Metabolic abnormalities in the idiopathic Fanconi syndrome: studies of carbohydrate metabolism in two patients.

Abstract:

:Two patients with idiopathic Fanconi syndrome and glucose intolerance were studied from a metabolic perspective. They had fasting hyperglycemia, massive glucosuria, insulinopenia, ketosis, and elevated serum free fatty acids. There was a markedly blunted insulin secretory response to glucagon, tolbutamide, glucose, and arginine. One patient had the findings of diabetic retinopathy and a sensory neuropathy. Neither patient could convert galactose to glucose, but they did not have galactosemia. As a result of these studies, and previous reports in which similar changes were noted, we conclude that diabetes mellitus may occur in patients who have had idiopathic Fanconi syndrome for many years.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Chesney RW,Kaplan BS,Teitel D,Colle E,McInnes RR,Goldman H,Scriver CR

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

113-8

issue

1

eissn

0031-4005

issn

1098-4275

journal_volume

67

pub_type

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