Abstract:
OBJECTIVE:To investigate the association between neonatal hyperbilirubinemia and autism spectrum disorders (ASD). METHODS:We conducted a large case-control study nested within the cohort of singleton term infants born between 1995 and 1998 at a northern California Kaiser Permanente hospital. Case subjects (n = 338) were children with an ASD diagnosis recorded in Kaiser Permanente outpatient databases; control subjects (n = 1817) were children without an ASD diagnosis, who were randomly sampled and frequency-matched to case subjects according to gender, birth year, and birth hospital. RESULTS:Approximately 28% of case and control subjects received > or =1 bilirubin test in the first 30 days of life. No case-control differences were observed for maximal bilirubin levels of > or =15 mg/dL (10.1% vs 12.1%), > or =20 mg/dL (2.1% vs 2.5%), or > or =25 mg/dL (0.3% vs 0.2%). Compared with children whose maximal neonatal bilirubin levels were <15 mg/dL or not measured, children with any degree of bilirubin level elevation were not at increased risk of ASD, after adjustment for gender, birth facility, maternal age, maternal race/ethnicity, maternal education, and gestational age (for bilirubin levels of 15-19.9 mg/dL: odds ratio: 0.7; 95% confidence interval: 0.5-1.2; for bilirubin levels of 20-24.9 mg/dL: odds ratio: 0.7; 95% confidence interval: 0.3-1.6; for bilirubin levels of > or =25 mg/dL: odds ratio: 1.1; 95% confidence interval: 0.1-11.2). CONCLUSION:These data suggest that neonatal hyperbilirubinemia is not a risk factor for ASD.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Croen LA,Yoshida CK,Odouli R,Newman TBdoi
10.1542/peds.2004-1870subject
Has Abstractpub_date
2005-02-01 00:00:00pages
e135-8issue
2eissn
0031-4005issn
1098-4275pii
115/2/e135journal_volume
115pub_type
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