Executive functioning of 4 children with hyperphenylalaninemia from childhood to adolescence.

Abstract:

:Hyperphenylalaninemia is a variant of phenylketonuria, and debate remains as to what, if any, active management of this condition is required to preserve cognitive function and psychological well-being. This study is the first to examine longitudinally the executive function (EF) in adolescents with hyperphenylalaninemia. Two sibling pairs with mild hyperphenylalaninemia underwent neuropsychological examination in early childhood and again in adolescence using EF tests that were highly sensitive to phenylalanine exposure. By early adolescence, none of the 4 children demonstrated EF impairment. The children demonstrated a typical developmental trajectory of EF from childhood to adolescence, given phenylalanine exposure consistent with their condition.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Sharman R,Sullivan KA,Jones T,Young RM,McGill J

doi

10.1542/peds.2013-4200

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

e1072-4

issue

4

eissn

0031-4005

issn

1098-4275

pii

peds.2013-4200

journal_volume

135

pub_type

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