authors: Li J,Thompson TD,Miller JW,Pollack LA,Stewart SL

    更新日期:2008-06-01 00:00:00

  • Evaluation of psychopathological conditions in children with heavy prenatal alcohol exposure.

    abstract:OBJECTIVE:This study compared the prevalence of psychopathological conditions in children with heavy prenatal alcohol exposure (N = 39) and nonexposed, typically developing peers (N = 30), matched with respect to age, gender, and socioeconomic status. METHODS:Caregivers were interviewed with either the Kiddie Schedule...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1606

    authors: Fryer SL,McGee CL,Matt GE,Riley EP,Mattson SN

    更新日期:2007-03-01 00:00:00

  • Parents' Perspectives Regarding Age Restrictions for Tackling in Youth Football.

    abstract:BACKGROUND:In ice hockey and soccer, age restrictions exist for body checking and heading because of injury risk. There are currently no age restrictions for tackling in youth football. METHODS:We surveyed a nationally representative sample of US parents regarding their support for age restrictions on tackling in foot...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-2402

    authors: Chrisman SPD,Whitlock KB,Kroshus E,Schwien C,Herring SA,Rivara FP

    更新日期:2019-05-01 00:00:00

  • Clinical disease in children associated with newly described coronavirus subtypes.

    abstract:OBJECTIVES:Coronaviruses cause upper respiratory illness and occasionally lower tract disease in susceptible populations. In this study we examined the prevalence of 4 human coronaviruses, including subtypes OC43, 229E, and the recently described NL63 and HKU1 in a pediatric population presenting to a children's hospit...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1406

    authors: Kuypers J,Martin ET,Heugel J,Wright N,Morrow R,Englund JA

    更新日期:2007-01-01 00:00:00

  • Epidemiology of inguinal hernia in preterm neonates.

    abstract::We have studied the epidemiology of inguinal hernias in preterm infants. Inguinal hernias occur with increased frequency in infants less than or equal to 32 weeks' gestational age or less than or equal to 1,250 g birth weight. Among infants less than or equal to 32 weeks' gestational age, intrauterine growth retardati...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Peevy KJ,Speed FA,Hoff CJ

    更新日期:1986-02-01 00:00:00

  • Impact of income and income inequality on infant health outcomes in the United States.

    abstract:OBJECTIVES:The goal was to investigate the relationships of income and income inequality with neonatal and infant health outcomes in the United States. METHODS:The 2000-2004 state data were extracted from the Kids Count Data Center. Health indicators included proportion of preterm births (PTBs), proportion of infants ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2009-3378

    authors: Olson ME,Diekema D,Elliott BA,Renier CM

    更新日期:2010-12-01 00:00:00

  • Controlled evaluation of muscle relaxation in the ventilated neonate.

    abstract::To assess the effects of muscle relaxation on the critically ill ventilated neonate, pancuronium bromide was administered for a 12-hour period to ten low-birth-weight neonates (960 to 2,000 gm) of 26 to 34 weeks gestation, all whom required mechanical ventilation and were studied within 48 hours of birth (six to 39 ho...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Finer NN,Tomney PM

    更新日期:1981-05-01 00:00:00

  • Pediatric residents' continuity clinics: how are we really doing?

    abstract::The Accreditation Council for Graduate Medical Education (ACGME) established guidelines in 1989 requiring pediatric residents to attend a continuity clinic (CC) one half-day per week. OBJECTIVE. To assess pediatric residents' CCs, with an emphasis on those factors potentially affecting house staff education and patien...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Dumont-Driscoll MC,Barbian LT,Pollock BH

    更新日期:1995-10-01 00:00:00

  • Visceral larva migrans associated with earthworm ingestion: clinical evolution in an adolescent patient.

    abstract::A 16-year-old girl developed a cough, hypereosinophilia (absolute eosinophil count: 32000/mm3), hypergammaglobulinemia, and multiple noncavitary pulmonary nodules 1 month after having ingested an earthworm on a dare. Spirometry revealed moderate restriction and reduced gas diffusion. Parabronchial biopsy demonstrated ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1596

    authors: Cianferoni A,Schneider L,Schantz PM,Brown D,Fox LM

    更新日期:2006-02-01 00:00:00