Four patterns of response to inhaled nitric oxide for persistent pulmonary hypertension of the newborn.

Abstract:

OBJECTIVE:To determine the clinical role of inhaled nitric oxide (iNO) in the treatment of persistent pulmonary hypertension of the newborn (PPHN). STUDY DESIGN:Prospective open observational clinical study. SETTING:A regional cardiac and pediatric intensive care unit. METHODS:Twenty-five consecutive near-term neonates (> 35 weeks gestation) with severe PPHN (oxygenation index [OI] > 25) were given a trial of iNO of 20 ppm for 20 minutes. Neonates who showed a greater than 20% improvement in PaO2 as well as a decrease in the OI to below 40 were defined as responders and continued on this therapy. RESULTS:Four patterns of response emerged to the iNO therapy: Pattern 1 neonates (n = 2) did not respond to the initial trial of iNO-one survived. Pattern 2 neonates (n = 9) responded to the initial trial of iNO, but failed to sustain this response over 36 hours, as defined by a rise in the OI to > 40. Six survived, five with extracorporeal membrane oxygenation. Pattern 3 neonates (n = 11) responded to the initial trial of iNO, sustained this response, and were successfully weaned from iNO within 5 days--all survived to discharge. Pattern 4 neonates (n = 3) responded to the initial trial of iNO, but developed a sustained dependence on iNO for 3 to 6 weeks. All three died and lung histology revealed severe pulmonary hypoplasia and dysplasia. These neonates (pattern 4) not only required iNO for a longer period of time than did the sustained responders (pattern 3), but they required significantly higher doses of iNO during their first 5 days of iNO therapy. CONCLUSIONS:Early responses to iNO may not be sustained. Neonates with pulmonary hypoplasia and dysplasia may have a decreased sensitivity and differing time course of response to iNO when compared with patients who have PPHN in fully developed lungs.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Goldman AP,Tasker RC,Haworth SG,Sigston PE,Macrae DJ

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

706-13

issue

4 Pt 1

eissn

0031-4005

issn

1098-4275

journal_volume

98

pub_type

临床试验,杂志文章
  • Reassessment of the indications for ribavirin therapy in respiratory syncytial virus infections. American Academy of Pediatrics Committee on Infectious Diseases.

    abstract::The purpose of this statement is to inform practitioners about new information concerning lack of demonstrated clinical effectiveness of ribavirin in the treatment of infants with respiratory syncytial virus (RSV) disease. The intent of the new recommendation is to allow practitioners to decide whether ribavirin thera...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引,评审

    doi:

    authors:

    更新日期:1996-01-01 00:00:00

  • Current pediatrician practices in identifying high-risk behaviors of adolescents.

    abstract:OBJECTIVE:In the United States, 15- to 24-year-olds represent approximately 14% of HIV cases diagnosed in 2006 and almost 50% of the 19 million sexually transmitted infections (STIs) reported annually. This survey assessed pediatricians' practices regarding preventive health care screening, provision of reproductive he...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2009-0271

    authors: Henry-Reid LM,O'Connor KG,Klein JD,Cooper E,Flynn P,Futterman DC

    更新日期:2010-04-01 00:00:00

  • Principles of patient safety in pediatrics.

    abstract::The American Academy of Pediatrics and its members are committed to improving the health care system to provide the best and safest health care for infants, children, adolescents, and young adults. In response to a 1999 Institute of Medicine report on building a safer health system, a set of principles was established...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.6.1473

    authors: Lannon CM,Coven BJ,Lane France F,Hickson GB,Miles PV,Swanson JT,Takayama JI,Wood DL,Yamamoto L,National Initiative for Children's Health Care Quality Project Advisory Committee.

    更新日期:2001-06-01 00:00:00

  • Ophthalmia neonatorum: a chart review.

    abstract::Cases of ophthalmia neonatorum diagnosed at Grady Memorial Hospital 1967-1973 were reviewed. Of 302 cases 43 could be diagnosed as gonococcal, 86 chlamydial, 3 gonococcal and chlamydial, 31 staphylococcal, and 5 chemical. Silver nitrate prophylaxis was routinely employed. Gonococcal cases peaked during the third quart...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Armstrong JH,Zacarias F,Rein MF

    更新日期:1976-06-01 00:00:00

  • Principles of Child Health Care Financing.

    abstract::After passage of the Patient Protection and Affordable Care Act, more children and young adults have become insured and have benefited from health care coverage than at any time since the creation of the Medicaid program in 1965. From 2009 to 2015, the uninsurance rate for children younger than 19 years fell from 9.7%...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-2098

    authors: Hudak ML,Helm ME,White PH,COMMITTEE ON CHILD HEALTH FINANCING.

    更新日期:2017-09-01 00:00:00

  • Coagulase-negative staphylococcal bacteremia among very low birth weight infants: relation to admission illness severity, resource use, and outcome.

    abstract:OBJECTIVE:To examine the impact of admission-day illness severity on nosocomial bacteremia risk after consideration of traditional risk determinants such as birth weight and length of stay. METHODS:The hospital courses for 302 consecutive very low birth weight (less than 1500 g) infants admitted to two neonatal intens...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gray JE,Richardson DK,McCormick MC,Goldmann DA

    更新日期:1995-02-01 00:00:00

  • Conceptions of illness in young adolescents.

    abstract::This study examined conceptions of illness in young adolescents. A group of 77 urban junior high school students aged 11 to 15 years were asked for their definitions of illness. Themes occurring in definitions of illness were identified and coded according to a previously developed coding scheme. Evidence in support o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Millstein SG,Adler NE,Irwin CE Jr

    更新日期:1981-12-01 00:00:00

  • Association of consumption of fried food away from home with body mass index and diet quality in older children and adolescents.

    abstract:OBJECTIVES:Rates of overweight have increased dramatically among children in the United States. Although an increase in consumption of food prepared away from home has paralleled overweight trends, few data exist relating food prepared away from home to change in BMI in children. The goals of this study were to (1) exa...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2732

    authors: Taveras EM,Berkey CS,Rifas-Shiman SL,Ludwig DS,Rockett HR,Field AE,Colditz GA,Gillman MW

    更新日期:2005-10-01 00:00:00

  • Patterns of work and retirement among pediatricians aged >or=50 years.

    abstract:OBJECTIVE:This study examined patterns of work and retirement among older pediatricians, including the determinants of part-time work and retirement, as well as extended participation in the pediatrician workforce. METHODS:A mail survey regarding recent and expected workforce participation was distributed to American ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-3090

    authors: Merline AC,Cull WL,Mulvey HJ,Katcher AL

    更新日期:2010-01-01 00:00:00

  • Middle ear function in learning-disabled children.

    abstract::To investigate the possible association of chronic otitis media and school learning problems, past and current middle ear status in 53 learning-disabled (LD) children was compared to that of 56 control children without learning problems. A history of recurrent otitis media was obtained in 23% of the LD children and in...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bennett FC,Ruuska SH,Sherman R

    更新日期:1980-08-01 00:00:00

  • A Sports-Based Youth Development Program, Teen Mental Health, and Physical Fitness: An RCT.

    abstract:OBJECTIVES:To assess the effectiveness of a positive youth development (PYD)-based sports mentorship program on the physical and mental well-being of adolescents recruited in a community setting. METHODS:This is a randomized controlled trial in which we recruited students from 12 secondary schools in Hong Kong, China....

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2017-1543

    authors: Ho FKW,Louie LHT,Wong WH,Chan KL,Tiwari A,Chow CB,Ho W,Wong W,Chan M,Chen EYH,Cheung YF,Ip P

    更新日期:2017-10-01 00:00:00

  • Recovery of left ventricular function following discontinuation of anthracycline chemotherapy in children.

    abstract::Echocardiographic evaluation of left ventricular (LV) performance was performed in 41 children during and following anthracycline chemotherapy. Prior to treatment LV function was normal in all patients; LV shortening fraction was 35.2 +/- 0.7% and percent of predicted velocity of circumferential fiber shortening was 1...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lewis AB,Crouse VL,Evans W,Takahashi M,Siegel SE

    更新日期:1981-07-01 00:00:00

  • Sleep environment and the risk of sudden infant death syndrome in an urban population: the Chicago Infant Mortality Study.

    abstract:OBJECTIVE:To examine risk factors for sudden infant death syndrome (SIDS) with the goal of reducing SIDS mortality among blacks, which continues to affect this group at twice the rate of whites. METHODS:We analyzed data from a population-based case-control study of 260 SIDS deaths that occurred in Chicago between 1993...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Hauck FR,Herman SM,Donovan M,Iyasu S,Merrick Moore C,Donoghue E,Kirschner RH,Willinger M

    更新日期:2003-05-01 00:00:00

  • Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial.

    abstract:OBJECTIVE:To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood. DESIGN:Prospective follow-up study of a randomized, double-blind, placebo-controlled trial. SETTING:National Women's Hospital (Auckland, New Zealand)...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.2004-0196

    authors: Dalziel SR,Liang A,Parag V,Rodgers A,Harding JE

    更新日期:2004-09-01 00:00:00

  • Lithium in the Acute Treatment of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Study.

    abstract:BACKGROUND:Lithium is a benchmark treatment for bipolar disorder in adults. Definitive studies of lithium in pediatric bipolar I disorder (BP-I) are lacking. METHODS:This multicenter, randomized, double-blind, placebo-controlled study of pediatric participants (ages 7-17 years) with BP-I/manic or mixed episodes compar...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2015-0743

    authors: Findling RL,Robb A,McNamara NK,Pavuluri MN,Kafantaris V,Scheffer R,Frazier JA,Rynn M,DelBello M,Kowatch RA,Rowles BM,Lingler J,Martz K,Anand R,Clemons TE,Taylor-Zapata P

    更新日期:2015-11-01 00:00:00

  • Determinants of health care use by children in rural western North Carolina: results from the Mountain Accessibility Project.

    abstract:OBJECTIVE:To assess determinants of health care visits among children in a 12-county region of western North Carolina representative of rural areas in the United States. METHODS:Households were randomly selected for surveys of household characteristics, health status, and health care use. Surveys were conducted June 1...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.2.e143

    authors: Woods CR,Arcury TA,Powers JM,Preisser JS,Gesler WM

    更新日期:2003-08-01 00:00:00

  • Effects of nurse home visiting on maternal and child functioning: age-9 follow-up of a randomized trial.

    abstract:OBJECTIVE:Our goal was to test the effect of prenatal and infancy home visits by nurses on mothers' fertility and children's functioning 7 years after the program ended at child age 2. METHODS:We conducted a randomized, controlled trial in a public system of obstetric and pediatric care. A total of 743 primarily black...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2006-2111

    authors: Olds DL,Kitzman H,Hanks C,Cole R,Anson E,Sidora-Arcoleo K,Luckey DW,Henderson CR Jr,Holmberg J,Tutt RA,Stevenson AJ,Bondy J

    更新日期:2007-10-01 00:00:00

  • Media literacy education for elementary school substance use prevention: study of media detective.

    abstract:OBJECTIVES:Media Detective is a 10-lesson elementary school substance use prevention program developed on the basis of the message interpretation processing model designed to increase children's critical thinking skills about media messages and reduce intent to use tobacco and alcohol products. The purpose of this stud...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2010-0068

    authors: Kupersmidt JB,Scull TM,Austin EW

    更新日期:2010-09-01 00:00:00

  • Attitudes toward neonatal intensive care treatment of preterm infants with a high risk of developing long-term disabilities.

    abstract:OBJECTIVES:To assess (1) the differences in attitudes toward disabilities of 3 groups of subjects involved in neonatal care decision-making: health care workers, mothers of term infants, and parents of preterm infants, and (2) the impact of subject characteristics on these attitudes including parental education level, ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2061

    authors: Lam HS,Wong SP,Liu FY,Wong HL,Fok TF,Ng PC

    更新日期:2009-06-01 00:00:00

  • Hospitalization of children with status asthmaticus: a review.

    abstract::A review of hospital admissions of patients with status asthmaticus at the Childrens Hospital of Los Angeles showed a marked increase in admissions in recent years. Asthma mortality did not increase. Patients tended to be young, boys, and black as compared with patients admitted to a general hospital. Interviews with ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Richards W

    更新日期:1989-07-01 00:00:00

  • Meningococcal Disease Among College-Aged Young Adults: 2014-2016.

    abstract::: media-1vid110.1542/5839998266001PEDS-VA_2018-2130Video Abstract BACKGROUND: Freshman college students living in residence halls have previously been identified as being at an increased risk for meningococcal disease. In this evaluation, we assess the incidence and characteristics of meningococcal disease in college-...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-2130

    authors: Mbaeyi SA,Joseph SJ,Blain A,Wang X,Hariri S,MacNeil JR

    更新日期:2019-01-01 00:00:00

  • Erythema Marginatum as an Early Symptom of Hereditary Angioedema: Case Report of 2 Newborns.

    abstract::Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare genetic disease that causes recurrent swelling attacks that may affect various body tissues. Angioedematous attacks can be fatal in the case of upper airway edema and are often preceded by prodromal symptoms like erythema marginatum. Initial s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-2411

    authors: Martinez-Saguer I,Farkas H

    更新日期:2016-02-01 00:00:00

  • Fatal hepatitis B in early infancy: the importance of identifying HBsAg-positive pregnant women and providing immunoprophylaxis to their newborns.

    abstract::Infants born to women who are asymptomatic hepatitis B surface antigen (HBsAg) carriers frequently acquire hepatitis B virus infection in infancy. The spectrum of disease in such affected infants includes mild transient acute hepatitis B, chronic active hepatitis with or without cirrhosis, chronic persistent hepatitis...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Delaplane D,Yogev R,Crussi F,Shulman ST

    更新日期:1983-08-01 00:00:00

  • Care to underserved children: Residents' attitudes and experiences.

    abstract:OBJECTIVES:To examine: 1) the relationship between residents' responses toward caring for underserved children and families during residency and their perceptions of their continuity clinic experience; and 2) which characteristics are related to continuing to care for the underserved after completion of training. DESI...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.5.1022

    authors: Weitzman CC,Freudigman K,Schonfeld DJ,Leventhal JM

    更新日期:2000-11-01 00:00:00

  • The population cost-effectiveness of interventions designed to prevent childhood depression.

    abstract:BACKGROUND AND OBJECTIVES:Depression in childhood and adolescence is common and often persists into adulthood. This study assessed the population-level cost-effectiveness of a preventive intervention that screens children and adolescents for symptoms of depression in schools and the subsequent provision of a psychologi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1823

    authors: Mihalopoulos C,Vos T,Pirkis J,Carter R

    更新日期:2012-03-01 00:00:00

  • Wernicke Encephalopathy in Adolescents After Bariatric Surgery: Case Report and Review.

    abstract::Roughly 1% of all weight loss surgery is performed in adolescents. There is strong evidence demonstrating significant postsurgical weight loss, improvement in quality of life, and reduction in comorbidities such as hypertension and diabetes. Reports of postoperative complications in adolescents are few because of the ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2016-1039

    authors: Armstrong-Javors A,Pratt J,Kharasch S

    更新日期:2016-12-01 00:00:00

  • Prepregnant overweight and obesity diminish the prolactin response to suckling in the first week postpartum.

    abstract:OBJECTIVE:The population subgroups with the highest proportion of overweight and obese women often are characterized by the lowest rates of initiation and shortest durations of breastfeeding. We previously documented that these 2 population-level trends may be related. In a population of white women who lived in a rura...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.5.e465

    authors: Rasmussen KM,Kjolhede CL

    更新日期:2004-05-01 00:00:00

  • Newborn Screening for Cystic Fibrosis in California.

    abstract:OBJECTIVES:This article describes the methods used and the program performance results for the first 5 years of newborn screening for cystic fibrosis (CF) in California. METHODS:From July 16, 2007, to June 30, 2012, a total of 2,573,293 newborns were screened for CF by using a 3-step model: (1) measuring immunoreactiv...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-0811

    authors: Kharrazi M,Yang J,Bishop T,Lessing S,Young S,Graham S,Pearl M,Chow H,Ho T,Currier R,Gaffney L,Feuchtbaum L,California Cystic Fibrosis Newborn Screening Consortium.

    更新日期:2015-12-01 00:00:00

  • Effects of environmental exposures on the cardiovascular system: prenatal period through adolescence.

    abstract::Exposures to drugs, chemical and biological agents, therapeutic radiation, and other factors before and after birth can lead to pediatric or adult cardiovascular anomalies. Furthermore, nutritional deficiencies in the perinatal period can cause cardiovascular anomalies. These anomalies may affect heart structure, the ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Mone SM,Gillman MW,Miller TL,Herman EH,Lipshultz SE

    更新日期:2004-04-01 00:00:00

  • Perinatal human immunodeficiency virus-1 transmission and intrauterine growth: a cohort study in Butare, Rwanda.

    abstract:OBJECTIVE:To study the association of perinatal human immunodeficiency virus (HIV)-1 transmission with birth outcomes, including birth weight, gestational age, ponderal index, head circumference, and weight/head ratio. METHODS:Data from a prospective cohort study of 627 pregnant women and their infants in Butare, Rwan...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.2.e24

    authors: Weng S,Bulterys M,Chao A,Stidley CA,Dushimimana A,Mbarutso E,Saah A

    更新日期:1998-08-01 00:00:00