Unexplained reduced microbiological efficacy of intramuscular benzathine penicillin G and of oral penicillin V in eradication of group a streptococci from children with acute pharyngitis.

Abstract:

OBJECTIVE:To evaluate the efficacy of oral penicillin V and intramuscular benzathine penicillin G (BPG) in eradicating group A streptococci from the upper respiratory tract. METHODOLOGY:Two randomized, single-blind, multicenter antibiotic efficacy trials in children using recommended doses of either oral penicillin V or intramuscular BPG for treatment of acute-onset pharyngitis associated with isolation of group A streptococci were conducted. Throat examinations and cultures were obtained at enrollment and on days 5 to 8, 10 to 14, and 29 to 31. RESULTS:Thirty-five percent of 284 evaluable patients treated with oral penicillin V and 37% of BPG-treated patients were microbiologic treatment failures at either 10 to 14 or 29 to 31 days. CONCLUSIONS:Although these findings do not provide sufficient evidence to change current treatment recommendations or public health policy, important questions are raised about currently recommended penicillin doses, about the role of the carrier state, and possibly about adequate bioavailability of intramuscular BPG. These findings require confirmation.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Kaplan EL,Johnson DR

doi

10.1542/peds.108.5.1180

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

1180-6

issue

5

eissn

0031-4005

issn

1098-4275

pii

108/5/1180

journal_volume

108

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    authors: Miles MV,Lawless ST,Tennison MB,Zaritsky AL,Greenwood RS

    更新日期:1990-08-01 00:00:00

  • Prenatal di(2-ethylhexyl)phthalate exposure and length of gestation among an inner-city cohort.

    abstract:OBJECTIVE:Our objective was to assess the relationship between di(2-ethylhexyl)phthalate (DEHP) exposure during pregnancy and gestational age at delivery among 311 African American or Dominican women from New York City. METHODS:Forty-eight-hour personal air and/or spot urine samples were collected during the third tri...

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    authors: Whyatt RM,Adibi JJ,Calafat AM,Camann DE,Rauh V,Bhat HK,Perera FP,Andrews H,Just AC,Hoepner L,Tang D,Hauser R

    更新日期:2009-12-01 00:00:00

  • Yield of diagnostic testing in infants who have had an apparent life-threatening event.

    abstract:OBJECTIVE:Many infants who have experienced an apparent life-threatening event (ALTE) seem normal by the time they reach the hospital. Nevertheless, they typically undergo an extensive evaluation to rule out serious underlying conditions. The purpose of the present investigation was to determine the yield of different ...

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    doi:10.1542/peds.2004-0847

    authors: Brand DA,Altman RL,Purtill K,Edwards KS

    更新日期:2005-04-01 00:00:00

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    abstract:BACKGROUND AND OBJECTIVES:Medication use may be a target for quality improvement, cost containment, and research. We aimed to identify medication classes associated with the highest expenditures among pediatric Medicaid enrollees and to characterize the demographic, clinical, and health service use of children prescrib...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-1095

    authors: Cohen E,Hall M,Lopert R,Bruen B,Chamberlain LJ,Bardach N,Gedney J,Zima BT,Berry JG

    更新日期:2017-09-01 00:00:00

  • Gender differences in presentation and course of disease in pediatric patients with Crohn disease.

    abstract:OBJECTIVE:The objective of this study was to determine gender differences in pediatric patients with Crohn disease. METHODS:We conducted a retrospective cohort study of 989 consecutive pediatric patients (566 boys, 423 girls) who had Crohn disease (aged 0 to 17 years at diagnosis) by using the Pediatric IBD Consortium...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0905

    authors: Gupta N,Bostrom AG,Kirschner BS,Ferry GD,Winter HS,Baldassano RN,Gold BD,Abramson O,Smith T,Cohen SA,Heyman MB

    更新日期:2007-12-01 00:00:00

  • Severe perinatal Marfan syndrome.

    abstract::The cardiovascular manifestations of the Marfan syndrome in older children and adults have been well described. Clinical, radiographic, and echocardiographic data regarding three patients with severe perinatal Marfan syndrome are described. Two of these patients had the syndrome at birth and died in infancy. The syndr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gross DM,Robinson LK,Smith LT,Glass N,Rosenberg H,Duvic M

    更新日期:1989-07-01 00:00:00

  • Breast-feeding incidence and duration in black and white women.

    abstract::The influence of sociodemographic factors on the incidence and duration of breast-feeding was evaluated in 668 black and 511 white women delivering their first child in the metropolitan Washington, DC, area. Breast-feeding rates were 84% among white and 49% among black women. Maternal educational level was strongly as...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kurinij N,Shiono PH,Rhoads GG

    更新日期:1988-03-01 00:00:00

  • Pediatric medication safety and the media: what does the public see?

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2017

    authors: Stebbing C,Kaushal R,Bates DW

    更新日期:2006-06-01 00:00:00

  • Experiences With Medical Exemptions After a Change in Vaccine Exemption Policy in California.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-1051

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    更新日期:2018-11-01 00:00:00

  • Dietary Fats and Atherosclerosis From Childhood to Adulthood.

    abstract:BACKGROUND:The association of dietary fat distribution with markers of subclinical atherosclerosis during early life is unknown. We examined whether success in achieving the main target of an infancy-onset dietary intervention based on the distribution of dietary fat was associated with aortic and carotid intima-media ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2019-2786

    authors: Laitinen TT,Nuotio J,Rovio SP,Niinikoski H,Juonala M,Magnussen CG,Jokinen E,Lagström H,Jula A,Viikari JSA,Rönnemaa T,Simell O,Raitakari OT,Pahkala K

    更新日期:2020-04-01 00:00:00

  • Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.5.1098

    authors: Gunn AJ,Gunn TR,Gunning MI,Williams CE,Gluckman PD

    更新日期:1998-11-01 00:00:00

  • The increasing number of children using psychiatric services: analysis of a cumulative psychiatric case register.

    abstract::Psychosocial problems of children have received increasing attention in the pediatric literature, but it remains unclear to what extent psychiatric services are available and used for the treatment of these problems. This paper examines the utilization of psychiatric services by children over an 18-year period in Monr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Roghmann KJ,Babigian HM,Goldberg ID,Zastowny TR

    更新日期:1982-11-01 00:00:00

  • Meningococcal Disease Among College-Aged Young Adults: 2014-2016.

    abstract::: media-1vid110.1542/5839998266001PEDS-VA_2018-2130Video Abstract BACKGROUND: Freshman college students living in residence halls have previously been identified as being at an increased risk for meningococcal disease. In this evaluation, we assess the incidence and characteristics of meningococcal disease in college-...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-2130

    authors: Mbaeyi SA,Joseph SJ,Blain A,Wang X,Hariri S,MacNeil JR

    更新日期:2019-01-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1278

    authors: Nelson DK,Skinner D,Guarda S,Choudhury S,Sideris J,Barnum L,Ten Haagen K,Heyward Q,Bailey DB Jr

    更新日期:2013-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1542/peds.2017-2238

    authors: Bester J,Sabatello M,van Karnebeek CDM,Lantos JD

    更新日期:2018-04-01 00:00:00

  • Etiology of childhood bacteremia and timely antibiotics administration in the emergency department.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-2061

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    更新日期:2015-04-01 00:00:00

  • Predictors of Medication Continuity in Children With ADHD.

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    pub_type: 杂志文章

    doi:10.1542/peds.2017-2580

    authors: Brinkman WB,Sucharew H,Majcher JH,Epstein JN

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    pub_type: 杂志文章

    doi:

    authors: Bordley WC,Margolis PA,Lannon CM

    更新日期:1996-04-01 00:00:00

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    abstract::Isolated sulfite oxidase deficiency is a rare but devastating neurologic disease that usually presents in early infancy with seizures and alterations in muscle tone. Only 21 cases have been reported in the literature. We report a case of a newborn infant boy with isolated sulfite oxidase deficiency who presented with ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2004-1897

    authors: Tan WH,Eichler FS,Hoda S,Lee MS,Baris H,Hanley CA,Grant PE,Krishnamoorthy KS,Shih VE

    更新日期:2005-09-01 00:00:00

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    pub_type: 杂志文章

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    authors: Irwin CE Jr,Millstein SG,Ellen JM

    更新日期:1993-07-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1542/peds.2013-0698

    authors: Zhou F,Shefer A,Wenger J,Messonnier M,Wang LY,Lopez A,Moore M,Murphy TV,Cortese M,Rodewald L

    更新日期:2014-04-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Belfer ML,Kaban LB

    更新日期:1982-05-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gäre BA,Fasth A

    更新日期:1992-12-01 00:00:00

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    authors: Cooper WO,Hickson GB,Mitchel EF Jr,Ray WA

    更新日期:1999-09-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Carver JD,Pimentel B,Cox WI,Barness LA

    更新日期:1991-08-01 00:00:00

  • Erythromelalgia.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Mandell F,Folkman J,Matsumoto S

    更新日期:1977-01-01 00:00:00

  • Corneal abrasions in young infants.

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    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Schuh S,Parkin P,Rajan A,Canny G,Healy R,Rieder M,Tan YK,Levison H,Soldin SJ

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    doi:

    authors: Ontell SJ,Gauderer MW

    更新日期:1985-07-01 00:00:00

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