Urinary beta 2-microglobulin in full-term newborns: evidence for proximal tubular dysfunction in infants with meconium-stained amniotic fluid.

Abstract:

:Urinary concentrations of beta 2-microglobulin (beta 2M) and creatinine were measured in normal term infants and in those born with meconium-stained amniotic fluid. None of the infants or their mothers had conditions known to modify beta 2M excretion. Measurements of beta 2M were made on urines collected by bagging; urines obtained from diapers were not satisfactory. Urinary beta 2M concentrations increased significantly (P less than .02) in the normal infants from the first day (0.36 +/- 0.29 mg/L: n = 29) to the third day (0.60 +/- 0.43 mg/L: n = 21) postpartum. Compared with the normal infants, values for the infants with meconium-stained amniotic fluid were increased significantly on days 1 (1.64 +/- 2.16 mg/L: n = 25: P less than .005) and 3 (2.12 +/- 2.04 mg/L: n = 23: P less than .005). Levels exceeded two standard deviations above the normal mean in 12 of the 26 infants with meconium-stained amniotic fluid on postpartum day 1, and 12 of the 23 infants with meconium-stained amniotic fluid on day 3. Urinary creatinine levels were similar in both the normal infants and those with meconium-stained amniotic fluid. All infants with meconium-stained amniotic fluid with a one-minute Apgar score of 6 or less had an elevated urinary beta 2M concentration. The elevated levels of urinary beta 2M in infants with meconium-stained amniotic fluid indicate the existence of tubular dysfunction, probably mild acute tubular necrosis secondary to hypoxia.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Cole JW,Portman RJ,Lim Y,Perlman JM,Robson AM

subject

Has Abstract

pub_date

1985-12-01 00:00:00

pages

958-64

issue

6

eissn

0031-4005

issn

1098-4275

journal_volume

76

pub_type

杂志文章
  • Association of race and ethnicity with management of abdominal pain in the emergency department.

    abstract:OBJECTIVE:To determine if race/ethnicity-based differences exist in the management of pediatric abdominal pain in emergency departments (EDs). METHODS:Secondary analysis of data from the 2006-2009 National Hospital Ambulatory Medical Care Survey regarding 2298 visits by patients ≤ 21 years old who presented to EDs wit...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-3127

    authors: Johnson TJ,Weaver MD,Borrero S,Davis EM,Myaskovsky L,Zuckerbraun NS,Kraemer KL

    更新日期:2013-10-01 00:00:00

  • Clinical disease caused by Klebsiella in 2 unrelated patients with interleukin 12 receptor beta1 deficiency.

    abstract::Patients with interleukin 12 (IL-12)p40 or IL-12 receptor β1 (IL12Rβ1) deficiencies are prone to develop infections caused by mycobacteria and salmonella; other infections have only been rarely observed. In this report we describe 2 unrelated patients with complete autosomal recessive IL12Rβ1 deficiency who suffered f...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2504

    authors: Pedraza S,Lezana JL,Samarina A,Aldana R,Herrera MT,Boisson-Dupuis S,Bustamante J,Pages P,Casanova JL,Picard C

    更新日期:2010-10-01 00:00:00

  • Weight Growth Velocity and Postnatal Growth Failure in Infants 501 to 1500 Grams: 2000-2013.

    abstract:BACKGROUND:Very low birth weight infants often gain weight poorly and demonstrate growth failure during the initial hospitalization. Although many of the major morbidities experienced by these infants during their initial NICU stays have decreased in recent years, it is unclear whether growth has improved. METHODS:We ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2015-0129

    authors: Horbar JD,Ehrenkranz RA,Badger GJ,Edwards EM,Morrow KA,Soll RF,Buzas JS,Bertino E,Gagliardi L,Bellù R

    更新日期:2015-07-01 00:00:00

  • Respiratory Management of the Patient With Duchenne Muscular Dystrophy.

    abstract::In 2010, Care Considerations for Duchenne Muscular Dystrophy, sponsored by the Centers for Disease Control and Prevention, was published in Lancet Neurology, and in 2018, these guidelines were updated. Since the publication of the first set of guidelines, survival of individuals with Duchenne muscular dystrophy has in...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2018-0333H

    authors: Sheehan DW,Birnkrant DJ,Benditt JO,Eagle M,Finder JD,Kissel J,Kravitz RM,Sawnani H,Shell R,Sussman MD,Wolfe LF

    更新日期:2018-10-01 00:00:00

  • A multiple-source method for studying the prevalence of developmental disabilities in children: the Metropolitan Atlanta Developmental Disabilities Study.

    abstract::The Metropolitan Atlanta Developmental Disabilities Study is the first US, population-based epidemiologic study of the prevalence of mental retardation, cerebral palsy, hearing impairment, and visual impairment among school-age children. The study population consisted of children who were 10 years of age between 1985 ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Yeargin-Allsopp M,Murphy CC,Oakley GP,Sikes RK

    更新日期:1992-04-01 00:00:00

  • A Multifaceted Approach to Improving Outcomes in the NICU: The Pediatrix 100 000 Babies Campaign.

    abstract:BACKGROUND AND OBJECTIVE:Despite advances in neonatal medicine, infants requiring neonatal intensive care continue to experience substantial morbidity and mortality. The purpose of this initiative was to generate large-scale simultaneous improvements in multiple domains of care in a large neonatal network through a pro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-0389

    authors: Ellsbury DL,Clark RH,Ursprung R,Handler DL,Dodd ED,Spitzer AR

    更新日期:2016-04-01 00:00:00

  • Long-term follow-up care for pediatric cancer survivors.

    abstract::Progress in therapy has made survival into adulthood a reality for most children, adolescents, and young adults diagnosed with cancer today. Notably, this growing population remains vulnerable to a variety of long-term therapy-related sequelae. Systematic ongoing follow-up of these patients, therefore, is important fo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-3688

    authors: American Academy of Pediatrics Section on Hematology\/Oncology Children's Oncology Group.

    更新日期:2009-03-01 00:00:00

  • Gender and uninsurance among young adults in the United States.

    abstract:OBJECTIVE:Although one third of young adults in the United States are uninsured, lack of insurance in this age group has been the subject of few published studies. Because opportunities to obtain public and private insurance are likely to differ for men and women, the objective of this study was to describe the gender-...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.2.291

    authors: Callahan ST,Cooper WO

    更新日期:2004-02-01 00:00:00

  • Hemoglobin S and C traits: contributing causes for decreased mean hematocrit in African-American children.

    abstract::Several nutritional surveys have shown that African-American children have lower mean hematocrit and hemoglobin values than white children. While the high prevalence of both alpha and beta thalassemias in African-American children can partly account for the lower hematologic values, the remaining differences cannot be...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Rana SR,Sekhsaria S,Castro OL

    更新日期:1993-04-01 00:00:00

  • Duration of poverty and child health in the Quebec Longitudinal Study of Child Development: longitudinal analysis of a birth cohort.

    abstract:OBJECTIVES:The objective of this study was to examine the relationship between duration of poverty and the health of preschool children in the Quebec Longitudinal Study of Child Development birth cohort. METHODS:Data from the Quebec Longitudinal Study of Child Development for 1950 children who were followed annually u...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1750

    authors: Séguin L,Nikiéma B,Gauvin L,Zunzunegui MV,Xu Q

    更新日期:2007-05-01 00:00:00

  • Technology Use for Adolescent Health and Wellness.

    abstract::As avid users of technology, adolescents are a key demographic to engage when designing and developing technology applications for health. There are multiple opportunities for improving adolescent health, from promoting preventive behaviors to providing guidance for adolescents with chronic illness in supporting treat...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2019-2056G

    authors: Radovic A,Badawy SM

    更新日期:2020-05-01 00:00:00

  • The emergency physician and the office-based pediatrician: an EMSC team. American Academy of Pediatrics. Committee on Pediatric Emergency Medicine.

    abstract::In a quality and cost-conscious health care environment, the pediatrician and emergency physician must work as a team. This statement clarifies important issues of this relationship, including coordination of patient care, communication between clinicians, provision of continuity care, and responsibility for quality e...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.5.936

    authors:

    更新日期:1998-05-01 00:00:00

  • Hearing assessment in infants and children: recommendations beyond neonatal screening.

    abstract::Congenital or acquired hearing loss in infants and children has been linked with lifelong deficits in speech and language acquisition, poor academic performance, personal-social maladjustments, and emotional difficulties. Identification of hearing loss through neonatal hearing screening, regular surveillance of develo...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2009-1997

    authors: Harlor AD Jr,Bower C,Committee on Practice and Ambulatory Medicine.,Section on Otolaryngology-Head and Neck Surgery.

    更新日期:2009-10-01 00:00:00

  • Ketonic diet in the management of pyruvate dehydrogenase deficiency.

    abstract::Two brothers, aged 11 years 6 months and 2 years 3 months, with psychomotor and growth retardation, episodes of weakness, ataxia, ophthalmoplegia, and elevated levels of blood pyruvate were shown to have a deficiency in the pyruvate dehydrogenase complex (PDH). When they ate a diet high enough in fats to cause ketonem...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Falk RE,Cederbaum SD,Blass JP,Gibson GE,Kark RA,Carrel RE

    更新日期:1976-11-01 00:00:00

  • Empyema hospitalizations increased in US children despite pneumococcal conjugate vaccine.

    abstract:OBJECTIVE:To determine if the incidence of empyema among children in the United States has changed since the introduction of the pneumococcal conjugate vaccine in 2000. METHODS:We used the nationally representative Kids' Inpatient Database to estimate the annual total number of hospitalizations of children < or = 18 y...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-0184

    authors: Li ST,Tancredi DJ

    更新日期:2010-01-01 00:00:00

  • Neurodevelopmental outcomes of extremely low birth weight infants exposed prenatally to dexamethasone versus betamethasone.

    abstract:OBJECTIVE:We compared the development of adverse neurodevelopmental outcomes at corrected ages of 18 to 22 months for extremely low birth weight infants exposed prenatally to dexamethasone, betamethasone, or no steroid. METHODS:Study infants were extremely low birth weight (401-1000 g) infants who were in the care of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-1103

    authors: Lee BH,Stoll BJ,McDonald SA,Higgins RD,National Institute of Child Health and Human Development Neonatal Research Network.

    更新日期:2008-02-01 00:00:00

  • Lack of pediatric drug formulations.

    abstract::Many drugs frequently used in infants and young children are not available in suitable dosage forms. Liquid dosage forms must be prepared extemporaneously, while using appropriate excipients. However, it is critical to determine the stability of various drugs at clinically important concentrations and practical storag...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Nahata MC

    更新日期:1999-09-01 00:00:00

  • Lowered electroencephalographic spectral edge frequency predicts the presence of cerebral white matter injury in premature infants.

    abstract:OBJECTIVE:Current methods for early identification of cerebral white matter injury in the premature infant at the bedside are inadequate. This study investigated the utility of advanced spectral analysis of the neonatal electroencephalogram (EEG) in the early diagnosis of white matter injury in the premature infant. Th...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.111.1.27

    authors: Inder TE,Buckland L,Williams CE,Spencer C,Gunning MI,Darlow BA,Volpe JJ,Gluckman PD

    更新日期:2003-01-01 00:00:00

  • Ophthalmia neonatorum: a chart review.

    abstract::Cases of ophthalmia neonatorum diagnosed at Grady Memorial Hospital 1967-1973 were reviewed. Of 302 cases 43 could be diagnosed as gonococcal, 86 chlamydial, 3 gonococcal and chlamydial, 31 staphylococcal, and 5 chemical. Silver nitrate prophylaxis was routinely employed. Gonococcal cases peaked during the third quart...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Armstrong JH,Zacarias F,Rein MF

    更新日期:1976-06-01 00:00:00

  • Treatment of plastic bronchitis in a Fontan patient with tissue plasminogen activator: a case report and review of the literature.

    abstract::Plastic bronchitis is a condition in which large, bronchial casts with rubber-like consistency develop in the tracheobronchial tree and cause airway obstruction. We describe a 4-year-old girl who had Fontan physiology and who developed plastic bronchitis and report for the first time the use of aerosolized tissue plas...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.109.4.e67

    authors: Costello JM,Steinhorn D,McColley S,Gerber ME,Kumar SP

    更新日期:2002-04-01 00:00:00

  • Prolonged neonatal jaundice and the diagnosis of biliary atresia: a single-center analysis of trends in age at diagnosis and outcomes.

    abstract::Age at diagnosis is a modifiable risk factor in outcomes after hepatoportoenterostomy in biliary atresia; however, distinguishing biliary atresia from other more common causes of prolonged neonatal jaundice can be difficult. To focus attention on diagnosis of biliary atresia, we analyzed secular trends in the age at d...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2709

    authors: Wadhwani SI,Turmelle YP,Nagy R,Lowell J,Dillon P,Shepherd RW

    更新日期:2008-05-01 00:00:00

  • Recognition of a Kawasaki disease shock syndrome.

    abstract:OBJECTIVE:We sought to define the characteristics that distinguish Kawasaki disease shock syndrome from hemodynamically normal Kawasaki disease. METHODS:We collected data prospectively for all patients with Kawasaki disease who were treated at a single institution during a 4-year period. We defined Kawasaki disease sh...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-1871

    authors: Kanegaye JT,Wilder MS,Molkara D,Frazer JR,Pancheri J,Tremoulet AH,Watson VE,Best BM,Burns JC

    更新日期:2009-05-01 00:00:00

  • Comparison of urinary lactic dehydrogenase with antibody-coated bacteria in the urine sediment as means of localizing the site of urinary tract infection.

    abstract::Two noninvasive methods of localizing the site of urinary tract infection, urinary lactic dehydrogenase (LDH) isoenzymes and antibody coating of bacteria in the urinary sediment, have been prospectively compared with the bladder washout technique in a series of children with urinary tract infection. Fifteen children h...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lorentz WB Jr,Resnick MI

    更新日期:1979-11-01 00:00:00

  • Two pediatric cases of variant neurogenic stress cardiomyopathy after intracranial hemorrhage.

    abstract::Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy, is an acquired form of left ventricular systolic dysfunction seen in the setting of physiologic stress and the absence of coronary artery disease. It is thought to be caused by excessive sympathetic stimulation. It is well described in the adult li...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-1881

    authors: Wittekind SG,Yanay O,Johnson EM,Gibbons EF

    更新日期:2014-10-01 00:00:00

  • Is my child normal yet? Correlates of vulnerability.

    abstract::There are some children whose parents believe them to be unusually susceptible to medical or developmental problems--"vulnerable"--despite a lack of objective evidence of any difficulty. The "vulnerable child syndrome" refers to a constellation of behaviors that are thought to develop as a result of this excessive par...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Perrin EC,West PD,Culley BS

    更新日期:1989-03-01 00:00:00

  • Isolation of toxin producing Clostridium difficile from two children with oxacillin- and dicloxacillin-associated diarrhea.

    abstract::Clostridium difficile was isolated from the feces of two infants who had developed watery diarrhea with blood-tinged stain. One child suffered from diarrhea after five days of parenteral oxacillin therapy; the diarrhea subsided within three days of cessation of therapy. The other infant developed diarrhea following fo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Brook I

    更新日期:1980-06-01 00:00:00

  • First-week protein and energy intakes are associated with 18-month developmental outcomes in extremely low birth weight infants.

    abstract:OBJECTIVE:We sought to evaluate the association between early protein and energy intake and neurodevelopment and growth of extremely low birth weight (<1000 g) infants. STUDY DESIGN:Daily protein and energy intakes were collected by chart review for the first 4 weeks of life on 148 extremely low birth weight survivors...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-0211

    authors: Stephens BE,Walden RV,Gargus RA,Tucker R,McKinley L,Mance M,Nye J,Vohr BR

    更新日期:2009-05-01 00:00:00

  • A systematic review of treatments for infant colic.

    abstract:OBJECTIVE:To conduct a systematic review of rigorously evaluated treatments for infant colic. METHODS:Online bibliographic databases were searched for the term "colic" in articles classified as clinical trials or randomized controlled trials and conducted in infants. Reference lists from review articles, meta-analyses...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:

    authors: Garrison MM,Christakis DA

    更新日期:2000-07-01 00:00:00

  • Severe renal osteodystrophy without elevated serum immunoreactive parathyroid hormone concentrations in hypomagnesemia due to renal magnesium wasting.

    abstract::An 8 1/2-year-old girl presented with a long history of seizures, growth retardation, muscle weakness, gait disturbance, and hearing loss. Her evaluation revealed chronic moderate renal failure (serum creatinine 2.2 mg/dL), severe hypocalcemia (5 mg/dL), hyperphosphatemia (8.1 mg/dL), hypomagnesemia (1.5 mg/dL), incre...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Zelikovic I,Dabbagh S,Friedman AL,Goelzer ML,Chesney RW

    更新日期:1987-03-01 00:00:00

  • Herpes simplex virus central nervous system relapse during treatment of infantile spasms with corticotropin.

    abstract::Here we report an infant who had herpes simplex virus (HSV) encephalitis and sustained severe bilateral damage to the posterior frontal lobes, postcentral gyri, and the thalami despite intravenous acyclovir treatment. At 7 months of age, the patient developed infantile spasms and was treated with corticotropin injecti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1867

    authors: Bonkowsky JL,Filloux FM,Byington CL

    更新日期:2006-05-01 00:00:00