Abstract:
BACKGROUND:Studies suggest that giving newly born preterm infants sustained lung inflation (SLI) may decrease their need for mechanical ventilation (MV) and improve their respiratory outcomes. METHODS:We randomly assigned infants born at 25 weeks 0 days to 28 weeks 6 days of gestation to receive SLI (25 cm H2O for 15 seconds) followed by nasal continuous positive airway pressure (nCPAP) or nCPAP alone in the delivery room. SLI and nCPAP were delivered by using a neonatal mask and a T-piece ventilator. The primary end point was the need for MV in the first 72 hours of life. The secondary end points included the need for respiratory supports and survival without bronchopulmonary dysplasia (BPD). RESULTS:A total of 148 infants were enrolled in the SLI group and 143 in the control group. Significantly fewer infants were ventilated in the first 72 hours of life in the SLI group (79 of 148 [53%]) than in the control group (93 of 143 [65%]); unadjusted odds ratio: 0.62 [95% confidence interval: 0.38-0.99]; P = .04). The need for respiratory support and survival without BPD did not differ between the groups. Pneumothorax occurred in 1% (n = 2) of infants in the control group compared with 6% (n = 9) in the SLI group, with an unadjusted odds ratio of 4.57 (95% confidence interval: 0.97-21.50; P = .06). CONCLUSIONS:SLI followed by nCPAP in the delivery room decreased the need for MV in the first 72 hours of life in preterm infants at high risk of respiratory distress syndrome compared with nCPAP alone but did not decrease the need for respiratory support and the occurrence of BPD.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Lista G,Boni L,Scopesi F,Mosca F,Trevisanuto D,Messner H,Vento G,Magaldi R,Del Vecchio A,Agosti M,Gizzi C,Sandri F,Biban P,Bellettato M,Gazzolo D,Boldrini A,Dani C,SLI Trial Investigators.doi
10.1542/peds.2014-1692subject
Has Abstractpub_date
2015-02-01 00:00:00pages
e457-64issue
2eissn
0031-4005issn
1098-4275pii
peds.2014-1692journal_volume
135pub_type
杂志文章,多中心研究,随机对照试验相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:Youth processed in the juvenile justice system are at great risk for early violent death. Groups at greatest risk, ie, racial/ethnic minorities, male youth, and urban youth, are overrepresented in the juvenile justice system. We compared mortality rates for delinquent youth with those for the general populati...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1459
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Previous growth studies on children born small for gestational age (SGA) indicate that birth length, weight, and target height are important predictors for postnatal catch-up growth in SGA. Their influences on different phases of catch-up growth are still not described. The aim of this study was to clarify th...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.6.e72
更新日期:1998-12-01 00:00:00
abstract::Epigenetics, the study of functionally relevant chemical modifications to DNA that do not involve a change in the DNA nucleotide sequence, is at the interface between research and clinical medicine. Research on epigenetic marks, which regulate gene expression independently of the underlying genetic code, has dramatica...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2013-1032F
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:In 2009, the National Children's Study (NCS) Vanguard Study tested the feasibility of household-based recruitment and participant enrollment using a birth-rate probability sample. In 2010, the NCS Program Office launched 3 additional recruitment approaches. We tested whether provider-based recruitment could i...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-4410E
更新日期:2016-06-01 00:00:00
abstract::Acute acetaminophen intoxication was studied in the dog to characterize pathogenesis and in the mouse as a model for antidotal research. In the dog, overt toxicity was manifested principally by cyanosis, facial and paw edema, gastrointestinal disturbance, and coma. Typical laboratory findings were methemoglobinemia, h...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract::The concentrations of total blood bilirubin, albumin-bound bilirubin, and the reserve and total bilirubin binding capacities of 35 neonatal blood samples (28 patients) were determined by automated front-face fluorometry ((hematofluorometer). These values were compared to results of diazo determinations, Sephadex gel f...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract:BACKGROUND:Prolonged mechanical ventilation is associated with lung injury in preterm infants. In these infants, weaning from synchronized intermittent mandatory ventilation may be delayed by their inability to cope with increased respiratory loads. The addition of pressure support to synchronized intermittent mandator...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2005-2923
更新日期:2006-10-01 00:00:00
abstract::Because of substantial clinical and laboratory evidence of the efficacy of glucocorticoids in the treatment of acute pulmonary surfactant deficiency in preterm newborns, we explored the hypothesis that maternal antenatal glucocorticoid receipt is followed by reduced risk of bronchopulmonary dysplasia (BPD). A sample o...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1990-09-01 00:00:00
abstract:CONTEXT:More than 4 decades of research indicate that parenting interventions are effective at preventing and treating mental, emotional, and behavioral disorders in children and adolescents. Pediatric primary care is a viable setting for delivery of these interventions. OBJECTIVE:Previous meta-analyses have shown tha...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-3548
更新日期:2020-07-01 00:00:00
abstract::Tumor-induced osteomalacia/rickets is a rare paraneoplastic disorder associated with a tumor-producing fibroblast growth factor 23 (FGF23). We present a child with symptoms of rickets as the first clinical sign of a central giant cell granuloma (CGCG) with high serum levels of FGF23, a hormone associated with decrease...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-2218
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:To review the relationship between parent and child literacy and child health outcomes and interventions designed to improve child health outcomes for children or parents with low literacy skills. METHODS:We searched Medline and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) for artic...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2009-1162B
更新日期:2009-11-01 00:00:00
abstract::Since 1961 the Committee on Nutrition of the American Academy of Pediatrics has recommended that prophylactic vitamin K be administered parenterally to all newborn infants, although the exact requirement for vitamin K in the newborn infant is unknown. There is little information about the vitamin K1 (phylloquinone, pr...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To characterize the atypical cutaneous presentations in the coxsackievirus A6 (CVA6)-associated North American enterovirus outbreak of 2011-2012. METHODS:We performed a retrospective case series of pediatric patients who presented with atypical cases of hand, foot, and mouth disease (HFMD) from July 2011 to ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-3175
更新日期:2013-07-01 00:00:00
abstract::A 1-year-old boy was admitted to the hospital with Haemophilus influenzae meningitis. On the second hospital day a heart murmur heard on admission seemed louder. No signs of congestive heart failure were present. An echocardiogram demonstrated a persistent echo-dense mass behind the anterior leaflet of the mitral valv...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-09-01 00:00:00
abstract:OBJECTIVE:We examined the frequency and characteristics of chromosomally integrated human herpesvirus 6 among congenitally infected children. METHODS:Infants with and without congenital human herpesvirus 6 infection were prospectively monitored. Cord blood mononuclear cell, peripheral blood mononuclear cell, saliva, u...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-2838
更新日期:2008-09-01 00:00:00
abstract::Most family members who are evaluated as kidney donors for children have high reactivity in a mixed lymphocyte culture test and are thus excluded from donation. Fifty children, most of whom had highly reactive mixed lymphocyte cultures with their donors, were challenged with three blood transfusions from their donors ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract:OBJECTIVE:Newborn infants are vitamin K deficient. Vitamin K status in full-term infants after intramuscular vitamin K supplementation at birth has been described. Similar information in growing premature infants has not been reported. The objective of this study was to assess vitamin K status in premature infants by m...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.5.1117
更新日期:2001-11-01 00:00:00
abstract::Fragile X syndrome (an FMR1-related disorder) is the most commonly inherited form of mental retardation. Early physical recognition is difficult, so boys with developmental delay should be strongly considered for molecular testing. The characteristic adult phenotype usually does not develop until the second decade of ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2010-3500
更新日期:2011-05-01 00:00:00
abstract::National morbidity figures show a decline in reported rubella and congenital rubella syndrome since 1969, concurrent with widespread use of rubella vaccine. In addition, no nationwide outbreak, such as the 1963-1964 epidemic, has occurred, though on the basis of long-term secular trends, one would be expected between ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:To describe patients who present to the pediatric emergency department (PED) and are subsequently diagnosed with pulmonary embolism (PE). METHODS:Electronic medical records from 2003 to 2011 of a tertiary care pediatric health care system was retrospectively reviewed to identify patients <21 years who had a ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-0126
更新日期:2013-10-01 00:00:00
abstract::A central tension in pediatric research ethics arises from our desire to protect children from harm while also allowing progress toward discoveries that could improve child health. A prime example of this tension is research on a controversial yet increasingly common practice: the use of cannabis by women to treat nau...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-0818R
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:As newborn screening (NBS) programs expand to include conditions that challenge traditional public health criteria, little is known about what influences physicians' attitudes toward screening. We examined the effect of state policy and perceived state policy on pediatricians' attitudes toward screening. MET...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1990
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:The anion exchanger gene (AE1) or band 3 encodes a chloride-bicarbonate (Cl(-)/HCO(3)(-)) exchanger expressed in the erythrocyte and in the renal alpha-intercalated cells involved in urine acidification. The purpose of the present study was to screen for mutations in the AE1 gene in 2 brothers (10 and 15 year...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.6.1361
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:End-of-life clinical care in cystic fibrosis (CF) differs substantially from terminal care in childhood cancer. To examine this difference, we reviewed the medical care of a cohort of CF patients treated at Children's Hospital, Boston, to document the use of preventive, therapeutic, and palliative care in the...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.100.2.205
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:The possible link between immunization and atopic diseases has been under intense debate in the last decade. OBJECTIVE:The aim of this study was to systematically review the available evidence on the association of whole-cell pertussis and BCG vaccination with the risk of asthma in childhood and adolescence...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:10.1542/peds.2006-3569
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:The growth of infants with atopic dermatitis (AD) has been poorly investigated based on the early type of feeding. The aim of this study was to assess the growth pattern of AD infants during the first 12 months of life in comparison to healthy infants, according to the early type of feeding (breastfed or nonb...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.5.e73
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:To study whether pretreatment of newborn lungs by captopril inhibits meconium-induced lung injury and inflammatory cytokine expression. DESIGN:Four groups of 2-week-old rabbit pups were used for the study: group 1, saline instilled rabbits; group 2, captopril-pretreated rabbits; group 3, meconium-instilled r...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-0274
更新日期:2006-05-01 00:00:00
abstract::Photoisomerization of native bilirubin to more polar configurational isomers (Z,E-bilirubin) and structural isomers (lumirubin) was studied in 20 premature infants with physiologic jaundice to determine the effect of low-dose (6 microW/cm2/nm) v high-dose (12 microW/cm2/nm) phototherapy. Patients were assigned prospec...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:To assess the effects of electronic health record-based clinical decision support (CDS) and physician performance feedback on adherence to guidelines for acute otitis media (AOM) and otitis media with effusion (OME). METHODS:We conducted a factorial-design cluster randomized trial with primary care practices...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2012-1988
更新日期:2013-04-01 00:00:00
abstract::The publication of guidelines calling for less aggressive treatment of jaundice in newborns has been followed by a reappearance of case reports of kernicterus. These case reports illustrate important issues for writers and consumers of practice guidelines. One issue is the particular salience of identified patients wi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00