Side effects of methylphenidate in children with attention deficit hyperactivity disorder: a systemic, placebo-controlled evaluation.

Abstract:

:The frequency and severity of 17 side effects presumably associated with stimulant medication were assessed during a rigorous, triple-blind, placebo-controlled, crossover evaluation of methylphenidate, 0.3 and 0.5 mg/kg twice a day, in 83 children with attention deficit hyperactivity disorder. Side effects were rated by parents and teachers at the end of each weekly drug condition. Three children (3.6%) had side effects that were sufficiently serious to warrant immediate discontinuation of medication. Parent ratings indicated that only the side effects of decreased appetite, insomnia, stomachaches, and headaches increased significantly in frequency and severity during the two active medication doses as compared with the placebo condition. Fewer than half of the children experienced these side effects and among those who did, ratings of mean severity remained in the mild range. Teacher ratings showed little change over drug conditions, except on ratings of staring, sadness, and anxiety, which declined with increasing dose of medication. Parent ratings indicated that only the side effects of decreased appetite, insomnia, stomachaches, and headaches increased significantly in frequency and severity during the two active medication doses as compared with the placebo condition. Fewer than half of the children experienced these side effects and among those who did, ratings of mean severity remained in the mild range. Teacher ratings showed little change over drug conditions, except on ratings of staring, sadness, and anxiety, which declined with increasing dose of medication. Surprisingly, a high frequency of these behavior side effects were reported during the placebo condition. Stimulant medication within this therapeutic range, therefore, results in few, generally mild side effects.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Pediatrics

journal_title

Pediatrics

authors

Barkley RA,McMurray MB,Edelbrock CS,Robbins K

subject

Has Abstract

pub_date

1990-08-01 00:00:00

pages

184-92

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

86

pub_type

临床试验,杂志文章,随机对照试验
  • Children plus all nonautomobile motorized vehicles (not just all-terrain vehicles) equals injuries.

    abstract:OBJECTIVES:The goals were to describe the epidemiological features of pediatric nonautomobile motorized vehicle-related injuries sustained between 1990 and 2003 and to compare all-terrain vehicle-related injuries with other types of nonautomobile motorized vehicle-related injuries. METHODS:An analysis of nationally re...

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    pub_type: 杂志文章

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    authors: Collins CL,Smith GA,Comstock RD

    更新日期:2007-07-01 00:00:00

  • Accuracy and precision of low-dose insulin administration.

    abstract:OBJECTIVE:To determine the lowest dose of concentrated (U100) insulin that can be reproducibly delivered. METHODS:A telephone survey was used to determine current practices in major pediatric hospitals regarding the administration of low doses of concentrated insulin. A sensitive gravitometric technique was used to de...

    journal_title:Pediatrics

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    doi:

    authors: Casella SJ,Mongilio MK,Plotnick LP,Hesterberg MP,Long CA

    更新日期:1993-06-01 00:00:00

  • Heated, humidified high-flow nasal cannula therapy: yet another way to deliver continuous positive airway pressure?

    abstract:OBJECTIVE:The goal was to estimate the level of delivered continuous positive airway pressure by measuring oral cavity pressure with the mouth closed in infants of various weights and ages treated with heated, humidified high-flow nasal cannula at flow rates of 1-5 L/minute. We hypothesized that clinically relevant lev...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0957

    authors: Kubicka ZJ,Limauro J,Darnall RA

    更新日期:2008-01-01 00:00:00

  • Enhancing developmentally oriented primary care: an Illinois initiative to increase developmental screening in medical homes.

    abstract::In 2005, the Enhancing Developmentally Oriented Primary Care (EDOPC) project of the Illinois chapter of the American Academy of Pediatrics and the Illinois Department of Healthcare and Family Services began a project to improve the delivery and financing of preventive health and developmental services for children in ...

    journal_title:Pediatrics

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    更新日期:2010-12-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1999-09-01 00:00:00

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    abstract:OBJECTIVE:Hepatitis B vaccine is recommended for all infants, and the series may be started during the delivery admission. For infants who are born either to women who are positive for hepatitis B surface antigen (HBsAg) or to women whose HBsAg status is unknown, vaccination should be started within 12 hours of birth t...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.111.6.e645

    authors: Biroscak BJ,Fiore AE,Fasano N,Fineis P,Collins MP,Stoltman G

    更新日期:2003-06-01 00:00:00

  • Thrombotic storm in a teenager with previously undiagnosed ulcerative colitis.

    abstract::Venous thrombosis can complicate inflammatory bowel diseases, both in adult and pediatric patients, and a few adult cases of thrombotic storm, ie, thrombosis at multiple sites occurring over a period of a few days to a few weeks, have been described. However, venous thrombosis as the first manifestation of an inflamma...

    journal_title:Pediatrics

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    doi:10.1542/peds.2012-2365

    authors: Maggi U,Rossi G,Avesani EC,Artoni A,Caprioli F,Napolitano L,Martinelli I

    更新日期:2013-04-01 00:00:00

  • Four patterns of response to inhaled nitric oxide for persistent pulmonary hypertension of the newborn.

    abstract:OBJECTIVE:To determine the clinical role of inhaled nitric oxide (iNO) in the treatment of persistent pulmonary hypertension of the newborn (PPHN). STUDY DESIGN:Prospective open observational clinical study. SETTING:A regional cardiac and pediatric intensive care unit. METHODS:Twenty-five consecutive near-term neona...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

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    更新日期:1996-10-01 00:00:00

  • Pediatric pain after ambulatory surgery: where's the medication?

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-3529

    authors: Fortier MA,MacLaren JE,Martin SR,Perret-Karimi D,Kain ZN

    更新日期:2009-10-01 00:00:00

  • The epidemiology and clinical features of Kawasaki disease in Australia.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-2936

    authors: Saundankar J,Yim D,Itotoh B,Payne R,Maslin K,Jape G,Ramsay J,Kothari D,Cheng A,Burgner D

    更新日期:2014-04-01 00:00:00

  • Common bile duct obstruction due to an intraluminal mass of candidiasis in a previously healthy child.

    abstract::A 3 6/12-year-old previously healthy girl had intermittent attacks of abdominal pain following a blunt abdominal trauma. At admission to the hospital, she had jaundice and hepatomegaly. Results of laboratory tests indicated an obstructive pattern, and ultrasonography revealed an intraluminal mass in the distal common ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Carstensen H,Nilsson KO,Nettelblad SC,Cederlund CG,Hildell J

    更新日期:1986-06-01 00:00:00

  • Hospitalizations of newborns with folate-sensitive birth defects before and after fortification of foods with folic acid.

    abstract:CONTEXT:The prevalence of neural tube defects is reduced in populations of women who receive folic acid supplementation. Since 1998, grain products in the United States have been fortified with folic acid. Fortification may have additional benefits by reducing the national prevalence of newborn hospitalizations for oth...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2784

    authors: Robbins JM,Tilford JM,Bird TM,Cleves MA,Reading JA,Hobbs CA

    更新日期:2006-09-01 00:00:00

  • A successful city-wide smoke detector giveaway program.

    abstract::Each year, 5,000 Americans die and 300,000 are hospitalized as a result of 2.8 million residential fires. Almost all house fires allow time for safe exit if an early warning is given. Smoke detectors are an effective, reliable, and inexpensive method of providing such warning. After an upsurge of deaths related to fir...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gorman RL,Charney E,Holtzman NA,Roberts KB

    更新日期:1985-01-01 00:00:00

  • Kwashiorkor in the United States.

    abstract::Kwashiorkor, with typical edema and skin rash is occasionally seen in affluent countries as a result of severe protein restriction. Treatment is with a lactose-free formula after rehydration and sometimes after a period of parenteral alimentation. Complications of therapy included: diarrhea, congestive heart failure, ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Chase HP,Kumar V,Caldwell RT,O'Brien D

    更新日期:1980-12-01 00:00:00

  • Adverse reactions and serologic response to a booster dose of acellular pertussis vaccine in children immunized with acellular or whole-cell vaccine as infants.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Blennow M,Granström M

    更新日期:1989-07-01 00:00:00

  • Administration of ondansetron is associated with lethal outcome.

    abstract::We report here the case of a child with a known muscular abnormality and susceptibility to malignant hyperthermia who abruptly died after receiving a therapeutic dose of ondansetron. Also, we discuss the pharmacodynamic relationship of ondansetron to malignant hyperthermia in a susceptible host. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2795

    authors: Gener B,Burns JM,Griffin S,Boyer EW

    更新日期:2010-06-01 00:00:00

  • Identifying children with chronic arthritis based on chief complaints: absence of predictive value for musculoskeletal pain as an indicator of rheumatic disease in children.

    abstract:OBJECTIVE:To examine complaints for which children were referred to a pediatric rheumatology service and to determine whether there are specific complaints that are more likely to indicate the presence of chronic arthritis or chronic, systemic inflammatory disease. METHODS:A retrospective chart review of 414 children ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.2.354

    authors: McGhee JL,Burks FN,Sheckels JL,Jarvis JN

    更新日期:2002-08-01 00:00:00

  • Energy dose for ventricular defibrillation of children.

    abstract::Transthoracic direct current shock is the recommended treatment for ventricular fibrillation in children as in adults. To determine the appropriate energy dose, data were collected from 71 defibrillation attempts in 27 children. Sixty-three of the 71 shocks (89%) were successful in terminating fibrillation. Fifty-seve...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gutgesell HP,Tacker WA,Geddes LA,Davis S,Lie JT,McNamara DG

    更新日期:1976-12-01 00:00:00

  • Factors influencing the epidemiology of Helicobacter pylori infection in children.

    abstract::The epidemiology of Helicobacter pylori infection was studied in 245 healthy children (between 3 and 20 years of age) who presented for day surgery at Arkansas Children's Hospital. H pylori infection was identified serologically using an enzyme-linked immunosorbent assay to detect the presence of IgG against the high ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Fiedorek SC,Malaty HM,Evans DL,Pumphrey CL,Casteel HB,Evans DJ Jr,Graham DY

    更新日期:1991-09-01 00:00:00

  • Participation in boxing by children, adolescents, and young adults. American Academy of Pediatrics Committee on Sports Medicine and Fitness.

    abstract::Because boxing may result in serious brain and eye injuries, the American Academy of Pediatrics opposes this sport. This policy statement summarizes the reasons. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

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    更新日期:1997-01-01 00:00:00

  • Previsit Screening for Parental Vaccine Hesitancy: A Cluster Randomized Trial.

    abstract:OBJECTIVE:To evaluate the effect of vaccine hesitancy screening on childhood vaccine uptake. METHODS:We conducted a cluster randomized controlled trial in pediatric primary care clinics in Washington state. Vaccine-hesitant parents (VHPs) with a healthy newborn receiving health supervision at participating clinics wer...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

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    authors: Opel DJ,Henrikson N,Lepere K,Hawkes R,Zhou C,Dunn J,Taylor JA

    更新日期:2019-11-01 00:00:00

  • Coarctation of the abdominal aorta and renal artery stenosis related to an umbilical artery catheter placement in a neonate.

    abstract::Umbilical artery catheters have been associated with thrombotic complications, such as partial or complete occlusion in the aorta, the renal arteries, and other blood vessels. There have been few reports of the long-term consequences of either symptomatic or asymptomatic thrombi. We report a patient, now 22 years of a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.3.e36

    authors: Adelman RD,Morrell RE

    更新日期:2000-09-01 00:00:00

  • Systematic evidence review of newborn screening and treatment of severe combined immunodeficiency.

    abstract:CONTEXT:Severe combined immunodeficiency (SCID) is a group of disorders that leads to early childhood death as a result of severe infections. Recent research has addressed potential newborn screening for SCID. OBJECTIVE:To conduct a systematic review of the evidence for newborn screening for SCID, including test chara...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2009-1567

    authors: Lipstein EA,Vorono S,Browning MF,Green NS,Kemper AR,Knapp AA,Prosser LA,Perrin JM

    更新日期:2010-05-01 00:00:00

  • Low-income parents' views on the redesign of well-child care.

    abstract:OBJECTIVE:To examine the perspectives of low-income parents on redesigning well-child care (WCC) for children aged 0 to 3 years, focusing on possible changes in 3 major domains: providers, locations, and formats. METHODS:Eight focus groups (4 English and 4 Spanish) were conducted with 56 parents of children aged 6 mon...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2608

    authors: Coker TR,Chung PJ,Cowgill BO,Chen L,Rodriguez MA

    更新日期:2009-07-01 00:00:00

  • Hyperammonemia associated with perinatal asphyxia.

    abstract::Twelve infants with severe perinatal asphyxia were found to have elevated blood ammonia levels (302 to 960 microgram/100 ml). In the seven survivors, hyperammonemia was associated with CNS irritability, hyperthermia, hypertension, and wide neonatal heart rate oscillations. Follow-up examinations revealed severe neurol...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Goldberg RN,Cabal LA,Sinatra FR,Plajstek CE,Hodgman JE

    更新日期:1979-09-01 00:00:00

  • Improvement of short- and long-term outcomes for very low birth weight infants: Edmonton NIDCAP trial.

    abstract:OBJECTIVE:Our objective was to determine the impact of Newborn Individualized Developmental Care and Assessment Program (NIDCAP)-based care on length of stay of very low birth weight (VLBW) infants. Secondary outcome measures were days of ventilation, incidence of chronic lung disease, and 18-month neurodevelopmental o...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2008-3808

    authors: Peters KL,Rosychuk RJ,Hendson L,Coté JJ,McPherson C,Tyebkhan JM

    更新日期:2009-10-01 00:00:00

  • Transition to adulthood: the important role of the pediatrician.

    abstract::This article, written by a parent of 2 youths with special health care needs and a pediatrician, builds on the Medical Home framework to give concrete examples of what physicians and families can and should do to prepare families for transition(s). The article consists of 3 parts. The first part is an introduction giv...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.3.e159

    authors: Olsen DG,Swigonski NL

    更新日期:2004-03-01 00:00:00

  • Marriage and the well-being of children.

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    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2012-2665

    authors: Garrett JR,Lantos JD

    更新日期:2013-03-01 00:00:00

  • On the front lines: lessons learned in implementing multidisciplinary peripheral venous access pain-management programs in pediatric hospitals.

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    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2008-1055i

    authors: Leahy S,Kennedy RM,Hesselgrave J,Gurwitch K,Barkey M,Millar TF

    更新日期:2008-11-01 00:00:00

  • Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors.

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