Abstract:
BACKGROUND:In 2013-2014, an outbreak of serogroup B meningococcal disease occurred among persons linked to a New Jersey university (University A). In the absence of a licensed serogroup B meningococcal (MenB) vaccine in the United States, the Food and Drug Administration authorized use of an investigational MenB vaccine to control the outbreak. An investigation of the outbreak and response was undertaken to determine the population at risk and assess vaccination coverage. METHODS:The epidemiologic investigation relied on compilation and review of case and population data, laboratory typing of meningococcal isolates, and unstructured interviews with university staff. Vaccination coverage data were collected during the vaccination campaign held under an expanded-access Investigational New Drug protocol. RESULTS:Between March 25, 2013, and March 10, 2014, 9 cases of serogroup B meningococcal disease occurred in persons linked to University A. Laboratory typing results were identical for all 8 isolates available. Through May 14, 2014, 89.1% coverage with the 2-dose vaccination series was achieved in the target population. From the initiation of MenB vaccination through February 1, 2015, no additional cases of serogroup B meningococcal disease occurred in University A students. However, the ninth case occurred in March 2014 in an unvaccinated close contact of University A students. CONCLUSIONS:No serogroup B meningococcal disease cases occurred in persons who received 1 or more doses of 4CMenB vaccine, suggesting 4CMenB may have protected vaccinated individuals from disease. However, the ninth case demonstrates that carriage of serogroup B Neisseria meningitidis among vaccinated persons was not eliminated.
journal_name
Pediatricsjournal_title
Pediatricsauthors
McNamara LA,Shumate AM,Johnsen P,MacNeil JR,Patel M,Bhavsar T,Cohn AC,Dinitz-Sklar J,Duffy J,Finnie J,Garon D,Hary R,Hu F,Kamiya H,Kim HJ,Kolligian J Jr,Neglia J,Oakley J,Wagner J,Wagner K,Wang X,Yu Y,Montanadoi
10.1542/peds.2014-4015subject
Has Abstractpub_date
2015-05-01 00:00:00pages
798-804issue
5eissn
0031-4005issn
1098-4275pii
peds.2014-4015journal_volume
135pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:Studies of US adolescents have linked exposure to movie smoking with smoking behavior. It is unclear whether European adolescents are also responsive to movie tobacco imagery. METHODS:A longitudinal study was conducted to assess exposure to movie smoking in 2711 German never-smokers (aged 10 to 16 years). Mo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1201
更新日期:2008-01-01 00:00:00
abstract::One hundred children with the hyperkinetic syndrome or minimal brain dysfunction syndrome were treated with medication: 60 with methylphenidate (Ritalin), 24 with dextroamphetamine (Dexedrine), and 16 with either imipramine or desipramine. The duration of treatment was for a minimum of two years, and averaged five yea...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1976-09-01 00:00:00
abstract:OBJECTIVE:Croup is the most common form of airway obstruction in children. Known to be primarily viral, the seasonality of croup has been examined largely through its association with the human parainfluenza viruses. This study examined the seasonal pattern of croup hospitalizations in relation to age and gender for th...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1892
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the roles of production and conjugation of bilirubin, individually and in combination, in the mechanism of neonatal jaundice. METHODS:A cohort of healthy, term male newborns was sampled on the third day of life, coincident with routine metabolic screening, for bloo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.110.4.e47
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:The reported increasing prevalence of autism spectrum disorder (ASD) and attendant health and family impact make monitoring of ASD prevalence a public health priority. METHODS:The prevalence of parent-reported diagnosis of ASD among US children aged 3 to 17 years was estimated from the 2007 National Survey ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-1522
更新日期:2009-11-01 00:00:00
abstract::Cocaine use during pregnancy was assessed by interviews and urine assays obtained prenatally and immediately postpartum from 679 urban women enrolled in prenatal care. Of these, 17% were found to have used cocaine at least once during pregnancy. Eight percent had urine assays positive for cocaine metabolites using the...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::Two patients with idiopathic Fanconi syndrome and glucose intolerance were studied from a metabolic perspective. They had fasting hyperglycemia, massive glucosuria, insulinopenia, ketosis, and elevated serum free fatty acids. There was a markedly blunted insulin secretory response to glucagon, tolbutamide, glucose, an...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Public Law 99-457 amends the Education of the Handicapped Act to include services for children from birth through 3 years. Inasmuch as detection and referral of children with developmental delays continues to reside largely with pediatricians and other health care professionals, developmental screening, using standard...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:Entertainment media exposure may predict teenager alcohol use, but few longitudinal studies have been reported. METHODS:A longitudinal study was conducted of 2708 German adolescents aged 10 to 16 years who had never drunk alcohol. Each adolescent was surveyed at school about daily television use, whether th...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-1465
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this work was to investigate whether using a muscle relaxant would improve intubation conditions in infants, thereby decreasing the incidence and duration of hypoxia and time and number of attempts needed to successfully complete the intubation procedure. PATIENTS/METHODS:This was a prospectiv...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2006-0590
更新日期:2006-10-01 00:00:00
abstract::A total of 322 physicians, Board-certified in pediatric hematology, responded to a survey designed to determine several aspects of their management of children with acute idiopathic thrombocytopenic purpura. The survey demonstrates that, in practice among specialists, a controversy exists as to whether or not bone mar...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:Youth processed in the juvenile justice system are at great risk for early violent death. Groups at greatest risk, ie, racial/ethnic minorities, male youth, and urban youth, are overrepresented in the juvenile justice system. We compared mortality rates for delinquent youth with those for the general populati...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1459
更新日期:2005-06-01 00:00:00
abstract::The possibility that arterial oxygen saturation (SaO2) decreases during sleep in children with chronic bronchial asthma was investigated. The relationship between decreases in sleep SaO2 and airflow obstruction and ventilatory drives, as characterized by ventilatory and inspiratory muscle activity responses to hypoxia...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1980-11-01 00:00:00
abstract:AIMS:To determine the galactopoietic response to recombinant human growth hormone (hGH) in mothers of premature infants with inadequate lactation. STUDY DESIGN:Prospective placebo-controlled, double-blind trial. SUBJECTS:Twenty healthy mothers on no concurrent medication, with infants born between 26 and 34 weeks' ge...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:To determine whether children with unilateral hearing loss (UHL) demonstrate worse language skills than their siblings with normal hearing, and whether children with UHL are more likely to receive extra assistance at school. PATIENTS AND METHODS:We conducted a case-control study of 6- to 12-year-old children...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-2448
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Few prospective studies have examined separate forms of screen time in relation to adiposity. Our objective was to assess independent relations of television, electronic games (video/computer), and digital versatile disc (DVD)/videos and total screen time with change in adolescent BMI. METHODS:Using data fro...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-0887
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To determine social factors associated with increased risk of hospital admission from diabetic ketoacidosis (DKA) or diabetic coma as well as risk of prolonged hospital stay. METHODS:A cohort of all children (=21 years) with type 1 diabetes mellitus (DM) in the National Inpatient Sample admitted for DKA or...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.109.1.40
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Data from the 1988 National Health Interview Survey--Child Health Supplement were used to examine the prevalence of selected developmental disabilities and their impact among children ages 0 through 17 years. DESIGN:The following conditions, identified through a structured in-person interview with a parent o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::Immune reconstitution inflammatory syndrome (IRIS) is a well-described complication of initiation of highly active antiretroviral therapy in HIV-infected patients. As the immune system recovers, an inappropriate inflammatory response often occurs that causes significant disease. It is most commonly seen in patients na...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-1246
更新日期:2012-09-01 00:00:00
abstract::After passage of the Patient Protection and Affordable Care Act, more children and young adults have become insured and have benefited from health care coverage than at any time since the creation of the Medicaid program in 1965. From 2009 to 2015, the uninsurance rate for children younger than 19 years fell from 9.7%...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-2098
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To characterize the atypical cutaneous presentations in the coxsackievirus A6 (CVA6)-associated North American enterovirus outbreak of 2011-2012. METHODS:We performed a retrospective case series of pediatric patients who presented with atypical cases of hand, foot, and mouth disease (HFMD) from July 2011 to ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-3175
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To estimate the incidence of clinical deterioration leading to intensive care unit transfer in previously healthy infants with respiratory syncytial virus (RSV) infection hospitalized on a general pediatric unit and, to assess the hypothesis that history, physical examination, oximetry, and chest radiographic...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.104.3.463
更新日期:1999-09-01 00:00:00
abstract::The presence of pulsus paradoxus (PP) in 13 episodes of status asthmaticus in 12 children, ages 13 months to 15 years, was compared sequentially to a clinical score, peak expiratory flow rate (PEFR), heart rate, arterialized capillary pH, carbon dioxide pressure (PCO2), and the ratio of inspired oxygen to oxygen press...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:Past studies have documented the acute benefits of cardiac rehabilitation in children with congenital heart disease. It is not known whether these benefits persist. PATIENTS AND METHODS:Fifteen patients, ages 8 to 17 years, with complex congenital heart disease, whose exercise function immediately after a 12...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:10.1542/peds.2006-0264
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:After a child's death, parents may experience depression, posttraumatic stress disorder (PTSD), and increased risk for cancers, diabetes, psychiatric hospitalization, and suicide. Racial/ethnic differences are unknown. This longitudinal study investigated health and functioning of Hispanic, black, and white ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-1194
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To determine whether making a low-fat entree available as one of two choices in an elementary school lunch program would reduce the fat content of meals selected by children. DESIGN:In this before-after trial, students had a daily choice between two entrees, one of which was sometimes low-fat. For 93% of sch...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract::The role of chloride deficiency in the generation of hypokalemic metabolic alkalosis with elevated plasma renin activity and plasma aldosterone levels, normal blood pressure, and a renal concentrating defect was studied in six infants given a soy formula that was deficient in chloride. A deceleration in linear growth,...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVE:We sought to determine the correlates of intent to breastfeed and of successful lactation and nursing at the breast in mothers of very low birth weight (VLBW; <1.5 kg) infants. METHODS:We conducted a prospective observational study of 119 mothers of singleton VLBW infants (mean birth weight: 1056 g; mean ges...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.109.4.e57
更新日期:2002-04-01 00:00:00
abstract::Two patients had prolonged retention of small round foreign bodies in the stomach. Both patients had a history of a pyloromyotomy. Radiographic examination revealed a prepyloric web in one patient and a deformed pylorus in the other. These findings were confirmed by surgery. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-10-01 00:00:00
abstract::An 8 1/2-year-old girl presented with a long history of seizures, growth retardation, muscle weakness, gait disturbance, and hearing loss. Her evaluation revealed chronic moderate renal failure (serum creatinine 2.2 mg/dL), severe hypocalcemia (5 mg/dL), hyperphosphatemia (8.1 mg/dL), hypomagnesemia (1.5 mg/dL), incre...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00