Cognitive function and brain structure in females with a history of adolescent-onset anorexia nervosa.

Abstract:

OBJECTIVE:Abnormalities in cognitive function and brain structure have been reported in acutely ill adolescents with anorexia nervosa, but whether these abnormalities persist or are reversible in the context of weight restoration remains unclear. Brain structure and cognitive function in female subjects with adolescent-onset anorexia nervosa assessed at long-term follow-up were studied in comparison with healthy female subjects, and associations with clinical outcome were investigated. PATIENTS AND METHODS:Sixty-six female subjects (aged 21.3 +/- 2.3 years) who had a diagnosis of adolescent-onset anorexia nervosa and treated 6.5 +/- 1.7 years earlier in a tertiary care hospital and 42 healthy female control subjects (aged 20.7 +/- 2.5 years) were assessed. All participants underwent a clinical examination, magnetic resonance brain scan, and cognitive evaluation. Clinical data were analyzed first as a function of weight recovery (n = 14, <85% ideal body weight; n = 52, >or=85% ideal body weight) and as a function of menstrual status (n = 18, absent/irregular menses; n = 29, oral contraceptive pill; n = 19, regular menses). Group comparisons were made across structural brain volumes and cognitive scores. RESULTS:Compared with control subjects, participants with anorexia nervosa who remained at low weight had larger lateral ventricles. Twenty-four-hour urinary free-cortisol levels were positively correlated with volumes of the temporal horns of the lateral ventricles and negatively correlated with volumes of the hippocampi in clinical participants. Participants who were amenorrheic or had irregular menses showed significant cognitive deficits across a broad range of many domains. CONCLUSIONS:Female subjects with adolescent-onset anorexia nervosa showed abnormal cognitive function and brain structure compared with healthy individuals despite an extended period since diagnosis. To our knowledge, this is the first study to report a specific relationship between menstrual function and cognitive function in this patient population. Possible mechanisms underlying neural and cognitive deficits with anorexia nervosa are discussed. Additional examination of the effects of estrogen on cognitive function in female subjects with anorexia nervosa is necessary.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Chui HT,Christensen BK,Zipursky RB,Richards BA,Hanratty MK,Kabani NJ,Mikulis DJ,Katzman DK

doi

10.1542/peds.2008-0170

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

e426-37

issue

2

eissn

0031-4005

issn

1098-4275

pii

122/2/e426

journal_volume

122

pub_type

杂志文章
  • Exemptions From Mandatory Immunization After Legally Mandated Parental Counseling.

    abstract:BACKGROUND:The success of health care provider counseling-based interventions to address vaccine hesitancy is not clear. In 2011, Washington State implemented Senate Bill 5005 (SB5005), requiring counseling and a signed form from a licensed health care provider to obtain an exemption. Evaluating the impact of a counsel...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-2364

    authors: Omer SB,Allen K,Chang DH,Guterman LB,Bednarczyk RA,Jordan A,Buttenheim A,Jones M,Hannan C,deHart MP,Salmon DA

    更新日期:2018-01-01 00:00:00

  • Successful implementation of a radiology sedation service staffed exclusively by pediatric emergency physicians.

    abstract:OBJECTIVE:As the number of diagnostic imaging studies performed has increased, the demand for sedation in support of these radiologic tests has also increased. Our objectives were to (1) assess the safety and efficacy of a radiology sedation service that is staffed exclusively by pediatric emergency medicine (PEM) phys...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1385

    authors: Pershad J,Gilmore B

    更新日期:2006-03-01 00:00:00

  • Ensuring Timely Connection to Early Intervention for Young Children With Developmental Delays.

    abstract:BACKGROUND AND OBJECTIVES:Timely provision of developmental services can improve outcomes for children 0 to 3 years old with developmental delays. Early Intervention (EI) provides free developmental services to children under age 3 years; however, data suggests that many children referred to EI never connect to the pro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-4017

    authors: Conroy K,Rea C,Kovacikova GI,Sprecher E,Reisinger E,Durant H,Starmer A,Cox J,Toomey SL

    更新日期:2018-07-01 00:00:00

  • A Healthy Toddler With Fever and Lethargy.

    abstract::A 21-month-old previously healthy girl presented to the emergency department initially with fever, rhinorrhea, and poor oral intake. She was subsequently discharged from the hospital on amoxicillin for treatment of acute otitis media but presented hours later on the same day with continued poor oral intake, decreased ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-0412

    authors: Suri NA,Meehan CW,Melwani A

    更新日期:2019-05-01 00:00:00

  • Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network.

    abstract:OBJECTIVE:Late-onset sepsis (occurring after 3 days of age) is an important problem in very low birth weight (VLBW) infants. To determine the current incidence of late-onset sepsis, risk factors for disease, and the impact of late-onset sepsis on subsequent hospital course, we evaluated a cohort of 6956 VLBW (401-1500 ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.110.2.285

    authors: Stoll BJ,Hansen N,Fanaroff AA,Wright LL,Carlo WA,Ehrenkranz RA,Lemons JA,Donovan EF,Stark AR,Tyson JE,Oh W,Bauer CR,Korones SB,Shankaran S,Laptook AR,Stevenson DK,Papile LA,Poole WK

    更新日期:2002-08-01 00:00:00

  • Media literacy education for elementary school substance use prevention: study of media detective.

    abstract:OBJECTIVES:Media Detective is a 10-lesson elementary school substance use prevention program developed on the basis of the message interpretation processing model designed to increase children's critical thinking skills about media messages and reduce intent to use tobacco and alcohol products. The purpose of this stud...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2010-0068

    authors: Kupersmidt JB,Scull TM,Austin EW

    更新日期:2010-09-01 00:00:00

  • Water-absorbing balls: a "growing" problem.

    abstract::Foreign body ingestion is a potentially serious clinical problem in children. We report a case of an 8-month-old infant who developed complete bowel obstruction requiring laparotomy due to ingestion of a superabsorbent polymer ball with advertised growth up to 400 times its original size. Most ingested foreign bodies ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-3685

    authors: Zamora IJ,Vu LT,Larimer EL,Olutoye OO

    更新日期:2012-10-01 00:00:00

  • Epidemiology of juvenile chronic arthritis in southwestern Sweden: a 5-year prospective population study.

    abstract::Previous epidemiological studies of juvenile chronic arthritis (JCA) report divergent results owing to differences in diagnostic criteria, patient retrieval, and study designs. To investigate incidence and prevalence of JCA in a total population, this prospective survey was performed in southwestern Sweden between 198...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gäre BA,Fasth A

    更新日期:1992-12-01 00:00:00

  • A program to limit donor exposures to neonates undergoing extracorporeal membrane oxygenation.

    abstract:OBJECTIVE:Extracorporeal membrane oxygenation (ECMO) has dramatically improved the survival of neonates with life-threatening respiratory and cardiac failure. However, ECMO requires numerous transfusions with significant risks. This study evaluated the effects of changing transfusion practices and blood component manag...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Rosenberg EM,Chambers LA,Gunter JM,Good JA

    更新日期:1994-09-01 00:00:00

  • Executive functioning of 4 children with hyperphenylalaninemia from childhood to adolescence.

    abstract::Hyperphenylalaninemia is a variant of phenylketonuria, and debate remains as to what, if any, active management of this condition is required to preserve cognitive function and psychological well-being. This study is the first to examine longitudinally the executive function (EF) in adolescents with hyperphenylalanine...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-4200

    authors: Sharman R,Sullivan KA,Jones T,Young RM,McGill J

    更新日期:2015-04-01 00:00:00

  • Adult outcomes of pediatric recurrent abdominal pain: do they just grow out of it?

    abstract:OBJECTIVE:To determine whether medically unexplained recurrent abdominal pain (RAP) in childhood predicts abdominal pain, irritable bowel syndrome (IBS), other somatic complaints, and psychiatric symptoms and disorders in young adulthood. METHODS:A sample of 28 young adults evaluated for RAP between the ages of 6 and ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.1.e1

    authors: Campo JV,Di Lorenzo C,Chiappetta L,Bridge J,Colborn DK,Gartner JC Jr,Gaffney P,Kocoshis S,Brent D

    更新日期:2001-07-01 00:00:00

  • Yield of chest radiography after removal of esophageal foreign bodies.

    abstract:OBJECTIVES:The aim of this study was to determine the benefit of routine postoperative chest radiography after removal of esophageal foreign bodies in children. METHODS:Medical records were reviewed of all patients evaluated with an esophageal foreign body at a single children's hospital over 10 years. Operative recor...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-3676

    authors: Fisher J,Mittal R,Hill S,Wulkan ML,Clifton MS

    更新日期:2013-05-01 00:00:00

  • Timing of Puberty Suppression and Surgical Options for Transgender Youth.

    abstract:OBJECTIVES:Puberty suppression (PS) is a cornerstone of treatment in youth experiencing gender dysphoria. In this study, we aim to inform prescribing professionals on the long-term effects of PS treatment on the development of sex characteristics and surgical implications. METHODS:Participants received PS according to...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-3653

    authors: van de Grift TC,van Gelder ZJ,Mullender MG,Steensma TD,de Vries ALC,Bouman MB

    更新日期:2020-11-01 00:00:00

  • Pediatric residents' continuity clinics: how are we really doing?

    abstract::The Accreditation Council for Graduate Medical Education (ACGME) established guidelines in 1989 requiring pediatric residents to attend a continuity clinic (CC) one half-day per week. OBJECTIVE. To assess pediatric residents' CCs, with an emphasis on those factors potentially affecting house staff education and patien...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Dumont-Driscoll MC,Barbian LT,Pollock BH

    更新日期:1995-10-01 00:00:00

  • Predicting adult stature without using skeletal age: the Khamis-Roche method.

    abstract:STUDY OBJECTIVE:To obtain reliable and accurate predictions of adult stature in white American children who are free of disease without using skeletal age. DESIGN:Apply a modification of the Roche-Wainer-Thissen stature prediction model to a sample of white American children. SETTING:Longitudinal data (every 6 months...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Khamis HJ,Roche AF

    更新日期:1994-10-01 00:00:00

  • Obesity and Mortality Risk in Critically Ill Children.

    abstract:BACKGROUND AND OBJECTIVES:Childhood obesity is epidemic and may be associated with PICU mortality. Using a large multicenter PICU database, we investigated the association between obesity and PICU mortality, adjusting for initial severity of illness. We further investigated whether height- and weight-based classificati...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2015-2035

    authors: Ross PA,Newth CJ,Leung D,Wetzel RC,Khemani RG

    更新日期:2016-03-01 00:00:00

  • A survey of community (out-of-hospital) sites used in pediatric training.

    abstract::A survey was completed of US pediatric residency programs about the use of community sites in training. A total of 85% of program directors responded and reported a wide use of the 21 identified survey sites. Further study is needed to determine the appropriate contribution that community sites can make to pediatric t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Alpert JJ,Blodgett FM,Gargas DC,Jenkins R,Kaplan DW,Kohrt A,Levine G,O'Hare D

    更新日期:1991-05-01 00:00:00

  • Two-year follow-up of an adolescent behavioral weight control intervention.

    abstract:OBJECTIVE:This study examined the 24-month outcomes of a randomized controlled trial of a group-based behavioral weight control (BWC) program combined with either activity-based peer intervention or aerobic exercise. METHODS:At baseline, 118 obese adolescents (68% female; BMI = 31.41 ± 3.33) ages 13 to 16 years (mean ...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2011-3283

    authors: Lloyd-Richardson EE,Jelalian E,Sato AF,Hart CN,Mehlenbeck R,Wing RR

    更新日期:2012-08-01 00:00:00

  • Principles of Care for Young Adults With Co-Occurring Psychiatric and Substance Use Disorders.

    abstract::Over 50% of young adults (defined as individuals aged 18-25 years) with substance use disorders (SUDs) have at least 1 co-occurring psychiatric disorder, and the presence of co-occurring disorders worsens SUD outcomes. Treatment of both co-occurring psychiatric disorders and SUDs in young adults is imperative for opti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-023523F

    authors: Spencer AE,Valentine SE,Sikov J,Yule AM,Hsu H,Hallett E,Xuan Z,Silverstein M,Fortuna L

    更新日期:2021-01-01 00:00:00

  • Microbiology of the vagina in children: normal and potentially pathogenic organisms.

    abstract::Vaginal cultures from 100 healthy girls, 2 months to 15 years of age, were examined for the presence of normal and potentially pathogenic microorganisms. Corynebacterium vaginale, yeast species, and genital mycoplasmas were isolated from vaginal cultures from 13.5 %, 28%, and 28% of the girls examined, respectively. C...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Hammerschlag MR,Alpert S,Rosner I,Thurston P,Semine D,McComb D,McCormack WM

    更新日期:1978-07-01 00:00:00

  • Self-regulation of slow cortical potentials: a new treatment for children with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:We investigated the effects of self-regulation of slow cortical potentials for children with attention-deficit/hyperactivity disorder. Slow cortical potentials are slow event-related direct-current shifts of the electroencephalogram. Slow cortical potential shifts in the electrical negative direction reflect ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2478

    authors: Strehl U,Leins U,Goth G,Klinger C,Hinterberger T,Birbaumer N

    更新日期:2006-11-01 00:00:00

  • Colic and crying syndromes in infants.

    abstract::Colic or excessive crying is one of the most frequent problems presented to pediatricians by new parents. Organic disease accounts for <5% of infants presenting with colic syndrome. Colic may be best viewed as a clinical manifestation of normal emotional development, in which an infant has diminished capacity to regul...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Barr RG

    更新日期:1998-11-01 00:00:00

  • Psychosocial outcomes of fetal alcohol syndrome in adulthood.

    abstract:BACKGROUND AND OBJECTIVE:Primary disabilities in children prenatally exposed to alcohol have a major impact on their daily life. It is suggested that these issues persist into adulthood, but few studies have addressed the outcome in adults with prenatal exposure, especially those with fetal alcohol syndrome (FAS). The ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-1915

    authors: Rangmar J,Hjern A,Vinnerljung B,Strömland K,Aronson M,Fahlke C

    更新日期:2015-01-01 00:00:00

  • Safety of the 9-Valent Human Papillomavirus Vaccine.

    abstract:BACKGROUND:The 9-valent human papillomavirus vaccine (9vHPV) was approved for females and males aged 9 to 26 years in 2014. We analyzed postlicensure surveillance reports to the Vaccine Adverse Event Reporting System (VAERS). METHODS:We searched VAERS data for US reports of adverse events (AEs) after 9vHPV from Decemb...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-1791

    authors: Shimabukuro TT,Su JR,Marquez PL,Mba-Jonas A,Arana JE,Cano MV

    更新日期:2019-12-01 00:00:00

  • Comprehensive evaluation of the child with intellectual disability or global developmental delays.

    abstract::Global developmental delay and intellectual disability are relatively common pediatric conditions. This report describes the recommended clinical genetics diagnostic approach. The report is based on a review of published reports, most consisting of medium to large case series of diagnostic tests used, and the proporti...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2014-1839

    authors: Moeschler JB,Shevell M,Committee on Genetics.

    更新日期:2014-09-01 00:00:00

  • Cortical hyperostosis: a complication of prolonged prostaglandin infusion in infants awaiting cardiac transplantation.

    abstract:BACKGROUND:Infants awaiting heart transplantation for congenital heart disease frequently require prostaglandin E1 (PGE1) infusion for prolonged periods. As a result, complications of prolonged PGE1 infusion, such as cortical hyperostosis, are being encountered more commonly. OBJECTIVE:To determine the incidence and s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Woo K,Emery J,Peabody J

    更新日期:1994-03-01 00:00:00

  • Foodborne Snow Mountain agent gastroenteritis in a school cafeteria.

    abstract::In 1984, an outbreak of gastroenteritis occurred at a school with 1,860 students in Brooklyn, NY. In a single-stage cluster sample of 375 students, 129 (34%) had illnesses that met our case definition of vomiting or diarrhea. The mean incubation period was 26 hours, and the mean illness duration was 24 hours. All case...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Guest C,Spitalny KC,Madore HP,Pray K,Dolin R,Herrmann JE,Blacklow NR

    更新日期:1987-04-01 00:00:00

  • Enuresis: a contrast of attitudes of parents and physicians.

    abstract::Questionnaires were used to survey 1,435 parents and 446 physicians in order to determine and compare attitudes and beliefs about enuresis. Although both groups thought that bed-wetting is a maturational problem, the parent group thought emotional causes were important and were less likely to accept small bladder size...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Shelov SP,Gundy J,Weiss JC,McIntire MS,Olness K,Staub HP,Jones DJ,Haque M,Ellerstein NS,Heagarty MC,Starfield B

    更新日期:1981-05-01 00:00:00

  • Usher syndrome in four hard-of-hearing siblings.

    abstract::Retinitis pigmentosa (RP) and congenital deafness comprise the autosomal recessive Usher syndrome. The four affected siblings discussed here have audiometric curves characteristic of the 10% of patients with the syndrome who are not profoundly deaf. The oldest already has RP. Even though the younger three siblings hav...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Davenport SL,O'Nuallain S,Omenn GS,Wilkus RJ

    更新日期:1978-10-01 00:00:00

  • Early intervention improves cognitive outcomes for preterm infants: randomized controlled trial.

    abstract:OBJECTIVE:The goal was to examine the effectiveness of an early intervention on cognitive and motor outcomes at corrected ages of 3 and 5 years for children with birth weights (BWs) of <2000 g. METHODS:A randomized controlled trial of a modified version of the Mother-Infant Transaction Program was performed. Outcomes ...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2010-0778

    authors: Nordhov SM,Rønning JA,Dahl LB,Ulvund SE,Tunby J,Kaaresen PI

    更新日期:2010-11-01 00:00:00