Comparison of cefpodoxime proxetil and cefixime in the treatment of acute otitis media in infants and children. Otitis Study Group.

Abstract:

OBJECTIVE:To compare the use of once-a-day cefpodoxime proxetil to once-a-day cefixime in the treatment of acute suppurative otitis media. DESIGN:Randomized, multicenter, investigator-blinded. SETTING:Outpatient. PATIENTS:A total of 368 patients (age 2 months to 17 years) were randomized to receive either cefpodoxime or cefixime in a 2:1 ratio (245 cefpodoxime, 123 cefixime); 236 patients (155 cefpodoxime, 81 cefixime) were evaluable for drug efficacy. INTERVENTIONS:Patients received either cefpodoxime proxetil oral suspension (10 mg/kg/day, once daily for 10 days) or cefixime oral suspension (8 mg/kg/day, once daily for 10 days). MAIN OUTCOME MEASURES:Clinical evaluations were performed before treatment (study day 1), at an interim visit (study day 3 through 6), at the end of therapy (study day 12 through 15), and at final follow-up (study day 25 through 38). Microbiologic evaluations were performed at enrollment and whenever appropriate thereafter. RESULTS:End-of-therapy clinical cure rates in evaluable patients were 56% for the cefpodoxime group and 54% for the cefixime group. Clinical improvement rates were 27% for both groups. Clinical response rates were not significantly different between treatment groups (P = .541; 95% confidence interval = -8.1%, 15.2%). At long-term follow-up, 17% of patients in the cefpodoxime group and 20% in the cefixime group had a recurrence of infection. Drug-related adverse events (eg, diarrhea, diaper rash, vomiting, rash) occurred in 23.3% of cefpodoxime-treated patients and 17.9% of cefixime-treated patients (P = .282). CONCLUSIONS:These findings suggest that cefpodoxime proxetil administered once daily is as effective and safe as cefixime given once daily in the treatment of acute suppurative otitis media in pediatric patients.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Asmar BI,Dajani AS,Del Beccaro MA,Mendelman PM

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

847-52

issue

6 Pt 1

eissn

0031-4005

issn

1098-4275

journal_volume

94

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Mull ES,Erdem G,Nicol K,Adler B,Shell R

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    authors: Nemet D,Oh Y,Kim HS,Hill M,Cooper DM

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    更新日期:2016-11-01 00:00:00

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    journal_title:Pediatrics

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    更新日期:2012-05-01 00:00:00

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    pub_type: 杂志文章

    doi:

    authors: Janik JP,Wayne ER,Janik JS

    更新日期:1995-09-01 00:00:00

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    更新日期:1980-05-01 00:00:00

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    doi:

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    更新日期:1996-12-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Garber M

    更新日期:1987-05-01 00:00:00

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    authors: Bruijning-Verhagen P,Quach C,Bonten M

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  • Respiratory syncytial virus immune globulin treatment of RSV lower respiratory tract infection in previously healthy children.

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    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.100.6.937

    authors: Rodriguez WJ,Gruber WC,Groothuis JR,Simoes EA,Rosas AJ,Lepow M,Kramer A,Hemming V

    更新日期:1997-12-01 00:00:00

  • Safe transportation of preterm and low birth weight infants at hospital discharge.

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    pub_type: 杂志文章

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    更新日期:2009-08-01 00:00:00

  • From concept to application: the impact of a community-wide intervention to improve the delivery of preventive services to children.

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    更新日期:2004-07-01 00:00:00

  • Improvement of short- and long-term outcomes for very low birth weight infants: Edmonton NIDCAP trial.

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    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2008-3808

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Seidman DJ,Nelson LB,Calhoun JH,Spaeth GL,Harley RD

    更新日期:1986-03-01 00:00:00

  • Epidemiologic aspects of Kawasaki disease in a Manhattan hospital.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

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    更新日期:1989-08-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0332

    authors: Peterson C,Grosse SD,Oster ME,Olney RS,Cassell CH

    更新日期:2013-09-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Leduc DG,Pless IB

    更新日期:1982-10-01 00:00:00

  • Variation in clinician recommendations for multiple injections during adoption of inactivated polio vaccine.

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    pub_type: 临床试验,杂志文章,随机对照试验

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