Toxicity of over-the-counter cough and cold medications.

Abstract:

:Over-the-counter (OTC) cough and cold medications are marketed widely for relief of common cold symptoms, and yet studies have failed to demonstrate a benefit of these medications for young children. In addition, OTC medications can be associated with significant morbidity and even mortality in both acute overdoses and when administered in correct doses for chronic periods of time. Physicians often do not inquire about OTC medication use, and parents (or other caregivers) often do not perceive OTCs as medications. We present 3 cases of adverse outcomes over a 13-month period-including 1 death-as a result of OTC cough and cold medication use. We explore the toxicities of OTC cough and cold medications, discuss mechanisms of dosing errors, and suggest why physicians should be more vigilant in specifically inquiring about OTCs when evaluating an ill child.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Gunn VL,Taha SH,Liebelt EL,Serwint JR

doi

10.1542/peds.108.3.e52

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

E52

issue

3

eissn

0031-4005

issn

1098-4275

journal_volume

108

pub_type

杂志文章
  • Accumulation of aluminum in a nondialyzed uremic child receiving aluminum hydroxide.

    abstract::A child with renal insufficiency was treated with the oral phosphate binder aluminum hydroxide from age 6 to 31 months. The prescribed dose of elemental aluminum varied from 31 to 108 mg/kg/d. Concurrently the patient developed vitamin D-resistant osteomalacia which failed to improve with parathyroidectomy. Encephalop...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Griswold WR,Reznik V,Mendoza SA,Trauner D,Alfrey AC

    更新日期:1983-01-01 00:00:00

  • Respiratory failure and hypercoagulability in a toddler with Lemierre's syndrome.

    abstract::A 3.5-year-old healthy boy with 4 days of fever was referred to the emergency department for respiratory distress. The physical examination was remarkable for stupor, tachycardia, tachypnea, and dyspnea. Initial blood tests showed pancytopenia. He rapidly developed torticollis. Computerized tomography of the neck reve...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2505

    authors: Schmid T,Miskin H,Schlesinger Y,Argaman Z,Kleid D

    更新日期:2005-05-01 00:00:00

  • From concept to application: the impact of a community-wide intervention to improve the delivery of preventive services to children.

    abstract:OBJECTIVE:To improve health outcomes of children, the US Maternal and Child Health Bureau has recommended more effective organization of preventive services within primary care practices and more coordination between practices and community-based agencies. However, applying these recommendations in communities is chall...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.108.3.e42

    authors: Margolis PA,Stevens R,Bordley WC,Stuart J,Harlan C,Keyes-Elstein L,Wisseh S

    更新日期:2001-09-01 00:00:00

  • Multiculturalism, chronic illness, and disability.

    abstract::To gain at least an initial understanding of the underlying beliefs and attitudes in a cross-cultural situation, we believe that the three key points discussed in this paper should prove a significant point of departure: 1. Traditional beliefs about the cause of chronic illness or disability will play a significant ro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Groce NE,Zola IK

    更新日期:1993-05-01 00:00:00

  • Children plus all nonautomobile motorized vehicles (not just all-terrain vehicles) equals injuries.

    abstract:OBJECTIVES:The goals were to describe the epidemiological features of pediatric nonautomobile motorized vehicle-related injuries sustained between 1990 and 2003 and to compare all-terrain vehicle-related injuries with other types of nonautomobile motorized vehicle-related injuries. METHODS:An analysis of nationally re...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3612

    authors: Collins CL,Smith GA,Comstock RD

    更新日期:2007-07-01 00:00:00

  • Quality of life for children with functional abdominal pain: a comparison study of patients' and parents' perceptions.

    abstract:OBJECTIVE:Children with chronic abdominal pain of nonorganic origin, termed functional abdominal pain (FAP), experience school absences and social withdrawal and report impaired physical ability. The aim of this study was to assess patients' and parents' perceptions of health-related quality of life (QoL) for children ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0114

    authors: Youssef NN,Murphy TG,Langseder AL,Rosh JR

    更新日期:2006-01-01 00:00:00

  • Lysosomal storage disorders in the newborn.

    abstract::Lysosomal storage disorders are rare inborn errors of metabolism, with a combined incidence of 1 in 1500 to 7000 live births. These relatively rare disorders are seldom considered when evaluating a sick newborn. A significant number of the >50 different lysosomal storage disorders, however, do manifest in the neonatal...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2008-0635

    authors: Staretz-Chacham O,Lang TC,LaMarca ME,Krasnewich D,Sidransky E

    更新日期:2009-04-01 00:00:00

  • The pivotal role of deep vein thrombophlebitis in the development of acute disseminated staphylococcal disease in children.

    abstract::Deep vein thrombophlebitis (DVT) and septic pulmonary emboli (PE) are rare in children. The association of DVT and acute disseminated staphylococcal disease (DSD) during childhood has not been previously reported. We report 3 children who developed a triad of DVT, septic PE, and acute osteomyelitis with Staphylococcus...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.6.e87

    authors: Gorenstein A,Gross E,Houri S,Gewirts G,Katz S

    更新日期:2000-12-01 00:00:00

  • Executive and memory function in adolescents born very preterm.

    abstract:BACKGROUND:Many preterm children display school difficulties, which may be mediated by impairment in executive function and memory. OBJECTIVE:To evaluate executive and memory function among adolescents born preterm compared with term controls at 16 years. METHODS:A total of 337 of 437 (77%) adolescents born in 1989 t...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2010-1421

    authors: Luu TM,Ment L,Allan W,Schneider K,Vohr BR

    更新日期:2011-03-01 00:00:00

  • Longitudinal Growth and Neuropsychological Functioning at Age 7 in Moderate and Late Preterms.

    abstract:OBJECTIVE:To determine the association between longitudinal growth measures (height, weight, head circumference, and extent of catch-up growth) and neuropsychological functioning at 7 years in moderately and late preterm children. METHODS:This study was part of a prospective, community-based cohort study. Data on grow...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-3638

    authors: Dotinga BM,Eshuis MS,Bocca-Tjeertes IF,Kerstjens JM,Van Braeckel KN,Reijneveld SA,Bos AF

    更新日期:2016-10-01 00:00:00

  • Detection of Kingella kingae osteoarticular infections in children by oropharyngeal swab PCR.

    abstract:OBJECTIVE:The purpose of this study was to investigate if oropharyngeal swab polymerase chain reaction (PCR) could predict osteoarticular infection (OAI) due to Kingella kingae in young children. METHODS:One hundred twenty-three consecutive children aged 6 to 48 months presenting with atraumatic osteoarticular complai...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0810

    authors: Ceroni D,Dubois-Ferriere V,Cherkaoui A,Gesuele R,Combescure C,Lamah L,Manzano S,Hibbs J,Schrenzel J

    更新日期:2013-01-01 00:00:00

  • Do young boys with fragile X syndrome have macroorchidism?

    abstract:OBJECTIVE:Macroorchidism is one of the most well-described clinical characteristics of men with fragile X syndrome, but little information has been available regarding macroorchidism in prepubertal boys with fragile X. The purpose of this study was to learn whether macroorchidism is a characteristic of fragile X syndro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lachiewicz AM,Dawson DV

    更新日期:1994-06-01 00:00:00

  • The effect of a community intervention trial on parental knowledge and awareness of antibiotic resistance and appropriate antibiotic use in children.

    abstract:BACKGROUND:Overuse of antibiotics for children's upper respiratory infections is widespread and contributes to the emergence of antibiotic-resistant bacteria. OBJECTIVE:To assess changes in knowledge and awareness regarding antibiotic resistance and appropriate antibiotic use after community-wide educational intervent...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.1.e6

    authors: Trepka MJ,Belongia EA,Chyou PH,Davis JP,Schwartz B

    更新日期:2001-01-01 00:00:00

  • Media literacy education for elementary school substance use prevention: study of media detective.

    abstract:OBJECTIVES:Media Detective is a 10-lesson elementary school substance use prevention program developed on the basis of the message interpretation processing model designed to increase children's critical thinking skills about media messages and reduce intent to use tobacco and alcohol products. The purpose of this stud...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2010-0068

    authors: Kupersmidt JB,Scull TM,Austin EW

    更新日期:2010-09-01 00:00:00

  • The Use of Pyridostigmine in a Child With Chronic Intestinal Pseudo-Obstruction.

    abstract::Chronic intestinal pseudo-obstruction is a rare disorder that affects the motility of the gastrointestinal tract. It results in acute or subacute intestinal obstruction symptoms in the absence of mechanical lesion. It can lead to intestinal failure in children with significant strain on nutrition, growth, and developm...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-0007

    authors: Choudhury A,Rahyead A,Kammermeier J,Mutalib M

    更新日期:2018-04-01 00:00:00

  • Practice of feeding premasticated food to infants: a potential risk factor for HIV transmission.

    abstract:OBJECTIVES:Although some caregivers are known to premasticate food for infants, usually during the weaning period, HIV transmission has not been linked to this practice. We describe 3 cases of HIV transmission in the United States possibly related to this practice. PATIENTS AND METHODS:Three cases of HIV infection wer...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-3614

    authors: Gaur AH,Dominguez KL,Kalish ML,Rivera-Hernandez D,Donohoe M,Brooks JT,Mitchell CD

    更新日期:2009-08-01 00:00:00

  • Usefulness of the serum electrolyte panel in the management of pediatric dehydration treated with intravenously administered fluids.

    abstract:BACKGROUND:The serum electrolyte panel (SEP) is a frequently ordered laboratory test, but it has unproven usefulness in the treatment of dehydrated pediatric patients. Our study purpose was to evaluate the usefulness of routinely ordering a SEP in the treatment of dehydrated pediatric patients receiving intravenous flu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-0457

    authors: Wathen JE,MacKenzie T,Bothner JP

    更新日期:2004-11-01 00:00:00

  • Delaying second births among adolescent mothers: a randomized, controlled trial of a home-based mentoring program.

    abstract:CONTEXT:Rates of rapid second births among low-income black adolescent mothers range from 20% to 50%. Most efforts to prevent rapid second births have been unsuccessful. OBJECTIVES:There were 4 objectives: (1) to examine whether a home-based mentoring intervention was effective in preventing second births within 2 yea...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2005-2318

    authors: Black MM,Bentley ME,Papas MA,Oberlander S,Teti LO,McNary S,Le K,O'Connell M

    更新日期:2006-10-01 00:00:00

  • Circulating pro- and counterinflammatory cytokine levels and severity in necrotizing enterocolitis.

    abstract:OBJECTIVES:To evaluate the relationship between the severity of necrotizing enterocolitis (NEC) and circulating concentrations of proinflammatory cytokines interleukin (IL)-1beta and IL-8 and counterinflammatory cytokines IL-1 receptor antagonist (IL-1ra) and IL-10. These cytokines have been associated with bowel injur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.4.766

    authors: Edelson MB,Bagwell CE,Rozycki HJ

    更新日期:1999-04-01 00:00:00

  • Not everything in the maxillary sinus is sinusitis: a case of a dentigerous cyst.

    abstract::A 4-year-old girl presented to a medical clinic with a painless right facial swelling. The treating physician ordered a radiograph of the sinuses and received a report of "maxillary sinusitis." After appropriate antibiotic treatment, the facial swelling increased, and the mother took the child to her community pediatr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1940

    authors: Haber R

    更新日期:2008-01-01 00:00:00

  • Vitamin K1 (phylloquinone) and vitamin K2 (menaquinone) status in newborns during the first week of life.

    abstract::Since 1961 the Committee on Nutrition of the American Academy of Pediatrics has recommended that prophylactic vitamin K be administered parenterally to all newborn infants, although the exact requirement for vitamin K in the newborn infant is unknown. There is little information about the vitamin K1 (phylloquinone, pr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Greer FR,Mummah-Schendel LL,Marshall S,Suttie JW

    更新日期:1988-01-01 00:00:00

  • Inattention, hyperactivity, and symptoms of sleep-disordered breathing.

    abstract:OBJECTIVE:Inattention and hyperactivity are frequent among children with sleep-disordered breathing (SDB) and often improve when SDB is treated. However, the frequency of SDB symptoms among inattentive and hyperactive children has received little study. DESIGN:Cross-sectional survey. SETTING:Two university-affiliated...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.109.3.449

    authors: Chervin RD,Archbold KH,Dillon JE,Panahi P,Pituch KJ,Dahl RE,Guilleminault C

    更新日期:2002-03-01 00:00:00

  • Sustaining and spreading the reduction of adverse drug events in a multicenter collaborative.

    abstract:OBJECTIVES:Adverse drug events (ADEs) occur more frequently in pediatric patients than adults. ADEs frequently cause serious harm to children and increase the cost of care. The purpose of this study was to decrease ADEs by targeting the entire medication-delivery system for all high-risk medications. METHODS:Thirteen ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2010-3772

    authors: Tham E,Calmes HM,Poppy A,Eliades AB,Schlafly SM,Namtu KC,Smith DM,Vitaska MC,McConnell C,Potts AL,Jastrzembski J,Logsdon TR,Hall M,Takata GS

    更新日期:2011-08-01 00:00:00

  • Cardiovascular risk factors from birth to 7 years of age: the Bogalusa Heart Study. Dietary intakes.

    abstract::Dietary patterns and racial differences in nutrient intake were observed in children 6 months to 4 years of age in the Bogalusa Heart Study. Even in this sample of young children, the composition of the intakes of the majority of children was not compatible with prudent recommendations of less than 35% and 10% of ener...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Nicklas TA,Farris RP,Major C,Frank GC,Webber LS,Cresanta JL,Berenson GS

    更新日期:1987-11-01 00:00:00

  • Safety of the 9-Valent Human Papillomavirus Vaccine.

    abstract:BACKGROUND:The 9-valent human papillomavirus vaccine (9vHPV) was approved for females and males aged 9 to 26 years in 2014. We analyzed postlicensure surveillance reports to the Vaccine Adverse Event Reporting System (VAERS). METHODS:We searched VAERS data for US reports of adverse events (AEs) after 9vHPV from Decemb...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-1791

    authors: Shimabukuro TT,Su JR,Marquez PL,Mba-Jonas A,Arana JE,Cano MV

    更新日期:2019-12-01 00:00:00

  • Neurodevelopmental Outcomes in Infants With Birth Weight ≤500 g at 3 Years of Age.

    abstract:OBJECTIVES:To determine neurodevelopmental outcomes at 3 years of age in children born with a birth weight (BW) of ≤500 g. METHODS:Infants who were born with a BW of ≤500 g from 2003 to 2012 in the Neonatal Research Network of Japan and survived to discharge from the NICU were eligible in this study. The study populat...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-4286

    authors: Inoue H,Ochiai M,Sakai Y,Yasuoka K,Tanaka K,Ichiyama M,Kurata H,Fujiyoshi J,Matsushita Y,Honjo S,Nonaka K,Taguchi T,Kato K,Ohga S,Neonatal Research Network of Japan.

    更新日期:2018-12-01 00:00:00

  • Maternal mosaicism confounds the neonatal diagnosis of type 1 Timothy syndrome.

    abstract::The presence of 2 distinct populations of somatic or germline cells within a single individual harboring different genotypes is termed mosaicism. Recent reports suggest that parental mosaicism is involved in the heritability of type 1 Timothy syndrome (TS1), an extremely rare and life-threatening multisystem disorder ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-2941

    authors: Dufendach KA,Giudicessi JR,Boczek NJ,Ackerman MJ

    更新日期:2013-06-01 00:00:00

  • The use of a crystalline amino acid mixture for parenteral nutrition in low-birth-weight infants.

    abstract::Thirty-six preterm, sick, low-birth-weight neonates were given either total or partial parenteral nutrition. The patients were divided into three groups according to their birth weights: group A -less than 1,000 gm, 12 patients: group B--between 1,000 and 1,500 gm, 15 patients: group C--more than 1,500 gm, 9 patients....

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Meng HC,Stahlman MT,Otten A,Dolanski EA,Caldwell MD,O'Neill JA

    更新日期:1977-05-01 00:00:00

  • Successful use of plasma exchange for profound hemolysis in a child with loxoscelism.

    abstract::We describe a 6-year-old boy who presented with massive hemolysis, shock, disseminated intravascular coagulopathy, and acute renal failure after loxosceles envenomation. In this patient, plasma exchange therapy (PEX) successfully cleared the plasma from an initial hemolytic index of 2000 (equivalent to 2 g/dL hemoglob...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-3338

    authors: Said A,Hmiel P,Goldsmith M,Dietzen D,Hartman ME

    更新日期:2014-11-01 00:00:00

  • HLA antigens in Kawasaki disease.

    abstract::Two hundred five patients with Kawasaki disease and 500 normal controls were HLA-typed, using a standard microcytotoxicity test of tissue typing. HLA-BW22 was more common in patients with Kawasaki disease than in normal controls (25.4% instead of 11.8%, corrected P less than .0005). Among subtypes of HLA-BW22 antigen,...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kato S,Kimura M,Tsuji K,Kusakawa S,Asai T,Juji T,Kawasaki T

    更新日期:1978-02-01 00:00:00