Hyperammonemia associated with perinatal asphyxia.

Abstract:

:Twelve infants with severe perinatal asphyxia were found to have elevated blood ammonia levels (302 to 960 microgram/100 ml). In the seven survivors, hyperammonemia was associated with CNS irritability, hyperthermia, hypertension, and wide neonatal heart rate oscillations. Follow-up examinations revealed severe neurologic dysfunction in five of seven infants. CNS depression, hyperthermia, hypertension, and a nonreactive, fixed heart rate characterized the infants that died. These findings suggest a clinical entity secondary to perinatal asphyxia whose signs and symptoms may be related to hyperammonemia.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Goldberg RN,Cabal LA,Sinatra FR,Plajstek CE,Hodgman JE

subject

Has Abstract

pub_date

1979-09-01 00:00:00

pages

336-41

issue

3

eissn

0031-4005

issn

1098-4275

journal_volume

64

pub_type

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