Abstract:
:Patients with interleukin 12 (IL-12)p40 or IL-12 receptor β1 (IL12Rβ1) deficiencies are prone to develop infections caused by mycobacteria and salmonella; other infections have only been rarely observed. In this report we describe 2 unrelated patients with complete autosomal recessive IL12Rβ1 deficiency who suffered from sepsis attributable to Klebsiella pneumoniae. A Mexican boy suffered from disseminated bacille Calmette-Guérin disease and infections caused by K pneumoniae and Candida albicans and had a fatal outcome. A Turkish girl living in France suffered from disseminated Nocardia nova infection and K pneumoniae sepsis. Therefore, Klebsiella infections should be considered in patients with IL12Rβ1 deficiency. Conversely, IL12Rβ1 deficiency should be considered in patients with unexplained klebsiellosis.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Pedraza S,Lezana JL,Samarina A,Aldana R,Herrera MT,Boisson-Dupuis S,Bustamante J,Pages P,Casanova JL,Picard Cdoi
10.1542/peds.2009-2504subject
Has Abstractpub_date
2010-10-01 00:00:00pages
e971-6issue
4eissn
0031-4005issn
1098-4275pii
peds.2009-2504journal_volume
126pub_type
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