Abstract:
:Twelve infants with severe perinatal asphyxia were found to have elevated blood ammonia levels (302 to 960 microgram/100 ml). In the seven survivors, hyperammonemia was associated with CNS irritability, hyperthermia, hypertension, and wide neonatal heart rate oscillations. Follow-up examinations revealed severe neurologic dysfunction in five of seven infants. CNS depression, hyperthermia, hypertension, and a nonreactive, fixed heart rate characterized the infants that died. These findings suggest a clinical entity secondary to perinatal asphyxia whose signs and symptoms may be related to hyperammonemia.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Goldberg RN,Cabal LA,Sinatra FR,Plajstek CE,Hodgman JEsubject
Has Abstractpub_date
1979-09-01 00:00:00pages
336-41issue
3eissn
0031-4005issn
1098-4275journal_volume
64pub_type
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