Abstract:
:Two patients with idiopathic Fanconi syndrome and glucose intolerance were studied from a metabolic perspective. They had fasting hyperglycemia, massive glucosuria, insulinopenia, ketosis, and elevated serum free fatty acids. There was a markedly blunted insulin secretory response to glucagon, tolbutamide, glucose, and arginine. One patient had the findings of diabetic retinopathy and a sensory neuropathy. Neither patient could convert galactose to glucose, but they did not have galactosemia. As a result of these studies, and previous reports in which similar changes were noted, we conclude that diabetes mellitus may occur in patients who have had idiopathic Fanconi syndrome for many years.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Chesney RW,Kaplan BS,Teitel D,Colle E,McInnes RR,Goldman H,Scriver CRsubject
Has Abstractpub_date
1981-01-01 00:00:00pages
113-8issue
1eissn
0031-4005issn
1098-4275journal_volume
67pub_type
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