Abstract:
BACKGROUND:The relation between smoke exposure in early life, the prenatal period in particular, and the vascular development of young children is largely unknown. METHODS:Data from the birth cohort participating in the WHISTLER-Cardio study were used to relate the smoking of parents during pregnancy to subsequent vascular properties in their children. In 259 participating children who turned 5 years of age, parental smoking data were updated and children's carotid artery intima-media thickness (CIMT) and arterial wall distensibility were measured by using ultrasonography. RESULTS:Children of mothers who had smoked throughout pregnancy had 18.8 μm thicker CIMT (95% confidence interval [CI] 1.1, 36.5, P = .04) and 15% lower distensibility (95% CI -0.3, -0.02, P = .02) after adjustment for child's age, maternal age, gender, and breastfeeding. The associations were not found in children of mothers who had not smoked in pregnancy but had smoked thereafter. The associations were strongest if both parents had smoked during pregnancy, with 27.7 μm thicker CIMT (95% CI 0.2, 55.3) and 21% lower distensibility (95% CI -0.4, -0.03). CONCLUSION:Exposure of children to parental tobacco smoke during pregnancy affects their arterial structure and function in early life.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Geerts CC,Bots ML,van der Ent CK,Grobbee DE,Uiterwaal CSdoi
10.1542/peds.2011-0249subject
Has Abstractpub_date
2012-01-01 00:00:00pages
45-54issue
1eissn
0031-4005issn
1098-4275pii
peds.2011-0249journal_volume
129pub_type
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