Abstract:
OBJECTIVES:To compare the detection of facial attributes by computer-based facial recognition software of 2-D images against standard, manual examination in fetal alcohol spectrum disorders (FASD). METHODS:Participants were gathered from the Fetal Alcohol Syndrome Epidemiology Research database. Standard frontal and oblique photographs of children were obtained during a manual, in-person dysmorphology assessment. Images were submitted for facial analysis conducted by the facial dysmorphology novel analysis technology (an automated system), which assesses ratios of measurements between various facial landmarks to determine the presence of dysmorphic features. Manual blinded dysmorphology assessments were compared with those obtained via the computer-aided system. RESULTS:Areas under the curve values for individual receiver-operating characteristic curves revealed the computer-aided system (0.88 ± 0.02) to be comparable to the manual method (0.86 ± 0.03) in detecting patients with FASD. Interestingly, cases of alcohol-related neurodevelopmental disorder (ARND) were identified more efficiently by the computer-aided system (0.84 ± 0.07) in comparison to the manual method (0.74 ± 0.04). A facial gestalt analysis of patients with ARND also identified more generalized facial findings compared to the cardinal facial features seen in more severe forms of FASD. CONCLUSIONS:We found there was an increased diagnostic accuracy for ARND via our computer-aided method. As this category has been historically difficult to diagnose, we believe our experiment demonstrates that facial dysmorphology novel analysis technology can potentially improve ARND diagnosis by introducing a standardized metric for recognizing FASD-associated facial anomalies. Earlier recognition of these patients will lead to earlier intervention with improved patient outcomes.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Valentine M,Bihm DCJ,Wolf L,Hoyme HE,May PA,Buckley D,Kalberg W,Abdul-Rahman OAdoi
10.1542/peds.2016-2028subject
Has Abstractpub_date
2017-12-01 00:00:00issue
6eissn
0031-4005issn
1098-4275pii
peds.2016-2028journal_volume
140pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:Frequent violent behavior among adolescents has been found to be associated with previous exposure to violence, personal victimization, depression, hopelessness, and older age. Although young adolescents engage in less severe violent behavior than older adolescents, their perceived normative expectations to u...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:Confessions are uncommon in abusive head trauma (AHT) cases, and there is debate over whether shaking alone can cause the injuries characteristic of AHT. The objective of this article is to correlate legal statements by perpetrators with medical documentation to offer insights into the mechanism of injury. M...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-3647
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Cysteinyl leukotrienes are implicated in the inflammation of bronchiolitis. Recently, a specific cysteinyl leukotriene receptor antagonist, montelukast (Singulair [MSD, Haarlem, Netherlands]), has been approved for infants in granule sachets. OBJECTIVE:Our goal was to evaluate the effect of montelukast on c...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2008-1744
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Timely provision of developmental services can improve outcomes for children 0 to 3 years old with developmental delays. Early Intervention (EI) provides free developmental services to children under age 3 years; however, data suggests that many children referred to EI never connect to the pro...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-4017
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:In recent years there has been increasing emphasis on the mental health aspects of primary health care for children and adolescents. The Health Resources and Services Administration's Maternal and Child Health Bureau has contributed to efforts aimed at strengthening primary care not only in early identificat...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.99.4.e5
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:The serum electrolyte panel (SEP) is a frequently ordered laboratory test, but it has unproven usefulness in the treatment of dehydrated pediatric patients. Our study purpose was to evaluate the usefulness of routinely ordering a SEP in the treatment of dehydrated pediatric patients receiving intravenous flu...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-0457
更新日期:2004-11-01 00:00:00
abstract::The package inserts of live viral vaccines include immunodeficiency as a contraindication. Nevertheless, patients with mild forms of immunodeficiency may benefit from vaccination. No published guidelines exist for the administration of these vaccines specifically to patients with chromosome 22q11.2 deletion syndrome. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.4.e325
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:Because of case reports describing hypoxemia on withdrawal of inhaled nitric oxide (I-NO), we prospectively examined this safety issue in newborns with persistent pulmonary hypertension who were classified as treatment successes or failures during a course of I-NO therapy. METHODS:Randomized, placebo-control...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.104.2.231
更新日期:1999-08-01 00:00:00
abstract::In an effort to characterize significant neonatal apnea and evaluate the nursing diagnosis of apnea, apnea type and frequency were determined in 27 infants by continuous computer recording of heart rate, respiratory impedance, end-tidal CO2, and either or both transcutaneous oxygen and pulse oximetry. Of the 1,266 rec...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVE:The Neonatal Individualized Developmental Care Program (NIDCAP) for very low birth weight (VLBW) preterm infants has been suggested by Als et al to improve several medical outcome variables such as time on ventilator, time to nipple feed, the duration of hospital stay, better behavioral performance on Assessm...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.100.6.e9
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:Our goal was to determine the prevalence of intestinal parasites in internationally adopted children, to examine factors associated with infection, and to determine if evaluating multiple stool specimens increases the yield of parasite identification. METHODS:We evaluated internationally adopted children wit...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-3032
更新日期:2011-09-01 00:00:00
abstract::In February 1981, a measles outbreak occurred in a pediatric practice in DeKalb County, GA. The source case, a 12-year-old boy vaccinated against measles at 11 1/2 months of age, was in the office for one hour on the second day of rash, primarily in a single examining room. On examination, he was noted to be coughing ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract:OBJECTIVE:The SunWise School Program is a school-based sun safety education program that was developed by the US Environmental Protection Agency and aims to teach children how to protect themselves from overexposure to the sun. The objectives of this study were to assess the health benefits of the SunWise School Progra...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1400
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:On July 7, 1999, the American Academy of Pediatrics and the US Public Health Service issued a joint statement calling for removal of thimerosal, a mercury-containing preservative, from vaccines. This action was prompted in part by a risk assessment from the Food and Drug Administration that is presented here...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.107.5.1147
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVES:Rural Alaska Natives have a high prevalence of iron deficiency and Helicobacter pylori infection. The objective of this study was to estimate the prevalence of iron deficiency, iron-deficiency anemia, and active H pylori infection among school-aged children in rural Alaska. METHODS:We enrolled 68% (688) of ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1129
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To determine appropriate upper limits for gestational age and birth weight when screening infants for retinopathy of prematurity (ROP). DESIGN:Retrospective survey. SETTING:Tertiary neonatal intensive care nursery. PATIENTS:Seven hundred seven infants born July 1, 1990 to June 30, 1996 and screened for ROP...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.1.31
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVES:We tested the hypotheses that apolipoprotein E genotype, in particular carriage of the epsilon4 allele, is more likely to be associated with cerebral palsy and that children with more severe neurologic impairment are more likely to carry this allele. METHODS:In this cross-sectional study, 209 children with ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1083
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Many preterm children display school difficulties, which may be mediated by impairment in executive function and memory. OBJECTIVE:To evaluate executive and memory function among adolescents born preterm compared with term controls at 16 years. METHODS:A total of 337 of 437 (77%) adolescents born in 1989 t...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2010-1421
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To assess whether the adequate antibody response observed in former extremely premature infants after the primary series of immunizations is sustained after the first booster vaccines. SUBJECTS AND METHODS:Sixteen former extremely premature (<29 weeks, <1000 g at birth) and 17 former full-term (>37 weeks) in...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.101.4.597
更新日期:1998-04-01 00:00:00
abstract::A 16-month-old child who ingested rat poison, according to her parents, was noted to have signs of cholinergic poisoning. In the emergency department, the child was intubated and given atropine via the endotracheal tube until venous access was established. Phytonadione (vitamin K) and pralidoxime (2-PAM) were also adm...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:This population-based study investigated the psychological problems associated with daytime wetting in children. METHODS:A sample of 8213 children (age range: 7 years 6 months to 9 years 3 months) who were enrolled in the population-based Avon Longitudinal Study of Parents and Children participated in this s...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0894
更新日期:2006-11-01 00:00:00
abstract::Osteogenesis imperfecta may be difficult to differentiate from nonaccidental trauma. Social history may prejudice the physician in favor of or against considering the diagnosis of child abuse. Three cases of osteogenesis imperfecta that were initially diagnosed as nonaccidental trauma are presented. The availability o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract::Three infants with infant botulism are presented to illustrate how atypical, early, and severe features may obscure or delay diagnosis. Two boys aged 6 weeks and 20 days, respectively, presented with rapid deterioration after brief periods of poor feeding, one with an apparent life-threatening event at home and the ot...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-0297
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Approximately half of women with intellectual and developmental disabilities (IDDs) lose custody of their children at some point in their child's development, but their rates of and risk factors for newborn discharge to child protective services from the birth hospitalization are relatively unknown. METHODS...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-1416
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Pediatric victims of blunt trauma have developmental and anatomic characteristics that can make it difficult to assess their risk of cervical spine injury (CSI). Previous reports, all retrospective in nature, have not identified any cases of CSI in either children or adults in the absence of neck pain, neurol...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.108.2.e20
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:We tested the hypothesis that survival is highest for infants born in the same weight range whether mothers are adolescent or adult, comparing the weights at which infants of these mothers achieve lowest neonatal mortality. METHODS:The relationship between birth weight and neonatal mortality was studied in b...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:To determine the value of performing computed tomography (CT) on magnetic resonance imaging (MRI) studies in children with chronic headaches. BACKGROUND:Headache is a common complaint in children. With the proliferation of brain imaging centers and the increasing patient demand for CT or MRI studies, brain i...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:To assess growth retardation in male adolescent patients who have a diagnosis of anorexia nervosa (AN) and the effect of weight restoration on catch-up growth. METHODS:Medical charts of all male adolescent AN patients (n = 12) who were admitted to the Pediatric Psychosomatic Department at the Sheba Medical C...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.111.2.270
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:Although prior population-based studies have found that children in foster care use more mental health services than their Medicaid peers, less is known about how different experiences in foster care impact the likelihood of mental health service use. The primary aim of this study is to test the hypothesis th...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.113.5.1336
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:There has been a gradual decrease in the proportion of children covered by private health insurance in Colorado and the United States with a commensurate increase in those with public insurance or having no insurance which may impact access to care and outcomes. OBJECTIVE:The purpose of this work was to det...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0162
更新日期:2006-08-01 00:00:00