Abstract:
:Bevacizumab is a human monoclonal immunoglobulin G1 antibody to vascular endothelial growth factor indicated in several adult diseases. Emerging literature and expert opinion support the off-label use of intravitreal bevacizumab in the treatment of retinopathy of prematurity (ROP), a common disease process seen in premature neonates. One of the most common side effects of systemic therapy in adults is hypertension; however, this has not been well described in infants receiving bevacizumab for ROP. In this report, we review a case of a former 25-week premature infant treated for stage 3 ROP with administration of intravitreal bevacizumab. The immediate posttreatment course was uncomplicated; however, at 10 days posttreatment, he developed new-onset systemic hypertension. In addition, neuroimaging revealed new areas of vasogenic edema, which improved over time. To the best of our knowledge and after a review of the literature, neither of these effects has been described in neonates after intravitreal bevacizumab for ROP.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Twitty G,Weiss M,Albayram MS,O'Mara K,Mowitz MEdoi
10.1542/peds.2019-1814subject
Has Abstractpub_date
2020-01-01 00:00:00issue
1eissn
0031-4005issn
1098-4275pii
peds.2019-1814journal_volume
145pub_type
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