Hypokalemic metabolic alkalosis in normotensive infants with elevated plasma renin activity and hyperaldosteronism: role of dietary chloride deficiency.

Abstract:

:The role of chloride deficiency in the generation of hypokalemic metabolic alkalosis with elevated plasma renin activity and plasma aldosterone levels, normal blood pressure, and a renal concentrating defect was studied in six infants given a soy formula that was deficient in chloride. A deceleration in linear growth, weight gain, and head circumference with age and delayed neurologic development were noted in every infant during the first six months of life. Microscopic hematuria and persistent elevation of plasma creatinine were noted in four of the infants. A renal biopsy in two infants revealed no juxtaglomerular hyperplasia, but interstitial tubular calcification was observed in one, and interstitial fibrosis was found in both. The generation of the hypokalemic metabolic alkalosis in these infants was explained by the reduced intake of chloride, and the addition of chloride alone to the diet resulted in a correction of the electrolyte abnormalities and the alkalosis.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Roy S 3rd,Arant BS Jr

subject

Has Abstract

pub_date

1981-03-01 00:00:00

pages

423-9

issue

3

eissn

0031-4005

issn

1098-4275

journal_volume

67

pub_type

杂志文章
  • Computer-facilitated substance use screening and brief advice for teens in primary care: an international trial.

    abstract:OBJECTIVE:Primary care providers need effective strategies for substance use screening and brief counseling of adolescents. We examined the effects of a new computer-facilitated screening and provider brief advice (cSBA) system. METHODS:We used a quasi-experimental, asynchronous study design in which each site served ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1542/peds.2011-1624

    authors: Harris SK,Csémy L,Sherritt L,Starostova O,Van Hook S,Johnson J,Boulter S,Brooks T,Carey P,Kossack R,Kulig JW,Van Vranken N,Knight JR

    更新日期:2012-06-01 00:00:00

  • Parents' Perspectives Regarding Age Restrictions for Tackling in Youth Football.

    abstract:BACKGROUND:In ice hockey and soccer, age restrictions exist for body checking and heading because of injury risk. There are currently no age restrictions for tackling in youth football. METHODS:We surveyed a nationally representative sample of US parents regarding their support for age restrictions on tackling in foot...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-2402

    authors: Chrisman SPD,Whitlock KB,Kroshus E,Schwien C,Herring SA,Rivara FP

    更新日期:2019-05-01 00:00:00

  • Should pediatric echocardiography be performed in adult laboratories?

    abstract:OBJECTIVES:Current health care management has resulted in a change in referral patterns. The present study was undertaken to define the efficacy and value of pediatric echocardiography performed and interpreted in adult laboratories. METHODS:We reviewed the findings in 100 consecutive pediatric patients 1 month to 18 ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.2.e15

    authors: Hurwitz RA,Caldwell RL

    更新日期:1998-08-01 00:00:00

  • Cow's Milk Allergy and Bone Mineral Density in Prepubertal Children.

    abstract:BACKGROUND AND OBJECTIVES:Recent data suggest that cow's milk allergy (CMA) has become more persistent, prolonging treatment via strict elimination of cow's milk products into a period of skeletal growth. The objectives of this study were to compare bone mineral density (BMD), vitamin D status, and dietary intakes of c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-1742

    authors: Mailhot G,Perrone V,Alos N,Dubois J,Delvin E,Paradis L,Des Roches A

    更新日期:2016-05-01 00:00:00

  • Fibromyalgia syndrome in children and adolescents: clinical features at presentation and status at follow-up.

    abstract:OBJECTIVES:To 1) describe the characteristic features of fibromyalgia syndrome (FS) in a pediatric population, 2) note similarities and differences with FS in adults, and 3) determine outcome after treatment. SETTING AND DESIGN:The Pediatric Rheumatology Clinic at the University of Rochester Medical Center is staffed ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.3.377

    authors: Siegel DM,Janeway D,Baum J

    更新日期:1998-03-01 00:00:00

  • Early violent death among delinquent youth: a prospective longitudinal study.

    abstract:OBJECTIVE:Youth processed in the juvenile justice system are at great risk for early violent death. Groups at greatest risk, ie, racial/ethnic minorities, male youth, and urban youth, are overrepresented in the juvenile justice system. We compared mortality rates for delinquent youth with those for the general populati...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-1459

    authors: Teplin LA,McClelland GM,Abram KM,Mileusnic D

    更新日期:2005-06-01 00:00:00

  • Acute poststreptococcal glomerulonephritis: a manifestation of immune reconstitution inflammatory syndrome.

    abstract::Immune reconstitution inflammatory syndrome (IRIS) is a well-described complication of initiation of highly active antiretroviral therapy in HIV-infected patients. As the immune system recovers, an inappropriate inflammatory response often occurs that causes significant disease. It is most commonly seen in patients na...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1246

    authors: Martin J,Kaul A,Schacht R

    更新日期:2012-09-01 00:00:00

  • Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections.

    abstract:OBJECTIVE:The incidence of nosocomial infections, predominantly gastrointestinal and respiratory, in children in developed countries is high, ranging from 5% to 44%. There is no effective strategy for preventing these infections. The objective of our study was to investigate the role of Lactobacillus GG (LGG) in preven...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2009-2568

    authors: Hojsak I,Abdović S,Szajewska H,Milosević M,Krznarić Z,Kolacek S

    更新日期:2010-05-01 00:00:00

  • Acute confusional migraine in an adolescent: response to intravenous valproate.

    abstract::Acute confusional migraine (ACM) is a dramatic, rare manifestation of migraine described mostly for children and adolescents. There are few data on the treatment of an ACM attack. Prochlorperazine has been suggested as an effective drug. The authors of some reports have suggested that valproic acid may play a role in ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2717

    authors: Avraham SB,Har-Gil M,Watemberg N

    更新日期:2010-04-01 00:00:00

  • Pediatrician Perspectives on Feasibility and Acceptability of the MOCA-Peds 2017 Pilot.

    abstract:BACKGROUND AND OBJECTIVES:The American Board of Pediatrics (ABP) certifies that general and subspecialty pediatricians meet standards of excellence established by their peers, immediately after training and over the course of their careers (ie, Maintenance of Certification [MOC]). In 2015-2016, the ABP developed the Ma...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-2303

    authors: Leslie LK,Turner AL,Smith AC,Dounoucos V,Olmsted MG,Althouse L

    更新日期:2019-12-01 00:00:00

  • Primary care physician supply and children's health care use, access, and outcomes: findings from Canada.

    abstract:OBJECTIVES:To describe the relationship of primary care physician (PCP) supply for children and measures of health care access, use, and outcomes. METHODS:We conducted a population-based, cross-sectional study of all Ontario children from 2003 to 2005. We used health administrative data to calculate county-level suppl...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2821

    authors: Guttmann A,Shipman SA,Lam K,Goodman DC,Stukel TA

    更新日期:2010-06-01 00:00:00

  • On the front lines: lessons learned in implementing multidisciplinary peripheral venous access pain-management programs in pediatric hospitals.

    abstract::Venipuncture and intravenous cannulation are among the most common and widespread medical procedures performed on children today. Therefore, effective treatment of venous access pain can benefit from an integrated systems approach that enlists multiple players in the health care system. By using case studies that anal...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2008-1055i

    authors: Leahy S,Kennedy RM,Hesselgrave J,Gurwitch K,Barkey M,Millar TF

    更新日期:2008-11-01 00:00:00

  • Bladder retention of urine as a result of continuous intravenous infusion of fentanyl: 2 case reports.

    abstract::Sedation has been commonly used in the neonate to decrease the stress and pain from the noxious stimuli and invasive procedures in the neonatal intensive care unit, as well as to facilitate synchrony between ventilator and spontaneous breaths. Fentanyl, an opioid analgesic, is frequently used in the neonatal intensive...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.4.1012

    authors: Das UG,Sasidharan P

    更新日期:2001-10-01 00:00:00

  • Oxygen Saturation Targets in Preterm Infants and Outcomes at 18-24 Months: A Systematic Review.

    abstract:CONTEXT:The optimal oxygen saturation target for extremely preterm infants remains unclear. OBJECTIVE:To systematically review evidence evaluating the effect of lower (85%-89%) versus higher (91%-95%) pulse oxygen saturation (Spo2) target on mortality and neurodevelopmental impairment (NDI) at 18 to 24 months. DATA S...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2016-1609

    authors: Manja V,Saugstad OD,Lakshminrusimha S

    更新日期:2017-01-01 00:00:00

  • Improving adherence to otitis media guidelines with clinical decision support and physician feedback.

    abstract:OBJECTIVE:To assess the effects of electronic health record-based clinical decision support (CDS) and physician performance feedback on adherence to guidelines for acute otitis media (AOM) and otitis media with effusion (OME). METHODS:We conducted a factorial-design cluster randomized trial with primary care practices...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2012-1988

    authors: Forrest CB,Fiks AG,Bailey LC,Localio R,Grundmeier RW,Richards T,Karavite DJ,Elden L,Alessandrini EA

    更新日期:2013-04-01 00:00:00

  • Adoption as a risk factor for attempted suicide during adolescence.

    abstract:OBJECTIVE:Depression, impulsivity, and aggression during adolescence have been associated with both adoption and suicidal behavior. Studies of adopted adults suggest that impulsivity, even more than depression, may be an inherited factor that mediates suicidal behavior. However, the association between adoption and ado...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.2.e30

    authors: Slap G,Goodman E,Huang B

    更新日期:2001-08-01 00:00:00

  • Clinical Prediction Rule for Distinguishing Bacterial From Aseptic Meningitis.

    abstract:BACKGROUND:New biomarkers like procalcitonin and C-reactive protein may help design an accurate decision support tool used to identify children with pleocytosis at low or high risk of bacterial meningitis. Our objective was to develop and validate a score (that we call the meningitis score for emergencies [MSE]) to dis...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-1126

    authors: Mintegi S,García S,Martín MJ,Durán I,Arana-Arri E,Fernandez CL,Benito J,Hernández-Bou S,Meningitis Group of the Spanish Society of Pediatric Emergencies.

    更新日期:2020-09-01 00:00:00

  • Asymptomatic Kawasaki Disease in a 3-Month-Old Infant.

    abstract::Kawasaki disease (KD) is the leading cause of acquired heart disease in children in the United States. It is a systemic vasculitis characterized by diffuse inflammation of medium and small blood vessels. If untreated it can lead to myocardial infarction, ischemic heart disease, or sudden death. Early recognition and t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-3936

    authors: Pinches H,Dobbins K,Cantrell S,May J,Lopreiato J

    更新日期:2016-08-01 00:00:00

  • Neonatal hyperbilirubinemia and risk of autism spectrum disorders.

    abstract:OBJECTIVE:To investigate the association between neonatal hyperbilirubinemia and autism spectrum disorders (ASD). METHODS:We conducted a large case-control study nested within the cohort of singleton term infants born between 1995 and 1998 at a northern California Kaiser Permanente hospital. Case subjects (n = 338) we...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-1870

    authors: Croen LA,Yoshida CK,Odouli R,Newman TB

    更新日期:2005-02-01 00:00:00

  • Elective high-frequency oscillatory ventilation versus conventional ventilation in preterm infants with pulmonary dysfunction: systematic review and meta-analyses.

    abstract:OBJECTIVES:To systematically review the evidence to determine whether the routine use of high-frequency oscillatory ventilation (HFOV) as compared with conventional ventilation (CV) is beneficial or harmful in preterm infants requiring mechanical ventilation for pulmonary failure principally due to respiratory distress...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.100.5.e6

    authors: Bhuta T,Henderson-Smart DJ

    更新日期:1997-11-01 00:00:00

  • Thyroid-Stimulating Hormone Reference Ranges for Preterm Infants.

    abstract:BACKGROUND AND OBJECTIVES:Many newborn screening (NBS) programs now perform repeat or serial NBS to detect congenital hypothyroidism. There is wide variation in thyroid-stimulating hormone (TSH) cutoffs used by NBS programs. Data on TSH reference ranges in preterm infants at increasing postnatal age are limited. Our st...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-0290

    authors: Kaluarachchi DC,Allen DB,Eickhoff JC,Dawe SJ,Baker MW

    更新日期:2019-08-01 00:00:00

  • Stature and weight status of children in an urban kindergarten population.

    abstract::To assess the prevalence of growth problems among school entrants in an urban population who were not preselected on poverty or other nutritional risk criteria, we analyzed height and weight measurements for 5170 4- and 5-year-old children (91.9% black, 5.5% white, and 2.6% Hispanic) who enrolled in District of Columb...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kumanyika SK,Huffman SL,Bradshaw ME,Waller H,Ross A,Serdula M,Paige D

    更新日期:1990-05-01 00:00:00

  • Down Syndrome and the Risk of Severe RSV Infection: A Meta-analysis.

    abstract:CONTEXT:Down syndrome (DS) is the most common chromosomal condition in live-born infants worldwide, and lower respiratory infection caused by respiratory syncytial virus (RSV) is a leading cause of hospital admissions. OBJECTIVE:To evaluate RSV-associated morbidity among children with DS compared with a population wit...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.2018-0225

    authors: Beckhaus AA,Castro-Rodriguez JA

    更新日期:2018-09-01 00:00:00

  • Toxicity of over-the-counter cough and cold medications.

    abstract::Over-the-counter (OTC) cough and cold medications are marketed widely for relief of common cold symptoms, and yet studies have failed to demonstrate a benefit of these medications for young children. In addition, OTC medications can be associated with significant morbidity and even mortality in both acute overdoses an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.3.e52

    authors: Gunn VL,Taha SH,Liebelt EL,Serwint JR

    更新日期:2001-09-01 00:00:00

  • Comparison of cefpodoxime proxetil and cefixime in the treatment of acute otitis media in infants and children. Otitis Study Group.

    abstract:OBJECTIVE:To compare the use of once-a-day cefpodoxime proxetil to once-a-day cefixime in the treatment of acute suppurative otitis media. DESIGN:Randomized, multicenter, investigator-blinded. SETTING:Outpatient. PATIENTS:A total of 368 patients (age 2 months to 17 years) were randomized to receive either cefpodoxim...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Asmar BI,Dajani AS,Del Beccaro MA,Mendelman PM

    更新日期:1994-12-01 00:00:00

  • Diabetes in Pregnancy and Childhood Cognitive Development: A Systematic Review.

    abstract:CONTEXT:The effect of diabetes during pregnancy on the cognitive development of offspring is unclear because of inconsistent findings from limited studies. OBJECTIVE:This review was aimed to provide the best available scientific evidence on the associations between maternal pregnancy diabetes and the cognitive develop...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2015-4234

    authors: Adane AA,Mishra GD,Tooth LR

    更新日期:2016-05-01 00:00:00

  • The walking school bus and children's physical activity: a pilot cluster randomized controlled trial.

    abstract:OBJECTIVE:To evaluate the impact of a "walking school bus" program on children's rates of active commuting to school and physical activity. METHODS:We conducted a pilot cluster randomized controlled trial among 4th-graders from 8 schools in Houston, Texas (N = 149). Random allocation to treatment or control conditions...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2010-3486

    authors: Mendoza JA,Watson K,Baranowski T,Nicklas TA,Uscanga DK,Hanfling MJ

    更新日期:2011-09-01 00:00:00

  • Total but not resting energy expenditure is increased in infants with ventricular septal defects.

    abstract:OBJECTIVE:The purpose of this study was to determine the effect of left-to-right shunting on the resting energy expenditure (REE), total energy expenditure (TEE), and energy intake in a group of 3- to 5-month-old infants with moderate to large unrepaired ventricular septal defects (VSDs) compared with age-matched, heal...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.5.1172

    authors: Ackerman IL,Karn CA,Denne SC,Ensing GJ,Leitch CA

    更新日期:1998-11-01 00:00:00

  • Cross-Cultural Differences in Communication About a Dying Child.

    abstract::There are more migrants, refugees, and immigrants adrift in the world today than at any time in the recent past. Doctors and hospitals must care for people from many different cultures, countries, and religious backgrounds. We sometimes find our own deeply held beliefs and values challenged. In this "Ethics Rounds," w...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-0690

    authors: Cochran D,Saleem S,Khowaja-Punjwani S,Lantos JD

    更新日期:2017-11-01 00:00:00

  • Iron overload in children who are treated for acute lymphoblastic leukemia estimated by liver siderosis and serum iron parameters.

    abstract:OBJECTIVE:To evaluate a secondary liver iron overload and its fate in children who are treated conventionally for acute lymphoblastic leukemia and to assess whether serum soluble transferrin receptor (sTfR) is useful in detecting iron load. METHODS:Liver siderosis was estimated histologically from liver biopsy specime...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.111.1.91

    authors: Halonen P,Mattila J,Suominen P,Ruuska T,Salo MK,Mäkipernaa A

    更新日期:2003-01-01 00:00:00