Abstract:
OBJECTIVE:To study the effect of dexamethasone in preterm infants with chronic lung disease (CLD) on antibody response to routine immunization against diphtheria, tetanus, and pertussis (DTP). METHODS:Serum samples were obtained before and after immunization with DTP (Trivax-AD) from an unselected cohort of 93 preterm infants in the United Kingdom. Antibodies to diphtheria and tetanus and to 4 pertussis antigens (pertussis toxin, filamentous hemagglutinin, pertactin, and fimbrial agglutinogens 2 + 3) were measured by an enzyme-linked immunosorbent assay. Linear regression models were fitted to the natural log of antibody titers to compare the dexamethasone-treated and -untreated infants adjusting for potential risk factors. RESULTS:Sixty-seven (72%) of 93 infants received dexamethasone. Preimmunization geometric mean titers (GMTs) were comparable in both groups for all antibodies. The rise in GMT after immunization was reduced in the dexamethasone-treated group. Final GMT was significantly lower for tetanus, diphtheria, pertussis toxin, and fimbrial agglutinogens 2 + 3 but not for filamentous hemagglutinin or pertactin. Using the minimum protective titer of 0.01 IU/mL, there was no significant reduction in protection for diphtheria and tetanus in the dexamethasone-treated infants. Using the higher reference titer of 0.1 IU/mL, there was a 16% reduction in protection for diphtheria (95% confidence interval: 3%-27%) and a 9% reduction in protection for tetanus (95% confidence interval: -7% to 20%). CONCLUSIONS:The use of dexamethasone for CLD in preterm infants is associated with a reduction in antibody titer to routine immunization against diphtheria and tetanus. Antibody responses to 2 of 4 pertussis antigens are reduced, but the clinical significance of this observation is unclear. Protection against tetanus and diphtheria is not impaired when the lower reference value for protective antibody is used. On the basis of this study of UK preterm infants who were treated with dexamethasone for the management of CLD, we conclude that the current DTP immunization schedule is adequate and do not recommend additional booster protection against tetanus or diphtheria during early infancy. When diphtheria prevalence is increased, however, additional protection should be considered.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Robinson MJ,Heal C,Gardener E,Powell P,Sims DGdoi
10.1542/peds.113.4.733subject
Has Abstractpub_date
2004-04-01 00:00:00pages
733-7issue
4eissn
0031-4005issn
1098-4275journal_volume
113pub_type
杂志文章,多中心研究相关文献
PEDIATRICS文献大全abstract::After passage of the Patient Protection and Affordable Care Act, more children and young adults have become insured and have benefited from health care coverage than at any time since the creation of the Medicaid program in 1965. From 2009 to 2015, the uninsurance rate for children younger than 19 years fell from 9.7%...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-2098
更新日期:2017-09-01 00:00:00
abstract::We are reporting a previously well 5-year-old child with varicella-zoster meningitis who had a history of a previous immunization against varicella. This child also developed a transient sensorineural hearing loss. The child was treated with acyclovir and made a full recovery. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.114.2.e273
更新日期:2004-08-01 00:00:00
abstract::Children who have suffered early abuse or neglect may later present with significant health and behavior problems that may persist long after the abusive or neglectful environment has been remediated. Neurobiological research suggests that early maltreatment may result in an altered psychological and physiologic respo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-0100
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:We sought to document health-related quality of life (HRQoL) impairment and depressive symptomatology in adolescents with extreme obesity considering surgical weight loss. STUDY DESIGN:A retrospective review of clinical data was conducted for 33 consecutive extremely obese adolescents presenting for evaluati...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1141
更新日期:2006-04-01 00:00:00
abstract::A workgroup meeting on the use of family history information in pediatric primary care and public health sponsored by the National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention was held February 24 to 25, 2006. The workgroup participants met to discuss how to ...
journal_title:Pediatrics
pub_type:
doi:10.1542/peds.2007-1010H
更新日期:2007-09-01 00:00:00
abstract::A 4-month-old boy with past medical history of eczema presented with fever and cough; a chest radiograph showed lung consolidation, and he was initially treated with amoxicillin for presumed community-acquired pneumonia. After several days, his fever persisted. He was also profoundly anemic. Antibiotic coverage was br...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-3856
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to determine the attitudes of a variety of health care providers toward the recommendations that should be made to parents regarding the resuscitation of infants who are born at the margins of viability. METHODS:A written questionnaire was distributed to the medical and nursi...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2006-0913O
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To review systematically and to summarize the existing literature regarding performance of rapid diagnostic tests for urinary tract infection (UTI) in children. DESIGN:Systematic review and meta-analysis. METHODS:Published articles reporting the performance of urine dipstick tests (leukocyte esterase [LE] a...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:10.1542/peds.104.5.e54
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVES:Severe neonatal jaundice is a common clinical manifestation of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and the most difficult to manage; kernicterus is not an uncommon outcome. We assessed in healthy, direct Coombs test-negative Greek newborns of >/=38 weeks' gestational age 1) the current burd...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.1.25
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:The goal of this investigation was to determine how current parenteral nutrition and enteral nutrition practice intentions for preterm infants compare with published recommendations and previous feeding practices. METHODS:A survey of feeding strategies for 3 preterm infant weight groups was sent to NICU dire...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-3644
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To establish the diagnostic profile in children who present with cyclic vomiting. METHODS:We studied 225 children < 18 years of age who presented to our pediatric gastroenterology service from 1986 to 1997 with at least three discrete episodes of vomiting between which they were well. To determine the diagno...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.3.583
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:The goal was to describe the epidemiological features of physical education (PE)-related injuries treated in US emergency departments. METHODS:A retrospective analysis was conducted with data for children and adolescents (5-18 years of age) from the National Electronic Injury Surveillance Study of the US Con...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-3843
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:Pediatric obstructive sleep apnea syndrome (OSAS) is associated with neurocognitive and endothelial dysfunction. However, it is unclear whether these 2 frequent morbidities of OSAS in children represent similar or different underlying pathophysiological processes, because they have never been concurrently ass...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-0688
更新日期:2010-11-01 00:00:00
abstract::The Child Abuse Recognition Experience Study revealed that primary care clinicians did not always follow the legal mandate to report suspected child abuse to child protective services. National child abuse experts representing different disciplines met in a 2-day conference in January 2007 to discuss and develop new s...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-0715c
更新日期:2008-09-01 00:00:00
abstract::Fertility preservation in prepubertal and young adolescent girls scheduled for chemotherapy is a demanding situation. Despite the recent impressive improvements of ovarian cortex cryopreservation, significant limitations persist. The technique remains experimental, it exposes the girl to the risks of surgery and to an...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-0291
更新日期:2016-10-01 00:00:00
abstract::The American Academy of Pediatrics (AAP) supports development and universal implementation of a comprehensive electronic infrastructure to support pediatric information functions of the medical home. These functions include (1) timely and continuous management and tracking of health data and services over a patient's ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2011-0454
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:In 2006, routine immunization of US infants against rotavirus was initiated. We assessed national, regional, and local trends in rotavirus testing and detection before and after vaccine introduction. METHODS:We examined data for July 2000 through June 2008 from a national network of approximately 70 US labo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-3528
更新日期:2009-08-01 00:00:00
abstract::Chylothorax, the accumulation of chyle in the pleural space, is a relatively rare cause of pleural effusion in children. It can cause significant respiratory morbidity, as well as lead to malnutrition and immunodeficiency. Thus, a chylothorax requires timely diagnosis and treatment. This review will first discuss the ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2013-2072
更新日期:2014-04-01 00:00:00
abstract::Foreign body ingestion is a potentially serious clinical problem in children. We report a case of an 8-month-old infant who developed complete bowel obstruction requiring laparotomy due to ingestion of a superabsorbent polymer ball with advertised growth up to 400 times its original size. Most ingested foreign bodies ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-3685
更新日期:2012-10-01 00:00:00
abstract::One of the most difficult ethical dilemmas in pediatrics today arises when a child has complex chronic conditions that are not curable and cause discomfort with no prospect of any improvement on quality of life. In the context of medical futility, it is harmful to prolong medical treatment. The question is: How can me...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-0548
更新日期:2015-03-01 00:00:00
abstract::Anaphylaxis presents in children with rapid involvement of typically 2 or more organ systems including cutaneous, gastrointestinal, and respiratory. Caustic ingestions (CI) may also present with acute involvement of cutaneous, gastrointestinal, and respiratory systems. We present 2 cases of "missed diagnosis" that ill...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2014-2394
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:4-Aminopyridine (4-AP) is a potassium channel blocker used to increase muscle strength in the treatment of demyelinating diseases such as multiple sclerosis. We describe a case of ingestion by an 8-month-old child that resulted in severe but transient symptoms. CASE REPORT:An 8-month-old boy was found wit...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.111.1.e82
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:We tested the hypothesis that survival is highest for infants born in the same weight range whether mothers are adolescent or adult, comparing the weights at which infants of these mothers achieve lowest neonatal mortality. METHODS:The relationship between birth weight and neonatal mortality was studied in b...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the prevalence of severe fatigue in adolescent boys and girls, to explore the role of lifestyle factors in fatigue, and to investigate whether severe fatigue in a healthy population is associated with depression, anxiety, and comorbid factors also observed in chronic...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-2575
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Primary disabilities in children prenatally exposed to alcohol have a major impact on their daily life. It is suggested that these issues persist into adulthood, but few studies have addressed the outcome in adults with prenatal exposure, especially those with fetal alcohol syndrome (FAS). The ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-1915
更新日期:2015-01-01 00:00:00
abstract::The 863 patients, aged 10 years and younger, treated at the Children's Chest Clinic of Bellevue Hospital during three decades (1953 through 1981) clearly indicated the success of antituberculosis therapy. There were no deaths from tuberculosis. Early treatment is associated with a reduction in the serious forms of dis...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract:CONTEXT:Intranasal dexmedetomidine (IND) is an emerging agent for procedural distress in children. OBJECTIVE:To explore the effectiveness of IND for procedural distress in children. DATA SOURCES:We performed electronic searches of Medline (1946-2019), Embase (1980-2019), Google Scholar (2019), Cumulative Index to Nur...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-1623
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Despite the fact that 20% of sudden infant death syndrome (SIDS) deaths occur in child care settings, many child care providers continue to be unaware of the association of SIDS and infant sleep position and/or are misinformed as to the risks and benefits of the various sleep positions. The objective of this ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.4.878
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:We aimed to investigate differences in upper and lower respiratory tract symptoms in relation to respiratory viral infections detected with polymerase chain reaction assays in young children with cystic fibrosis and healthy control subjects. METHODS:In a 6-month winter period, 20 young children with cystic f...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-3139
更新日期:2008-12-01 00:00:00
abstract::Much of medical education remains teacher centered, as exemplified by the continued emphasis on lectures. Increasingly, however, the importance of the learner is being recognized and acknowledged in medical school curricula. The distinction between teaching and learning is also an issue for graduate medical education;...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00