Hypertension and Neuroimaging Changes After Bevacizumab for Retinopathy of Prematurity.

Abstract:

:Bevacizumab is a human monoclonal immunoglobulin G1 antibody to vascular endothelial growth factor indicated in several adult diseases. Emerging literature and expert opinion support the off-label use of intravitreal bevacizumab in the treatment of retinopathy of prematurity (ROP), a common disease process seen in premature neonates. One of the most common side effects of systemic therapy in adults is hypertension; however, this has not been well described in infants receiving bevacizumab for ROP. In this report, we review a case of a former 25-week premature infant treated for stage 3 ROP with administration of intravitreal bevacizumab. The immediate posttreatment course was uncomplicated; however, at 10 days posttreatment, he developed new-onset systemic hypertension. In addition, neuroimaging revealed new areas of vasogenic edema, which improved over time. To the best of our knowledge and after a review of the literature, neither of these effects has been described in neonates after intravitreal bevacizumab for ROP.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Twitty G,Weiss M,Albayram MS,O'Mara K,Mowitz ME

doi

10.1542/peds.2019-1814

subject

Has Abstract

pub_date

2020-01-01 00:00:00

issue

1

eissn

0031-4005

issn

1098-4275

pii

peds.2019-1814

journal_volume

145

pub_type

杂志文章
  • Developmental Assessments in Preterm Children: A Meta-analysis.

    abstract:CONTEXT:Developmental outcomes of very preterm (gestational age ≤32 weeks) or very low birth weight (<1500 g) children are commonly reported before age 3 years although the predictive validity for later outcomes are uncertain. OBJECTIVE:To determine the validity of early developmental assessments in predicting school-...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.2016-0251

    authors: Wong HS,Santhakumaran S,Cowan FM,Modi N,Medicines for Neonates Investigator Group.

    更新日期:2016-08-01 00:00:00

  • Infection in the first 2 years of life and autism spectrum disorders.

    abstract:OBJECTIVE:The purpose of this work was to investigate the association between infections in the first 2 years and subsequent diagnosis of autism spectrum disorders. METHODS:We conducted a case-control study among children born at Kaiser Permanente Northern California from 1995 to 1999. Case subjects (n = 403) were chi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1788

    authors: Rosen NJ,Yoshida CK,Croen LA

    更新日期:2007-01-01 00:00:00

  • Treatment of apnea of prematurity with aminophylline.

    abstract::The effectiveness of aminophylline in the treatment of apnea of prematurity was evaluated in 13 premature infants (mean birthweight, 1.13 kg; mean gestational age, 29 weeks). Apnea was recorded by direct observation in combination with impedance monitoring. Rectal suppositories of aminophylline (5 mg) were given at si...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bednarek FJ,Roloff DW

    更新日期:1976-09-01 00:00:00

  • Evaluation and treatment of the human immunodeficiency virus-1--exposed infant.

    abstract::In developed countries, care and treatment are available for pregnant women and infants that can decrease the rate of perinatal human immunodeficiency virus type 1 (HIV-1) infection to 2% or less. The pediatrician has a key role in prevention of mother-to-child transmission of HIV-1 by identifying HIV-exposed infants ...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.114.2.497

    authors: King SM,American Academy of Pediatrics Committee on Pediatric AIDS.,American Academy of Pediatrics Infectious Diseases and Immunization Committee.

    更新日期:2004-08-01 00:00:00

  • Children riding in the back of pickup trucks: a neglected safety issue.

    abstract::Motor vehicle-related trauma is the leading cause of death in children in the United States. All states have pediatric restraint requirements for passenger vehicles to help prevent these deaths and injuries. Only a few states, however, possess safety laws or restrictions for passengers who ride in the back of pickup t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Woodward GA,Bolte RG

    更新日期:1990-11-01 00:00:00

  • Determination of cerebral death in the pediatric intensive care unit.

    abstract::The clinical course, laboratory data, outcome, and autopsy findings in 61 pediatric patients with suspected brain death were reviewed. In 58% of patients, the initial EEG was isoelectric, and cerebral blood flow was absent. In six of nine children, the initial EEG, which showed activity, became isoelectric by 72 hours...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Drake B,Ashwal S,Schneider S

    更新日期:1986-07-01 00:00:00

  • Improving Access to Care at Autism Treatment Centers: A System Analysis Approach.

    abstract:OBJECTIVE:The prevalence of autism spectrum disorder is steadily increasing and placing more demands on already overburdened diagnostic and treatment systems. A thoughtful, systematic reorganization of autism service delivery may reduce delays and better meet the growing need. METHODS:Two clinical centers in the Autis...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-2851M

    authors: Austin J,Manning-Courtney P,Johnson ML,Weber R,Johnson H,Murray D,Ratliff-Schaub K,Tadlock AM,Murray M

    更新日期:2016-02-01 00:00:00

  • Sexual history documentation in adolescent emergency department patients.

    abstract:OBJECTIVES:To determine the frequency of physician-documented sexual histories in female adolescents who presented to an emergency department (ED) with symptoms suggestive of a sexually transmitted infection (STI). Our secondary objectives were to determine if physician-documented sexual history is associated with incr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-1775

    authors: Goyal M,McCutcheon M,Hayes K,Mollen C

    更新日期:2011-07-01 00:00:00

  • Breast-feeding incidence and duration in black and white women.

    abstract::The influence of sociodemographic factors on the incidence and duration of breast-feeding was evaluated in 668 black and 511 white women delivering their first child in the metropolitan Washington, DC, area. Breast-feeding rates were 84% among white and 49% among black women. Maternal educational level was strongly as...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kurinij N,Shiono PH,Rhoads GG

    更新日期:1988-03-01 00:00:00

  • Sleep duration and adolescent obesity.

    abstract:OBJECTIVES:Short sleep has been associated with adolescent obesity. Most studies used a cross-sectional design and modeled BMI categories. We sought to determine if sleep duration was associated with BMI distribution changes from age 14 to 18. METHODS:Adolescents were recruited from suburban high schools in Philadelph...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-2368

    authors: Mitchell JA,Rodriguez D,Schmitz KH,Audrain-McGovern J

    更新日期:2013-05-01 00:00:00

  • Trends in mortality and morbidity for very low birth weight infants, 1991-1999.

    abstract:BACKGROUND:Medical care for very low birth weight (VLBW) infants and their mothers has changed dramatically during the 1990s, yet it is unclear how these changes have affected mortality and morbidity. OBJECTIVE:We used the Vermont Oxford Network Database to identify trends in clinical practice and patient outcomes for...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.110.1.143

    authors: Horbar JD,Badger GJ,Carpenter JH,Fanaroff AA,Kilpatrick S,LaCorte M,Phibbs R,Soll RF,Members of the Vermont Oxford Network.

    更新日期:2002-07-01 00:00:00

  • Motivational Interviewing to Treat Overweight Children: 24-Month Follow-Up of a Randomized Controlled Trial.

    abstract:BACKGROUND:Pediatrician-led motivational interviewing can be an effective way of controlling BMI in overweight children in the short term. Its long-term efficacy is unknown. The primary aim was to determine whether the short-term (12-month) impact of family pediatrician-led motivational interviews on the BMI of overwei...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2015-1979

    authors: Broccoli S,Davoli AM,Bonvicini L,Fabbri A,Ferrari E,Montagna G,Panza C,Pinotti M,Storani S,Tamelli M,Candela S,Bellocchio E,Giorgi Rossi P

    更新日期:2016-01-01 00:00:00

  • Mirrored symptoms in mother and child with chronic fatigue syndrome.

    abstract:OBJECTIVE:Our aim with this study was to assess the relation between chronic fatigue syndrome in adolescents and fatigue and associated symptoms in their fathers and mothers, more specifically the presence of chronic fatigue syndrome-like symptoms and psychologic distress. METHOD:In this cross-sectional study, 40 adol...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2307

    authors: van de Putte EM,van Doornen LJ,Engelbert RH,Kuis W,Kimpen JL,Uiterwaal CS

    更新日期:2006-06-01 00:00:00

  • Not everything in the maxillary sinus is sinusitis: a case of a dentigerous cyst.

    abstract::A 4-year-old girl presented to a medical clinic with a painless right facial swelling. The treating physician ordered a radiograph of the sinuses and received a report of "maxillary sinusitis." After appropriate antibiotic treatment, the facial swelling increased, and the mother took the child to her community pediatr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1940

    authors: Haber R

    更新日期:2008-01-01 00:00:00

  • Osteonecrosis of the hip (Legg-Calvé-Perthes disease) in human immunodeficiency virus-infected children.

    abstract:OBJECTIVE:Osteonecrosis of the hip has been reported in human immunodeficiency virus (HIV)-infected adults; whether this is related to HIV infection or its treatment is unknown. There has been 1 report of osteonecrosis among HIV-infected children. Specifically, avascular necrosis of the hip consistent with Legg-Calvé-P...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.5.e74

    authors: Gaughan DM,Mofenson LM,Hughes MD,Seage GR 3rd,Ciupak GL,Oleske JM,Pediatric AIDS Clinical Trials Group Protocol 219 Team.

    更新日期:2002-05-01 00:00:00

  • Serial immune markers do not correlate with clinical exacerbations in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections.

    abstract:OBJECTIVE:Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections is hypothesized to be a poststreptococcal autoimmune disorder. If clinical exacerbations are triggered by a streptococcal infection that activates cross-reacting antibodies against neuronal tissue or alters the production...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2658

    authors: Singer HS,Gause C,Morris C,Lopez P,Tourette Syndrome Study Group.

    更新日期:2008-06-01 00:00:00

  • Dietary Fats and Atherosclerosis From Childhood to Adulthood.

    abstract:BACKGROUND:The association of dietary fat distribution with markers of subclinical atherosclerosis during early life is unknown. We examined whether success in achieving the main target of an infancy-onset dietary intervention based on the distribution of dietary fat was associated with aortic and carotid intima-media ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2019-2786

    authors: Laitinen TT,Nuotio J,Rovio SP,Niinikoski H,Juonala M,Magnussen CG,Jokinen E,Lagström H,Jula A,Viikari JSA,Rönnemaa T,Simell O,Raitakari OT,Pahkala K

    更新日期:2020-04-01 00:00:00

  • Treatment of chronic childhood asthma with beclomethasone dipropionate aerosols: II. Effect on pituitary-adrenal function after substitution for oral corticosteroids.

    abstract::The effects of beclomethasone, dipropionate aerosol (DBA) (400 microgram/day) on clinical course, pulmonary function, and pituitary-adrenal function was studied in 34 steroid-dependent asthmatic children. Asthma severity was assessed by daily symptom and medication scores, peak flow measured three times a day, and wee...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Kershnar H,Klein R,Waldman D,Berger W,Rachelefsky G,Katz R,Siegel S

    更新日期:1978-08-01 00:00:00

  • Recurring digital fibrous tumors of childhood: a review.

    abstract::Two new cases that conform to the clinical and histopathological features of recurring digital fibrous tumor of childhood, described by Reye in 1965, are reported. This tumor, which is considered a distinct entity among the juvenile fibromatoses, characteristically presents in infancy and early childhood, involves onl...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Beckett JH,Jacobs AH

    更新日期:1977-03-01 00:00:00

  • Urinary beta 2-microglobulin in full-term newborns: evidence for proximal tubular dysfunction in infants with meconium-stained amniotic fluid.

    abstract::Urinary concentrations of beta 2-microglobulin (beta 2M) and creatinine were measured in normal term infants and in those born with meconium-stained amniotic fluid. None of the infants or their mothers had conditions known to modify beta 2M excretion. Measurements of beta 2M were made on urines collected by bagging; u...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Cole JW,Portman RJ,Lim Y,Perlman JM,Robson AM

    更新日期:1985-12-01 00:00:00

  • Neurologic history and examination results and their relationship to human immunodeficiency virus type 1 serostatus in hemophilic subjects: results from the hemophilia growth and development study.

    abstract::In a prospective study of the growth and neuropsychologic function of hemophilic subjects, 333 boys, median age of 12.3 years, had baseline neurologic examinations. The study population included 207 individuals (62%) who were seropositive for human immunodeficiency virus type 1 (HIV-1). Overall results indicated that ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Bale JF Jr,Contant CF,Garg B,Tilton A,Kaufman DM,Wasiewski W

    更新日期:1993-04-01 00:00:00

  • The effects of multisystemic therapy on diabetes stress among adolescents with chronically poorly controlled type 1 diabetes: findings from a randomized, controlled trial.

    abstract:OBJECTIVE:The goal of this study was to determine whether multisystemic therapy (MST), an intensive, home-based psychotherapy, could decrease diabetes-related stress among adolescents with chronically poorly controlled type 1 diabetes. Stress was also evaluated as a mediator of the effect of MST on adherence and metabo...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2005-0638

    authors: Ellis DA,Frey MA,Naar-King S,Templin T,Cunningham PB,Cakan N

    更新日期:2005-12-01 00:00:00

  • Foreign body granuloma of the external auditory canal.

    abstract::External auditory canal polyps are most commonly inflammatory in nature but may also manifest more severe disease. Prolonged conservative therapy may delay the correct diagnosis and appropriate intervention. A case is presented of a child with chronic otorrhea treated for 4 months with topical drops and antibiotics. O...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.4.e371

    authors: Harris KC,Conley SF,Kerschner JE

    更新日期:2004-04-01 00:00:00

  • Reduced endothelial progenitor cells in children with hemodialysis but not predialysis chronic kidney disease.

    abstract::In adults with chronic kidney disease (CKD), reduced levels of vasculoprotective endothelial progenitor cells (EPCs) may contribute to their increased risk of cardiovascular disease. Children with CKD also show signs of cardiovascular disease. However, to our knowledge, there have been no studies on circulating EPC le...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-3346

    authors: Jie KE,Lilien MR,Goossens MH,Westerweel PE,Klein MK,Verhaar MC

    更新日期:2010-10-01 00:00:00

  • Recent advances in management and treatment of hereditary angioedema.

    abstract:CONTEXT:Hereditary angioedema (HAE) is a rare autosomal-dominant disease characterized by recurrent self-limiting episodes of skin and mucosal edema. Morbidity and mortality are significant, and new and pending therapies are now available to reduce the risk associated with the disease. OBJECTIVE:To update the reader o...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2011-0546

    authors: Sardana N,Craig TJ

    更新日期:2011-12-01 00:00:00

  • Obesity and Mortality Risk in Critically Ill Children.

    abstract:BACKGROUND AND OBJECTIVES:Childhood obesity is epidemic and may be associated with PICU mortality. Using a large multicenter PICU database, we investigated the association between obesity and PICU mortality, adjusting for initial severity of illness. We further investigated whether height- and weight-based classificati...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2015-2035

    authors: Ross PA,Newth CJ,Leung D,Wetzel RC,Khemani RG

    更新日期:2016-03-01 00:00:00

  • Comparison of urinary lactic dehydrogenase with antibody-coated bacteria in the urine sediment as means of localizing the site of urinary tract infection.

    abstract::Two noninvasive methods of localizing the site of urinary tract infection, urinary lactic dehydrogenase (LDH) isoenzymes and antibody coating of bacteria in the urinary sediment, have been prospectively compared with the bladder washout technique in a series of children with urinary tract infection. Fifteen children h...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lorentz WB Jr,Resnick MI

    更新日期:1979-11-01 00:00:00

  • The emergency physician and the office-based pediatrician: an EMSC team. American Academy of Pediatrics. Committee on Pediatric Emergency Medicine.

    abstract::In a quality and cost-conscious health care environment, the pediatrician and emergency physician must work as a team. This statement clarifies important issues of this relationship, including coordination of patient care, communication between clinicians, provision of continuity care, and responsibility for quality e...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.5.936

    authors:

    更新日期:1998-05-01 00:00:00

  • The Questionnaire for Identifying Children with Chronic Conditions: a measure based on a noncategorical approach.

    abstract:OBJECTIVE:To report on the development of the Questionnaire for Identifying Children with Chronic Conditions (QuICCC). This new instrument identifies children and adolescents who have chronic health conditions based on the noncategorical conceptual framework outlined in our earlier work. It uses the consequences of con...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.99.4.513

    authors: Stein RE,Westbrook LE,Bauman LJ

    更新日期:1997-04-01 00:00:00

  • Identifying and treating a substandard housing cluster using a medical-legal partnership.

    abstract:BACKGROUND AND OBJECTIVE:There is a documented connection between the home environment and health. Medical-legal partnerships (MLPs) can address social and environmental determinants of health. Our objective was to describe a cluster of substandard housing identified and treated by an MLP based in a pediatric primary c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0769

    authors: Beck AF,Klein MD,Schaffzin JK,Tallent V,Gillam M,Kahn RS

    更新日期:2012-11-01 00:00:00