Abstract:
:A 720-g premature newborn developed disseminated candidiasis during treatment with systemic antibiotics and total parenteral nutrition through an umbilical arterial catheter. Clinical features were typical for candidal skeletal infection at this age and included warmth and fusiform swelling of the lower extremities together with radiographic evidence of osteolysis and cortical bone erosion. Candida albicans was cultured from blood, urine, joint fluid, and a bone aspirate. The infection was cured with a 44-day course of amphotericin B and flucytosine (5-fluorocytosine). Antifungal therapy was monitored closely with serum drug levels and laboratory tests for bone marrow toxicity and renal dysfunction. Serum levels of both drugs were comparable to those achieved in older patients treated with similar doses. Significant concentrations of amphotericin B were detected in serum four and 17 days after completion of therapy, indicating a slow rate of elimination similar to that which occurs in adults. There was no evidence of drug-induced toxicity other than transient elevation in the fractional urinary excretion of sodium. This suggests that antifungal therapy may be effectively and safely administered to infants in dose schedules similar to those used for older patients.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Ward RM,Sattler FR,Dalton AS Jrsubject
Has Abstractpub_date
1983-08-01 00:00:00pages
234-8issue
2eissn
0031-4005issn
1098-4275journal_volume
72pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:To determine hepatitis A vaccination coverage and factors associated with not receiving hepatitis A vaccine among children. METHODS:A random cluster sample survey was conducted of parents of children who attended kindergarten in Butte County, California, in 2000. Because of a history of recurrent epidemics, ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.4.e269
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:The 2011 Pediatric Infectious Diseases Society/Infectious Diseases Society of America community-acquired pneumonia (CAP) guideline recommends narrow-spectrum antimicrobial therapy for most children hospitalized with CAP. However, few studies have assessed the effectiveness of this strategy. METHODS:Using da...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2013-1614
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine whether risks of impaired cognitive function could be predicted for children or groups of children with adenotonsillar hypertrophy who were suspected of having obstructive sleep-disordered breathing, from historical and polysomnographic variables used separately or i...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0173
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To find the time of the serum gonadotropin peak after depot leuprolide injection in children and to show that depot leuprolide therapy can be monitored by measuring serum luteinizing hormone (LH) immediately after injections. STUDY DESIGN:We measured concentrations of leuprolide, LH, and follicle-stimulating...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.109.2.e30
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:Pulse oximetry (POX) has been confirmed as a specific screening modality for critical congenital heart disease (CCHD), with moderate sensitivity. However, POX is not able to detect most serious and critical cardiac lesions (major congenital heart disease [CHD]) without hypoxemia. In this study, we investigat...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2017-1154
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:Each year, children die from heat stroke after being left unattended in motor vehicles. In 2003, the total was 42, up from a national average of 29 for the past 5 years. Previous studies found that on days when ambient temperatures exceeded 86 degrees F, the internal temperatures of the vehicle quickly reache...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-2368
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence and most common etiologies of scalp scaling in infants and prepubertal children and the specificity of head and neck lymphadenopathy for the diagnosis of tinea capitis associated with scalp scaling. DESIGN/METHODS:A cross-sectional study of 300 children, 200 from an urban general ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1616
更新日期:2005-01-01 00:00:00
abstract::Hyperphenylalaninemia is a variant of phenylketonuria, and debate remains as to what, if any, active management of this condition is required to preserve cognitive function and psychological well-being. This study is the first to examine longitudinally the executive function (EF) in adolescents with hyperphenylalanine...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-4200
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Pneumonia is a leading cause of hospitalization and readmission in children. Understanding the patient characteristics associated with pneumonia readmissions is necessary to inform interventions to reduce avoidable hospitalizations and related costs. The objective of this study was to characte...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2014-0331
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood. DESIGN:Prospective follow-up study of a randomized, double-blind, placebo-controlled trial. SETTING:National Women's Hospital (Auckland, New Zealand)...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.2004-0196
更新日期:2004-09-01 00:00:00
abstract::The recognition of fabricated illness (FI) in a child represents a diagnostic challenge. The suspicion of FI often arises from the discrepancy between laboratory tests and clinical history. For instance, (unnecessary) insulin injections by caregivers has been widely described as a common cause of factitious hypoglycem...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-4165
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:To determine the frequency of symptomatic congenital cytomegalovirus (CMV) infection in the offspring of women with a recurrent maternal CMV infection and to characterize the demographic and newborn findings. METHODS:Study subjects consisted of infants with symptomatic congenital CMV infection identified by...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.104.1.55
更新日期:1999-07-01 00:00:00
abstract::Thirty-two 5- to 17-year-old children who had severe, acute asthma were randomly assigned to receive either high doses (0.15 mg/kg of body weight per dose) or low doses (0.05 mg/kg of body weight per dose) of nebulized albuterol every 20 minutes for six doses. Compared with the low-dose regimen, the high-dose regimen ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Material hardship has been associated with adverse health care use patterns for children with special health care needs (CSHCN). In this study, we assessed if resilience factors were associated with lower emergency department (ED) visits and unmet health care needs and if they buffered associations between m...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-1975
更新日期:2020-02-01 00:00:00
abstract::Human breast milk samples were collected from lactating mothers, and aliquots were maintained at room temperature, frozen, and pasteurized. Samples were inoculated with 10 to 50 colony-forming units per milliliter (cfu/ml) of Escherichia coli or group B streptococcus, and incubated at 37 C. Quantitative growth was mea...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-04-01 00:00:00
abstract::Aerosolized racemic epinephrine, but not L-epinephrine, is commonly used in treating croup. The efficacy and adverse effects of nebulized racemic and L-epinephrine in the treatment of laryngotracheitis were compared. Children 6 months to 6 years of age with a croup score of 6 or above were assigned in a randomized dou...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-02-01 00:00:00
abstract:OBJECTIVE:The goal of this study was to determine if congenital human herpesvirus-6 (HHV-6) infection influences early neurodevelopment. METHODS:We enrolled 57 newborns with HHV-6 congenital infection and 242 control newborns without congenital infection into a prospective, double-blind study with 4 visits between 4 a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-0886
更新日期:2014-12-01 00:00:00
abstract::Children who have suffered early abuse or neglect may later present with significant health and behavior problems that may persist long after the abusive or neglectful environment has been remediated. Neurobiological research suggests that early maltreatment may result in an altered psychological and physiologic respo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-0100
更新日期:2017-04-01 00:00:00
abstract::The Haemophilus influenzae vaccine consisting of purified type b capsular polysaccharide (polyribosylribitol-phosphate [PRP]) was shown in Finland to be protective, with 90% efficacy in children older than 18 to 23 months of age. However, a wide range of estimates of vaccine efficacy has been reported in the United St...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-04-01 00:00:00
abstract::To test the commonly held premise that prematurity is a risk factor for problems of behavior and social interaction, as well as cognitive and physical development, temperament and behavior of children born preterm and full-term control subjects were compared at five separate time periods from infancy through early sch...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract::There is an increasing threat that chemical and biological weapons will be used on a civilian population in an act of domestic terrorism. Casualties among adults and children could be significant in such an event. Federal, state, and local authorities have begun extensive planning to meet a chemical-biological inciden...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.105.3.662
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Adoption and implementation of evidence-based measures for catheter care leads to reductions in central line-associated bloodstream infection (CLABSI) rates in the NICU. The purpose of this study is to evaluate whether this rate reduction is sustainable for at least 1 year and to identify key d...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-2523
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:There are not enough pediatric neurologists to meet the many needs of pediatric neurology patients. The Hospital for Sick Children has responded by expanding the nursing role in the pediatric neurology outpatient clinic. The objective of this study was to examine the use of a telephone nursing line in this ho...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.5.1083
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:To compare the effects of a single nocturnal dose of 3 honey products (eucalyptus honey, citrus honey, or labiatae honey) to placebo (silan date extract) on nocturnal cough and difficulty sleeping associated with childhood upper respiratory tract infections (URIs). METHODS:A survey was administered to paren...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2011-3075
更新日期:2012-09-01 00:00:00
abstract::Immunodeficiency-centromeric instability-facial dysmorphism syndrome, characterized by variable immunodeficiency, centromeric instability, and facial anomalies caused by epigenetic dysregulation resulting in hypomethylation, is caused in many patients by mutations in DNMT3B, a DNA methyltransferase gene; associated in...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-0640
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:More than 25 million children in the United States are dependent on federal and state medical insurance programs for their health care needs. In California, 3.25 million children depend on Medi-Cal for their health insurance. In Southern California alone, the figure is as high as 1.81 million. However, 9.30 m...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-0210
更新日期:2004-11-01 00:00:00
abstract::Bevacizumab is a human monoclonal immunoglobulin G1 antibody to vascular endothelial growth factor indicated in several adult diseases. Emerging literature and expert opinion support the off-label use of intravitreal bevacizumab in the treatment of retinopathy of prematurity (ROP), a common disease process seen in pre...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-1814
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:CHARGE (coloboma, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, ear anomalies/deafness) syndrome and chromosome 22q11.2 deletion syndrome are known to have significant clinical overlap including cardiac anomalies, ear abnormalities, hearing loss, developmental delay, ren...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-3400
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To determine whether an adequate volume of sweat could be obtained routinely from infants younger than 6 weeks old and to evaluate sweat chloride levels in infants with known genotype statuses, including heterozygote carriers for cystic fibrosis (CF). METHODOLOGY:Infants were evaluated using pilocarpine iont...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::One of the most divisive issues in pediatrics today concerns the proper response by pediatricians to parents who refuse routine childhood immunizations for their children. Many pediatricians refuse to care for such families. Others continue to provide care and continue to try to convince parents that the benefits of i...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-1597
更新日期:2016-10-01 00:00:00