Isolation of toxin producing Clostridium difficile from two children with oxacillin- and dicloxacillin-associated diarrhea.

Abstract:

:Clostridium difficile was isolated from the feces of two infants who had developed watery diarrhea with blood-tinged stain. One child suffered from diarrhea after five days of parenteral oxacillin therapy; the diarrhea subsided within three days of cessation of therapy. The other infant developed diarrhea following four days of oral dicloxacillin; the diarrhea subsided within two days of cessation of therapy. C difficile was no longer detectable in the stools of the infants at that time. Tissue culture assay showed the presence of preformed fecal toxin and demonstrated the toxigenicity of the fecal isolates of C. difficile and reference strains. These findings show that C difficile may play a role in diarrhea associated with oxacillin and dicloxacillin in children.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Brook I

subject

Has Abstract

pub_date

1980-06-01 00:00:00

pages

1154-6

issue

6

eissn

0031-4005

issn

1098-4275

journal_volume

65

pub_type

杂志文章
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