Acute Tc-99m DMSA scan for identifying dilating vesicoureteral reflux in children: a meta-analysis.

Abstract:

:Controversy exists regarding the type and/or sequence of imaging studies needed during the first febrile urinary tract infection (UTI) in young children. Several investigators have claimed that because acute-phase Tc-99m dimercaptosuccinic acid (DMSA) renal-scan results are abnormal in the presence of dilating vesicoureteral reflux, a normal DMSA-scan result makes voiding cystourethrography (VCUG) unnecessary in the primary examination of infants with UTI. To evaluate the accuracy of acute-phase DMSA scanning in identifying dilating (grades III through V) vesicoureteral reflux documented by VCUG in children with a first febrile UTI, we performed a meta-analysis of the accuracy of diagnostic tests as reported from relevant studies identified through the PubMed and Scopus databases. Patient-based and renal unit-based analyses were performed. Overall, 13 cohort studies were identified. Nine studies involved patients younger than 2 years, 3 involved children aged 16 years or younger, and 1 involved exclusively neonates. Girls constituted 22% to 85% of the involved children. Pooled (95% confidence intervals) sensitivity and specificity rates of DMSA scanning were 79% and 53%, respectively, for the patient-based analysis (8 studies) and 60% and 65% for the renal unit-based analysis (5 studies). The respective areas under the hierarchical summary receiver operating curves were 0.71 and 0.67. Marked statistical heterogeneity was observed in both analyses, as indicated by I(2) test values of 91% and 87%, respectively. Acute-phase DMSA renal scanning cannot be recommended as replacement for VCUG in the evaluation of young children with a first febrile UTI.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Mantadakis E,Vouloumanou EK,Georgantzi GG,Tsalkidis A,Chatzimichael A,Falagas ME

doi

10.1542/peds.2010-3460

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

e169-79

issue

1

eissn

0031-4005

issn

1098-4275

pii

peds.2010-3460

journal_volume

128

pub_type

杂志文章,meta分析
  • Clot dissolution: a novel treatment of midgut volvulus.

    abstract::Midgut volvulus due to malrotation may result in loss of the small bowel. Until now, after derotation of the volvulus, pediatric surgeons do not deal with the mesenteric thrombosis, which causes continuing ischemia of the intestine. On occasion, a "second look" laparotomy is performed in the hope that some improvement...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-2115

    authors: Kiely EM,Pierro A,Pierce C,Cross K,De Coppi P

    更新日期:2012-06-01 00:00:00

  • The effect of instituting a prehospital-discharge newborn bilirubin screening program in an 18-hospital health system.

    abstract:OBJECTIVE:Kernicterus is a rare but devastating condition. The prevention of bilirubin-induced brain injury is based on the detection of infants at risk for developing severe hyperbilirubinemia. In an 18-hospital health system, Intermountain Health Care (IHC), we initiated a program of predischarge bilirubin screening ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2005-1338

    authors: Eggert LD,Wiedmeier SE,Wilson J,Christensen RD

    更新日期:2006-05-01 00:00:00

  • Impact of maternal diabetes mellitus on mortality and morbidity of preterm infants (24-33 weeks' gestation).

    abstract:OBJECTIVE:We hypothesized that maternal diabetes mellitus (DM) increases the risk for mortality, respiratory distress syndrome (RDS), and major complications of prematurity. METHODS:Analysis of prospectively collected (1995-2007) Israel National Very Low Birth Weight Infant Database. Maternal DM was recorded as preges...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-3443

    authors: Bental Y,Reichman B,Shiff Y,Weisbrod M,Boyko V,Lerner-Geva L,Mimouni FB,Collaboration With the Israel Neonatal Network.

    更新日期:2011-10-01 00:00:00

  • Invasive pneumococcal disease in infants younger than 90 days before and after introduction of PCV7.

    abstract:BACKGROUND:Introduction of the heptavalent pneumococcal conjugate vaccine (PCV7) changed the epidemiology of invasive pneumococcal disease (IPD). We evaluated the changes that occurred after PCV7 introduction among Utah infants aged 1 to 90 days, too young to be fully immunized. METHODS:We identified children <18 year...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-3900

    authors: Olarte L,Ampofo K,Stockmann C,Mason EO,Daly JA,Pavia AT,Byington CL

    更新日期:2013-07-01 00:00:00

  • Self-regulation of slow cortical potentials: a new treatment for children with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:We investigated the effects of self-regulation of slow cortical potentials for children with attention-deficit/hyperactivity disorder. Slow cortical potentials are slow event-related direct-current shifts of the electroencephalogram. Slow cortical potential shifts in the electrical negative direction reflect ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2478

    authors: Strehl U,Leins U,Goth G,Klinger C,Hinterberger T,Birbaumer N

    更新日期:2006-11-01 00:00:00

  • Respiratory syncytial virus infection in patients with phagocyte defects.

    abstract::Patients with phagocyte defects frequently develop bacterial or fungal pneumonias, but they are not considered to be at increased risk for viral infections. We describe 3 patients with known phagocyte immunodeficiencies who developed lower respiratory tract infections (LRTI) caused by respiratory syncytial virus (RSV)...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.4.835

    authors: Uzel G,Premkumar A,Malech HL,Holland SM

    更新日期:2000-10-01 00:00:00

  • Role of nutrition in pregnancy with phenylketonuria and birth defects.

    abstract:OBJECTIVE:The maternal phenylketonuria (PKU) syndrome is caused by high blood phenylalanine (Phe) levels during pregnancy, leading to a host of birth defects, especially microcephaly and congenital heart disease (CHD). For finding whether the maternal PKU syndrome could be prevented, an international collaborative stud...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Matalon KM,Acosta PB,Azen C

    更新日期:2003-12-01 00:00:00

  • Neisseria meningitidis bacteremia in children: quantitation of bacteremia and spontaneous clinical recovery without antibiotic therapy.

    abstract::The relationship between the magnitude of bacteremia due to Neisseria meningitidis and the clinical diagnosis was determined for 43 children who had fever in the presence or absence of focal signs of infection. Bacteremia was quantitated by the previously described procedure using heparinized blood (0.2 to 1.0 mL). Ad...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Sullivan TD,LaScolea LJ Jr

    更新日期:1987-07-01 00:00:00

  • Should fewer premature infants be screened for retinopathy of prematurity in the managed care era?

    abstract:OBJECTIVE:To determine appropriate upper limits for gestational age and birth weight when screening infants for retinopathy of prematurity (ROP). DESIGN:Retrospective survey. SETTING:Tertiary neonatal intensive care nursery. PATIENTS:Seven hundred seven infants born July 1, 1990 to June 30, 1996 and screened for ROP...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.1.31

    authors: Wright K,Anderson ME,Walker E,Lorch V

    更新日期:1998-07-01 00:00:00

  • Temporomandibular joint dysfunction with facial pain in children.

    abstract::Temporomandibular joint dysfunction with myofascial pain, a well-known clinical disorder in adults, is reported in children. In a series of 400 patients, 40 children less than 16 years of age were seen. Of these pediatric patients, 35% had a reactive depression as primary psychopathology. The multifactorial nature of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Belfer ML,Kaban LB

    更新日期:1982-05-01 00:00:00

  • The hair collar sign: marker for cranial dysraphism.

    abstract:OBJECTIVE:To call attention to a cutaneous marker for neural tube closure defects of the scalp, the "hair collar" sign. This finding consists of a ring of long, dark, coarse hair surrounding a midline scalp nodule. METHODS AND RESULTS:Four children with small congenital scalp nodules and the hair collar sign were stud...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Drolet BA,Clowry L Jr,McTigue MK,Esterly NB

    更新日期:1995-08-01 00:00:00

  • Relationship between periventricular intraparenchymal echodensities and germinal matrix-intraventricular hemorrhage in the very low birth weight neonate.

    abstract::The pathogenesis of the periventricular intraparenchymal echodense lesion (IPE) observed in association with germinal matrix-intraventricular hemorrhage (GM-IVH) in premature neonates is unclear. The objectives of this study were to determine (1) the temporal characteristics of GM-IVH and IPE, (2) the basic characteri...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Perlman JM,Rollins N,Burns D,Risser R

    更新日期:1993-02-01 00:00:00

  • Two pediatric cases of variant neurogenic stress cardiomyopathy after intracranial hemorrhage.

    abstract::Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy, is an acquired form of left ventricular systolic dysfunction seen in the setting of physiologic stress and the absence of coronary artery disease. It is thought to be caused by excessive sympathetic stimulation. It is well described in the adult li...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-1881

    authors: Wittekind SG,Yanay O,Johnson EM,Gibbons EF

    更新日期:2014-10-01 00:00:00

  • Health Care Use and Health Behaviors Among Young Adults With History of Parental Incarceration.

    abstract:OBJECTIVES:To determine if longitudinal associations exist between parental incarceration (PI) and health care use or health behaviors among a national sample of young adults. METHODS:We used the National Longitudinal Survey of Adolescent to Adult Health to examine associations between history of mother incarceration ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-4314

    authors: Heard-Garris N,Winkelman TNA,Choi H,Miller AK,Kan K,Shlafer R,Davis MM

    更新日期:2018-09-01 00:00:00

  • Acquired immunodeficiency syndrome transmission: changes in knowledge and behaviors among teenagers, Massachusetts statewide surveys, 1986 to 1988.

    abstract::Despite substantial progress, adolescents remain at high risk for human immunodeficiency virus (HIV) infection. Two independent random digit dial statewide Massachusetts surveys of 16- to 19-year-old persons conducted August through September 1986 and 1988 revealed that the proportion of teenagers who had discussed ac...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Hingson R,Strunin L,Berlin B

    更新日期:1990-01-01 00:00:00

  • Chemical-biological terrorism and its impact on children: a subject review. American Academy of Pediatrics. Committee on Environmental Health and Committee on Infectious Diseases.

    abstract::There is an increasing threat that chemical and biological weapons will be used on a civilian population in an act of domestic terrorism. Casualties among adults and children could be significant in such an event. Federal, state, and local authorities have begun extensive planning to meet a chemical-biological inciden...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.105.3.662

    authors:

    更新日期:2000-03-01 00:00:00

  • Rumination--a new complication of neonatal intensive care.

    abstract::The infant rumination syndrome has not been previously reported in a neonatal intensive care setting. We recently managed three infants in our newborn intensive care unit who developed rumination following chronic courses in the unit. The events leading to this condition in each infant are described, as well as the su...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Sheagren TG,Mangurten HH,Brea F,Lutostanski S

    更新日期:1980-10-01 00:00:00

  • Intentional poisoning of children--an overlooked category of child abuse: report of seven cases and review of the literature.

    abstract::Seven instances of child abuse due to poisoning are reported; two of the children died. Forty-one cases of this form of poisoning are found in the literature. Of the total of 48 children, eight (17%) died as a result of the incident; and one was mentally retarded. The seven different agents described here are alcohol,...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Dine MS,McGovern ME

    更新日期:1982-07-01 00:00:00

  • Relative effects of drugs and diet on hyperactive behaviors: an experimental study.

    abstract::In a test of Feingold's hypothesis that food additives trigger the hyperactive response, 26 hyperactive children were randomly assigned to treatment conditions whereby they were given active or placebo medications in combination with challenge cookies with artificial food colors or control cookies without the additive...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Williams JI,Cram DM,Tausig FT,Webster E

    更新日期:1978-06-01 00:00:00

  • General pediatric attending physicians' and residents' knowledge of inpatient hospital finances.

    abstract:BACKGROUND AND OBJECTIVE:There is evidence suggesting that physicians have a limited foundation of knowledge on health care finances and limited awareness of hospital costs and charges. The objective was to analyze general pediatric attending physicians' and residents' knowledge of costs, charges, and reimbursements fo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1753

    authors: Rock TA,Xiao R,Fieldston E

    更新日期:2013-06-01 00:00:00

  • Pulse Oximetry and Auscultation for Congenital Heart Disease Detection.

    abstract:OBJECTIVES:Pulse oximetry (POX) has been confirmed as a specific screening modality for critical congenital heart disease (CCHD), with moderate sensitivity. However, POX is not able to detect most serious and critical cardiac lesions (major congenital heart disease [CHD]) without hypoxemia. In this study, we investigat...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2017-1154

    authors: Hu XJ,Ma XJ,Zhao QM,Yan WL,Ge XL,Jia B,Liu F,Wu L,Ye M,Liang XC,Zhang J,Gao Y,Zhai XW,Huang GY

    更新日期:2017-10-01 00:00:00

  • Exploring emergency contraception knowledge, prescription practices, and barriers to prescription for adolescents in the emergency department.

    abstract:OBJECTIVE:The objective of this study was to assess the proportion of emergency medicine physicians who had prescribed emergency contraception pills to adolescents, to identify potential barriers to emergency contraception pill prescription for adolescents, and to assess physician knowledge of emergency contraception p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-0193

    authors: Goyal M,Zhao H,Mollen C

    更新日期:2009-03-01 00:00:00

  • Out-of-school suspension and expulsion. American Academy of Pediatrics Committee on School Health.

    abstract::Suspension and expulsion from school are used to punish students, alert parents, and protect other students and school staff. Unintended consequences of these practices require more attention from health care professionals. Suspension and expulsion may exacerbate academic deterioration, and when students are provided ...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.112.5.1206

    authors: American Academy of Pediatrics Committee on School Health.

    更新日期:2003-11-01 00:00:00

  • Severe perinatal Marfan syndrome.

    abstract::The cardiovascular manifestations of the Marfan syndrome in older children and adults have been well described. Clinical, radiographic, and echocardiographic data regarding three patients with severe perinatal Marfan syndrome are described. Two of these patients had the syndrome at birth and died in infancy. The syndr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gross DM,Robinson LK,Smith LT,Glass N,Rosenberg H,Duvic M

    更新日期:1989-07-01 00:00:00

  • Special needs of vulnerable and underserved populations: models, existing and proposed, to meet them.

    abstract::The rapidly changing environment in the health care industry offers great challenges, especially to those providers who traditionally have cared for vulnerable and underserved populations. These populations have special health care needs resulting from various factors, including race, geography, environment, and lack ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Shirley A

    更新日期:1995-10-01 00:00:00

  • Infant-feeding methods and childhood sleep-disordered breathing.

    abstract:OBJECTIVE:Childhood sleep-disordered breathing has an adverse impact on cognitive development, behavior, quality of life, and use of health care resources. Early viral infections and other immune-mediated responses may contribute to development of the chronic inflammation of the upper airway and hypertrophic upper airw...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0722

    authors: Montgomery-Downs HE,Crabtree VM,Sans Capdevila O,Gozal D

    更新日期:2007-11-01 00:00:00

  • Effect of ampicillin and chloramphenicol against Haemophilus influenzae.

    abstract::Synergy, determined by isobolograms constructed from the minimal inhibitory concentrations of combinations of ampicillin and chloramphenicol, was observed against six of 13 ampicillin-susceptible Haemophilus influenzae type b isolates and against five of eight ampicillin-resistant strains by using a small inoculum of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.61.3.406

    authors: Feldman WE

    更新日期:1978-03-01 00:00:00

  • Using registries to identify adverse events in rheumatic diseases.

    abstract::The proven effectiveness of biologics and other immunomodulatory products in inflammatory rheumatic diseases has resulted in their widespread use as well as reports of potential short- and long-term complications such as infection and malignancy. These complications are especially worrisome in children who often have ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2013-0755

    authors: Lionetti G,Kimura Y,Schanberg LE,Beukelman T,Wallace CA,Ilowite NT,Winsor J,Fox K,Natter M,Sundy JS,Brodsky E,Curtis JR,Del Gaizo V,Iyasu S,Jahreis A,Meeker-O'Connell A,Mittleman BB,Murphy BM,Peterson ED,Raymond SC

    更新日期:2013-11-01 00:00:00

  • Exposure to smoking in internationally distributed American movies and youth smoking in Germany: a cross-cultural cohort study.

    abstract:OBJECTIVE:Studies of US adolescents have linked exposure to movie smoking with smoking behavior. It is unclear whether European adolescents are also responsive to movie tobacco imagery. METHODS:A longitudinal study was conducted to assess exposure to movie smoking in 2711 German never-smokers (aged 10 to 16 years). Mo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-1201

    authors: Hanewinkel R,Sargent JD

    更新日期:2008-01-01 00:00:00

  • Idiopathic disseminated bacillus Calmette-Guérin infection: a French national retrospective study.

    abstract:OBJECTIVE:Disseminated bacillus Calmette-Guérin (BCG) infection after inoculation of live vaccine is considered to result from impaired immunity of the child. However, in half of the cases, regarded as idiopathic, no well-defined immunodeficiency condition can account for the infection. The objective of the present stu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Casanova JL,Blanche S,Emile JF,Jouanguy E,Lamhamedi S,Altare F,Stéphan JL,Bernaudin F,Bordigoni P,Turck D,Lachaux A,Albertini M,Bourrillon A,Dommergues JP,Pocidalo MA,Le Deist F,Gaillard JL,Griscelli C,Fischer A

    更新日期:1996-10-01 00:00:00