Abstract:
OBJECTIVE:Previous studies have shown that selected strains of Lactobacillus have the capacity to antagonize rotavirus-induced diarrhea. However, only a few reports have documented their efficacy against nonrotavirus diarrhea. This study involved an experimental investigation and a clinical trial of the antisecretory activity of Lactobacillus acidophilus strain LB in the context of nonrotavirus diarrhea. METHODS:The activity of a culture of L. acidophilus LB or of the lyophilized, heat-killed L. acidophilus LB bacteria plus their spent culture medium was tested in inhibiting the formation of fluid-formed domes in cultured human intestinal Caco-2/TC7 cell monolayers infected with diarrheagenic, diffusely adhering Afa/Dr Escherichia coli C1845 bacteria. A randomized, double-blind, placebo-controlled clinical trial of male or female children who were 10 months of age and presented with nonrotavirus, well-established diarrhea was conducted to evaluate the therapeutic efficacy of a pharmaceutical preparation that contains 10 billion heat-killed L. acidophilus LB plus 160 mg of spent culture medium. RESULTS:Infection of the cells with C1845 bacteria that were treated with L. acidophilus LB culture or the lyophilized, heat-killed L. acidophilus LB bacteria plus their culture medium produced a dosage-dependent decrease in the number of fluid-formed domes as compared with cells that were infected with untreated C1845 bacteria. The clinical results show that in selected and controlled homogeneous groups of children with well-established, nonrotavirus diarrhea, adding lyophilized, heat-killed L. acidophilus LB bacteria plus their culture medium to a solution of oral rehydration solution shortened by 1 day the recovery time (ie, the time until the first normal stool was passed) as compared with children who received placebo oral rehydration solution. CONCLUSIONS:Heat-killed L. acidophilus LB plus its culture medium antagonizes the C1845-induced increase in paracellular permeability in intestinal Caco-2/TC7 cells and produces a clinically significant benefit in the management of children with nonrotavirus, well-established diarrhea.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Liévin-Le Moal V,Sarrazin-Davila LE,Servin ALdoi
10.1542/peds.2006-2930subject
Has Abstractpub_date
2007-10-01 00:00:00pages
e795-803issue
4eissn
0031-4005issn
1098-4275pii
peds.2006-2930journal_volume
120pub_type
杂志文章,随机对照试验相关文献
PEDIATRICS文献大全abstract::An important adaptation of the gastrointestinal tract to the extrauterine environment is its development of a mucosal barrier against the penetration of proteins and protein fragments. To combat the potential danger of invasion across the mucosal barrier the newborn infant must develop within the lumen and on the lumi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVES:The current study is a 1-year follow-up analysis of data from a randomized controlled trial of Enhanced Milieu Teaching (EMT) for toddlers with language delays. Outcomes and predictors of child language and parent intervention implementation were examined 6 and 12 months after the end of the intervention. M...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2016-3646
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Physicians have a major influence on parental vaccine decisions. We tested a physician-targeted communication intervention designed to (1) reduce vaccine hesitancy in mothers of infants seen by trained physicians and (2) increase physician confidence in communicating about vaccines. METHODS:W...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2014-3199
更新日期:2015-07-01 00:00:00
abstract::A growing body of scientific literature demonstrates that children who grow up with 1 or 2 gay and/or lesbian parents fare as well in emotional, cognitive, social, and sexual functioning as do children whose parents are heterosexual. Children's optimal development seems to be influenced more by the nature of the relat...
journal_title:Pediatrics
pub_type:
doi:10.1542/peds.109.2.341
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:To examine the association between child maltreatment (abuse and neglect) and long-term cognitive outcomes within a prospective birth cohort. METHODS:A birth cohort of 7223 children was recruited. Independent reports of suspected child maltreatment were confidentially linked to the longitudinal study databas...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-3479
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Circumcision is a common neonatal surgical procedure routinely performed without the use of anesthesia. The purpose of this study was to evaluate the safety and efficacy of topical lidocaine cream as an anesthetic for circumcision. METHODS:Thirty newborns were studied in a randomized, double-blind, placebo-c...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:Inhaled nitric oxide (iNO) reduces the use of extracorporeal membrane oxygenation (ECMO)/incidence of death in term and near-term neonates with severe hypoxic respiratory failure. We conducted a randomized, double masked, multicenter trial to determine whether administration of iNO earlier in respiratory fail...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.113.3.559
更新日期:2004-03-01 00:00:00
abstract::An overview and update are offered on difficulties experienced by children with monaural sensorineural deafness. It is the general consensus that children with unilateral hearing loss experience few, if any, communication and/or educational problems. The medical and educational status of a group (N = 60) of children w...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1984-08-01 00:00:00
abstract:OBJECTIVES:Health consequences of shaken baby syndrome, or pediatric abusive head trauma (AHT), can be severe and long-lasting. We aimed to estimate the multiyear medical cost attributable to AHT. METHODS:Using Truven Health MarketScan data, 2003-2011, we identified children 0 to 4 years old with commercial or Medicai...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-0117
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:Our goal was to test the hypothesis that increased fruit juice intake and parental restriction of children's eating are associated with increased adiposity gain and whether exposure to nutritional counseling predicted reduced adiposity gain among children. PATIENTS AND METHODS:A sample of parents or guardian...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1117
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate if oropharyngeal swab polymerase chain reaction (PCR) could predict osteoarticular infection (OAI) due to Kingella kingae in young children. METHODS:One hundred twenty-three consecutive children aged 6 to 48 months presenting with atraumatic osteoarticular complai...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-0810
更新日期:2013-01-01 00:00:00
abstract::Population-based data on varicella complications are presented using information both from national sample surveys of hospitalizations and physician office visits and from reviews of medical records for all cases occurring within one community (Olmsted County, Minnesota) during a specified period. Acute cerebellar ata...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract:OBJECTIVES:The long-acting beta2-adrenergic agonist salmeterol prevents exercise-induced asthma, but tolerance may develop to its bronchoprotective effect. We wanted to ascertain if the development of tolerance could be prevented by using a low-dose treatment regimen of 50 microg once daily, instead of the usual dose o...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.99.5.655
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To determine the incidence of symptomatic children with inherited organic acid disorders (OADs) and fatty acid oxidation disorders (FAODs) in Germany. METHODS:An active surveillance of symptomatic children with inherited OADs and FAODs was conducted during a time period of 24 months (1999-2000) in Germany. M...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.110.6.1204
更新日期:2002-12-01 00:00:00
abstract::The findings reported in this article are based on a nationwide survey of the attitudes and practices of pediatric surgeons and pediatricians with respect to some of the difficult ethical choices confronting them in medical practice. Four hundred fifty-seven physicians completed a questionnaire in the spring of 1975 i...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-10-01 00:00:00
abstract::During a 12-month period 80 children greater than 3 months of age seen at an emergency room with acute fevers greater than or equal to 39.7 C (103.5 F) and no localizing signs of infection were studied using blood and buffy coat cultures to isolate bacteria and viruses. Bacteremia was identified in three children (3.8...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-08-01 00:00:00
abstract:OBJECTIVES:To estimate the association between maternal use of acetaminophen during pregnancy and of paternal use before pregnancy with attention-deficit/hyperactivity disorder (ADHD) in offspring while adjusting for familial risk for ADHD and indications of acetaminophen use. METHODS:Diagnoses were obtained from the ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-3840
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:Incomplete subspecialty referrals, whether unscheduled or unattended, represent unmet patient needs and an opportunity to improve patient safety and experiences. Our objectives were to describe the rates of appointment scheduling and visit attendance after pediatric subspecialty referral and to examine patie...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-0545
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis that affects children mainly in temperate areas, with exacerbations in spring and summer. Eyelashes provide natural protection for the eyes from sunshine, wind, and foreign bodies. These factors induce a worsening of signs and symptoms in VKC, wher...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1555
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Much effort has been directed toward increasing the training of physicians from underrepresented minority groups, yet few direct comparisons have examined the diversity of the racial/ethnic backgrounds of the physicians relative to the patient populations they serve, either currently or into the future. This...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.105.1.27
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:In 2011, the Neonatal Resuscitation Program (NRP) added consideration of continuous positive airway pressure (CPAP) for spontaneously breathing infants with labored breathing or hypoxia in the delivery room (DR). The objective of this study was to determine if DR-CPAP is associated with symptomatic pneumotho...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-0756
更新日期:2019-09-01 00:00:00
abstract::Neuromuscular deficits have been described in 47,XXY and 47,XYY boys, but gross and fine motor development of girls with sex chromosome aneuploidy has not been extensively studied. Twenty-one propositae 8 to 19 years of age, identified through newborn screening to be 45,X, 47,XXX, or 45,X mosaic, and 11 control girls ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Adolescent men who have sex with men (AMSM) have a high rate of HIV diagnoses. An estimated 14.5% of HIV infections in the United States are undiagnosed; but among 13- to 24-year-olds, the rate is 51.4%. We describe HIV testing rates and identifies salient individual, family, school, and health care influenc...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-2322
更新日期:2020-03-01 00:00:00
abstract::Metoclopramide treatment has been shown to augment milk production by stimulating prolactin secretion in women in whom lactational insufficiency develops after a full-term pregnancy. The effect of metoclopramide therapy in 23 women who were delivered of premature infants (birth weight 1,314 +/- 115 g, gestational age ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract::Objective. To determine the safety and efficacy of prophylaxis with palivizumab in reducing the incidence of hospitalization because of respiratory syncytial virus (RSV) infection in high-risk infants. Methods. A randomized, double-blind, placebo-controlled trial was conducted at 139 centers in the United States, the ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:We describe patient characteristics and postoperative morbidity and mortality rates for patients with Down syndrome undergoing congenital heart disease surgery. METHODS:This retrospective cohort study used the Society of Thoracic Surgeons Congenital Heart Surgery Database to compare patient characteristics a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-3245
更新日期:2010-08-01 00:00:00
abstract::Inhaled corticosteroids have become an important therapeutic option in the treatment of childhood asthma. The preparations currently available for pediatric use (beclomethasone dipropionate and triamcinolone acetonide) do not, in general, cause significant hypothalamic-pituitary-adrenal axis suppression and physical s...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract::In 1992, the Committee on Infectious Diseases and Committee on Fetus and Newborn of the American Academy of Pediatrics provided guidelines for prevention of early-onset group B streptococcal (GBS) disease through intrapartum chemoprophylaxis of selected maternal GBS carriers. The guidelines were based on demonstrated ...
journal_title:Pediatrics
pub_type: 指南,杂志文章,实务指引
doi:10.1542/peds.99.3.489
更新日期:1997-03-01 00:00:00
abstract::The American Academy of Pediatrics endorses and accepts as its policy the position on bed sharing as articulated below by a panel of experts convened by the National Institute of Child Health and Human Development (NICHD). The Panel attended a conference sponsored by the NICHD entitled "Infant Sleep Environment and SI...
journal_title:Pediatrics
pub_type: 指南,杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract::This article provides background information on acoustic impedance testing and illustrates utilization of test results in pediatric clinical practice. Acoustic impedance measurement devices are presently being used successfully by hearing screening programs and by otorhinolaryngologists in clinical and hospital setti...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00