Intestinal lesions containing coronavirus-like particles in neonatal necrotizing enterocolitis: an ultrastructural analysis.

Abstract:

:Since the outbreaks of neonatal necrotizing enterocolitis occurring in maternity hospitals of Paris and suburbs in 1979-1980, it has been possible to examine by light and electron microscopy gut specimens from ten newborns with this illness. Coronavirus-like particles, enclosed in intracytoplasmic vesicles of damaged epithelial cells of the intestinal mucosa, were observed in the small intestine, appendix, and colon. The ultrastructural study, supported by bacteriologic findings, suggests the role of coronavirus-like particles in the appearance of the lesions. Secondary proliferation of mainly anaerobic bacteria, probably responsible for pneumatosis, may aggravate the disease.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Rousset S,Moscovici O,Lebon P,Barbet JP,Helardot P,Macé B,Bargy F,Le Tan Vinh,Chany C

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

218-24

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

73

pub_type

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