Abstract:
OBJECTIVE:Helicobacter pylori induces gastric inflammation and the the production of cytokines in infected individuals. Theoretically, this increased production of cytokines could be deleterious for the control of the glycemia of patients with diabetes. This study aimed to describe the insulin requirement among patients with type 1 diabetes and H pylori infection compared with uninfected counterparts. METHODS:Cross-sectional design. Demographic information (age, gender, race, annual family income, and number of individuals per room in the household) and clinical information (age at diagnosis of diabetes, duration of illness, weight, height, compliance with clinical appointments, daily insulin units per kilogram of body weight [IU/kg/d], and glycosylated hemoglobin A level) was obtained from children and adolescents with diagnosis of type 1 diabetes mellitus who were seen at Children's Hospital in New Orleans. A total of 2 mL of blood was also collected and sera were tested for H pylori-specific immunoglobulin G antibodies using an enzyme immunoassay. The daily insulin requirement among infected and uninfected children was compared, and the effect of other variables was evaluated with multiple linear regression. RESULTS:Of the 71 subjects who were evaluated (median age: 11 years), 11 (15.5%) were found to be infected. H pylori infection was more frequent among subjects who were older, who had a lower family income, and who were black. Infected children were found to require more insulin (1.2 vs 0.9 IU/Kg/d) and their glycosylated hemoglobin A level was higher (14.9 vs 11.8) than the level found in uninfected subjects. Multiple linear regression analysis identified H pylori infection duration of illness, race (black), body mass index, and gender (female), to be associated independently with increased daily insulin requirement (IU/kg/d). CONCLUSION:n our study population, children with type 1 diabetes and H pylori infection had an increased daily insulin requirement compared with the requirement of their uninfected peers. The reason for this association requires additional investigation.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Begue RE,Mirza A,Compton T,Gomez R,Vargas Adoi
10.1542/peds.103.6.e83subject
Has Abstractpub_date
1999-06-01 00:00:00pages
e83issue
6eissn
0031-4005issn
1098-4275journal_volume
103pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract::This is a summary of the presentation on airway clearance in neuromuscular disorders presented as part of the program on airway clearance in Duchenne muscular dystrophy at the 30th annual Carrell-Krusen Neuromuscular Symposium on February 20, 2008. ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2008-2952G
更新日期:2009-05-01 00:00:00
abstract::Clinicians have long recognized and attorneys have disputed that physical evidence of injury, sexually transmitted diseases, and seminal fluid are often absent in cases of child sexual abuse. To determine the frequency and significance of physical evidence in legally "proven" felony cases with penetration, a retrospec...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract:INTRODUCTION:Transfer of lead from bone to the bloodstream increases during lactation. However, the effect of maternal lead burden on growth in breastfed newborns is still unknown. This study examined early postnatal growth in a cohort of healthy breastfed newborns in relation to maternal bone lead burden. METHODS:Lea...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.5.1016
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:Current methods for early identification of cerebral white matter injury in the premature infant at the bedside are inadequate. This study investigated the utility of advanced spectral analysis of the neonatal electroencephalogram (EEG) in the early diagnosis of white matter injury in the premature infant. Th...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:10.1542/peds.111.1.27
更新日期:2003-01-01 00:00:00
abstract::Concentrations of 11 plasma proteins were measured in 28 healthy, growing, very low birth weight, appropriate-for-gestational-age infants fed varying levels of human milk protein intake (range 1.7 to 3.9 g/kg per day). Significant positive correlations were found between mean protein intake and concentrations of 7 of ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::A 1-year-old boy was admitted to the hospital with Haemophilus influenzae meningitis. On the second hospital day a heart murmur heard on admission seemed louder. No signs of congestive heart failure were present. An echocardiogram demonstrated a persistent echo-dense mass behind the anterior leaflet of the mitral valv...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-09-01 00:00:00
abstract:BACKGROUND:We reviewed the impact of HIV, HIV exposure, and antiretroviral therapy/prophylaxis on neurodevelopmental outcomes of HIV-infected and HIV-exposed-uninfected infants and children. METHODS:A literature search of Medline, Embase, PsychINFO, Web of Science, PubMed, and conference Web sites (1990-March 2011) us...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2012-0405
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:Efforts are under way to articulate environmental, psychosocial, and biological conditions that may predispose the development and maintenance of obesity. There is increasing evidence that adverse childhood experiences such as childhood abuse may be implicated in the development of obesity. Given the dearth o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-3058
更新日期:2007-07-01 00:00:00
abstract::: media-1vid110.1542/5972300121001PEDS-VA_2018-1771Video Abstract OBJECTIVES: To examine agreement between parent and adolescent reports of adolescents' suicidal thoughts and explore demographic and clinical factors associated with agreement in a large community sample. METHODS:Participants included 5137 adolescents ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-1771
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To determine if race/ethnicity-based differences exist in the management of pediatric abdominal pain in emergency departments (EDs). METHODS:Secondary analysis of data from the 2006-2009 National Hospital Ambulatory Medical Care Survey regarding 2298 visits by patients ≤ 21 years old who presented to EDs wit...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-3127
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To assess whether weight-related teasing predicts the development of binge eating, unhealthy weight control behaviors, and frequent dieting among male and female adolescents. METHODS:A prospective study was conducted with an ethnically and socioeconomically diverse sample of 2516 adolescents who completed su...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1242
更新日期:2006-02-01 00:00:00
abstract::We present a case in which human coronavirus was detected in the cerebrospinal fluid of a child presumed to have acute disseminated encephalomyelitis. In murine models, coronavirus has been found to cause a chronic demyelinating condition that resembles multiple sclerosis. Additionally, there is in vitro evidence of h...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.113.1.e73
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:Youth processed in the juvenile justice system are at great risk for early violent death. Groups at greatest risk, ie, racial/ethnic minorities, male youth, and urban youth, are overrepresented in the juvenile justice system. We compared mortality rates for delinquent youth with those for the general populati...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1459
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Substance abuse remains one of the major threats to adolescent health in Western cultures. The study aim was to ascertain the extent of association between pubertal development and early adolescent substance use. METHODS:The design was a cross-sectional survey of 10- to 15-year-old subjects in the states of ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2003-0626-F
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:Type 2 diabetes is a growing problem among adolescents, but little is known about self-management behaviors in this population. Our aim was to examine self-management behaviors and glycemic control among adolescents with type 2 diabetes. METHODS:From 2003 to 2005, a telephone survey of adolescents with type ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1484
更新日期:2008-04-01 00:00:00
abstract::Approximately 1 out of 5 children worldwide suffers from childhood malnutrition or stunting and associated health conditions, including an increased susceptibility to infections and inflammation. Due to improved early interventions, most children even in low-resource settings now survive early childhood malnutrition, ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2016-2828I
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:The National Heart, Lung, and Blood Institute Growth and Health Study (NGHS) is a 10-year study to investigate the development of obesity in black and white girls during adolescence and its environmental and psychosocial correlates. The purpose of this report was to examine changes in the annual prevalence ra...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.110.5.e54
更新日期:2002-11-01 00:00:00
abstract::Acute confusional migraine (ACM) is a dramatic, rare manifestation of migraine described mostly for children and adolescents. There are few data on the treatment of an ACM attack. Prochlorperazine has been suggested as an effective drug. The authors of some reports have suggested that valproic acid may play a role in ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-2717
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Erythropoietin therapy is effective in decreasing transfusions to varying degrees in preterm infants. Recent animal studies using erythropoietin doses to achieve serum concentrations > 1000 mU/mL report neuroprotective effects. We evaluated the relationship between erythropoietin concentrations and neurodevel...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2005-3186
更新日期:2006-09-01 00:00:00
abstract::Hyperphenylalaninemia is a variant of phenylketonuria, and debate remains as to what, if any, active management of this condition is required to preserve cognitive function and psychological well-being. This study is the first to examine longitudinally the executive function (EF) in adolescents with hyperphenylalanine...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-4200
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:Preterm infants are frequently discharged from the hospital growth retarded and show reduced growth throughout childhood. In a large efficacy and safety trial, we tested the hypothesis that nutritional intervention in the first 9 months postterm would reverse postdischarge growth deficits and improve neurode...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.108.3.703
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:Many children with human immunodeficiency virus-1 (HIV-1) have chronic problems with growth and nutrition, yet limited information is available to identify infected children at high risk for growth abnormalities. Using data from the prospective, multicenter P2C2 HIV study, we evaluated the relationships betwe...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.108.6.1287
更新日期:2001-12-01 00:00:00
abstract::Appropriate prescribing practices for fluoroquinolones, as well as all antimicrobial agents, are essential as evolving resistance patterns are considered, additional treatment indications are identified, and the toxicity profile of fluoroquinolones in children has become better defined. Earlier recommendations for sys...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2016-2706
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:The goal was to determine whether patients seen in a referral clinic are experiencing initial allergic reactions to peanuts earlier, compared with a similar population profiled at a different medical center 10 years ago, and to investigate other changes in clinical characteristics of the patients between the ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-0350
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:Methamphetamine use among pregnant women is an increasing problem in the United States. Effects of methamphetamine use during pregnancy on fetal growth have not been reported in large, prospective studies. We examined the neonatal growth effects of prenatal methamphetamine exposure in the multicenter, longitu...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2005-2564
更新日期:2006-09-01 00:00:00
abstract::Every child with failure to thrive has at least one organic medical disease: malnutrition. It is well documented that lead and other heavy metals are absorbed more readily in the presence of both malnutrition and iron deficiency anemia. Malnutrition and lead exposure tend to be found in the same population groups. Fur...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
abstract::A recent population-based study in the Canadian province of British Columbia showed that, since the mid-1960s, there has been a significant increase in the incidence of retinopathy of prematurity-induced blindness in infants weighing 750 to 999 g at birth. To determine the impact of changing birth weight-specific surv...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract::A 21-month-old previously healthy girl presented to the emergency department initially with fever, rhinorrhea, and poor oral intake. She was subsequently discharged from the hospital on amoxicillin for treatment of acute otitis media but presented hours later on the same day with continued poor oral intake, decreased ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-0412
更新日期:2019-05-01 00:00:00
abstract::Assay of ornithine transcarbamylase (OTC) activity in multiple small bits of liver (approximately 5 mg) that were obtained from a single surgical biopsy in a patient with OTC deficiency revealed a 10- to 40-fold variation in enzyme activity. Similar studies with control autopsy liver specimens varied 2.5-fold at most....
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
abstract:OBJECTIVE:Increasing numbers of parents use alternative vaccination schedules that differ from the recommended childhood vaccination schedule for their children. We sought to describe national patterns of alternative vaccination schedule use and the potential "malleability" of parents' current vaccination schedule choi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-0400
更新日期:2011-11-01 00:00:00