Zinc protoporphyrin/heme ratio for diagnosis of preanemic iron deficiency.

Abstract:

OBJECTIVE:Iron deficiency anemia is known to impair cognitive and psychomotor development. The zinc protoporphyrin/heme (ZPP/H) ratio is a simple, accurate, and sensitive laboratory screening test that detects early iron depletion before the onset of anemia. The objective of this work was to evaluate this test in a primary pediatric practice setting. METHODS:The iron status of a cohort of 361 children was screened during routine examinations at a community pediatric practice. Whole blood hemoglobin concentration, hematocrit ratio, serum transferrin saturation, ferritin concentration, and the ZPP/H ratio were measured. The ZPP/H ratio then was evaluated as a single indicator of iron status by comparing it with other tests for detecting the onset of iron deficiency and for monitoring recovery after iron supplementation. RESULTS:Significant age- and sex-related differences in the ZPP/H ratio were found. In this cohort, serum ferritin concentration and the ZPP/H ratio independently identified the same fraction of iron-deficient patients (3%-4%), and both tests were more specific than was either hemoglobin or hematocrit. A concordance of three iron status parameters changed the prediction of iron deficiency to

journal_name

Pediatrics

journal_title

Pediatrics

authors

Rettmer RL,Carlson TH,Origenes ML,Jack RM,Labb RF

doi

10.1542/peds.104.3.e37

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

e37

issue

3

eissn

0031-4005

issn

1098-4275

journal_volume

104

pub_type

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