A double-blind, placebo-controlled, randomized trial of montelukast for acute bronchiolitis.

Abstract:

BACKGROUND:Cysteinyl leukotrienes are implicated in the inflammation of bronchiolitis. Recently, a specific cysteinyl leukotriene receptor antagonist, montelukast (Singulair [MSD, Haarlem, Netherlands]), has been approved for infants in granule sachets. OBJECTIVE:Our goal was to evaluate the effect of montelukast on clinical progress and on cytokines in acute bronchiolitis. METHODS:This was a randomized, placebo-controlled, double-blind, parallel-group study in 2 medical centers. Fifty-three infants (mean age: 3.8+/-3.5 months) with a first episode of acute bronchiolitis were randomly assigned to receive either 4-mg montelukast sachets or placebo, every day, from hospital admission until discharge. The primary outcome was length of stay, and secondary outcomes included clinical severity score (maximum of 12) and changes in type 1 and 2 cytokine levels (including interleukin4/IFN-gamma ratio as a surrogate for the T-helper 2/T-helper 1 ratio) in nasal lavage. RESULTS:Both groups were comparable at baseline, and cytokine levels correlated positively with disease severity. There were neither differences in length of stay (4.63+/-1.88 [placebo group] vs 4.65+/-1.97 days [montelukast group]) nor in clinical severity score and cytokine levels between the 2 groups. No differences in interleukin 4/IFN-gamma ratio between the 2 groups were seen. There was a slight tendency for infants in the montelukast group to recover more slowly than those in the placebo group (clinical severity score at discharge: 6.1+/-2.4 vs 4.8+/-2.2, respectively). CONCLUSIONS:Montelukast did not improve the clinical course in acute bronchiolitis. No significant effect of montelukast on the T-helper 2/T-helper 1 cytokine ratio when given in the early acute phase could be demonstrated.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Amirav I,Luder AS,Kruger N,Borovitch Y,Babai I,Miron D,Zuker M,Tal G,Mandelberg A

doi

10.1542/peds.2008-1744

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

e1249-55

issue

6

eissn

0031-4005

issn

1098-4275

pii

peds.2008-1744

journal_volume

122

pub_type

杂志文章,多中心研究,随机对照试验
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    authors: de Vries AP,Kassam-Adams N,Cnaan A,Sherman-Slate E,Gallagher PR,Winston FK

    更新日期:1999-12-01 00:00:00

  • Language problems in children with ADHD: a community-based study.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-3355

    authors: Sciberras E,Mueller KL,Efron D,Bisset M,Anderson V,Schilpzand EJ,Jongeling B,Nicholson JM

    更新日期:2014-05-01 00:00:00

  • Electrocardiograph monitor artifacts in a neonatal intensive care unit.

    abstract::A wide variety of artifacts may be found when monitoring the ECG in a neonatal intensive care unit. Many of the artifacts resemble arrhythmias, and unless they are recognized as artifacts they may lead to serious errors of diagnosis and therapy. Many of the artifacts are caused by patient movement such as seizures, tr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Stanger P,Lister G,Silverman NH,Hoffman JI

    更新日期:1977-11-01 00:00:00

  • Physical growth in phenylketonuria: II. Growth of treated children in the PKU collaborative study from birth to 4 years of age.

    abstract::Height, weight, and head circumference data up to age 4 years are reported for 124 children with phenylketonuria (PKU) who had been started on diet management before 4 months (121 days) of age and who were participating in the Collaborative Study of Children Treated for Phenylketonuria. Growth measurements of both the...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Holm VA,Kronmal RA,Williamson M,Roche AF

    更新日期:1979-05-01 00:00:00

  • Tumor-induced rickets in a child with a central giant cell granuloma: a case report.

    abstract::Tumor-induced osteomalacia/rickets is a rare paraneoplastic disorder associated with a tumor-producing fibroblast growth factor 23 (FGF23). We present a child with symptoms of rickets as the first clinical sign of a central giant cell granuloma (CGCG) with high serum levels of FGF23, a hormone associated with decrease...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-2218

    authors: Fernández-Cooke E,Cruz-Rojo J,Gallego C,Romance AI,Mosqueda-Peña R,Almaden Y,Sánchez del Pozo J

    更新日期:2015-06-01 00:00:00

  • b-CAPSA I Haemophilus influenzae, type b, capsular polysaccharide vaccine safety.

    abstract::The b-CAPSA I capsular polysaccharide vaccine for Haemophilus influenzae type b was given to 87,541 children 2 through 5 years of age in the Kaiser Permanente Medical Care Program, and the children were then followed using a multiple modality surveillance. Phase 1 consisted of 24-hour recall of immediate side effects ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Black SB,Shinefield HR

    更新日期:1987-03-01 00:00:00

  • Preparedness for pediatric emergencies encountered in the practitioner's office.

    abstract::Pediatricians in the Washington, DC, metropolitan area were surveyed to assess their readiness to deal with life-threatening emergencies in their offices. Information about emergency equipment, prearranged emergency plans, advanced life support training, and emergency medical services assistance was elicited. Recommen...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Altieri M,Bellet J,Scott H

    更新日期:1990-05-01 00:00:00

  • Anxiety and Mood Disorder in Children With Autism Spectrum Disorder and ADHD.

    abstract:OBJECTIVES:Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur. Understanding the endophenotype of children with both ASD and ADHD may impact clinical management. In this study, we compare the comorbidity of anxiety and mood disorders in children with ASD, with and wit...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-1377

    authors: Gordon-Lipkin E,Marvin AR,Law JK,Lipkin PH

    更新日期:2018-04-01 00:00:00

  • Effects of nurse home visiting on maternal and child functioning: age-9 follow-up of a randomized trial.

    abstract:OBJECTIVE:Our goal was to test the effect of prenatal and infancy home visits by nurses on mothers' fertility and children's functioning 7 years after the program ended at child age 2. METHODS:We conducted a randomized, controlled trial in a public system of obstetric and pediatric care. A total of 743 primarily black...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2006-2111

    authors: Olds DL,Kitzman H,Hanks C,Cole R,Anson E,Sidora-Arcoleo K,Luckey DW,Henderson CR Jr,Holmberg J,Tutt RA,Stevenson AJ,Bondy J

    更新日期:2007-10-01 00:00:00

  • Family member knowledge of children's medical problems: the need for universal application of an emergency data set.

    abstract:OBJECTIVE:Advances in medical care have led to a growing population of special needs children who are at risk for suboptimal care when they present to a physician with no previous knowledge of their medical history. This risk may be amplified in the emergency department setting when time-sensitive interventions must be...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.2.367

    authors: Carraccio CL,Dettmer KS,duPont ML,Sacchetti AD

    更新日期:1998-08-01 00:00:00

  • Emergency medical services system changes reduce pediatric epinephrine dosing errors in the prehospital setting.

    abstract:OBJECTIVE:The goal was to describe the change in the rate of epinephrine dosing errors in the treatment of pediatric patients in prehospital cardiopulmonary arrest after the Los Angeles County Emergency Medical Services Agency instituted a program in which paramedics were required to use the Broselow tape and to report...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0854

    authors: Kaji AH,Gausche-Hill M,Conrad H,Young KD,Koenig WJ,Dorsey E,Lewis RJ

    更新日期:2006-10-01 00:00:00

  • Prenatal cocaine exposure and child behavior.

    abstract:OBJECTIVE:The aim of this study was to evaluate previous teacher reports that children exposed to cocaine prenatally have more problem behaviors. METHODS:A historical, prospective design was used. Maternal subjects (n = 116) of 6-year-old singleton, term (>/=36 weeks) children, and the children's first-grade teachers ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.4.945

    authors: Delaney-Black V,Covington C,Templin T,Ager J,Martier S,Sokol R

    更新日期:1998-10-01 00:00:00

  • Effects of acutely increasing systemic vascular resistance on oxygen tension in tetralogy of Fallot.

    abstract::Effects of phenylephrine hydrochloride on the degree of hypoxia were studied in six cyanotic patients with tetralogy of Fallot. Baseline aortic and right atrial oxygen saturations, blood gas tensions, pH, and indicator-dilution curves were obtained under stable conditions. Phenylephrine was infused while systemic arte...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Nudel DB,Berman MA,Talner NS

    更新日期:1976-08-01 00:00:00

  • Preterm birth and inhaled corticosteroid use in 6- to 19-year-olds: a Swedish national cohort study.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-3083

    authors: Vogt H,Lindström K,Bråbäck L,Hjern A

    更新日期:2011-06-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Conners CK,Goyette CH,Southwick DA,Lees JM,Andrulonis PA

    更新日期:1976-08-01 00:00:00

  • Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy.

    abstract:OBJECTIVE:Knowing risk factors at birth for the development of childhood obesity could help to identify children who are in need of early obesity prevention efforts. The objective of this study was to determine whether children whose mothers were obese in early pregnancy were more likely to be obese at 2 to 4 years of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.114.1.e29

    authors: Whitaker RC

    更新日期:2004-07-01 00:00:00

  • Chronic illness and mental health problems in pediatric practice: results from a survey of primary care providers.

    abstract::The prevalence of chronic physical illnesses and their association with mental disorders was assessed using data collected by primary care pediatricians. A chronic illness was diagnosed in 1573 (15.6%) of 10,058 children aged 4 to 16 years, 945 (9.4%) of whom had a "serious" disorder, 535 (5.3%) had a minor disorder (...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Weiland SK,Pless IB,Roghmann KJ

    更新日期:1992-03-01 00:00:00

  • Impact of visual impairment on measures of cognitive function for children with congenital toxoplasmosis: implications for compensatory intervention strategies.

    abstract:OBJECTIVES:The purpose of this work was to determine whether visual impairment caused by toxoplasmic chorioretinitis is associated with impaired performance of specific tasks on standardized tests of cognitive function. If so, then we worked to determine whether there are patterns in these difficulties that provide a l...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1530

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    更新日期:2006-08-01 00:00:00

  • Detection of Kingella kingae osteoarticular infections in children by oropharyngeal swab PCR.

    abstract:OBJECTIVE:The purpose of this study was to investigate if oropharyngeal swab polymerase chain reaction (PCR) could predict osteoarticular infection (OAI) due to Kingella kingae in young children. METHODS:One hundred twenty-three consecutive children aged 6 to 48 months presenting with atraumatic osteoarticular complai...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0810

    authors: Ceroni D,Dubois-Ferriere V,Cherkaoui A,Gesuele R,Combescure C,Lamah L,Manzano S,Hibbs J,Schrenzel J

    更新日期:2013-01-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0480

    authors: Simon AE,Chan KS,Forrest CB

    更新日期:2008-01-01 00:00:00

  • Epidemiologic features of the presentation of critical congenital heart disease: implications for screening.

    abstract:OBJECTIVE:Critical congenital heart disease has been proposed as a target of newborn screening. This study aimed to define the incidence and timing of significant physiologic compromise attributable to critical congenital heart disease as well as the distribution of vulnerable lesions. These descriptive parameters must...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0421

    authors: Schultz AH,Localio AR,Clark BJ,Ravishankar C,Videon N,Kimmel SE

    更新日期:2008-04-01 00:00:00

  • Cardiac output changes in newborns with hyperbilirubinemia treated with phototherapy.

    abstract::Phototherapy is known to increase peripheral blood flow in neonates, but information on the associated cardiovascular effects is not available. Using pulsed Doppler echocardiography we evaluated cardiac output and stroke volume in 12 preterm and 13 term neonates during and after phototherapy. We concomitantly measured...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Walther FJ,Wu PY,Siassi B

    更新日期:1985-12-01 00:00:00

  • Assessment of antifungal therapy in an 800-gram infant with candidal arthritis and osteomyelitis.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ward RM,Sattler FR,Dalton AS Jr

    更新日期:1983-08-01 00:00:00

  • A national survey of pediatrician knowledge and attitudes regarding human papillomavirus vaccination.

    abstract:OBJECTIVE:A human papillomavirus vaccine was licensed in June 2006. The vaccine is quadrivalent, protecting against 2 human papillomavirus strains that cause cervical cancer and 2 that cause genital warts. The objective of this study was to determine physician characteristics, knowledge, and attitudes associated with a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1946

    authors: Daley MF,Liddon N,Crane LA,Beaty BL,Barrow J,Babbel C,Markowitz LE,Dunne EF,Stokley S,Dickinson LM,Berman S,Kempe A

    更新日期:2006-12-01 00:00:00

  • A Case of a 15-Month-Old With Periorbital Edema and Severe Anemia.

    abstract::This is the case of a previously healthy 15-month-old girl who initially presented to her primary pediatrician with a 2-week history of intermittent periorbital edema. The edema had improved by the time of the visit, and a urine specimen was unable to be obtained in the clinic. A routine fingerstick demonstrated anemi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-0391

    authors: Kamzan AD,Newcomer CA,Wozniak LJ,Federman NC,Kim LS

    更新日期:2020-03-01 00:00:00

  • Acquired immunodeficiency syndrome transmission: changes in knowledge and behaviors among teenagers, Massachusetts statewide surveys, 1986 to 1988.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Hingson R,Strunin L,Berlin B

    更新日期:1990-01-01 00:00:00

  • Helicobacter pylori infection and insulin requirement among children with type 1 diabetes mellitus.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.6.e83

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    更新日期:1999-06-01 00:00:00

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    abstract::Since the American Academy of Pediatrics published a statement titled "Infection Control in Physicians' Offices" (Pediatrics. 2000;105[6]:1361-1369), there have been significant changes that prompted this updated statement. Infection prevention and control is an integral part of pediatric practice in ambulatory medica...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2007-1734

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    更新日期:2007-09-01 00:00:00

  • Infant acceptance of breast milk after maternal exercise.

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    pub_type: 临床试验,杂志文章

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    更新日期:2002-04-01 00:00:00

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    pub_type: 杂志文章

    doi:

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    更新日期:1989-11-01 00:00:00