High-versus low-dose, frequently administered, nebulized albuterol in children with severe, acute asthma.

Abstract:

:Thirty-two 5- to 17-year-old children who had severe, acute asthma were randomly assigned to receive either high doses (0.15 mg/kg of body weight per dose) or low doses (0.05 mg/kg of body weight per dose) of nebulized albuterol every 20 minutes for six doses. Compared with the low-dose regimen, the high-dose regimen resulted in significantly greater improvement in forced expiratory volume in 1 second, forced vital capacity, and wheeze score and a lower hospitalization rate. The changes in heart rate, respiratory rate, blood pressure, white blood cell count, and serum potassium concentration did not differ significantly between the groups. The incidence of side effects, which included tremor, hyperactivity, and vomiting, was not significantly different in the two populations. Serum albuterol levels varied widely, but there was no correlation between the levels and the increase in heart rate or other side effects. high-dose, frequently administered, nebulized albuterol appears both safe and effective in treating severe, acute asthma in children.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Schuh S,Parkin P,Rajan A,Canny G,Healy R,Rieder M,Tan YK,Levison H,Soldin SJ

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

513-8

issue

4

eissn

0031-4005

issn

1098-4275

journal_volume

83

pub_type

临床试验,杂志文章,随机对照试验
  • Safety and efficacy of long-term diet and diet plus bile acid-binding resin cholesterol-lowering therapy in 73 children heterozygous for familial hypercholesterolemia.

    abstract::Our specific aim was to examine the efficacy and safety of long-term cholesterol-lowering diet and bile acid-binding resin therapy in 73 children heterozygous for familial hypercholesterolemia (FH). We prospectively followed accretion of height and weight in 40 FH children for 5.8 years on diet alone and in 33 FH chil...

    journal_title:Pediatrics

    pub_type: 杂志文章,收录出版

    doi:

    authors: Glueck CJ,Mellies MJ,Dine M,Perry T,Laskarzewski P

    更新日期:1986-08-01 00:00:00

  • Recommendations for influenza immunization of children.

    abstract::Epidemiologic studies indicate that children of all ages with certain chronic conditions and otherwise healthy children younger than 24 months of age are hospitalized for influenza infection and its complications at high rates similar to those experienced by the elderly. Annual influenza immunization is recommended fo...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.113.5.1441

    authors: American Academy of Pediatrics Committee on Infectious Diseases.

    更新日期:2004-05-01 00:00:00

  • Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial.

    abstract:OBJECTIVE:To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood. DESIGN:Prospective follow-up study of a randomized, double-blind, placebo-controlled trial. SETTING:National Women's Hospital (Auckland, New Zealand)...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.2004-0196

    authors: Dalziel SR,Liang A,Parag V,Rodgers A,Harding JE

    更新日期:2004-09-01 00:00:00

  • Emergency Department and Hospital Use Among Adolescents With Justice System Involvement.

    abstract:OBJECTIVES:Adolescents with justice system involvement have high rates of physical and behavioral health disorders and are potentially high users of costly health care services. We examined emergency department (ED) and hospital use among a national sample of adolescents with various levels of justice involvement. MET...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-1144

    authors: Winkelman TNA,Genao I,Wildeman C,Wang EA

    更新日期:2017-11-01 00:00:00

  • The relationship between reported sleep quality and sleep hygiene in Italian and American adolescents.

    abstract:OBJECTIVE:The purpose of the study was to examine the relationship between self-reported sleep quality and sleep hygiene in Italian and American adolescents and to assess whether sleep-hygiene practices mediate the relationship between culture and sleep quality. METHODS:Two nonprobability samples were collected from p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-0815H

    authors: LeBourgeois MK,Giannotti F,Cortesi F,Wolfson AR,Harsh J

    更新日期:2005-01-01 00:00:00

  • Identifying and treating a substandard housing cluster using a medical-legal partnership.

    abstract:BACKGROUND AND OBJECTIVE:There is a documented connection between the home environment and health. Medical-legal partnerships (MLPs) can address social and environmental determinants of health. Our objective was to describe a cluster of substandard housing identified and treated by an MLP based in a pediatric primary c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0769

    authors: Beck AF,Klein MD,Schaffzin JK,Tallent V,Gillam M,Kahn RS

    更新日期:2012-11-01 00:00:00

  • Features of invasive staphylococcal disease in neonates.

    abstract:OBJECTIVE:Most clinical descriptions of invasive staphylococcal disease (ISD) in neonates date from before the mid-1980s, when neonatal viability and intensive care differed substantially from current standards. We aimed to describe the contemporary incidence, clinical features, and outcome of infants with ISD in a neo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-0043

    authors: Healy CM,Palazzi DL,Edwards MS,Campbell JR,Baker CJ

    更新日期:2004-10-01 00:00:00

  • Population-based impact of pneumococcal conjugate vaccine in young children.

    abstract:OBJECTIVE:To determine the population impact of pneumococcal conjugate vaccine (PCV) on pneumococcal-related diseases, including pneumonia and otitis media. METHODS:Using administrative data from Tennessee Medicaid and 3 commercial insurance plans in upstate New York, we measured annual rates of medical visits for pne...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2003-0592-F

    authors: Poehling KA,Lafleur BJ,Szilagyi PG,Edwards KM,Mitchel E,Barth R,Schwartz B,Griffin MR

    更新日期:2004-09-01 00:00:00

  • No change in the incidence of ampicillin-resistant, neonatal, early-onset sepsis over 18 years.

    abstract:OBJECTIVE:The objective of this study was to assess the effect of maternal antibiotic exposure on neonatal early-onset sepsis (EOS) rates over an 18-year period. METHODS:A review was performed of infant and maternal records for all culture- proven cases of EOS in infants delivered at the Brigham and Women's Hospital (...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-1573

    authors: Puopolo KM,Eichenwald EC

    更新日期:2010-05-01 00:00:00

  • Consequences of the delayed diagnosis of ataxia-telangiectasia.

    abstract:OBJECTIVES:Ataxia-telangiectasia (AT) is a rare, autosomal recessive neurodegenerative disorder in which the diagnosis is obvious when ataxia and telangiectasia are both present. However, the diagnosis can be made upon the onset of ataxia and before the appearance of telangiectasia if confirmed by laboratory tests. Ear...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.1.98

    authors: Cabana MD,Crawford TO,Winkelstein JA,Christensen JR,Lederman HM

    更新日期:1998-07-01 00:00:00

  • Treatment of plastic bronchitis in a Fontan patient with tissue plasminogen activator: a case report and review of the literature.

    abstract::Plastic bronchitis is a condition in which large, bronchial casts with rubber-like consistency develop in the tracheobronchial tree and cause airway obstruction. We describe a 4-year-old girl who had Fontan physiology and who developed plastic bronchitis and report for the first time the use of aerosolized tissue plas...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.109.4.e67

    authors: Costello JM,Steinhorn D,McColley S,Gerber ME,Kumar SP

    更新日期:2002-04-01 00:00:00

  • Universal hepatitis B immunization.

    abstract:OBJECTIVE:To determine the practices of US nurseries, neonatal intensive care units (NICUs), and pediatricians regarding universal hepatitis B vaccination. DESIGN:Descriptive cross-sectional survey. PARTICIPANTS:One hundred forty term nurseries, 152 NICUs, and 157 pediatricians. Selection procedure. Nurseries and NIC...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kim SC,Sinai LN,Casey R,Pinto-Martin JA

    更新日期:1995-05-01 00:00:00

  • Trends in Candida central line-associated bloodstream infections among NICUs, 1999-2009.

    abstract:OBJECTIVES:To assess trends in incidence of Candida spp. central line-associated bloodstream infections (CLABSIs) in US NICUs, 1999-2009. METHODS:Data from NICUs participating in the National Nosocomial Infections Surveillance (1999-2004) and National Healthcare Safety Network (2006-2009) were analyzed. Overall and bi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-3620

    authors: Chitnis AS,Magill SS,Edwards JR,Chiller TM,Fridkin SK,Lessa FC

    更新日期:2012-07-01 00:00:00

  • Accumulation of aluminum in a nondialyzed uremic child receiving aluminum hydroxide.

    abstract::A child with renal insufficiency was treated with the oral phosphate binder aluminum hydroxide from age 6 to 31 months. The prescribed dose of elemental aluminum varied from 31 to 108 mg/kg/d. Concurrently the patient developed vitamin D-resistant osteomalacia which failed to improve with parathyroidectomy. Encephalop...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Griswold WR,Reznik V,Mendoza SA,Trauner D,Alfrey AC

    更新日期:1983-01-01 00:00:00

  • Cumulative prevalence of arrest from ages 8 to 23 in a national sample.

    abstract:OBJECTIVE:To estimate the cumulative proportion of youth who self-report having been arrested or taken into custody for illegal or delinquent offenses (excluding arrests for minor traffic violations) from ages 8 to 23 years. METHODS:Self-reported arrest history data (excluding arrests for minor traffic violations) fro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-3710

    authors: Brame R,Turner MG,Paternoster R,Bushway SD

    更新日期:2012-01-01 00:00:00

  • Maternal Depression in Early Childhood and Developmental Vulnerability at School Entry.

    abstract:OBJECTIVES:To assess the relation between exposure to maternal depression before age 5 and 5 domains of developmental vulnerability at school entry, overall, and by age at exposure. METHODS:This cohort study included all children born in Manitoba, Canada, who completed the Early Development Instrument between 2005 and...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-0794

    authors: Wall-Wieler E,Roos LL,Gotlib IH

    更新日期:2020-09-01 00:00:00

  • Developing circadian rhythmicity in infants.

    abstract::Circadian rhythms are endogenously generated rhythms with a period length of approximately 24 hours. Evidence gathered during the past decade indicates that the circadian timing system develops prenatally and the suprachiasmatic nuclei, the site of a circadian clock, is present by midgestation in primates. Recent evid...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.112.2.373

    authors: Rivkees SA

    更新日期:2003-08-01 00:00:00

  • Systematic review of screening for bilirubin encephalopathy in neonates.

    abstract:CONTEXT:Severe neonatal hyperbilirubinemia is associated with chronic bilirubin encephalopathy (kernicterus). OBJECTIVE:To systematically review the effectiveness of specific screening modalities to prevent neonatal bilirubin encephalopathy. METHODS:We identified studies through Medline searches, perusing reference l...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2008-3545

    authors: Trikalinos TA,Chung M,Lau J,Ip S

    更新日期:2009-10-01 00:00:00

  • From the American Academy of Pediatrics: Technical report--Secondhand and prenatal tobacco smoke exposure.

    abstract::Secondhand tobacco smoke (SHS) exposure of children and their families causes significant morbidity and mortality. In their personal and professional roles, pediatricians have many opportunities to advocate for elimination of SHS exposure of children, to counsel tobacco users to quit, and to counsel children never to ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2120

    authors: Best D,Committee on Environmental Health.,Committee on Native American Child Health.,Committee on Adolescence.

    更新日期:2009-11-01 00:00:00

  • The role of parental preferences in the management of fever without source among 3- to 36-month-old children: a decision analysis.

    abstract:OBJECTIVES:Recent analyses assessing the impact of the conjugate pneumococcal vaccine on the care of febrile children do not reflect the role parental preferences play in physicians' decisions. The objective of this study was to identify the management strategy that would best suit parents, on the basis of their values...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1865

    authors: Madsen KA,Bennett JE,Downs SM

    更新日期:2006-04-01 00:00:00

  • An investigation into the benefits of resiting nasoenteric feeding tubes.

    abstract::Partial nasal obstruction in preterm infants increases the airway resistance. In spite of this, nasal feeding tubes are often used, if only because oral tubes are difficult to secure. A palatal appliance has been devised that maintains the position of oroenteric feeding tube(s) and is not associated with local complic...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: van Someren V,Linnett SJ,Stothers JK,Sullivan PG

    更新日期:1984-09-01 00:00:00

  • Mental development and growth in children with chronic liver disease of early and late onset.

    abstract::Comparison was made of the mental function and physical growth of 21 children in whom liver disease occurred in the first year of life with 15 patients with late (17 months of age to 12 years of age) manifestation of liver disease. Ages (mean +/- SD) at testing for the two groups was 8 +/- 3 years for the early group ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Stewart SM,Uauy R,Kennard BD,Waller DA,Benser M,Andrews WS

    更新日期:1988-08-01 00:00:00

  • A Framework for Evaluation of the Higher-Risk Infant After a Brief Resolved Unexplained Event.

    abstract::In 2016, the American Academy of Pediatrics published a clinical practice guideline that more specifically defined apparent life-threatening events as brief resolved unexplained events (BRUEs) and provided evidence-based recommendations for the evaluation of infants who meet lower-risk criteria for a subsequent event ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-4101

    authors: Merritt JL 2nd,Quinonez RA,Bonkowsky JL,Franklin WH,Gremse DA,Herman BE,Jenny C,Katz ES,Krilov LR,Norlin C,Sapién RE,Tieder JS

    更新日期:2019-08-01 00:00:00

  • Amplification of bacterial DNA using highly conserved sequences: automated analysis and potential for molecular triage of sepsis.

    abstract:OBJECTIVE:The clinical diagnosis of sepsis remains difficult, particularly in the young child, and would be improved by a rapid and reliable method for identification of bacteria in blood and other body fluids. Polymerase chain reaction (PCR) amplification of highly conserved DNA sequences found in all bacteria would p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: McCabe KM,Khan G,Zhang YH,Mason EO,McCabe ER

    更新日期:1995-02-01 00:00:00

  • Helping parents cope with the diagnosis of congenital heart defect: an experimental study.

    abstract::An experimental study was designed to help parents cope with the implications of the diagnosis of congenital heart disease. Intervention strategies involving clarification of medical information, discussion of psychological issues, and a combination of the two, were more effective than no intervention in helping paren...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kupst MJ,Blatterbauer S,Westman J,Schulman JL,Paul MH

    更新日期:1977-02-01 00:00:00

  • Safety of hospitalized ventilator-dependent children outside of the intensive care unit.

    abstract:OBJECTIVE:Hospitalization of clinically stable ventilator-dependent children in an intensive care unit (ICU) remains the standard in most pediatric centers. The aim of this study was to determine whether chronically ventilator-dependent children could be hospitalized safely in a non-ICU setting. METHODS:All ventilator...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.2.257

    authors: Ambrosio IU,Woo MS,Jansen MT,Keens TG

    更新日期:1998-02-01 00:00:00

  • Perspectives on obesity programs at children's hospitals: insights from senior program administrators.

    abstract:OBJECTIVE:The obesity epidemic has resulted in an increasing number of children needing multidisciplinary obesity treatment. To meet this need, pediatric obesity programs have arisen, particularly in children's hospitals. In 2008, the National Association of Children's Hospitals and Related Institutions (NACHRI) conven...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0480I

    authors: Eneli I,Norwood V,Hampl S,Ferris M,Hibbeln T,Patterson K,Pomietto M,Hassink S

    更新日期:2011-09-01 00:00:00

  • Behavioral and self-concept changes after six months of enuresis treatment: a randomized, controlled trial.

    abstract:BACKGROUND:Previous studies have suggested changes in self-concept with successful treatment of primary nocturnal enuresis (PNE), but behavioral changes have not been reported as a consistent associated finding. OBJECTIVE:To determine if self-concept and behavior change after 6 months of treatment of monosymptomatic P...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Longstaffe S,Moffatt ME,Whalen JC

    更新日期:2000-04-01 00:00:00

  • In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment among young Mexican American children.

    abstract:OBJECTIVE:We investigated the relationship between prenatal exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment of Mexican farm-workers' children in California. METHODS:Participants from the Center for the Health Assessment of Mothers and Children of Salina...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-3117

    authors: Eskenazi B,Marks AR,Bradman A,Fenster L,Johnson C,Barr DB,Jewell NP

    更新日期:2006-07-01 00:00:00

  • Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease: a mimicker of sepsis in the pediatric intensive care unit.

    abstract::A rare complication of infection with the Epstein-Barr virus is the development of hemophagocytic lymphohistiocytosis. Although most cases of Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis develop in immunocompetent individuals, the rare immunodeficiency X-linked lymphoproliferative disease is often unm...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1534

    authors: Mischler M,Fleming GM,Shanley TP,Madden L,Levine J,Castle V,Filipovich AH,Cornell TT

    更新日期:2007-05-01 00:00:00