Symptomatic liver involvement in neonatal hereditary hemorrhagic telangiectasia.

Abstract:

:High-flow hepatic vascular anomalies with arteriovenous shunting commonly manifest during the neonatal period with signs and symptoms of congestive heart failure, but to our knowledge, they have never been described in patients with hereditary hemorrhagic telangiectasia (HHT). We report here our experience with 3 patients with hepatic arteriovenous malformations (AVMs) who presented with symptoms of high-output congestive heart failure during the neonatal period and were subsequently diagnosed with HHT. Imaging showed large hypervascular lesions and multiple hepatic arteriovenous shunts that differentiated these lesions from liver hemangiomas. Transcatheter embolization was performed in all cases. One infant died of sepsis shortly after embolization; follow-up at the age of 2.5 years of the surviving infants revealed involution of the vascular lesions and no evidence of symptom recurrence. We conclude that severe symptoms related to hepatic AVMs in HHT can occur in the neonatal period and that HHT should therefore be included in the differential diagnosis of symptomatic neonatal hepatic vascular malformations. Imaging plays a key role in differentiating hepatic AVMs from hemangiomas, because the latter require additional pharmacologic treatments. Early transcatheter embolization seems to be effective, but long-term outcomes still need to be assessed.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Al-Saleh S,John PR,Letarte M,Faughnan ME,Belik J,Ratjen F

doi

10.1542/peds.2010-2366

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

e1615-20

issue

6

eissn

0031-4005

issn

1098-4275

pii

peds.2010-2366

journal_volume

127

pub_type

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