Abstract:
:Hyperphenylalaninemia is a variant of phenylketonuria, and debate remains as to what, if any, active management of this condition is required to preserve cognitive function and psychological well-being. This study is the first to examine longitudinally the executive function (EF) in adolescents with hyperphenylalaninemia. Two sibling pairs with mild hyperphenylalaninemia underwent neuropsychological examination in early childhood and again in adolescence using EF tests that were highly sensitive to phenylalanine exposure. By early adolescence, none of the 4 children demonstrated EF impairment. The children demonstrated a typical developmental trajectory of EF from childhood to adolescence, given phenylalanine exposure consistent with their condition.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Sharman R,Sullivan KA,Jones T,Young RM,McGill Jdoi
10.1542/peds.2013-4200subject
Has Abstractpub_date
2015-04-01 00:00:00pages
e1072-4issue
4eissn
0031-4005issn
1098-4275pii
peds.2013-4200journal_volume
135pub_type
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