Abstract：
OBJECTIVE:Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis that affects children mainly in temperate areas, with exacerbations in spring and summer. Eyelashes provide natural protection for the eyes from sunshine, wind, and foreign bodies. These factors induce a worsening of signs and symptoms in VKC, whereas mechanical protection of the eyes produces relief. The aim of this study was to evaluate eyelash length in a large series of VKC patients and in age- and gender-matched healthy subjects. METHODS:Upper eyelash length was measured in 93 VKC patients (mean age: 8.7 years; range: 4-18 years) with a digital caliper. History, clinical form, type of presentation, degree of severity, and drug therapy were evaluated. Skin tests and serum-specific immunoglobulin E for common allergens, serum-total immunoglobulin E, peripheral blood eosinophil counts, and serum eosinophil cationic protein were determined. Two age- and gender-matched control subjects for each VKC patient underwent the same eyelash measurement. RESULTS:The upper eyelashes were significantly longer in VKC patients than in control subjects (mean +/- SD: 8.9 +/- 1.17 mm vs 7.9 +/- 1.07 mm). In healthy subjects, a negative correlation was found between eyelash length and age. With multivariate analysis, unlike control subjects, the eyelash length in VKC patients did not correlate with age, was positively correlated with the degree of severity of VKC, and was negatively correlated with the use of topical cyclosporine. CONCLUSIONS:Patients with VKC had longer eyelashes than healthy matched subjects. The ocular inflammation, by unknown chemical mediators, was likely responsible for the excessive eyelash growth. The finding may represent a defensive mechanism against physical agents that might have a crucial role in the etiopathogenesis of this disease.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Pucci N,Novembre E,Lombardi E,Massai C,Bernardini R,Caputo R,Campa L,de Libero C,Vierucci Adoi
10.1542/peds.2004-1555subject
Has Abstractpub_date
2005-01-01 00:00:00pages
e86-91issue
1eissn
0031-4005issn
1098-4275pii
115/1/e86journal_volume
115pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract：:Young patients and their parents often are unsure about what represents normal menstrual patterns, and clinicians also may be unsure about normal ranges for menstrual cycle length and amount and duration of flow through adolescence. It is important to be able to educate young patients and their parents regarding what ...
journal_title：Pediatrics
pub_type： 杂志文章,评审
doi：10.1542/peds.2006-2481
更新日期：2006-11-01 00:00:00
abstract：:Rising global temperatures are causing major physical, chemical, and ecological changes in the planet. There is wide consensus among scientific organizations and climatologists that these broad effects, known as "climate change," are the result of contemporary human activity. Climate change poses threats to human heal...
journal_title：Pediatrics
pub_type： 指南,杂志文章
doi：10.1542/peds.2015-3232
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:To describe the impact of a community bicycle helmet campaign on helmet use and the incidence of bicycle-related head injuries. SETTING:Metropolitan community and a large health maintenance organization. INTERVENTIONS:Communitywide bicycle helmet campaign. OUTCOMES:Rate of observed bicycle helmet use in th...
journal_title：Pediatrics
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:Pneumatic otoscopy was performed on 81 healthy full-term babies during the first 72 hours of life and at routine well-baby follow-up visits. Only 14 of 115 (12%) of the eardrums visualized during the first three days of life moved briskly to insufflation as compared with 29 of 65 (44%) and 50 of 71 (71%) by 3 weeks an...
journal_title：Pediatrics
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：:A review of hospital admissions of patients with status asthmaticus at the Childrens Hospital of Los Angeles showed a marked increase in admissions in recent years. Asthma mortality did not increase. Patients tended to be young, boys, and black as compared with patients admitted to a general hospital. Interviews with ...
journal_title：Pediatrics
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:Primary type V hyperlipoproteinemia was identified in two preadolescent children. The propositus (kindred N) was a 10-year-old girl with severely creamy plasma, lipemia retinalis, hypertriglyceridemia (triglyceridelevel, 6,800 mg/100 ml), and ypercholesterolemia (cholesterol level, 490 mg/100 ml). Her parents and an 8...
journal_title：Pediatrics
pub_type： 杂志文章
doi：
更新日期：1977-04-01 00:00:00
abstract：:All physicians who care for children require a knowledge of normal growth and development in order to detect and interpret abnormalities. Yet traditional instruction tends to focus on the ill child and rarely provides students the opportunity to follow up the cases of healthy children over a prolonged period of time. ...
journal_title：Pediatrics
pub_type： 杂志文章
doi：
更新日期：1978-11-01 00:00:00
abstract：BACKGROUND:Infants awaiting heart transplantation for congenital heart disease frequently require prostaglandin E1 (PGE1) infusion for prolonged periods. As a result, complications of prolonged PGE1 infusion, such as cortical hyperostosis, are being encountered more commonly. OBJECTIVE:To determine the incidence and s...
journal_title：Pediatrics
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:This clinical report defines common terms of use and provides information on current practice, research, and limitations of assistive technology that can be used in systems for communication. The assessment process to determine the best devices for use with a particular child (ie, the best fit of a device) is also rev...
journal_title：Pediatrics
pub_type： 杂志文章,实务指引
doi：10.1542/peds.2008-0695
更新日期：2008-06-01 00:00:00
abstract：:The current status of nursery routines of prophylaxis against ophthalmia neonatorum were surveyed by mail questionnaire to 100 leading maternity hospitals. More than 20% of the respondents were not using silver nitrate, mainly because of chemical conjunctivitis. The clinical significance and incidence of chemical conj...
journal_title：Pediatrics
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
abstract：OBJECTIVE:The goal was to examine the relationships between management after confirmation, family participation, and speech and language outcomes in the same group of children with permanent childhood hearing impairment. METHODS:Speech, oral language, and nonverbal abilities, expressed as z scores and adjusted in a re...
journal_title：Pediatrics
pub_type： 杂志文章
doi：10.1542/peds.2006-2116
更新日期：2007-09-01 00:00:00
abstract：:All very low-birth-weight infants live-born to residents of an urban southern Ontario county were studied before (1964 to 1969) and after (1973 to 1977) the introduction of neonatal intensive care. Mortality at hospital discharge decreased from 89.4% to 77.6% among infants whose birth weights were 500 to 999 gm and fr...
journal_title：Pediatrics
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
abstract：:Behavioral state, heart rate, and respiration were monitored during heelstick procedures in samples of healthy, term neonates (N = 48) and preterm neonates treated in minimal care (N = 48) and intensive care (N = 48) nurseries. The treated infants who were given pacifiers spent significantly less time fussing and cryi...
journal_title：Pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1984-12-01 00:00:00
abstract：OBJECTIVE:To assess the frequency of clinician-reported delivery of counseling for avoidance of child environmental tobacco smoke (ETS) exposure and tobacco use at periodic well-child visits and at illness visits for asthma and otitis media (OM). METHODS:Combined data from the National Ambulatory Medical Care Survey a...
journal_title：Pediatrics
pub_type： 杂志文章
doi：10.1542/peds.111.2.e162
更新日期：2003-02-01 00:00:00
abstract：:Since the American Academy of Pediatrics published a statement titled "Infection Control in Physicians' Offices" (Pediatrics. 2000;105[6]:1361-1369), there have been significant changes that prompted this updated statement. Infection prevention and control is an integral part of pediatric practice in ambulatory medica...
journal_title：Pediatrics
pub_type： 杂志文章,实务指引
doi：10.1542/peds.2007-1734
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:β blockers are widely used in the treatment of hypertensive disorders during pregnancy. These medications cross the placenta and may cause physiologic changes in neonates exposed in utero. We sought to define the risks of neonatal hypoglycemia and bradycardia associated with maternal exposure ...
journal_title：Pediatrics
pub_type： 杂志文章
doi：10.1542/peds.2016-0731
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The Value in Inpatient Pediatrics Network sponsored the Improving Care in Community Acquired Pneumonia collaborative with the goal of increasing evidence-based management of children hospitalized with community acquired pneumonia (CAP). Project aims included: increasing use of narrow-spectrum ...
journal_title：Pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1542/peds.2016-1411
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:This study evaluated the impact of changes in perinatal management on neurodevelopmental impairment (NDI) at 18 to 22 months' corrected age of low gestation (22-26 weeks) and higher gestation (27-32 weeks) extremely low birth weight infants (401-1000 g birth weight) who were cared for in the National Institut...
journal_title：Pediatrics
pub_type： 杂志文章
doi：10.1542/peds.2004-2247
更新日期：2005-09-01 00:00:00
abstract：:This report describes an adolescent boy who has Tourette's syndrome and developed a subtle but significant increase in vocal tics after an 8-month respite. The increase in vocal tics was associated with an acute increase in psychological stressors and resulted in recurrent air swallowing, which, in turn, caused abdomi...
journal_title：Pediatrics
pub_type： 杂志文章
doi：10.1542/peds.2005-2914
更新日期：2006-06-01 00:00:00
abstract：:Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with a worldwide incidence of approximately 1 per 2500 to 3000 individuals. Caused by a germ-line-inactivating mutation in the NF1 gene on chromosome 17, the disease is associated with increased morbidity and mortality. In the past several years, signif...
journal_title：Pediatrics
pub_type： 杂志文章,评审
doi：10.1542/peds.2007-3204
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:To determine whether medically unexplained recurrent abdominal pain (RAP) in childhood predicts abdominal pain, irritable bowel syndrome (IBS), other somatic complaints, and psychiatric symptoms and disorders in young adulthood. METHODS:A sample of 28 young adults evaluated for RAP between the ages of 6 and ...
journal_title：Pediatrics
pub_type： 杂志文章
doi：10.1542/peds.108.1.e1
更新日期：2001-07-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to create and validate new intrauterine weight, length, and head circumference growth curves using a contemporary, large, racially diverse US sample and compare with the Lubchenco curves. METHODS:Data on 391 681 infants (Pediatrix Medical Group) aged 22 to 42 weeks at birth fr...
journal_title：Pediatrics
pub_type： 杂志文章
doi：10.1542/peds.2009-0913
更新日期：2010-02-01 00:00:00
abstract：:Since the outbreaks of neonatal necrotizing enterocolitis occurring in maternity hospitals of Paris and suburbs in 1979-1980, it has been possible to examine by light and electron microscopy gut specimens from ten newborns with this illness. Coronavirus-like particles, enclosed in intracytoplasmic vesicles of damaged ...
journal_title：Pediatrics
pub_type： 杂志文章
doi：
更新日期：1984-02-01 00:00:00
abstract：:Epigenetics, the study of functionally relevant chemical modifications to DNA that do not involve a change in the DNA nucleotide sequence, is at the interface between research and clinical medicine. Research on epigenetic marks, which regulate gene expression independently of the underlying genetic code, has dramatica...
journal_title：Pediatrics
pub_type： 杂志文章,评审
doi：10.1542/peds.2013-1032F
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVE:Current methods for early identification of cerebral white matter injury in the premature infant at the bedside are inadequate. This study investigated the utility of advanced spectral analysis of the neonatal electroencephalogram (EEG) in the early diagnosis of white matter injury in the premature infant. Th...
journal_title：Pediatrics
pub_type： 临床试验,杂志文章
doi：10.1542/peds.111.1.27
更新日期：2003-01-01 00:00:00
abstract：:The interests of the public and both the medical and legal professions are best served when scientifically sound and unbiased expert witness testimony is readily available in civil and criminal proceedings. As members of the medical community, patient advocates, and private citizens, pediatricians have ethical and pro...
journal_title：Pediatrics
pub_type： 杂志文章
doi：10.1542/peds.2009-1132
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVES:To determine whether adjunctive therapy with recombinant human granulocyte colony-stimulating factor (rhG-CSF) could reverse sepsis-associated neonatal neutropenia and improve neonatal survival compared with conventional therapy in a phase I/II-type trial. STUDY DESIGN:An intravenous infusion of rhG-CSF (10...
journal_title：Pediatrics
pub_type： 临床试验,杂志文章
doi：10.1542/peds.100.1.e6
更新日期：1997-07-01 00:00:00
abstract：OBJECTIVE:To identify correlates of objectively measured sedentary behavior in a diverse sample of preschool children. METHODS:A total of 331 children (51% male, 51% black) from a wide range of ethnic and socioeconomic backgrounds in greater Columbia, South Carolina, were recruited for this study. Sedentary behavior (...
journal_title：Pediatrics
pub_type： 杂志文章
doi：10.1542/peds.2011-0748
更新日期：2011-11-01 00:00:00
abstract：:Two noninvasive methods of localizing the site of urinary tract infection, urinary lactic dehydrogenase (LDH) isoenzymes and antibody coating of bacteria in the urinary sediment, have been prospectively compared with the bladder washout technique in a series of children with urinary tract infection. Fifteen children h...
journal_title：Pediatrics
pub_type： 杂志文章
doi：
更新日期：1979-11-01 00:00:00
abstract：:To distinguish spermatic cord torsion from other intrascrotal pathology, scrotal ultrasound and radionuclide scanning have been highly recommended on the basis of both clinical and experimental studies. We review the data from six patients in whom ultrasound or nuclear medicine examination was misleading. We emphasize...
journal_title：Pediatrics
pub_type： 杂志文章
doi：
更新日期：1985-12-01 00:00:00
