Abstract:
OBJECTIVE:Many children with human immunodeficiency virus-1 (HIV-1) have chronic problems with growth and nutrition, yet limited information is available to identify infected children at high risk for growth abnormalities. Using data from the prospective, multicenter P2C2 HIV study, we evaluated the relationships between maternal and infant clinical and laboratory factors and impaired growth in this cohort. METHODS:Children of HIV-1-infected women were enrolled prenatally or within the first 28 days of life. Failure to thrive (FTT) was defined as an age- and sex-adjusted weight z score < or =-2.0 SD. Maternal baseline covariates included age, race, illicit drug use, zidovudine use, CD4+ T-cell count, and smoking. Infant baseline predictors included sex, race, CD4+ T-cell count, Centers for Disease Control stage, HIV-1 RNA, antiretroviral therapy, pneumonia, heart rate, cytomegalovirus, and Epstein-Barr virus infection status. RESULTS:The study cohort included 92 HIV-1-infected and 439 uninfected children. Infected children had a lower mean gestational age, but birth weights, lengths, and head circumferences in the 2 groups were similar. Mothers of growth-delayed infants were more likely to have smoked tobacco and used illicit drugs during pregnancy. In repeated-measures analyses of weight and length or height z scores, the means of the HIV-1-infected group were significantly lower at 6 months of age (P <.001) and remained lower throughout the first 5 years of life. In a multivariable Cox regression analysis, FTT was associated with a history of pneumonia (relative risk [RR] = 8.78; 95% confidence interval [CI]: 3.59-21.44), maternal use of cocaine, crack, or heroin during pregnancy (RR = 3.17; 95% CI: 1.51-6.66), infant CD4+ T-cell count z score (RR = 2.13 per 1 SD decrease; 95% CI: 1.25-3.57), and any antiretroviral therapy by 3 months of age (RR = 2.77; 95% CI: 1.16-6.65). After adjustment for pneumonia and antiretroviral therapy, HIV-1 RNA load remained associated with FTT in the subset of children whose serum was available for viral load analysis. CONCLUSIONS:Clinical and laboratory factors associated with FTT among HIV-1-infected children include history of pneumonia, maternal illicit drug use during pregnancy, lower infant CD4+ T-cell count, exposure to antiretroviral therapy by 3 months of age (non-protease inhibitor), and HIV-1 RNA viral load.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Miller TL,Easley KA,Zhang W,Orav EJ,Bier DM,Luder E,Ting A,Shearer WT,Vargas JH,Lipshultz SE,Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group.,National Heart, Lung,doi
10.1542/peds.108.6.1287subject
Has Abstractpub_date
2001-12-01 00:00:00pages
1287-96issue
6eissn
0031-4005issn
1098-4275pii
108/6/1287journal_volume
108pub_type
杂志文章,多中心研究相关文献
PEDIATRICS文献大全abstract::A 34-day-old previously healthy boy born full term presented to the emergency department with fever at home (38.1°C), fussiness, and decreased oral intake for 1 day. He was difficult to console at home. He had decreased oral intake without emesis, diarrhea, or a change in urine output. He did not have rhinorrhea, coug...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-1406
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Dental caries is a common, chronic disease of childhood. The impact of contemporary changes in beverage patterns, specifically decreased milk intakes and increased 100% juice and soda pop intakes, on dental caries in young children is unknown. We describe associations among caries experience and intakes of da...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.3.e184
更新日期:2003-09-01 00:00:00
abstract::Controversy exists regarding the type and/or sequence of imaging studies needed during the first febrile urinary tract infection (UTI) in young children. Several investigators have claimed that because acute-phase Tc-99m dimercaptosuccinic acid (DMSA) renal-scan results are abnormal in the presence of dilating vesicou...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:10.1542/peds.2010-3460
更新日期:2011-07-01 00:00:00
abstract::Extracorporeal piezoelectric lithotripsy is an effective method for treating renal pelvic stones in children. Treatment with the Wolf lithotriptor is essentially painless and can be performed without anesthesia on an outpatient basis. Real-time ultrasound is used to localize stones. In a 1-year period at the Universit...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::Three groups of 30 Greek neonates each (an adoptive group from the Metera orphanage, a lower-class group, and a middle-class group) were evaluated at days 1, 5, and 10 after birth using a behavioral scale of 21 items and a neurologic evaluation of 16 items. Behaviors were examined for group differences and group-by-ag...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-02-01 00:00:00
abstract::Physician health and wellness is a critical issue gaining national attention because of the high prevalence of physician burnout. Pediatricians and pediatric trainees experience burnout at levels equivalent to other medical specialties, highlighting a need for more effective efforts to promote health and well-being in...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-2278
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:Medication reconciliation errors on hospital admission can lead to significant patient harm. A pediatric intermediate care unit initiated a quality improvement project and aimed to reduce errors in admission medication reconciliation by 50% in 12 months. METHODS:From August 2017 to December 2018, a multidis...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-2464
更新日期:2020-12-01 00:00:00
abstract::All physicians who care for children require a knowledge of normal growth and development in order to detect and interpret abnormalities. Yet traditional instruction tends to focus on the ill child and rarely provides students the opportunity to follow up the cases of healthy children over a prolonged period of time. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract::Compliance, or adherence, as it relates to health care is the extent to which a person's behavior coincides with medical or health advice. Medication compliance is critical for all aspects of pediatrics, specifically in successful treatment, disease prevention, and health promotion. Compliance depends on the patient's...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2004-1133
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Small pilot studies support the appropriateness of engaging adolescents with chronic or life-limiting illnesses in pediatric advance care planning (pACP). We do not yet know if pACP is acceptable, feasible, and worthwhile, even if emotionally intense, in a fully powered randomized controlled tr...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2016-1854
更新日期:2016-12-01 00:00:00
abstract::Given the pervasive use of screen-based media and the high prevalence of insufficient sleep among American youth and teenagers, this brief report summarizes the literature on electronic media and sleep and provides research recommendations. Recent systematic reviews of the literature reveal that the vast majority of s...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2016-1758J
更新日期:2017-11-01 00:00:00
abstract::National morbidity figures show a decline in reported rubella and congenital rubella syndrome since 1969, concurrent with widespread use of rubella vaccine. In addition, no nationwide outbreak, such as the 1963-1964 epidemic, has occurred, though on the basis of long-term secular trends, one would be expected between ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:To compare findings on hard copies of cranial ultrasound (US) and magnetic resonance imaging (MRI) obtained between birth and term in a group of preterm infants. PARTICIPANTS AND METHODS:Infants born at or below a gestational age of 30 weeks who underwent cranial US scan and MRI on the same day were eligible...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.4.719
更新日期:2001-04-01 00:00:00
abstract::: media-1vid110.1542/5972300121001PEDS-VA_2018-1771Video Abstract OBJECTIVES: To examine agreement between parent and adolescent reports of adolescents' suicidal thoughts and explore demographic and clinical factors associated with agreement in a large community sample. METHODS:Participants included 5137 adolescents ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-1771
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Siblings and other children who share a home with a physically abused child are thought to be at high risk for abuse, but rates of injury in these contact children are unknown and screening of contacts is highly variable. Our objective was to determine the prevalence of abusive injuries identified by a common...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-0085
更新日期:2012-08-01 00:00:00
abstract::To define predictive or contributory risk factors for pancreatitis in human immunodeficiency virus-infected children receiving dideoxyinosine (ddI), the authors evaluated 95 children, 3 months to 18 years of age, who had received ddI at 60 to 540 mg/m2 per day for a mean of 56 weeks. Pancreatitis developed in 7 patien...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Previous studies have shown an association between prematurity and attention- abstract deficit/hyperactivity disorder (ADHD). Results concerning late preterm infants are controversial, and studies examining fetal growth represented by weight for gestational age are scarce. Our objective was to examine the as...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-1043
更新日期:2015-09-01 00:00:00
abstract::Extensive data available from more than 30 years of research reveal that children raised by gay and lesbian parents have demonstrated resilience with regard to social, psychological, and sexual health despite economic and legal disparities and social stigma. Many studies have demonstrated that children's well-being is...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2013-0377
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Many preterm children display school difficulties, which may be mediated by impairment in executive function and memory. OBJECTIVE:To evaluate executive and memory function among adolescents born preterm compared with term controls at 16 years. METHODS:A total of 337 of 437 (77%) adolescents born in 1989 t...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2010-1421
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Pacifier use has been reported to be associated with a reduced risk of sudden infant death syndrome (SIDS), but most countries around the world, including the United States, have been reluctant to recommend the use of pacifiers because of concerns about possible adverse effects. This meta-analysis was underta...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:10.1542/peds.2004-2631
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:To address the "millennial morbidities," pediatricians must partner with community-based organizations to develop interventions. Little is known about the capacity of the resulting programs for program evaluation or the importance of evaluation in project success and sustainability. The objective of this stu...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-3273
更新日期:2008-09-01 00:00:00
abstract::Our specific aim was to examine the efficacy and safety of long-term cholesterol-lowering diet and bile acid-binding resin therapy in 73 children heterozygous for familial hypercholesterolemia (FH). We prospectively followed accretion of height and weight in 40 FH children for 5.8 years on diet alone and in 33 FH chil...
journal_title:Pediatrics
pub_type: 杂志文章,收录出版
doi:
更新日期:1986-08-01 00:00:00
abstract::In a randomized multicenter trial, involving the collaboration of eight European neonatal intensive care units, the efficacy of replacement therapy with a new surfactant preparation (Curosurf) was tested in 146 patients with severe neonatal respiratory distress syndrome. Criteria for entry included birth weight 700 to...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVES:To examine: 1) the relationship between residents' responses toward caring for underserved children and families during residency and their perceptions of their continuity clinic experience; and 2) which characteristics are related to continuing to care for the underserved after completion of training. DESI...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.5.1022
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:To determine whether early versus late treatment with porcine surfactant (Curosurf) reduces the requirement of mechanical ventilation in very preterm infants primarily supported by nasal continuous positive airway pressure (nasal CPAP). DESIGN:Multicenter randomized, controlled trial. PATIENTS:The study pop...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.103.2.e24
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:To compare the use of once-a-day cefpodoxime proxetil to once-a-day cefixime in the treatment of acute suppurative otitis media. DESIGN:Randomized, multicenter, investigator-blinded. SETTING:Outpatient. PATIENTS:A total of 368 patients (age 2 months to 17 years) were randomized to receive either cefpodoxim...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-12-01 00:00:00
abstract:OBJECTIVE:Newborn infants are vitamin K deficient. Vitamin K status in full-term infants after intramuscular vitamin K supplementation at birth has been described. Similar information in growing premature infants has not been reported. The objective of this study was to assess vitamin K status in premature infants by m...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.5.1117
更新日期:2001-11-01 00:00:00
abstract::The Accreditation Council for Graduate Medical Education (ACGME) established guidelines in 1989 requiring pediatric residents to attend a continuity clinic (CC) one half-day per week. OBJECTIVE. To assess pediatric residents' CCs, with an emphasis on those factors potentially affecting house staff education and patien...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract:OBJECTIVE:Past studies have documented the acute benefits of cardiac rehabilitation in children with congenital heart disease. It is not known whether these benefits persist. PATIENTS AND METHODS:Fifteen patients, ages 8 to 17 years, with complex congenital heart disease, whose exercise function immediately after a 12...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:10.1542/peds.2006-0264
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:We present a long-term safety, immunogenicity, and effectiveness study of a quadrivalent human papillomavirus (HPV4) vaccine. METHODS:Sexually naive boys and girls aged 9 to 15 years (N = 1781) were assigned (2:1) to receive HPV4 vaccine or saline placebo at day 1 and months 2 and 6. At month 30, the placeb...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2013-4144
更新日期:2014-09-01 00:00:00