HLA antigens in Kawasaki disease.

Abstract:

:Two hundred five patients with Kawasaki disease and 500 normal controls were HLA-typed, using a standard microcytotoxicity test of tissue typing. HLA-BW22 was more common in patients with Kawasaki disease than in normal controls (25.4% instead of 11.8%, corrected P less than .0005). Among subtypes of HLA-BW22 antigen, Kawasaki disease was associated with HLA-BW22J2, which was found specifically in Japanese and not in Caucasians. These facts may suggest that there is a gene controlling the susceptibility to Kawasaki disease and linked with a Japanese-specific HLA antigen.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Kato S,Kimura M,Tsuji K,Kusakawa S,Asai T,Juji T,Kawasaki T

subject

Has Abstract

pub_date

1978-02-01 00:00:00

pages

252-5

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

61

pub_type

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