Abstract:
BACKGROUND AND OBJECTIVES:Neonatal arterial ischemic stroke (NAIS) is associated with considerable lifetime burdens such as cerebral palsy, epilepsy, and cognitive impairment. Prospective epidemiologic studies that include outcome assessments are scarce. This study aimed to provide information on the epidemiology, clinical manifestations, infarct characteristics, associated clinical variables, treatment strategies, and outcomes of NAIS in a prospective, population-based cohort of Swiss children. METHODS:This prospective study evaluated the epidemiology, clinical manifestations, vascular territories, associated clinical variables, and treatment of all full-term neonates diagnosed with NAIS and born in Switzerland between 2000 and 2010. Follow-up was performed 2 years (mean 23.3 months, SD 4.3 months) after birth. RESULTS:One hundred neonates (67 boys) had a diagnosis of NAIS. The NAIS incidence in Switzerland during this time was 13 (95% confidence interval [CI], 11-17) per 100,000 live births. Seizures were the most common symptom (95%). Eighty-one percent had unilateral (80% left-sided) and 19% had bilateral lesions. Risk factors included maternal risk conditions (32%), birth complications (68%), and neonatal comorbidities (54%). Antithrombotic and antiplatelet therapy use was low (17%). No serious side effects were reported. Two years after birth, 39% were diagnosed with cerebral palsy and 31% had delayed mental performance. CONCLUSIONS:NAIS in Switzerland shows a similar incidence as other population-based studies. About one-third of patients developed cerebral palsy or showed delayed mental performance 2 years after birth, and children with normal mental performance may still develop deficits later in life.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Grunt S,Mazenauer L,Buerki SE,Boltshauser E,Mori AC,Datta AN,Fluss J,Mercati D,Keller E,Maier O,Poloni C,Ramelli GP,Schmitt-Mechelke T,Steinlin Mdoi
10.1542/peds.2014-1520subject
Has Abstractpub_date
2015-05-01 00:00:00pages
e1220-8issue
5eissn
0031-4005issn
1098-4275pii
peds.2014-1520journal_volume
135pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract::Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder with characteristic vascular malformations of the skin, gastrointestinal system, and, less often, other organ systems. The characteristic cutaneous lesions consist of deep-blue, soft, rubbery blebs, which are easily compressible. The most serious complication ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-3611
更新日期:2012-04-01 00:00:00
abstract::Clarity of speech normally improves throughout the first few years of life, with acquisition of complete intelligibility by 4 years of age. Delayed emergence of intelligibility, or frankly unintelligible speech, often signify the presence of a major disturbance of language, overall cognitive development, or hearing. N...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVE:Greater maternal prepregnancy adiposity has been associated with behavioral problems, such as attention-deficit/hyperactivity disorder, and lower intellectual function in offspring. However, few studies of humans have explored this, and it is unclear if intrauterine mechanisms or confounding factors drive the...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-0651
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Hepatic and neurologic injury developed in two infants after ingestion of mint tea. Examination of the mint plants, from which the teas were brewed, indicated that they contained the toxic agent pennyroyal oil. METHODS:Sera from each infant were analyzed for the toxic constituents of pennyroyal oil, includi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract:CONTEXT:Late-preterm infants born at 34 to 36 weeks' gestation have increased risks of various health problems. Health service utilization (HSU) of late-preterm infants has not been systematically summarized before. OBJECTIVES:To summarize the published literature on short- and long-term HSU by late-preterm infants ve...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析,评审
doi:10.1542/peds.2017-0266
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVES:The purpose of this work was to compare the efficacy of propofol, a hypnotic agent, to the regimen of morphine, atropine, and suxamethonium as an induction agent for nonemergency neonatal endotracheal intubation. We hypothesized that propofol aids intubation by allowing the continuation of spontaneous breath...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2006-2708
更新日期:2007-06-01 00:00:00
abstract::The American Academy of Pediatrics recommends annual influenza immunization for all children with high-risk conditions who are 6 months of age and older, for all healthy children ages 6 through 59 months, for all household contacts and out-of-home caregivers of children with high-risk conditions and of healthy childre...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2008-0160
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:To determine the impact of antibiotic resistance on the frequency, clinical features, and management/outcome of mastoiditis attributable to Streptococcus pneumoniae. DESIGN:Retrospective review of the medical records of children with mastoiditis caused by S pneumoniae from September 1993 through December 199...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.106.4.695
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Individuals with fragile X syndrome (FXS) are frequently codiagnosed with autism spectrum disorder (ASD). Most of our current knowledge about ASD in FXS comes from family surveys and small studies. The objective of this study was to examine the impact of the ASD diagnosis in a large clinic-base...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2016-1159F
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To investigate whether excessive television viewing throughout childhood and adolescence is associated with increased antisocial behavior in early adulthood. METHODS:We assessed a birth cohort of 1037 individuals born in Dunedin, New Zealand, in 1972-1973, at regular intervals from birth to age 26 years. We ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-1582
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Introduction of the heptavalent pneumococcal conjugate vaccine (PCV7) changed the epidemiology of invasive pneumococcal disease (IPD). We evaluated the changes that occurred after PCV7 introduction among Utah infants aged 1 to 90 days, too young to be fully immunized. METHODS:We identified children <18 year...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-3900
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:To systematically review the evidence to determine whether the routine use of high-frequency oscillatory ventilation (HFOV) as compared with conventional ventilation (CV) is beneficial or harmful in preterm infants requiring mechanical ventilation for pulmonary failure principally due to respiratory distress...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:10.1542/peds.100.5.e6
更新日期:1997-11-01 00:00:00
abstract::We report 2 life-threatening cases of Burkholderia cepacia sepsis caused by infusate contamination during compounding. Bacterial isolates from the patients' blood cultures and the infusate were indistinguishable by pulsed-field gel electrophoresis. Proper quality controls at a local and national level are important fo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-2617
更新日期:2006-07-01 00:00:00
abstract::The enzyme alcohol dehydrogenase metabolizes ingested ethylene glycol (EG) to the toxic compounds glycolic and oxalic acids. Renal failure, acidosis, hypocalcemia, and death may follow. Traditional treatment of EG poisoning may require ethanol, a competitive substrate of alcohol dehydrogenase, and hemodialysis, that r...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.6.1489
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:Our purpose was to examine the significance of diffuse chorioamniotic hemosiderosis (DCH) on neonatal morbidity and mortality. METHODS:Using data from a retrospective case-control study, we analyzed 46 singleton placentas with DCH from infants who were delivered and/or admitted to the neonatal intensive care...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.113.4.800
更新日期:2004-04-01 00:00:00
abstract::The Federation of Pediatric Organizations engaged members of the pediatric community in an 18-month process to envision the future of the workforce in pediatrics, culminating in a Visioning Summit on the Future of the Workforce in Pediatrics. This article documents the planning process and methods used. Four working g...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-3493
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:New biomarkers like procalcitonin and C-reactive protein may help design an accurate decision support tool used to identify children with pleocytosis at low or high risk of bacterial meningitis. Our objective was to develop and validate a score (that we call the meningitis score for emergencies [MSE]) to dis...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-1126
更新日期:2020-09-01 00:00:00
abstract::High-quality pediatric emergency care can be provided only through the collaborative efforts of many health care professionals and child advocates working together throughout a continuum of care that extends from prevention and the medical home to prehospital care, to emergency department stabilization, to critical ca...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2007-1109
更新日期:2007-07-01 00:00:00
abstract::A 23-month-old girl died after 2 days' illness with rash, fever, and convulsions. Neuropathologic findings were consistent with viral hemorrhagic encephalitis in pontine tegmentum and medial thalamic areas. Human herpesvirus 6 (HHV-6) DNA was detected in pontine nuclei by in situ hybridization. In addition, polymerase...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.105.2.431
更新日期:2000-02-01 00:00:00
abstract::This report describes the first known case of Mucopolysaccharidosis type IIIA presenting with respiratory symptoms and characteristic lung pathology. This case highlights under-recognized areas of systemic involvement and earlier modes of presentation in lysosomal storage disorders as well as the importance of investi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-2765
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To assess the relationship between adolescent and parent reports of adolescent health-related quality of life (HRQL) and between adolescent pulmonary function (forced expiratory volume in 1 second as percent of predicted) and reporter perceptions of adolescent health. METHODS:Twenty-four adolescents with cysti...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.5.e70
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to examine the relationship between duration of poverty and the health of preschool children in the Quebec Longitudinal Study of Child Development birth cohort. METHODS:Data from the Quebec Longitudinal Study of Child Development for 1950 children who were followed annually u...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1750
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:In 2013-2014, an outbreak of serogroup B meningococcal disease occurred among persons linked to a New Jersey university (University A). In the absence of a licensed serogroup B meningococcal (MenB) vaccine in the United States, the Food and Drug Administration authorized use of an investigational MenB vaccin...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-4015
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:Restless legs syndrome, a common neurologic sleep disorder, occurs in 5% to 10% of adults in the United States and Western Europe. Although approximately 25% of adults with restless legs syndrome report onset of symptoms between the ages of 10 and 20 years, there is very little literature looking directly at...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-2767
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:A placebo-controlled, randomized, double-blind study was performed to determine whether prenatal dexamethasone (DEX) treatment improves the outcome of the preterm infant when exogenous surfactant is available. METHODS:157 pregnant women at five hospitals with threatened preterm delivery and with lengths of ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVE:The goal was to describe variable costs to providers of delivering childhood immunizations. METHODS:We documented variable costs (costs that vary with the amount of services rendered), including time spent by pediatric staff members and physicians on immunization-related activities, as well as supply costs a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-1542H
更新日期:2009-12-01 00:00:00
abstract::Ventricular arrhythmia in the perinatal period is observed with greater frequency than reported in the literature. Four cases from the authors' experience and an analysis of the literature are presented. Of the total of 45 cases, nine were detected in utero, three persisted beyond the neonatal period, and two resulted...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND:Children with sickle cell anemia (SCA) are at increased risk for invasive pneumococcal disease; antibiotic prophylaxis significantly reduces this risk. We calculated the proportion of children with SCA who received ≥300 days of antibiotic prophylaxis and identified predictors of such receipt. METHODS:Childr...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-2182
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:The goals of this study were to: (1) determine if management according to a standardized clinical management pathway/algorithm (compared with usual treatment) improves clinical outcomes by 6 weeks; and (2) assess the reliability and validity of a standardized clinical management pathway for chronic cough in ...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2012-3318
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of maternally derived antibody on the immunogenicity and reactogenicity of acellular (DTaP) or whole-cell (DTP) pertussis vaccine with diphtheria and tetanus toxoids combined. METHODS:A total of 2342 infants were randomized to receive one of 13 DTaP or 2 DTP vaccines at 2, 4, and 6 mon...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1995-09-01 00:00:00