Abstract:
:Thirty-two 5- to 17-year-old children who had severe, acute asthma were randomly assigned to receive either high doses (0.15 mg/kg of body weight per dose) or low doses (0.05 mg/kg of body weight per dose) of nebulized albuterol every 20 minutes for six doses. Compared with the low-dose regimen, the high-dose regimen resulted in significantly greater improvement in forced expiratory volume in 1 second, forced vital capacity, and wheeze score and a lower hospitalization rate. The changes in heart rate, respiratory rate, blood pressure, white blood cell count, and serum potassium concentration did not differ significantly between the groups. The incidence of side effects, which included tremor, hyperactivity, and vomiting, was not significantly different in the two populations. Serum albuterol levels varied widely, but there was no correlation between the levels and the increase in heart rate or other side effects. high-dose, frequently administered, nebulized albuterol appears both safe and effective in treating severe, acute asthma in children.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Schuh S,Parkin P,Rajan A,Canny G,Healy R,Rieder M,Tan YK,Levison H,Soldin SJsubject
Has Abstractpub_date
1989-04-01 00:00:00pages
513-8issue
4eissn
0031-4005issn
1098-4275journal_volume
83pub_type
临床试验,杂志文章,随机对照试验相关文献
PEDIATRICS文献大全abstract::Our specific aim was to examine the efficacy and safety of long-term cholesterol-lowering diet and bile acid-binding resin therapy in 73 children heterozygous for familial hypercholesterolemia (FH). We prospectively followed accretion of height and weight in 40 FH children for 5.8 years on diet alone and in 33 FH chil...
journal_title:Pediatrics
pub_type: 杂志文章,收录出版
doi:
更新日期:1986-08-01 00:00:00
abstract::Epidemiologic studies indicate that children of all ages with certain chronic conditions and otherwise healthy children younger than 24 months of age are hospitalized for influenza infection and its complications at high rates similar to those experienced by the elderly. Annual influenza immunization is recommended fo...
journal_title:Pediatrics
pub_type: 指南,杂志文章,实务指引
doi:10.1542/peds.113.5.1441
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood. DESIGN:Prospective follow-up study of a randomized, double-blind, placebo-controlled trial. SETTING:National Women's Hospital (Auckland, New Zealand)...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.2004-0196
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVES:Adolescents with justice system involvement have high rates of physical and behavioral health disorders and are potentially high users of costly health care services. We examined emergency department (ED) and hospital use among a national sample of adolescents with various levels of justice involvement. MET...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-1144
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:The purpose of the study was to examine the relationship between self-reported sleep quality and sleep hygiene in Italian and American adolescents and to assess whether sleep-hygiene practices mediate the relationship between culture and sleep quality. METHODS:Two nonprobability samples were collected from p...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-0815H
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:There is a documented connection between the home environment and health. Medical-legal partnerships (MLPs) can address social and environmental determinants of health. Our objective was to describe a cluster of substandard housing identified and treated by an MLP based in a pediatric primary c...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-0769
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:Most clinical descriptions of invasive staphylococcal disease (ISD) in neonates date from before the mid-1980s, when neonatal viability and intensive care differed substantially from current standards. We aimed to describe the contemporary incidence, clinical features, and outcome of infants with ISD in a neo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-0043
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To determine the population impact of pneumococcal conjugate vaccine (PCV) on pneumococcal-related diseases, including pneumonia and otitis media. METHODS:Using administrative data from Tennessee Medicaid and 3 commercial insurance plans in upstate New York, we measured annual rates of medical visits for pne...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2003-0592-F
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to assess the effect of maternal antibiotic exposure on neonatal early-onset sepsis (EOS) rates over an 18-year period. METHODS:A review was performed of infant and maternal records for all culture- proven cases of EOS in infants delivered at the Brigham and Women's Hospital (...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-1573
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:Ataxia-telangiectasia (AT) is a rare, autosomal recessive neurodegenerative disorder in which the diagnosis is obvious when ataxia and telangiectasia are both present. However, the diagnosis can be made upon the onset of ataxia and before the appearance of telangiectasia if confirmed by laboratory tests. Ear...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.1.98
更新日期:1998-07-01 00:00:00
abstract::Plastic bronchitis is a condition in which large, bronchial casts with rubber-like consistency develop in the tracheobronchial tree and cause airway obstruction. We describe a 4-year-old girl who had Fontan physiology and who developed plastic bronchitis and report for the first time the use of aerosolized tissue plas...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.109.4.e67
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To determine the practices of US nurseries, neonatal intensive care units (NICUs), and pediatricians regarding universal hepatitis B vaccination. DESIGN:Descriptive cross-sectional survey. PARTICIPANTS:One hundred forty term nurseries, 152 NICUs, and 157 pediatricians. Selection procedure. Nurseries and NIC...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVES:To assess trends in incidence of Candida spp. central line-associated bloodstream infections (CLABSIs) in US NICUs, 1999-2009. METHODS:Data from NICUs participating in the National Nosocomial Infections Surveillance (1999-2004) and National Healthcare Safety Network (2006-2009) were analyzed. Overall and bi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-3620
更新日期:2012-07-01 00:00:00
abstract::A child with renal insufficiency was treated with the oral phosphate binder aluminum hydroxide from age 6 to 31 months. The prescribed dose of elemental aluminum varied from 31 to 108 mg/kg/d. Concurrently the patient developed vitamin D-resistant osteomalacia which failed to improve with parathyroidectomy. Encephalop...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:To estimate the cumulative proportion of youth who self-report having been arrested or taken into custody for illegal or delinquent offenses (excluding arrests for minor traffic violations) from ages 8 to 23 years. METHODS:Self-reported arrest history data (excluding arrests for minor traffic violations) fro...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-3710
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:To assess the relation between exposure to maternal depression before age 5 and 5 domains of developmental vulnerability at school entry, overall, and by age at exposure. METHODS:This cohort study included all children born in Manitoba, Canada, who completed the Early Development Instrument between 2005 and...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-0794
更新日期:2020-09-01 00:00:00
abstract::Circadian rhythms are endogenously generated rhythms with a period length of approximately 24 hours. Evidence gathered during the past decade indicates that the circadian timing system develops prenatally and the suprachiasmatic nuclei, the site of a circadian clock, is present by midgestation in primates. Recent evid...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.112.2.373
更新日期:2003-08-01 00:00:00
abstract:CONTEXT:Severe neonatal hyperbilirubinemia is associated with chronic bilirubin encephalopathy (kernicterus). OBJECTIVE:To systematically review the effectiveness of specific screening modalities to prevent neonatal bilirubin encephalopathy. METHODS:We identified studies through Medline searches, perusing reference l...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2008-3545
更新日期:2009-10-01 00:00:00
abstract::Secondhand tobacco smoke (SHS) exposure of children and their families causes significant morbidity and mortality. In their personal and professional roles, pediatricians have many opportunities to advocate for elimination of SHS exposure of children, to counsel tobacco users to quit, and to counsel children never to ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-2120
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:Recent analyses assessing the impact of the conjugate pneumococcal vaccine on the care of febrile children do not reflect the role parental preferences play in physicians' decisions. The objective of this study was to identify the management strategy that would best suit parents, on the basis of their values...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1865
更新日期:2006-04-01 00:00:00
abstract::Partial nasal obstruction in preterm infants increases the airway resistance. In spite of this, nasal feeding tubes are often used, if only because oral tubes are difficult to secure. A palatal appliance has been devised that maintains the position of oroenteric feeding tube(s) and is not associated with local complic...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1984-09-01 00:00:00
abstract::Comparison was made of the mental function and physical growth of 21 children in whom liver disease occurred in the first year of life with 15 patients with late (17 months of age to 12 years of age) manifestation of liver disease. Ages (mean +/- SD) at testing for the two groups was 8 +/- 3 years for the early group ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract::In 2016, the American Academy of Pediatrics published a clinical practice guideline that more specifically defined apparent life-threatening events as brief resolved unexplained events (BRUEs) and provided evidence-based recommendations for the evaluation of infants who meet lower-risk criteria for a subsequent event ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-4101
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:The clinical diagnosis of sepsis remains difficult, particularly in the young child, and would be improved by a rapid and reliable method for identification of bacteria in blood and other body fluids. Polymerase chain reaction (PCR) amplification of highly conserved DNA sequences found in all bacteria would p...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::An experimental study was designed to help parents cope with the implications of the diagnosis of congenital heart disease. Intervention strategies involving clarification of medical information, discussion of psychological issues, and a combination of the two, were more effective than no intervention in helping paren...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-02-01 00:00:00
abstract:OBJECTIVE:Hospitalization of clinically stable ventilator-dependent children in an intensive care unit (ICU) remains the standard in most pediatric centers. The aim of this study was to determine whether chronically ventilator-dependent children could be hospitalized safely in a non-ICU setting. METHODS:All ventilator...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.101.2.257
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:The obesity epidemic has resulted in an increasing number of children needing multidisciplinary obesity treatment. To meet this need, pediatric obesity programs have arisen, particularly in children's hospitals. In 2008, the National Association of Children's Hospitals and Related Institutions (NACHRI) conven...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-0480I
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Previous studies have suggested changes in self-concept with successful treatment of primary nocturnal enuresis (PNE), but behavioral changes have not been reported as a consistent associated finding. OBJECTIVE:To determine if self-concept and behavior change after 6 months of treatment of monosymptomatic P...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:We investigated the relationship between prenatal exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment of Mexican farm-workers' children in California. METHODS:Participants from the Center for the Health Assessment of Mothers and Children of Salina...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-3117
更新日期:2006-07-01 00:00:00
abstract::A rare complication of infection with the Epstein-Barr virus is the development of hemophagocytic lymphohistiocytosis. Although most cases of Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis develop in immunocompetent individuals, the rare immunodeficiency X-linked lymphoproliferative disease is often unm...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1534
更新日期:2007-05-01 00:00:00